730 research outputs found
Zur Frage der Integration qualitativer und quantitativer Forschung in der Psychologie: eine EinfĂŒhrung und ein Diskussionsbeitrag
"In dem erweiterten Editorial zum Schwerpunktteil
âDie Integration qualitativer
und quantitativer Forschung (IQQF) in
der Psychologieâ werden zunĂ€chst fĂŒnf aktuelle,
genuine IQQF-Konzeptionen vorgestellt
und hinsichtlich ihrer Perspektiven
auf Grenzen und Möglichkeiten von Integrationsdesigns
verglichen. Hierbei wird
ein besonderes Augenmerk auf die Frage
gerichtet, welche dieser Designs fĂŒr die
Psychologie als eher unproblematisch und
welche als besonders herausfordernd zu
bewerten sind; als zu letzterer zugehörig
wird die gleichrangige Integration von
qualitativen und quantitativen Ergebnissen
zu einer Forschungsfrage identifiziert.
Speziell dazu wird ein Disposition-Sinn-
Modell vorgeschlagen, anhand dessen sich
zukĂŒnftige Entwicklungsmöglichkeiten
von mixed methods in der Psychologie diskutieren
lassen. Das Editorial schlieĂt mit
einer Ăbersicht der im Schwerpunktteil
versammelten BeitrÀge, die als Beispiele
fĂŒr in der Psychologie gĂ€ngigen IQQFVarianten
stehen und Anregungen bieten
fĂŒr die weiterfĂŒhrende Methodenentwicklung
in der psychologischen Forschung." (Autorenreferat)"This extended editorial introduces into the
special issue on âThe integration of qualitative
and quantitative research (IQQR) in
psychologyâ and also presents a genuine
contribution to the debate. We begin with a
brief description of five current methodological
conceptions on IQQR provided in the
literature and compare them concerning
their specific perspectives on chances and
limitations of mixed methods designs.
Herein, we give our attention to the question
of which of these designs may be easily
adopted by psychological research and
which, in contrast, may be particularly challenging.
As a good example of the latter we
identify designs in which qualitative and
quantitative research findings are integrated
in an approach that attaches equal
value to both methodological strands. Specifically
to this point, we then propose a
Disposition-Meaning-Model which we use in
order to discuss the chances of the future
development of mixed methods in psychology.
This editorial ends with a brief presentation
of the papers contributing to this special
issue and with the recommendation to
make use of their thematic and methodological
diversity for the further development
of methods in psychological research." (author's abstract
In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients
The present study was performed to investigate the capability of gemcitabine and pemetrexed to synergistically interact with respect to cytotoxicity and apoptosis in T24 and J82 bladder cancer cells, and to establish a correlation between drug activity and gene expression of selected genes in tumour samples. The interaction between gemcitabine and pemetrexed was synergistic; indeed, pemetrexed favoured gemcitabine cytotoxicity by increasing cellular population in S-phase, reducing Akt phosphorylation as well as by inducing the expression of a major gemcitabine uptake system, the human equilibrative nucleoside transporter-1 (hENT1), and the key activating enzyme deoxycytidine kinase (dCK) in both cell lines. Bladder tumour specimens showed an heterogeneous gene expression pattern and patients with higher levels of dCK and hENT1 had better response. Moreover, human nucleoside concentrative transporter-1 was detectable only in 3/12 patients, two of whom presented a complete response to gemcitabine. These data provide evidence that the chemotherapeutic activity of the combination of gemcitabine and pemetrexed is synergistic against bladder cancer cells in vitro and that the assessment of the expression of genes involved in gemcitabine uptake and activation might be a possible determinant of bladder cancer response and may represent a new tool for treatment optimization
Search for Kaluza-Klein Graviton Emission in Collisions at TeV using the Missing Energy Signature
We report on a search for direct Kaluza-Klein graviton production in a data
sample of 84 of \ppb collisions at = 1.8 TeV, recorded
by the Collider Detector at Fermilab. We investigate the final state of large
missing transverse energy and one or two high energy jets. We compare the data
with the predictions from a -dimensional Kaluza-Klein scenario in which
gravity becomes strong at the TeV scale. At 95% confidence level (C.L.) for
=2, 4, and 6 we exclude an effective Planck scale below 1.0, 0.77, and 0.71
TeV, respectively.Comment: Submitted to PRL, 7 pages 4 figures/Revision includes 5 figure
Measurement of the average time-integrated mixing probability of b-flavored hadrons produced at the Tevatron
We have measured the number of like-sign (LS) and opposite-sign (OS) lepton
pairs arising from double semileptonic decays of and -hadrons,
pair-produced at the Fermilab Tevatron collider. The data samples were
collected with the Collider Detector at Fermilab (CDF) during the 1992-1995
collider run by triggering on the existence of and candidates
in an event. The observed ratio of LS to OS dileptons leads to a measurement of
the average time-integrated mixing probability of all produced -flavored
hadrons which decay weakly, (stat.)
(syst.), that is significantly larger than the world average .Comment: 47 pages, 10 figures, 15 tables Submitted to Phys. Rev.
Measurement of the Ratio of Branching Fractions B(D0 -> K+ pi-)/B(D0 -> K- pi+) using the CDF II Detector
We present a measurement of R_B, the ratio of the branching fraction for the
rare decay D0 -> K+ pi- to that for the Cabibbo-favored decay D0 -> K- pi+.
Charge conjugate decays are implicitly included. A signal of 2005 +/- 104
events for the decay D0 -> K+ pi- is obtained using the CDF II detector at the
Fermilab Tevatron collider. The data set corresponds to an integrated
luminosity of 0.35 1/fb produced in p-bar/p collisions at sqrt{s}=1.96 TeV.
Assuming no mixing, we find R_B = [ 4.05 +/- 0.21 (stat) +/- 0.11 (syst) ] x
10(-3). This measurement is consistent with the world average, and comparable
in accuracy with the best measurements from other experiments.Comment: 7 pages, 3 figure
Measurement of the W+W-gamma Cross Section and Direct Limits on Anomalous Quartic Gauge Boson Couplings at LEP
The process e+e- -> W+W-gamma is analysed using the data collected with the
L3 detector at LEP at a centre-of-mass energy of 188.6GeV, corresponding to an
integrated luminosity of 176.8pb^-1. Based on a sample of 42 selected W+W-
candidates containing an isolated hard photon, the W+W-gamma cross section,
defined within phase-space cuts, is measured to be: sigma_WWgamma = 290 +/- 80
+/- 16 fb, consistent with the Standard Model expectation. Including the
process e+e- -> nu nu gamma gamma, limits are derived on anomalous
contributions to the Standard Model quartic vertices W+W- gamma gamma and W+W-Z
gamma at 95% CL: -0.043 GeV^-2 < a_0/Lambda^2 < 0.043 GeV^-2 0.08 GeV^-2 <
a_c/Lambda^2 < 0.13 GeV^-2 0.41 GeV^-2 < a_n/Lambda^2 < 0.37 GeV^-2
Production of Single W Bosons at \sqrt{s}=189 GeV and Measurement of WWgamma Gauge Couplings
Single W boson production in electron-positron collisions is studied with the
L3 detector at LEP. The data sample collected at a centre-of-mass energy of
\sqrt{s} = 188.7GeV corresponds to an integrated luminosity of 176.4pb^-1.
Events with a single energetic lepton or two acoplanar hadronic jets are
selected. Within phase-space cuts, the total cross-section is measured to be
0.53 +/- 0.12 +/- 0.03 pb, consistent with the Standard Model expectation.
Including our single W boson results obtained at lower \sqrt{s}, the WWgamma
gauge couplings kappa_gamma and lambda_gamma are determined to be kappa_gamma =
0.93 +/- 0.16 +/- 0.09 and lambda_gamma = -0.31 +0.68 -0.19 +/- 0.13
Search for an invisibly decaying Higgs boson in e^+e^- collisions at \sqrt{s} = 183 - 189 GeV
A search for a Higgs boson decaying into invisible particles is performed
using the data collected at LEP by the L3 experiment at centre-of-mass energies
of 183 GeV and 189 GeV. The integrated luminosities are respectively 55.3 pb^-1
and 176.4 pb^-1. The observed candidates are consistent with the expectations
from Standard Model processes. In the hypothesis that the production cross
section of this Higgs boson equals the Standard Model one and the branching
ratio into invisible particles is 100%, a lower mass limit of 89.2 GeV is set
at 95% confidence level
Search for Neutral Higgs Bosons of the Minimal Supersymmetric Standard Model in e+e- Interactions at \sqrt{s} = 189 GeV
A search for the lightest neutral scalar and neutral pseudoscalar Higgs
bosons in the Minimal Supersymmetric Standard Model is performed using 176.4
pb^-1 of integrated luminosity collected by L3 at a center-of-mass energy of
189 GeV. No signal is observed, and the data are consistent with the expected
Standard Model background. Lower limits on the masses of the lightest neutral
scalar and pseudoscalar Higgs bosons are given as a function of tan(beta).
Lower mass limits for tan(beta)>1 are set at the 95% confidence level to be m_h
> 77.1 GeV and m_A > 77.1 GeV
Measurement of Bose-Einstein Correlations in e+e- -> W+W- at root(s)=189GeV
We investigate Bose-Einstein correlations (BEC) in W-pair production at
root(s)=189GeV using the L3 detector at LEP. We observe BEC between particles
from a single W decay in good agreement with those from a light-quark Z decay
sample. We investigate their possible existence between particles coming from
different W's. No evidence for such inter-W BEC is found
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