Leishmanicidal activity of fractions rich in aporphine alkaloids from amazonian unonopsis species

In vitro evaluation of alkaloidal fractions of twigs, barks and leaves from two Unonopsis species, Unonopsis guatterioides R.E. Fr. and Unonopsis duckei R.E. Fr., Annonaceae, against promastigote forms of Leishmania amazonensis revealed these species as sources of substances with promising leishmanicidal potential. All alkaloidal fractions from twigs, barks and leaves of U. guatterioides were classified as highly active, with IC50 1.07, 1.90, and 2.79 mg/mL, respectively. Only the alkaloidal fraction from the twigs of U. duckei was classified as inactive2261368137

Leishmanicidal activity of fractions rich in aporphine alkaloids from Amazonian Unonopsis species

In vitro evaluation of alkaloidal fractions of twigs, barks and leaves from two Unonopsis species, Unonopsis guatterioides R.E. Fr. and Unonopsis duckei R.E. Fr., Annonaceae, against promastigote forms of Leishmania amazonensis revealed these species as sources of substances with promising leishmanicidal potential. All alkaloidal fractions from twigs, barks and leaves of U. guatterioides were classified as highly active, with IC50 1.07, 1.90, and 2.79 mg/mL, respectively. Only the alkaloidal fraction from the twigs of U. duckei was classified as inactive.2261368137

Classical behavior of deformed sine-Gordon models

In this work we deform the phi^4 model with distinct deformation functions, to propose a diversity of sine-Gordon-like models. We investigate the proposed models and we obtain all the topological solutions they engender. In particular, we introduce non-polynomial potentials which support some exotic two-kink solutions.Comment: 12 pages, 12 figures; version to appear in Physica

Probing the atmosphere of a solar-like star by galactic microlensing at high magnification

We report a measurement of limb darkening of a solar-like star in the very high magnification microlensing event MOA 2002-BLG-33. A 15 hour deviation from the light curve profile expected for a single lens was monitored intensively in V and I passbands by five telescopes spanning the globe. Our modelling of the light curve showed the lens to be a close binary system whose centre-of-mass passed almost directly in front of the source star. The source star was identified as an F8-G2 main sequence turn-off star. The measured stellar profiles agree with current stellar atmosphere theory to within ~4% in two passbands. The effective angular resolution of the measurements is <1 micro-arcsec. These are the first limb darkening measurements obtained by microlensing for a Solar-like star.Comment: Accepted for publication in A&A Letters. 5 pages, 2 embedded colour ps figures plus 1 jpg figure. Version with all figures embedded available from: http://www.roe.ac.uk/~iab/moa33paper

A SURVEY of CHRONIC GVHD and OTHER OUTCOMES - A SNAPSHOT of BRAZILIAN ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION (HCT) CENTERS

Univ Fed Parana, BR-80060000 Curitiba, Parana, BrazilNatl Canc Inst, Rio de Janeiro, BrazilState Univ São Paulo, São Paulo, BrazilUniv Estadual Campinas, Campina, BrazilUniv Fed Rio de Janeiro, Rio de Janeiro, BrazilAmaral Carvalho Hosp, Jau, BrazilAmaral Carvalho Hosp, São Paulo, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilAlbert Einstein Hosp, São Paulo, BrazilCanc Hosp Barretos, São Paulo, BrazilUniv Fed Rio Grande do Sul, Porto Alegre, RS, BrazilPernambuco Blood Bank, Recife, PE, BrazilUniv Fed Minas Gerais, Belo Horizonte, MG, BrazilUniv State Univ São Paulo, Ribeirao Preto, BrazilFred Hutchinson Canc Res Ctr, Seattle, WA 98104 USAUniversidade Federal de São Paulo, São Paulo, BrazilWeb of Scienc

Acanthoic acid and other constituents from the stem of Annona amazonica (Annonaceae)

The present work reports the isolation of acanthoic acid, a promising pimaradiene-type diterpene with several important biological activities described in the literature, from the stems of Annona amazonica. We found that acanthoic acid has significant trypanocidal activity against the epimastigote forms of Trypanosoma cruzi. This diterpene is the major constituent of the plant, comprising at least 65% of the hexane extract, demonstrating that A. amazonica is a new renewable natural source for this compound. The chemical investigation also resulted in the isolation of the alkaloids liriodenine and cassythicine, and other compounds including terpenes, sterols, and fatty acids. Additionally, the complete and unequivocal ¹H and 13C NMR chemical shift assignments for cassythicine are provided

Construction of topological defect networks with complex scalar fields

This work deals with the construction of networks of topological defects in models described by a single complex scalar field. We take advantage of the deformation procedure recently used to describe kinklike defects in order to build networks of topological defects, which appear from complex field models with potentials that engender a finite number of isolated minima, both in the case where the minima present discrete symmetry, and in the non symmetric case. We show that the presence of symmetry guide us to the construction of regular networks, while the non symmetric case gives rise to irregular networks which spread throughout the complex field space. We also discuss bifurcation, a phenomenon that appear in the non symmetric case, but is washed out by the deformation procedure used in the present work.Comment: 25 pages, 14 figures; new version to appear in NP

Differential allelic expression and co-expression revealed oxidative stress-dependent proteolysis as a key regulator of nelore beef tenderness.

These findings suggest the impact of cis-regulatory variants on both the gene expression and phenotypic variation of Nelore muscle. These results can guide the investigation of regulatory variants affecting the expression of candidate genes for animal breeding, focusing on the genomic regions that affect the phenotypes of interest.e-book. Na publicação: Adhemar Zerlotini