53 research outputs found
Ultrasound-Assisted CO2 Flooding to Improve Oil Recovery
The authors would like to gratefully acknowledge and appreciate the School of Engineering, University of Aberdeen, Aberdeen, Scotland, United Kingdom, for the provision of the laboratory facilities necessary for completing this work.Peer reviewedPostprin
Clinical and electrophysiological predictors of device-detected new-onset atrial fibrillation during 3 years after cardiac surgery
Postoperative atrial fibrillation (POAF) after cardiac surgery is an independent predictor of stroke and mortality
late after discharge. We aimed to determine the burden and predictors of early (up to 5th postoperative day) and
late (after 5th postoperative day) new-onset atrial fibrillation (AF) using implantable loop recorders (ILRs) in
patients undergoing open chest cardiac surgery
Seventy-nine patients without a history of AF undergoing cardiac surgery underwent peri-operative high-resolution
mapping of electrically induced AF and were followed 36 months after surgery using an ILR (Reveal XTTM). Clinical
and electrophysiological predictors of late POAF were assessed. POAF occurred in 46 patients (58%), with early
POAF detected in 27 (34%) and late POAF in 37 patients (47%). Late POAF episodes were short-lasting (mostly
between 2 min and 6 h) and showed a circadian rhythm pattern with a peak of episode initiation during daytime. In
POAF patients, electrically induced AF showed more complex propagation patterns than in patients without
POAF. Early POAF, right atrial (RA) volume, prolonged PR time, and advanced age were independent predictors of
late POAF
Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo
The polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic risk funnels through these pathways to translate into syndromic illness. Using tensor decomposition, we analyze gene co-expression in the caudate nucleus, hippocampus, and dorsolateral prefrontal cortex of post-mortem brain samples from 358 individuals. We identify a set of genes predominantly expressed in the caudate nucleus and associated with both clinical state and genetic risk for schizophrenia that shows dopaminergic selectivity. A higher polygenic risk score for schizophrenia parsed by this set of genes predicts greater dopamine synthesis in the striatum and greater striatal activation during reward anticipation. These results translate dopamine-linked genetic risk variation into in vivo neurochemical and hemodynamic phenotypes in the striatum that have long been implicated in the pathophysiology of schizophrenia
Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences
The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & NemĂ©sio 2007; Donegan 2008, 2009; NemĂ©sio 2009aâb; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported
by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on
18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based
researchers who signed it in the short time span from 20 September to 6 October 2016
Hybrid cosmic ray measurements using the IceAct telescopes in coincidence with the IceCube and IceTop detectors
IceAct is a proposed surface array of compact (50 cm diameter) and cost-effective Imaging Air Cherenkov Telescopes installed at the site of the IceCube Neutrino Observatory at the geographic South Pole. Since January 2019, two IceAct telescope demonstrators, featuring 61 silicon photomultiplier (SiPM) pixels have been taking data in the center of the IceTop surface array during the austral winter. We present the first analysis of hybrid cosmic ray events detected by the IceAct imaging air-Cherenkov telescopes in coincidence with the IceCube Neutrino Observatory, including the IceTop surface array and the IceCube in-ice array. By featuring an energy threshold of about 10 TeV and a wide field-of-view, the IceAct telescopes show promising capabilities of improving current cosmic ray composition studies: measuring the Cherenkov light emissions in the atmosphere adds new information about the shower development not accessible with the current detectors, enabling significantly better primary particle type discrimination on a statistical basis. The hybrid measurement also allows for detailed feasibility studies of detector cross-calibration and of cosmic ray veto capabilities for neutrino analyses. We present the performance of the telescopes, the results from the analysis of two years of data, and an outlook of a hybrid simulation for a future telescope array
BLOOM: A 176B-Parameter Open-Access Multilingual Language Model
Large language models (LLMs) have been shown to be able to perform new tasks
based on a few demonstrations or natural language instructions. While these
capabilities have led to widespread adoption, most LLMs are developed by
resource-rich organizations and are frequently kept from the public. As a step
towards democratizing this powerful technology, we present BLOOM, a
176B-parameter open-access language model designed and built thanks to a
collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer
language model that was trained on the ROOTS corpus, a dataset comprising
hundreds of sources in 46 natural and 13 programming languages (59 in total).
We find that BLOOM achieves competitive performance on a wide variety of
benchmarks, with stronger results after undergoing multitask prompted
finetuning. To facilitate future research and applications using LLMs, we
publicly release our models and code under the Responsible AI License
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Does preinjury alcohol use or blood alcohol level influence cognitive functioning after traumatic brain injury?
New-onset perioperative atrial fibrillation in cardiac surgery patients:transient trouble or persistent problem?-Authors' reply
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