Por don Cristoual Ortiz Rojano de Morales, familiar del Santo Oficio de la Inquisicion, vezino de la villa de Vaena en el pleito que contra el trata doña Maria de Ordaz vezina de dicha villa

Título tomado de la cabecera del textoFecha y lugar de impresión deducidos del textoSign.: A

Construcción de cursos hipermedia adaptativos basados en Web utilizando AHA

In this paper we are going to introduce a system to build adaptive hypermedia web-based courses. Using it, any teacher can quickly creates a web-based course that lets the adaptation both the presentation and the navigation depend on the level of each particular student’s knowledge. In order to develop it we have used the AHA generic adaptive systems (de Bra, 98). We have performed it several modification on it to specialize and power it in the educational area. We are going to show a linux course as example of using our system. Currently this course is being used by students of the University of Cordoba. The linux course Cristóbal Romero Morales, Sebastián Ventura Soto, Carlos de Castro together with our system can be downloaded from Internet free. We are also developing an author tool so that the teacher can build easily the course without having to know the AHA internal structure.En el este artículo vamos a presentar una sistema para la construcción de curso hipermedia adaptativos basados en web. Cualquier profesor utilizando nuestro sistema puede crear rápidamente un curso basado en web que además permite la adaptación tanto de la presentación como de la navegación dependiendo del nivel de conocimiento de cada alumno en particular. Para desarrollarlo hemos utilizado de base el sistema adaptativo genérico AHA (de Bra, 98), al que le hemos realizado varias modificaciones importantes para especializarlo y potenciarlo en el área de educación. Como ejemplo de utilización vamos a mostrar un curso de linux que hemos construido utilizando nuestro sistema y que actualmente está siendo utilizado por estudiantes de la Universidad de Córdoba. También estamos desarrollando una herramienta autor para que el profesor pueda construir el curso fácilmente sin la necesidad de conocer la estructura interna de AHA

Inequalities in the Information and Knowledge Society: From the Digital Divide to Digital Inequality

Depto. de Sociología AplicadaFac. de Ciencias Políticas y SociologíaTRUEMinisterio de Economía y Competitivadpu

UVICO: Universidad Virtual de Córdoba

The Industrial Technology Center (Crí) and the research group EATCO of the university of Córdoba with the collaboration of the Polytechnic University of Madrid and the company GARBEN, they have developed the Córdoba Virtual University (UVICO). UVICO is an client-server Java application that seeks to simulate as much the aspect as the services of a real University to serve from support to the current present classes. The pro fessors that want to use it in some course can supplement the present hours of theory and practical with the new computer services based on net that UVICO provides, like they are: virtual sailing, discussion chats, electronic mail, download of notes and complementar,’ materials, mensajería, etc. Its main objective is that the students car,y out complete courses or supplement regular lectures, besides following sessions of tutorships and to communicate with other co-worker of the course.El Centro Tecnológico Industrial y el grupo de Investigación EATCO de la UNIVERSIDAD de Córdoba con la colaboración de la Universidad Politécnica de Madrid y la empresa GARBEN, han desarrollado la Universidad Virtual de Córdoba (UVICO). UVICO es una aplicación Java cliente-servidor que pretende simular tanto el aspecto como los servicios de una Universidad real para servir de apoyo a las clases presenciales actuales. Los profesores que deseen utilizarlo en alguna asignatura pueden complementar las horas presenciales de teoría y prácticas con los nuevos servicios informáticos basados en red que proporciona UVICO, como son: navegación virtual, charlas de discusión, correo electrónico, descarga de apuntes y materiales complementarios, mensajería, etc. Su principal objetivo es que los alumnos realicen cursos completos o complementen cursos presenciales, además de seguir sesiones de tutorías y/o comunicarse con otros compañeros del curso

Gas6, una proteína dependiente de la vitamina k implicada en la respuesta a la infección por sars-cov-2

Trabajo presentado en el LXIII Congreso Nacional SEHH/ XXXVII Congreso Nacional SETH, celebrado en Pamplona (Navarra) del 14 al 16 de octubre de 2021

Growth Arrest-Specific Factor 6 (GAS6) Is Increased in COVID-19 Patients and Predicts Clinical Outcome

Producción CientíficaBackground: Growth arrest-specific factor 6 (GAS6) and the Tyro3, AXL, and MERTK (TAM) receptors counterbalance pro-inflammatory responses. AXL is a candidate receptor for SARS-CoV-2, particularly in the respiratory system, and the GAS6/AXL axis is targeted in current clinical trials against COVID-19. However, GAS6 and TAMs have not been evaluated in COVID-19 patients at emergency admission. Methods: Plasma GAS6, AXL, and MERTK were analyzed in 132 patients consecutively admitted to the emergency ward during the first peak of COVID-19. Results: GAS6 levels were higher in the SARS-CoV-2-positive patients, increasing progressively with the severity of the disease. Patients with initial GAS6 at the highest quartile had the worst outcome, with a 3-month survival of 65%, compared to a 90% survival for the rest. Soluble AXL exhibited higher plasma concentration in deceased patients, without significant differences in MERTK among SARS-CoV-2-positive groups. GAS6 mRNA was mainly expressed in alveolar cells and AXL in airway macrophages. Remarkably, THP-1 human macrophage differentiation neatly induces AXL, and its inhibition (bemcentinib) reduced cytokine production in human macrophages after LPS challenge. Conclusions: Plasma GAS6 and AXL levels reflect COVID-19 severity and could be early markers of disease prognosis, supporting a relevant role of the GAS6/AXL system in the immune response in COVID-19.Ministerio de Ciencia, Innovación y Universidades (project RTI2018-095672-B-I00)Instituto de Salud Carlos III - Fondo de Investigación Sanitaria (grants PI15/00531 and PI19/01410)Fundació La Marató TV3 (grants 20153030 and 20153031)Consejo Superior de Investigaciones Científicas (project CSIC-COV19-016/202020E155)Junta de Castilla y León (project 07.04.467B04.74011.0

Characterization of New Proteomic Biomarker Candidates in Mucopolysaccharidosis Type IVA

Mucopolysaccharidosis type IVA (MPS IVA) is a lysosomal storage disease caused by mutations in the N-acetylgalactosamine-6-sulfatase (GALNS) gene. Skeletal dysplasia and the related clinical features of MPS IVA are caused by disruption of the cartilage and its extracellular matrix, leading to a growth imbalance. Enzyme replacement therapy (ERT) with recombinant human GALNS has yielded positive results in activity of daily living and endurance tests. However, no data have demonstrated improvements in bone lesions and bone grow thin MPS IVA after ERT, and there is no correlation between therapeutic efficacy and urine levels of keratan sulfate, which accumulates in MPS IVA patients. Using qualitative and quantitative proteomics approaches, we analyzed leukocyte samples from healthy controls (n = 6) and from untreated (n = 5) and ERT-treated (n = 8, sampled before and after treatment) MPS IVA patients to identify potential biomarkers of disease. Out of 690 proteins identified in leukocytes, we selected a group of proteins that were dysregulated in MPS IVA patients with ERT. From these, we identified four potential protein biomarkers, all of which may influence bone and cartilage metabolism: lactotransferrin, coronin 1A, neutral alpha-glucosidase AB, and vitronectin. Further studies of cartilage and bone alterations in MPS IVA will be required to verify the validity of these proteins as potential biomarkers of MPS IVAS

Evolución del control de la corrupción desde la Carta Magna; perspectivas filosófica, ética y constitucional

La Facultad de Ciencias Políticas y Relaciones Internacionales de la Universidad Autónoma de Nuevo León en su responsabilidad de socializar y difundir el conocimiento y en conmemoración del Centenario de la Constitución Política de los Estados Unidos Mexicanos, generó el presente libro buscando llevar a los lectores, las diferentes vertientes que ha generado la carta magna

Patients' and physicians' preferences for type 2 diabetes mellitus treatments in Spain and Portugal: a discrete choice experiment

Objective To assess Spanish and Portuguese patients’ and physicians’ preferences regarding type 2 diabetes mellitus (T2DM) treatments and the monthly willingness to pay (WTP) to gain benefits or avoid side effects. Methods An observational, multicenter, exploratory study focused on routine clinical practice in Spain and Portugal. Physicians were recruited from multiple hospitals and outpatient clinics, while patients were recruited from eleven centers operating in the public health care system in different autonomous communities in Spain and Portugal. Preferences were measured via a discrete choice experiment by rating multiple T2DM medication attributes. Data were analyzed using the conditional logit model. Results Three-hundred and thirty (n=330) patients (49.7% female; mean age 62.4 [SD: 10.3] years, mean T2DM duration 13.9 [8.2] years, mean body mass index 32.5 [6.8] kg/m2, 41.8% received oral + injected medication, 40.3% received oral, and 17.6% injected treatments) and 221 physicians from Spain and Portugal (62% female; mean age 41.9 [SD: 10.5] years, 33.5% endocrinologists, 66.5% primary-care doctors) participated. Patients valued avoiding a gain in bodyweight of 3 kg/6 months (WTP: €68.14 [95% confidence interval: 54.55–85.08]) the most, followed by avoiding one hypoglycemic event/month (WTP: €54.80 [23.29–82.26]). Physicians valued avoiding one hypoglycemia/week (WTP: €287.18 [95% confidence interval: 160.31–1,387.21]) the most, followed by avoiding a 3 kg/6 months gain in bodyweight and decreasing cardiovascular risk (WTP: €166.87 [88.63–843.09] and €154.30 [98.13–434.19], respectively). Physicians and patients were willing to pay €125.92 (73.30–622.75) and €24.28 (18.41–30.31), respectively, to avoid a 1% increase in glycated hemoglobin, and €143.30 (73.39–543.62) and €42.74 (23.89–61.77) to avoid nausea. Conclusion Both patients and physicians in Spain and Portugal are willing to pay for the health benefits associated with improved diabetes treatment, the most important being to avoid hypoglycemia and gaining weight. Decreased cardiovascular risk and weight reduction became the third most valued attributes for physicians and patients, respectively