Management of COVID-19 myopericarditis with reversal of cardiac dysfunction after blunting of cytokine storm: a case report.

Background:Coronavirus disease 2019 (COVID-19) is a syndrome that has been associated with multiple cardiac complications including myopericarditis. The pathophysiology and treatment for myopericarditis in the setting of COVID-19 infection is still under investigation. Case summary:We present a case of a 60-year-old male admitted for dyspnoea due to COVID-19. He developed new ST-segment elevation, elevated cardiac enzymes, severe left ventricular dysfunction, and high inflammatory markers in the setting of haemodynamic and respiratory collapse from the viral illness. He was diagnosed with COVID-19-induced myopericarditis. He showed rapid clinical improvement with a rapid wean off pressure support, resolution of electrocardiogram (ECG) findings, and recovery of left ventricular systolic function following treatment with intravenous immunoglobulin (IVIG) and methylprednisolone. Discussion:COVID-19\u27s complex and devastating complications continue to create new challenges for clinicians. Cardiac complications, specifically, have been shown to be a signal for worse prognosis in these patients. IVIG and steroids can inhibit the inflammatory cascade and decrease myocardial injury, with implications in treatment of severe myopericarditis

Discussions about the landscape of possibilities for treatments of cosmic inflation involving continuous spontaneous localization models

In this work we consider a wide variety of alternatives opened when applying the continuous spontaneous localization (CSL) dynamical collapse theory to the inflationary era. The definitive resolution of many of the issues discussed here will have to await, not only for a general relativistic CSL theory, but for a fully workable theory of quantum gravity. Our concern here is to explore these issues, and to warn against premature conclusions. This exploration includes: two different approaches to deal with quantum field theory and gravitation, the identification of the collapse-generating operator and the general nature and values of the parameters of the CSL theory. All the choices connected with these issues have the potential to dramatically alter the conclusions one can draw. We also argue that the incompatibilities found in a recent paper, between the CSL parameter values and the cosmic microwave background observational data, are associated with specific choices made for the extrapolation to the cosmological context of the CSL theory (as it is known to work in non-relativistic laboratory situations) which do not represent the most natural ones.Fil: Bengochea, Gabriel Roman. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Leon Garcia, Gabriel. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Área Física Teórica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Pearle, Philip. Hamilton College; Estados UnidosFil: Sudarsky, Daniel. Universidad Nacional Autónoma de México. Instituto de Ciencias Nucleares; Méxic

Statin pretreatment diminishes the levels of myocardial ischemia markers not only in CABG

A response to Ege E, Dereli Y, Kurban S, Sarigul A: Atorvastatin pretreatment diminishes the levels of myocardial ischemia markers early after CABG operation: an observational study. J Cardiothorac Surg 2010, 5:60

Cosmology with Hu-Sawicki gravity in Palatini Formalism

Cosmological models based on f(R)-gravity may exhibit a natural acceleration mechanism without introducing a dark energy component. In this paper, we investigate cosmological consequences of the so-called Hu-Sawicki f(R)-gravity in the Palatini formalism. We derive theoretical constraints on the model parameters and perform a statistical analysis to determine the parametric space allowed by current observational data. We find that this class of models is indistinguishable from the standard \Lambda CDM model at the background level. Differently, from previous results in the metric approach, we show that these scenarios are able to produce the sequence of radiation-dominated, matter-dominated, and accelerating periods without need of dark energy.Comment: 7 pages, 3 figures, LaTeX. arXiv admin note: substantial text overlap with arXiv:1012.394

Hippocampal–anterior thalamic pathways for memory: uncovering a network of direct and indirect actions

This review charts recent advances from a variety of disciplines that create a new perspective on why the multiple hippocampal–anterior thalamic interconnections are together vital for human episodic memory and rodent event memory. Evidence has emerged for the existence of a series of parallel temporal–diencephalic pathways that function in a reciprocal manner, both directly and indirectly, between the hippocampal formation and the anterior thalamic nuclei. These extended pathways also involve the mammillary bodies, the retrosplenial cortex and parts of the prefrontal cortex. Recent neuropsychological findings reveal the disproportionate importance of these hippocampal–anterior thalamic systems for recollective rather than familiarity-based recognition, while anatomical studies highlight the precise manner in which information streams are kept separate but can also converge at key points within these pathways. These latter findings are developed further by electrophysiological stimulation studies showing how the properties of the direct hippocampal–anterior thalamic projections are often opposed by the indirect hippocampal projections via the mammillary bodies to the thalamus. Just as these hippocampal–anterior thalamic interactions reflect an interdependent system, so it is also the case that pathology in one of the component sites within this system can induce dysfunctional changes to distal sites both directly and indirectly across the system. Such distal effects challenge more traditional views of neuropathology as they reveal how extensive covert pathology might accompany localised overt pathology, and so impair memory

Complements alimentaris: control oficial

Complements alimentaris; Control oficial; Guia; Seguretat alimentàriaComplementos alimenticios; Control oficial ; Guia; Seguridad alimentariaFood supplements; Official controls; Guide; Food safetyAquesta publicació pretén donar una visió general del control oficial dels complements alimentaris a Catalunya mitjançant el recull de les diferents fonts normatives i documentals existents relatives als complements alimentaris, amb la finalitat principal de tenir una eina de suport al personal de l’Agència de Salut Pública de Catalunya, així com a altres administracions i professionals del sector. A més, amb l’elaboració d’aquesta guia es vol ajudar a entendre què són els complements alimentaris i donar a conèixer què es fa des de les administracions públiques per mantenir la seguretat alimentària. El document s’estructura en diversos apartats, que inclouen la inscripció al registre sanitari de les empreses que comercialitzen complements alimentaris, la notificació d’aquests complements i la normativa aplicable, sense deixar d’aprofundir en aspectes relacionats amb la composició, l’envasament, l’etiquetatge, els contaminants i els criteris microbiològics. Aquesta guia inclou taules de consulta per identificar els ingredients que intervenen en la composició dels complements alimentaris i un protocol per a la revisió de l’etiquetatge correcte. Índe