O SIGNIFICADO E O SENTIDO NA UNIDADE DA TRADUÇÃO

The paper approach aspects on unit of translation in training of translators. Presents  some reviews and critical about some translations the work of Jorge Amado, performed to Russian language. Reports historical facts about the translation in Russia. Also discusses the issues of meaning and sense in the work of L.S.Vigotski and points to possible ways of working in the field of training of translators.O artigo aborda aspectos relativos à unidade da tradução na formação de tradutores. Apresenta algumas opiniões a respeito e faz criticas a algumas traduções da obra de Jorge Amado, realizadas para a língua russa. Relata fatos históricos sobre a tradução na Rússia. Discute também as questões de significado e sentido na obra de L.S.Vigotski e aponta para possíveis formas de trabalhar no campo de formação de tradutores

Identification of Fe3O4 Nanoparticles Biomedical Purpose by Magnetometric Methods

The application of magnetic nanoparticles for biomedical research is an interdisciplinary problem. The use of nano‐ and microsized powder materials as developed technology for obtaining bionanomaterials with magnetocatalytic properties has been investigated. Control over immobilization can be carried by means of magnetic properties. Synthesis of superparamagnetic nanoparticles is developed not only for the benefit of fundamental science, but also for many technologies, such as technologies of magnetic storage media, magnetic ink for printers, but mainly for biosensors and medical applications. All the biomedical applications require that the nanoparticles have high enough levels of saturation of magnetization; their size should be less than 100 nm with a small deviation in size. Appropriate coating of the surface of magnetic nanoparticles should be nontoxic, biocompatible with the target of bioorganic compound. The techniques of measurement of magnetic nanoparticle properties by means of vibrational magnetometers, as well as by means of a set of smart sensor devices in accordance with new concept of Internet of Things (IoTh), were described. The first method is based on vibrating sample magnetometer technique. The second method is based on direct measurement of three dimensions (3D) of nanoparticles’ magnetic field components

Диагностика приобретенного токсоплазмоза у беременных

Catedra de Boli Infecţioase Tropicale şi Parazitologie Medicală, USMF N. Testemiţanu, IMSP Spitalul Clinic de Boli Infecţioase Toma CiorbăSummary. To this study were subjected 112 pregnant women with acquired toxoplasmosis, of which for 41 was subacute evolution and to 71 was chronic evolution of this disease. The diagnosis was established based on clinical data base, epidemiological, imaging and laboratory. ELISA antitoxo IgG results – weakly positive. For pregnant women with chronic acquired toxoplasmosis antitoxo IgG – was weakly positive. For pregnant women with chronic acquired toxoplasmosis antitoxo IgM was negative, antitoxo IgG was positive. To all 112 women with acquired toxoplasmosis children were born healthy.Резюме. Были обследованы 112 беременных женщин, из которых 41 – с острым течением и 71 женщина – с хроническим течением болезни. Для постановки диагноза использовались клинические, эпидемиологические, инструментальные и лабораторные данные. У больных с подострым течением болезни antitoxo IgM, выявленные ELISA, были повышены в 2-4 раза, antitoxo Ig – слабоположительные. При хроническом приобретенном токсоплазмозе antitoxo IgM были отрицательные. У всех 112 беременных с приобретенным токсоплазмозом родились здоровые дети

David Vygodsky, the Translator

The article presents some important details of the life and work trajectory of literary critic, poet, writer and translator David Vygodsky. Virtually unknown in Brazil, David played an important role, in the early years of the Soviet Union, in publicizing works by writers from Spain, Portugal and Latin America. This article presents material found in archives in Moscow, raises some questions about the translation of the tale of the Brazilian writer Alcides Maya, which appears in a collection organized by David and brings the translation of a poem written by him before he died tragically.O artigo apresenta alguns detalhes importantes da trajetória de vida e obra do crítico literário, poeta, escritor e tradutor David Vigódski. Praticamente desconhecido no Brasil, David desempenhou um papel importante, nos primeiros anos da União Soviética, de divulgação de obras de escritores da Espanha, de Portugal e dos países da América Latina. O artigo apresenta um material encontrado em arquivos em Moscou, levanta algumas indagações a respeito da tradução do conto do escritor brasileiro Alcides Maya que figura em uma coletânea organizada por David e traz a tradução de um poema escrito por ele antes de morrer tragicamente

Construxercise!: Implementation of a construction-based approach to language pedagogy

We propose a construction-based approach to learning and teaching Russian as a second language (L2) and present an innovative pedagogical resource called Construxercise! Hands-on learning of Russian constructions (https://constructicon.github.io/construxercise-rus/) that implements this approach. The resource offers practical exercises for mastering Russian discourse constructions that are thoroughly described in the Russian Constructicon (https://constructicon.github.io/russian/), a large searchable database of Russian constructions. We argue that the Construxercise! resource fills an essential gap in available educational materials and provides a powerful alternative for successfully organizing conversational practice in L2 Russian. Targeting strategic and highly frequent discourse constructions in language learning brings the focus to conversation and strengthens text production skills. The article details our methodology, the choice of constructions, and the architecture of the website. The resource is built in close collaboration with our students and benefits from both native and non-native perspectives on L2 Russian

Estudos sobre a perspectiva histórico-cultural de Vigotski

Veresk é uma publicação internacional de Psicologia que se propõe a divulgar trabalhos que examinam e aprofundam o estudo do legado da teoria de Lev Semionovitch Vigotski. Os autores são especialmente convidados a apresentarem seus textos pelos Editores Associados ou pelo Conselho Editorial. Veresk é apresentada tanto no formato impresso, quanto no eletrônico, nas versões em russo, português e inglês. Sua publicação é patrocinada pelo Instituto de Psicologia L. S. Vigotski, da Universidade Estatal de Humanidades da Rússia, pela Faculdade de Educação da Universidade Federal Fluminense, Brasil e pela Faculdade de Ciências da Saúde, do Centro Universitário de Brasília, Brasil

Seeing touches early in life

Addabbo M, Longhi E, Bolognini N, et al. Seeing touches early in life. PLoS ONE. 2015;10(9): e0134549

How future surgery will benefit from SARS-COV-2-related measures: a SPIGC survey conveying the perspective of Italian surgeons

COVID-19 negatively affected surgical activity, but the potential benefits resulting from adopted measures remain unclear. The aim of this study was to evaluate the change in surgical activity and potential benefit from COVID-19 measures in perspective of Italian surgeons on behalf of SPIGC. A nationwide online survey on surgical practice before, during, and after COVID-19 pandemic was conducted in March-April 2022 (NCT:05323851). Effects of COVID-19 hospital-related measures on surgical patients' management and personal professional development across surgical specialties were explored. Data on demographics, pre-operative/peri-operative/post-operative management, and professional development were collected. Outcomes were matched with the corresponding volume. Four hundred and seventy-three respondents were included in final analysis across 14 surgical specialties. Since SARS-CoV-2 pandemic, application of telematic consultations (4.1% vs. 21.6%; p < 0.0001) and diagnostic evaluations (16.4% vs. 42.2%; p < 0.0001) increased. Elective surgical activities significantly reduced and surgeons opted more frequently for conservative management with a possible indication for elective (26.3% vs. 35.7%; p < 0.0001) or urgent (20.4% vs. 38.5%; p < 0.0001) surgery. All new COVID-related measures are perceived to be maintained in the future. Surgeons' personal education online increased from 12.6% (pre-COVID) to 86.6% (post-COVID; p < 0.0001). Online educational activities are considered a beneficial effect from COVID pandemic (56.4%). COVID-19 had a great impact on surgical specialties, with significant reduction of operation volume. However, some forced changes turned out to be benefits. Isolation measures pushed the use of telemedicine and telemetric devices for outpatient practice and favored communication for educational purposes and surgeon-patient/family communication. From the Italian surgeons' perspective, COVID-related measures will continue to influence future surgical clinical practice

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues