1,386 research outputs found

    Superdiffusive and Subdiffusive Exceptional Times in the Dynamical Discrete Web

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    The dynamical discrete web is a system of one-dimensional coalescing random walks that evolves in an extra dynamical time parameter. At any deterministic dynamical time, the paths behave as coalescing simple symmetric random walks. This paper studies the existence of (random) exceptional dynamical times at which the paths violate certain almost sure properties of random walks. It was shown in 2009 by Fontes, Newman, Ravishankar and Schertzer that there exist exceptional times at which the path starting from the origin violates the law of the iterated logarithm. Their results gave exceptional times at which the path is slightly subdiffusive in one direction. This paper extends this to obtain times at which the path is slightly superdiffusive in one direction and times at which the path is slightly subdiffusive in both directions. We also obtain upper and lower bounds for the Hausdorff dimensions of the sets of two-sided subdiffusive exceptional times, and a lower bound for the Hausdorff dimension of set of superdiffusive exceptional times.Comment: Accepted for publication in Stoch. Proc. Appli

    UV-B perceived by the UVR8 photoreceptor inhibits plant thermomorphogenesis

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    Small increases in ambient temperature can elicit striking effects on plant architecture, collectively termed thermomorphogenesis [1]. In Arabidopsis thaliana, these include marked stem elongation and leaf elevation, responses that have been predicted to enhance leaf cooling [ 2, 3, 4 and 5]. Thermomorphogenesis requires increased auxin biosynthesis, mediated by the bHLH transcription factor PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) [ 6, 7 and 8], and enhanced stability of the auxin co-receptor TIR1, involving HEAT SHOCK PROTEIN 90 (HSP90) [9]. High-temperature-mediated hypocotyl elongation additionally involves localized changes in auxin metabolism, mediated by the indole-3-acetic acid (IAA)-amido synthetase Gretchen Hagen 3 (GH3).17 [10]. Here we show that ultraviolet-B light (UV-B) perceived by the photoreceptor UV RESISTANCE LOCUS 8 (UVR8) [11] strongly attenuates thermomorphogenesis via multiple mechanisms inhibiting PIF4 activity. Suppression of thermomorphogenesis involves UVR8 and CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1)-mediated repression of PIF4 transcript accumulation, reducing PIF4 abundance. UV-B also stabilizes the bHLH protein LONG HYPOCOTYL IN FAR RED (HFR1), which can bind to and inhibit PIF4 function. Collectively, our results demonstrate complex crosstalk between UV-B and high-temperature signaling. As plants grown in sunlight would most likely experience concomitant elevations in UV-B and ambient temperature, elucidating how these pathways are integrated is of key importance to the understanding of plant development in natural environments

    Evidence for down-regulation of beta-2-adreno-ceptors in cirrhotic patients with severe ascites

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    The density and affinity of beta-2-adrenoceptors on mononuclear cells from peripheral blood were studied in fifteen patients with cirrhosis of different severity and in thirteen controls. There was no significant difference between cirrhotic patients and controls in density or affinity of beta-2 binding sites. Within the cirrhotic group, however, the number of binding sites per cell was significantly lower in patients with severe ascites than in patients with mild to moderate or no ascites. This down-regulation of beta-adrenoceptors could influence the haemodynamic response to beta-blockers

    Testing For Nonlinearity Using Redundancies: Quantitative and Qualitative Aspects

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    A method for testing nonlinearity in time series is described based on information-theoretic functionals -- redundancies, linear and nonlinear forms of which allow either qualitative, or, after incorporating the surrogate data technique, quantitative evaluation of dynamical properties of scrutinized data. An interplay of quantitative and qualitative testing on both the linear and nonlinear levels is analyzed and robustness of this combined approach against spurious nonlinearity detection is demonstrated. Evaluation of redundancies and redundancy-based statistics as functions of time lag and embedding dimension can further enhance insight into dynamics of a system under study.Comment: 32 pages + 1 table in separate postscript files, 12 figures in 12 encapsulated postscript files, all in uuencoded, compressed tar file. Also available by anon. ftp to santafe.edu, in directory pub/Users/mp/qq. To be published in Physica D., [email protected]

    Plant capitalism and company science: the Indian career of Nathaniel Wallich

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    The career of the Danish-born botanist Nathaniel Wallich, superintendent of the Calcutta Botanic Garden from 1815 to 1846, illustrates the complex nature of botanical science under the East India Company and shows how the plant life of South Asia was used as a capital resource both in the service of the Company's economic interests and for Wallich's own professional advancement and international reputation. Rather than seeing him as a pioneer of modern forest conservation or an innovative botanist, Wallich's attachment to the ideology of ‘improvement’ and the Company's material needs better explain his longevity as superintendent of the Calcutta garden. Although aspects of Wallich's career and botanical works show the importance of circulation between Europe and India, more significant was the hierarchy of knowledge in which indigenous plant lore and illustrative skill were subordinated to Western science and in which colonial science frequently lagged behind that of the metropolis

    Learner Perspective on English Pronunciation Teaching in an EFL Context

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    On the basis of the findings, the learners do not seem to have aspirations to native-like pronunciation, but rather aim at achieving intelligible and fluent speech. Only few reported an accent preference (British or American). The primary level learners expressed satisfaction with the amount of pronunciation teaching, whereas most of the lower and upper secondary level learners claimed that pronunciation teaching was insufficient. Despite their criticisms of their pronunciation teaching, the learners reported that they had learnt English pronunciation at school. In addition, many of the learners described learning pronunciation outside school, e.g. through media and personal encounters

    Sex-specific effects of N-acetylcysteine in neonatal rats treated with hypothermia after severe hypoxia-ischemia

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    AbstractApproximately half of moderate to severely hypoxic-ischemic (HI) newborns do not respond to hypothermia, the only proven neuroprotective treatment. N-acetylcysteine (NAC), an antioxidant and glutathione precursor, shows promise for neuroprotection in combination with hypothermia, mitigating post-HI neuroinflammation due to oxidative stress. As mechanisms of HI injury and cell death differ in males and females, sex differences must be considered in translational research of neuroprotection. We assessed the potential toxicity and efficacy of NAC in combination with hypothermia, in male and female neonatal rats after severe HI injury. NAC 50mg/kg/d administered 1h after initiation of hypothermia significantly decreased iNOS expression and caspase 3 activation in the injured hemisphere versus hypothermia alone. However, only females treated with hypothermia +NAC 50mg/kg showed improvement in short-term infarct volumes compared with saline treated animals. Hypothermia alone had no effect in this severe model. When NAC was continued for 6 weeks, significant improvement in long-term neuromotor outcomes over hypothermia treatment alone was observed, controlling for sex. Antioxidants may provide insufficient neuroprotection after HI for neonatal males in the short term, while long-term therapy may benefit both sexes

    Disguising Superman: how glasses affect unfamiliar face matching

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    Could a simple pair of glasses really fool us into thinking Superman and Clark Kent are two different people? Here, we investigated the perception of identity from face images with a task that relies on visual comparison rather than memory. Participants were presented with two images simultaneously and were asked whether the images depicted the same person or two different people. The image pairs showed neither image with glasses, both images with glasses, and ‘mixed’ pairs of one image with and one without glasses. Participants’ accuracies, measured by both percentage correct and d′ sensitivity, were significantly lower for ‘mixed’ trials. Analysis of response bias showed that when only one face wore glasses, people tended to respond ‘different’. We demonstrate that glasses affect face matching ability using unconstrained images, and this has implications for both disguise research and authenticating identity in the real world
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