Os padrões de metadados como recursos tecnológicos para a garantia da preservação digital

The guarantee of long-term digital preservation will only be possible with the effective implementation of metadata standards or schemas, because these will determine the description, representation, consistency and persistence of the digital resource/object in information environments, as well as defining interoperability between systems. The adoption of metadata for preservation supports the management of processes for the archiving and maintenance of access to digital information in the long term, guaranteeing authenticity, integrity and reliability. In this scenario, the aim of this study was to identify and describe metadata standards or schemas that could be considered by institutions that are developing their institutional repositories, so that digital preservation might be addressed. To that end, a literature review, and its systematization and content analysis were carried out. The following metadata standards and schemas were selected and analyzed: DUBLIN CORE (DC), MODS, EAD, ANSI/NISO Z39.87, METS and PREMIS. The results indicate that the descriptive and technical metadata DC, MODS, EAD and ANSI/NISO Z39.87 or MIX have a role that is more directed to supporting METS and PREMIS, both in discovering and recording the technical aspects of digital objects, and in the proof of its provenance, authenticity, context and integrity. Encompassing descriptive, structural, administrative and preservation metadata of PREMIS, METS can manage digital objects acting as a Submission Information Package (SIP), Archival Information Package (AIP) or Dissemination Information Package (DIP) in an Open Archival Information System (OAIS).La garantía de preservación digital a largo plazo sólo será posible con la adopción efetiva de estándares o esquemas de metadatos, pues son ellos los que determinarán la descripción, la representación, la consistencia y la persistencia del recurso/objeto digital en el ambiente de información, además de definir la interoperabilidad entre sistemas. La adopción de metadatos para la  preservación apoya la administración de los procesos relativos al archivado y al mantenimiento del acceso a la información digital a largo plazo, con garantías de autenticidad, integridad y fiabilidad. En este escenario, fue objetivo del trabajo identificar y describir estándares o esquemas de metadatos que podrían ser considerados por las instituciones que están desarrollando sus repositorios institucionales, para que puedan considerar la preservación digital. Para ello, fue desarrollada una investigación bibliográfica, sistematización y análisis de contenido. Fueron selecionados y analizados los siguientes esquemas y patrones de metadatos: DUBLIN CORE, MODS, EAD, ANSI/NISO Z39.87, METS y el PREMIS. El análisis de los resultados señala que los metadados descriptivos y técnicos del DC, MODS, EAD y ANSI/NISO Z39.87 o MIX, poseen un rol de directricez al considerar el METS y el PREMIS, tanto en el descubrimiento y en el registro de los aspectos técnicos del objeto digital, como en la comprovación de su procedencia, autenticidad, contexto e integridad. Englobando los metadados descriptivos, estructurales, administrativos y de preservación del PREMIS, el METS puede gestionar los objetos digitales actuando como un Paquete de Sumisión de Información (PSI), Paquete de Archivado de Información (PAI) o Paquete de Diseminación de Información (PDI) en un Sistema Abierto de Archivado de Información (SAAI).A garantia de preservação digital a longo prazo só será possível com a adoção efetiva de padrões ou esquemas de metadados, pois são eles que determinarão a descrição, a representação, a consistência e a persistência do recurso/objeto digital no ambiente informacional, além de definir a interoperabilidade entre sistemas. A adoção de metadados para preservação apoia a administração dos processos relativos ao arquivamento e à manutenção do acesso à informação digital a longo prazo, com garantias de autenticidade, de integridade e de confiabilidade. Neste cenário, foi objetivo do trabalho identificar e descrever padrões ou esquemas de metadados que poderiam ser considerados por instituições que estão desenvolvendo seus repositórios institucionais, para que possam contemplar a preservação digital. Para tanto, foi desenvolvida pesquisa bibliográfica e sistematização e análise de conteúdo. Foram selecionados e analisados os seguintes esquemas e padrões de metadados: DUBLIN CORE, MODS, EAD, ANSI/NISO Z39.87, METS e o PREMIS. A análise dos resultados indica que os metadados descritivos e técnicos do DC, MODS, EAD e ANSI/NISO Z39.87 ou MIX, possuem um papel mais direcionado a amparar o METS e o PREMIS, tanto na descoberta e no registro dos aspectos técnicos do objeto digital, como na comprovação de sua procedência, autenticidade, contexto e integridade. Englobando metadados descritivos, estruturais, administrativos e de preservação do PREMIS, o METS pode gerir os objetos digitais atuando como um Pacote de Submissão de Informação (PSI), Pacote de Arquivamento de Informação (PAI) ou Pacote de Disseminação de Informação (PDI) num Sistema Aberto de Arquivamento de Informação (SAAI)

Codesign and refinement of an optimised antenatal education session to better inform women and prepare them for labour and birth

Objective: Our objective was to codesign, implement, evaluate acceptability and refine an optimised antenatal education session to improve birth preparedness. Design: There were four distinct phases: codesign (focus groups and codesign workshops with parents and staff); implementation of intervention; evaluation (interviews, questionnaires, structured feedback forms) and systematic refinement. Setting: The study was set in a single maternity unit with approximately 5500 births annually. Participants: Postnatal and antenatal women/birthing people and birth partners were invited to participate in the intervention, and midwives were invited to deliver it. Both groups participated in feedback. Outcome measures: We report on whether the optimised session is deliverable, acceptable, meets the needs of women/birthing people and partners, and explain how the intervention was refined with input from parents, clinicians and researchers. Results: The codesign was undertaken by 35 women, partners and clinicians. Five midwives were trained and delivered 19 antenatal education (ACE) sessions to 142 women and 94 partners. 121 women and 33 birth partners completed the feedback questionnaire. Women/birthing people (79%) and birth partners (82%) felt more prepared after the class with most participants finding the content very helpful or helpful. Women/birthing people perceived classes were more useful and engaging than their partners. Interviews with 21 parents, a midwife focus group and a structured feedback form resulted in 38 recommended changes: 22 by parents, 5 by midwives and 11 by both. Suggested changes have been incorporated in the training resources to achieve an optimised intervention. Conclusions: Engaging stakeholders (women and staff) in codesigning an evidence-informed curriculum resulted in an antenatal class designed to improve preparedness for birth, including assisted birth, that is acceptable to women and their birthing partners, and has been refined to address feedback and is deliverable within National Health Service resource constraints. A nationally mandated antenatal education curriculum is needed to ensure parents receive high-quality antenatal education that targets birth preparedness

Factors influencing terrestriality in primates of the Americas and Madagascar

Among mammals, the order Primates is exceptional in having a high taxonomic richness in which the taxa are arboreal, semiterrestrial, or terrestrial. Although habitual terrestriality is pervasive among the apes and African and Asian monkeys (catarrhines), it is largely absent among monkeys of the Americas (platyrrhines), as well as galagos, lemurs, and lorises (strepsirrhines), which are mostly arboreal. Numerous ecological drivers and species-specific factors are suggested to set the conditions for an evolutionary shift from arboreality to terrestriality, and current environmental conditions may provide analogous scenarios to those transitional periods. Therefore, we investigated predominantly arboreal, diurnal primate genera from the Americas and Madagascar that lack fully terrestrial taxa, to determine whether ecological drivers (habitat canopy cover, predation risk, maximum temperature, precipitation, primate species richness, human population density, and distance to roads) or species-specific traits (bodymass, group size, and degree of frugivory) associate with increased terrestriality. We collated 150,961 observation hours across 2,227 months from 47 species at 20 sites in Madagascar and 48 sites in the Americas. Multiple factors were associated with ground use in these otherwise arboreal species, including increased temperature, a decrease in canopy cover, a dietary shift away from frugivory, and larger group size. These factors mostly explain intraspecific differences in terrestriality. As humanity modifies habitats and causes climate change, our results suggest that species already inhabiting hot, sparsely canopied sites, and exhibiting more generalized diets, are more likely to shift toward greater ground use

Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy initiation

Objectives: No randomized controlled trials have yet reported an individual patient benefit of initiating combination antiretroviral therapy (cART) at CD4 counts > 350 cells/μL. It is hypothesized that earlier initiation of cART in asymptomatic and otherwise healthy individuals may lead to poorer adherence and subsequently higher rates of resistance development. Methods: In a large cohort of HIV-positive individuals, we investigated the emergence of new resistance mutations upon virological treatment failure according to the CD4 count at the initiation of cART. Results: Of 7918 included individuals, 6514 (82.3%), 996 (12.6%) and 408 (5.2%) started cART with a CD4 count ≤ 350, 351-499 and ≥ 500 cells/μL, respectively. Virological rebound occurred while on cART in 488 (7.5%), 46 (4.6%) and 30 (7.4%) with a baseline CD4 count ≤ 350, 351-499 and ≥ 500 cells/μL, respectively. Only four (13.0%) individuals with a baseline CD4 count > 350 cells/μL in receipt of a resistance test at viral load rebound were found to have developed new resistance mutations. This compared to 107 (41.2%) of those with virological failure who had initiated cART with a CD4 count < 350 cells/μL. Conclusions: We found no evidence of increased rates of resistance development when cART was initiated at CD4 counts above 350 cells/μL. HIV Medicin

Factors influencing terrestriality in primates of the Americas and Madagascar

Among mammals, the order Primates is exceptional in having a high taxonomic richness in which the taxa are arboreal, semiterrestrial, or terrestrial. Although habitual terrestriality is pervasive among the apes and African and Asian monkeys (catarrhines), it is largely absent among monkeys of the Americas (platyrrhines), as well as galagos, lemurs, and lorises (strepsirrhines), which are mostly arboreal. Numerous ecological drivers and species-specific factors are suggested to set the conditions for an evolutionary shift from arboreality to terrestriality, and current environmental conditions may provide analogous scenarios to those transitional periods. Therefore, we investigated predominantly arboreal, diurnal primate genera from the Americas and Madagascar that lack fully terrestrial taxa, to determine whether ecological drivers (habitat canopy cover, predation risk, maximum temperature, precipitation, primate species richness, human population density, and distance to roads) or species-specific traits (body mass, group size, and degree of frugivory) associate with increased terrestriality. We collated 150,961 observation hours across 2,227 months from 47 species at 20 sites in Madagascar and 48 sites in the Americas. Multiple factors were associated with ground use in these otherwise arboreal species, including increased temperature, a decrease in canopy cover, a dietary shift away from frugivory, and larger group size. These factors mostly explain intraspecific differences in terrestriality. As humanity modifies habitats and causes climate change, our results suggest that species already inhabiting hot, sparsely canopied sites, and exhibiting more generalized diets, are more likely to shift toward greater ground use

Genomic investigations of unexplained acute hepatitis in children

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P &lt; 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

M-libraries e Information Commons: novos espaços, novas práticas

O universo atual da informação, da comunicação e da educação, tem se reconfigurado cada vez mais a partir de sua vinculação às tecnologias computacionais. Em um movimento sincrônico, se convergem a produção do conhecimento, as demandas de informação e os aparatos tecnológicos. Sobre estes, presenciamos o alucinante desenvolvimento e aperfeiçoamento de dispositivos móveis, que armazenam e tornam acessível, a qualquer momento, a informação. Neste mesmo momento, temos tido uma reconfiguração dos espaços físicos de pesquisa e acesso ao conhecimento, como o caso de Bibliotecas Públicas e Universitárias (Information Commons - IC). Estes espaços tem se remodelado arquitetonicamente para flexibilizar e otimizar uma interação de qualidade entre usuários, tecnologia e conhecimento. Neste contexto, o presente artigo pretende sinalizar os conceitos e as iniciativas que prerrogam a articulação dos saberes tradicionalmente articulados no âmbito das Bibliotecas, que são mediados agora também por celulares, iPads, Smartphones - M-libraries, e ainda, caracterizar os espaços IC, como uma tendência para Bibliotecas pragmáticas e interativas contemporâneas. A partir disto procura-se discutir o reposicionamento dos profissionais da informação diante do cenário atual de mobilidade da informação. 

Automated metadata collection from the researcher CV Lattes Platform to aid IR ingest

In 1999, the Brazilian National Council for Scientific and Technological Development (CNPq) launched the Lattes CV Platform, and all Brazilian HEIs oblige their researchers and staff to inform and update their publication metadata on the Platform. The Lattes CVs thus represent a rich source of metadata for Brazilian HEIs needing to identify which publications should be in their IR, populating the IR with this metadata in a concealed way until the full text file is ingested. Despite being publicly accessible on the web and belonging to HEIs, the automated extraction of data available on the Lattes Platform has been restricted by the recent addition of a CAPTCHA to the Platform. To overcome this, we developed a proxy server (available at https://github.com/nitmateriais/cnpqwsproxy) based on the OpenResty platform to share access to the Lattes SOAP services, and permits the HEI to manage its internal IP addresses that can access the services as well as guaranteeing that multiple apps from the same institution do not overload the CNPq servers by creating local data caches. These data are in XML format and are processed by scripts developed in Python, with the aid of the lxml library and the XPath standard. Publication duplicates (i.e. identical metadata published in different curricula pertaining to the different authors of the same paper) are detected by the DOI or from similar titles according to the Jaccard metric. In applying this solution, we were able to retrieve 1,166 curricula of researchers working at our HEI in 11 minutes, representing 573 MB of XML data composed of the metadata of 78,370 journal and Proceedings papers. In this way, the specific objective of gaining direct and official access to public metadata hosted on the Lattes Platform was attained