Wortelverbruiningsonderzoek bij suikerbieten: eindrapport : de rol van plantparasitaire aaltjes in het wortelverbruiningscomplex

In de jaren 2003 tot en met 2006 heeft het PPO onderzoek uitgevoerd aan wortelverbruining in suikerbieten. Het verschijnsel wortelverbruining komt voor op de zandgronden in het oosten en zuiden van Nederland. Pleksgewijs blijft de groei van de bieten achter. Wanneer de planten worden opgetrokken, blijkt het wortelstelsel er meestal bruin en ongezond uit te zien. Aangenomen wordt dat wortelverbruining wordt veroorzaakt door een complex van meerdere factoren. Het PPO heeft onderzoek gedaan naar de rol van plantparasitaire aaltje

How does our motor system determine its learning rate?

Motor learning is driven by movement errors. The speed of learning can be quantified by the learning rate, which is the proportion of an error that is corrected for in the planning of the next movement. Previous studies have shown that the learning rate depends on the reliability of the error signal and on the uncertainty of the motor system’s own state. These dependences are in agreement with the predictions of the Kalman filter, which is a state estimator that can be used to determine the optimal learning rate for each movement such that the expected movement error is minimized. Here we test whether not only the average behaviour is optimal, as the previous studies showed, but if the learning rate is chosen optimally in every individual movement. Subjects made repeated movements to visual targets with their unseen hand. They received visual feedback about their endpoint error immediately after each movement. The reliability of these error-signals was varied across three conditions. The results are inconsistent with the predictions of the Kalman filter because correction for large errors in the beginning of a series of movements to a fixed target was not as fast as predicted and the learning rates for the extent and the direction of the movements did not differ in the way predicted by the Kalman filter. Instead, a simpler model that uses the same learning rate for all movements with the same error-signal reliability can explain the data. We conclude that our brain does not apply state estimation to determine the optimal planning correction for every individual movement, but it employs a simpler strategy of using a fixed learning rate for all movements with the same level of error-signal reliability

CS 30322-023: an ultra metal-poor TP-AGB star?

With [Fe/H] = -3.5, CS 30322-023 is the most metal-poor star to exhibit a clear s-process signature and the most metal-poor ``lead star'' known. CS 30322-023 is also remarkable in having the lowest surface gravity (log g <= -0.3) among the metal-poor stars studied to date. The available evidence indicates that this star is presently a thermally-pulsing asymptotic giant branch (TP-AGB) star, with no strong indication of binarity thus far (although a signal of period 192 d is clearly present in the radial-velocity data, this is likely due to pulsation of the stellar envelope). We show that low-mass TP-AGB stars are not expected to be exceedingly rare in a magnitude-limited sample such as the HK survey, because their high luminosities make it possible to sample them over a very large volume. The strong N overabundance and the low 12C/13C ratio (4) in this star is typical of the operation of the CN cycle. Coupled with a Na overabundance and the absence of a strong C overabundance, this pattern seems to imply that hot-bottom burning operated in this star, which should then have a mass of at least 2 Msun. However, the luminosity associated with this mass would put the star at a distance of about 50 kpc, in the outskirts of the galactic halo. We explore alternative scenarios in which the observed abundance pattern results from some mixing mechanism yet to be identified occurring in a single low-metallicity 0.8 Msun AGB star, or from pollution by matter from an intermediate-mass AGB companion which has undergone hot-bottom burning. We stress, however, that our abundances may be subject to uncertainties due to NLTE or 3D granulation effects which were not taken into consideration.Comment: 17 pages, Astronomy & Astrophysics, in press; also available at http://www.astro.ulb.ac.be/Html/ps.html#PR

Дослідження підходів до оцінки стану конкурентоспроможності підприємств

Мета статті – наведення підходів до оцінки стану конкурентоспроможності підприємств

Oxidized and Aggregated Recombinant Human Interferon Beta is Immunogenic in Human Interferon Beta Transgenic Mice

PurposeTo study the effect of oxidation on the structure of recombinant human interferon beta-1a (rhIFNβ-1a) and its immunogenicity in wild-type and immune-tolerant transgenic mice.MethodsUntreated rhIFNβ-1a was degraded by metal-catalyzed oxidation, H2O2-mediated oxidation, and guanidine-mediated unfolding/refolding. Four rhIFNβ-1a preparations with different levels of oxidation and aggregation were injected intraperitoneally in mice 15× during 3 weeks. Both binding and neutralizing antibodies were measured.ResultsAll rhIFNβ-1a preparations contained substantial amounts of aggregates. Metal-catalyzed oxidized rhIFNβ-1a contained high levels of covalent aggregates as compared with untreated rhIFNβ-1a. H2O2-treated rhIFNβ-1a showed an increase in oligomer and unrecovered protein content by HP-SEC; RP-HPLC revealed protein oxidation. Guanidine-treated rhIFNβ-1a mostly consisted of dimers and oligomers and some non-covalent aggregates smaller in size than those in untreated rhIFNβ-1a. All degraded samples showed alterations in tertiary protein structure. Wild-type mice showed equally high antibody responses against all preparations. Transgenic mice were discriminative, showing elevated antibody responses against both metal-catalyzed oxidized and H2O2-treated rhIFNβ-1a as compared to untreated and guanidine-treated rhIFNβ-1a.ConclusionsOxidation-mediated aggregation increased the immunogenicity of rhIFNβ-1a in transgenic mice, whereas aggregated preparations devoid of measurable oxidation levels were hardly immunogenic

Multi-object spectroscopy of low-redshift EIS clusters IV. Reliability of matched-filter results at z~0.3-0.4

abridged) In this paper we present new redshifts for 747 galaxies in 23 ESO Imaging Survey (EIS) cluster fields. We use the "gap"-technique to search for significant overdensities in redshift space for identifying groups/clusters of galaxies. In this way we spectroscopically confirm systems in 10 of the 23 cluster candidate fields with a matched-filter estimated redshift z_MF=0.3-0.4 and with spectroscopic redshifts in the range from z=0.158 to z=0.534. We find that the systems identified in the present paper span a broad range of one-dimensional velocity dispersion (175-497 km/s) and richness (12L*<=L<=65L*). Both undersampling and contamination by substructures contribute to the uncertainty of these measurements. From the analysis of the colours of the galaxy populations we find that ~60% of the spectroscopically confirmed systems have a "significant" red sequence with a colour matching passive stellar evolution models. With this paper we complete our spectroscopic survey of the fields of 58 EIS cluster candidates with estimated redshifts z<=0.4. We have measured a total of 1954 galaxy redshifts in the range z=0.0065 to z=0.6706. Of the 58 systems we confirm 42 (~75%) with redshifts between z=0.095 and z=0.534.Comment: Accepted for publication in A&A, 19 pages, 11 figure

Interplay of erythropoietin, fibroblast growth factor 23, and erythroferrone in patients with hereditary hemolytic anemia

Recently, erythropoietin (EPO) was identified as regulator of fibroblast growth factor 23 (FGF23). Proteolytic cleavage of biologically active intact FGF23 (iFGF23) results in the formation of C-terminal fragments (cFGF23). An increase in cFGF23 relative to iFGF23 suppresses FGF receptor signaling by competitive inhibition. EPO lowers the i:cFGF23 ratio, thereby overcoming iFGF23-mediated suppression of erythropoiesis. We investigated EPO-FGF23 signaling and levels of erythroferrone (ERFE) in 90 patients with hereditary hemolytic anemia (www.trialregister.nl [NL5189]). We show, for the first time, the importance of EPO-FGF23 signaling in hereditary hemolytic anemia: there was a clear correlation between total FGF23 and EPO levels (r = +0.64; 95% confidence interval [CI], 0.09-0.89), which persisted after adjustment for iron load, inflammation, and kidney function. There was no correlation between iFGF23 and EPO. Data are consistent with a low i:cFGF23 ratio. Therefore, as expected, we report a correlation between EPO and ERFE in a diverse set of hereditary hemolytic anemias (r = +0.47; 95% CI, 0.14-0.69). There was no association between ERFE and total FGF23 or iFGF23, which suggests that ERFE does not contribute to the connection between FGF23 and EPO. These findings open a new area of research and might provide potentially new druggable targets with the opportunity to ameliorate ineffective erythropoiesis and the development of disease complications in hereditary hemolytic anemias

A primordial star in the heart of the Lion

Context: The discovery and chemical analysis of extremely metal-poor stars permit a better understanding of the star formation of the first generation of stars and of the Universe emerging from the Big Bang. aims: We report the study of a primordial star situated in the centre of the constellation Leo (SDSS J102915+172027). method: The star, selected from the low resolution-spectrum of the Sloan Digital Sky Survey, was observed at intermediate (with X-Shooter at VLT) and at high spectral resolution (with UVES at VLT). The stellar parameters were derived from the photometry. The standard spectroscopic analysis based on 1D ATLAS models was completed by applying 3D and non-LTE corrections. results: An iron abundance of [Fe/H]=--4.89 makes SDSS J102915+172927 one of the lowest [Fe/H] stars known. However, the absence of measurable C and N enhancements indicates that it has the lowest metallicity, Z<= 7.40x10^{-7} (metal-mass fraction), ever detected. No oxygen measurement was possible. conclusions: The discovery of SDSS J102915+172927 highlights that low-mass star formation occurred at metallicities lower than previously assumed. Even lower metallicity stars may yet be discovered, with a chemical composition closer to the composition of the primordial gas and of the first supernovae.Comment: To be published in A&