127 research outputs found
One-way multigrid method in electronic structure calculations
We propose a simple and efficient one-way multigrid method for
self-consistent electronic structure calculations based on iterative
diagonalization. Total energy calculations are performed on several different
levels of grids starting from the coarsest grid, with wave functions
transferred to each finer level. The only changes compared to a single grid
calculation are interpolation and orthonormalization steps outside the original
total energy calculation and required only for transferring between grids. This
feature results in a minimal amount of code change, and enables us to employ a
sophisticated interpolation method and noninteger ratio of grid spacings.
Calculations employing a preconditioned conjugate gradient method are presented
for two examples, a quantum dot and a charged molecular system. Use of three
grid levels with grid spacings 2h, 1.5h, and h decreases the computer time by
about a factor of 5 compared to single level calculations.Comment: 10 pages, 2 figures, to appear in Phys. Rev. B, Rapid Communication
WMAP constraint on the P-term inflationary model
In light of WMAP results, we examine the observational constraint on the
P-term inflation. With the tunable parameter , P-term inflation contains
richer physics than D-term and F-term inflationary models. We find the
logarithmic derivative spectral index with on large scales and on
small scales in agreement to observation. We obtained a reasonable range for
the choice of the gauge coupling constant in order to meet the requirements
of WMAP observation and the expected number of the e-foldings. Although tuning
and we can have larger values for the logarithmic derivative of the
spectral index, it is not possible to satisfy all observational requirements
for both, the spectral index and its logarithmic derivative at the same time.Comment: 6 pages, double column, 13 figures included. Version appearing in the
Physical Review
Denial of long-term issues with agriculture on tropical peatlands will have devastating consequences
Non peer reviewe
Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP
microarray intensity data of 38,303 women from cancer genome-wide association studies
(20,878 cases and 17,425 controls) and detected 124 mosaic X events42Mb in 97 (0.25%)
women. Here we show rates for X-chromosome mosaicism are four times higher than mean
autosomal rates; X mosaic events more often include the entire chromosome and participants
with X events more likely harbour autosomal mosaic events. X mosaicism frequency
increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and
autosomes. Methylation array analyses of 33 women with X mosaicism indicate events
preferentially involve the inactive X chromosome. Our results provide further evidence that
the sex chromosomes undergo mosaic events more frequently than autosomes, which could
have implications for understanding the underlying mechanisms of mosaic events and their
possible contribution to risk for chronic diseases
Detectable clonal mosaicism and its relationship to aging and cancer
In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases
Panax (ginseng) - Panacea or placebo? Molecular and cellular basis of its pharmacological activity
Annals of the Academy of Medicine Singapore29142-46AAMS
Incorporation of initiation, promotion and inhibition in the R ct concept and its application in determining the initiation and inhibition capacities of natural water in ozonation
10.1016/j.watres.2012.01.025Water Research4661990-1998WATR
Androgen receptor gene and male infertility
10.1093/humupd/dmg003Human Reproduction Update911-7HRUP
Mutations in the promoter region of the androgen receptor gene are not common in males with idiopathic infertility
Molecular Human Reproduction53287-290MHRE
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