APPLICATION OF STATISTICAL PROCESS CONTROL THEORY IN COAL AND GAS OUTBURST PREVENTION

With Chinese coal exploitation extending to depth rapidly, a large number of coal and gas outburst accidents happened and resulted in thousands of casualties in the last decade. Coal and gas outburst prevention project has become the prerequisite of underground coal mining, but its process control ability is especially poor. By integrating statistical process control theory into the process of coal and gas outburst prevention, three urgent problems were solved. First at all, data structure of the process inspection parameters was designed asvectors, which only consisted of principle elements and formed data series as time went by. Secondly, based on sample data of the experimental area, statistical characteristic of inspection parameters was gained and their X-Rs control charts were drawn. Finally, performance of process running statuses that might be in control or beyond control were analyzed in detail. When the process was in control, curves should slightly fluctuate around their center lines and between upper control limits and lower control limits. Otherwise, the process was beyond control, in which X control charts were used to identify anomalies of data value fluctuation and Rs control charts were used to identify anomalies of data fluctuation amplitudes. By the experimental application in Hexi colliery of China, the interdisciplinary research was proved to be helpful to improve process control ability and then prevent coal and gas outburst accidents

A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population.

Prostate cancer predisposition has been extensively investigated in European populations, but there have been few studies of other ethnic groups. To investigate prostate cancer susceptibility in the under-investigated Chinese population, we performed single-nucleotide polymorphism (SNP) array analysis on a cohort of Chinese cases and controls and then meta-analysis with data from the existing Chinese prostate cancer genome-wide association study (GWAS). Genotyping 211,155 SNPs in 495 cases and 640 controls of Chinese ancestry identified several new suggestive Chinese prostate cancer predisposition loci. However, none of them reached genome-wide significance level either by meta-analysis or replication study. The meta-analysis with the Chinese GWAS data revealed that four 8q24 loci are the main contributors to Chinese prostate cancer risk and the risk alleles from three of them exist at much higher frequencies in Chinese than European populations. We also found that several predisposition loci reported in Western populations have different effect on Chinese men. Therefore, this first extensive single-nucleotide polymorphism study of Chinese prostate cancer in comparison with European population indicates that four loci on 8q24 contribute to a great risk of prostate cancer in a considerable large proportion of Chinese men. Based on those four loci, the top 10% of the population have six- or two-fold prostate cancer risk compared with men of the bottom 10% or median risk respectively, which may facilitate the design of prostate cancer genetic risk screening and prevention in Chinese men. These findings also provide additional insights into the etiology and pathogenesis of prostate cancer.This work was conducted on behalf of the CHIPGECS and The PRACTICAL consortia (see Supplementary Consortia). We acknowledge the contribution of doctors, nurses and postgraduate research students at the CHIPGENCS sample collecting centers. We thank Orchid and Rosetrees for funding support. This work was also supported by National Natural Science foundation of China for funding support to H Zhang (Grant No: 30671793 and 81072377), N Feng (Grant No: 81272831), X Zhang (Grant No: 30572139, 30872924 and 81072095), S Zhao (Grant No: 81072092 and 81328017), Y Yu (Grant No: 81172448) and Program for New Century Excellent Talents in University from Department of Education of China (NCET-08-0223) and the National High Technology Research and Development Program of China (863 Program 2012AA021101) to X Zhang.This is the final version of the article. It first appeared from Impact Journals via http://dx.doi.org/10.18632/oncotarget.725

Peregrine and saker falcon genome sequences provide insights into evolution of a predatory lifestyle

As top predators, falcons possess unique morphological, physiological and behavioral adaptations that allow them to be successful hunters: for example, the peregrine is renowned as the world's fastest animal. To examine the evolutionary basis of predatory adaptations, we sequenced the genomes of both the peregrine (Falco peregrinus) and saker falcon (Falco cherrug), and we present parallel, genome-wide evidence for evolutionary innovation and selection for a predatory lifestyle. The genomes, assembled using Illumina deep sequencing with greater than 100-fold coverage, are both approximately 1.2 Gb in length, with transcriptome-assisted prediction of approximately 16,200 genes for both species. Analysis of 8,424 orthologs in both falcons, chicken, zebra finch and turkey identified consistent evidence for genome-wide rapid evolution in these raptors. SNP-based inference showed contrasting recent demographic trajectories for the two falcons, and gene-based analysis highlighted falcon-specific evolutionary novelties for beak development and olfaction and specifically for homeostasis-related genes in the arid environment–adapted saker

Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

Imputing genotypes from reference panels created by whole-genome sequencing (WGS) provides a cost-effective strategy for augmenting the single-nucleotide polymorphism (SNP) content of genome-wide arrays. The UK10K Cohorts project has generated a data set of 3,781 whole genomes sequenced at low depth (average 7x), aiming to exhaustively characterize genetic variation down to 0.1% minor allele frequency in the British population. Here we demonstrate the value of this resource for improving imputation accuracy at rare and low-frequency variants in both a UK and an Italian population. We show that large increases in imputation accuracy can be achieved by re-phasing WGS reference panels after initial genotype calling. We also present a method for combining WGS panels to improve variant coverage and downstream imputation accuracy, which we illustrate by integrating 7,562 WGS haplotypes from the UK10K project with 2,184 haplotypes from the 1000 Genomes Project. Finally, we introduce a novel approximation that maintains speed without sacrificing imputation accuracy for rare variants

Whole-genome sequence-based analysis of thyroid function

Tiina Paunio on työryhmän UK10K Consortium jäsen.Normal thyroid function is essential for health, but its genetic architecture remains poorly understood. Here, for the heritable thyroid traits thyrotropin (TSH) and free thyroxine (FT4), we analyse whole-genome sequence data from the UK10K project (N = 2,287). Using additional whole-genome sequence and deeply imputed data sets, we report meta-analysis results for common variants (MAF >= 1%) associated with TSH and FT4 (N = 16,335). For TSH, we identify a novel variant in SYN2 (MAF = 23.5%, P = 6.15 x 10(-9)) and a new independent variant in PDE8B (MAF = 10.4%, P = 5.94 x 10(-14)). For FT4, we report a low-frequency variant near B4GALT6/ SLC25A52 (MAF = 3.2%, P = 1.27 x 10(-9)) tagging a rare TTR variant (MAF = 0.4%, P = 2.14 x 10(-11)). All common variants explain >= 20% of the variance in TSH and FT4. Analysis of rare variants (MAFPeer reviewe

Graph Zn and some graphs related to Zn are determined by their spectrum

AbstractIt is proved that graph Zn is determined by its adjacency spectrum as well as its Laplacian spectrum; Zn1+Zn2+⋯+Znk is determined by its adjacency spectrum, where n1,n2,…,nk are integers at least 2; Wn is not determined by its adjacency spectrum but is determined by its Laplacian spectrum; kZn, Tn are determined by their Laplacian spectrum, respectively, where k is a positive integer

The Impact of Vehicle Ownership on Carbon Emissions in the Transportation Sector

As one of the important sources of carbon emissions, the transportation industry should be given attention. This study investigates the relationship between vehicle ownership, economic growth, and environmental pressure on the Chongqing transportation industry (CQTI) based on CQTI data, then constructs a comprehensive regression model and couples the EKC curve and Tapio model for integrated analysis, and finally constructs a LEAP-Chongqing model to forecast CQTI from multiple perspectives. The innovations are that the multi-model examines the effects of different variables and has a better classification of transportation modes in scenario simulation. The results show that: (1) there is an inverse N-shaped relationship between car ownership, economic growth, and environmental pressure of CQTI; (2) every 1% of transportation output, urbanization rate, or car ownership will cause 0.769%, 0.111%, and 0.096% of carbon emission change, respectively; (3) gasoline, diesel and aviation kerosene consumption account for 80–90%, private cars cause 41–52% of carbon emissions, and the energy structure and transportation structure of CQTI are unreasonable; (4) the results of a multi-scenario simulation show that the energy saving and emission reduction effect of a single policy is not satisfactory, and the integration of energy saving and emission reduction measures should be strengthened

The Impact of Vehicle Ownership on Carbon Emissions in the Transportation Sector

As one of the important sources of carbon emissions, the transportation industry should be given attention. This study investigates the relationship between vehicle ownership, economic growth, and environmental pressure on the Chongqing transportation industry (CQTI) based on CQTI data, then constructs a comprehensive regression model and couples the EKC curve and Tapio model for integrated analysis, and finally constructs a LEAP-Chongqing model to forecast CQTI from multiple perspectives. The innovations are that the multi-model examines the effects of different variables and has a better classification of transportation modes in scenario simulation. The results show that: (1) there is an inverse N-shaped relationship between car ownership, economic growth, and environmental pressure of CQTI; (2) every 1% of transportation output, urbanization rate, or car ownership will cause 0.769%, 0.111%, and 0.096% of carbon emission change, respectively; (3) gasoline, diesel and aviation kerosene consumption account for 80–90%, private cars cause 41–52% of carbon emissions, and the energy structure and transportation structure of CQTI are unreasonable; (4) the results of a multi-scenario simulation show that the energy saving and emission reduction effect of a single policy is not satisfactory, and the integration of energy saving and emission reduction measures should be strengthened

Effective Insensitiveness of Melamine Urea-Formaldehyde Resin via Interfacial Polymerization on Nitramine Explosives

Abstract To improve the safety of ammonium nitrate explosives, the melamine urea-formaldehyde resin (MUF resin) was selected for the preparation of three typical nitramine explosives (cyclotetramethylenetetranitramine, HMX; cryclo-trimethylenetrinitramine, RDX; and hexanitrohexaazaisowurtzitane, CL-20) based green polymer-bonded explosives (GPBXs) via interfacial polymerization. Meanwhile, the corresponding composite particles prepared by physical mixing and drying bath methods were studied and compared. The particle morphology, crystal structure, thermal stability, and safety performance of the resultant composite particles were characterized by scanning electron microscopy (SEM), powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectra, differential scanning calorimeter (DSC), and impact sensitivity test, respectively. SEM results showed that MUF was successfully coated on the surface of the three explosives, and different composite particles prepared by the same method have their own unique characteristics. Such effect is attributed to the resin’s ability to isolate and buffer external stimuli. It is obvious that the interfacial polymerization is an effective desensitization technique to prepare core-shell composite particles for explosives

Fabrication of Nanoparticle-Stacked 1,1-Diamino-2,2-Dinitroethylene (FOX-7) Microspheres with Increased Thermal Stability

Nanoparticle-stacked 1,1-diamino-2,2-dinitroethylene (FOX-7) microspheres were successfully prepared by spray-drying, and rod-shaped FOX-7 was obtained by the solvent/nonsolvent method for comparison. The microstructure features of samples were characterized using scanning electron microscopy (SEM) and powder X-ray diffraction (XRD), and the thermal properties were also investigated by differential scanning calorimetry (DSC). From the SEM analysis, the particle size of the rod-shaped FOX-7 is about 10 μm, whereas FOX-7 microspheres having a particle size ranging from 1 to 5 μm are formed by stacking nanoparticles with size of 100-250 nm. The crystal form of the samples prepared by the two methods did not change. The thermal performance test results showed that the rd-shaped FOX-7 had no significant change compared with the raw FOX-7, while the nanoparticle-stacked FOX-7 microspheres had higher thermal stability