1,974 research outputs found
Growth factor for therapeutic angiogenesis in ischemic heart disease: A meta-analysis of randomized controlled trials
Aim: This study was designed to systematically evaluate the effects of growth factor (GF) for therapeutic angiogenesis on ischemic heart disease (IHD) by pooling the results of randomized controlled trials (RCTs).Methods and Results: PubMed, EMBASE, and CENTRAL databases were searched from inception to October 2022. RCTs, investigating the effects of GF therapy on IHD, were included. The risk bias of included study was assessed according to Cochrane tool. Weighted mean difference (WMD), calculated with fixed effect model or random effect model, was used to evaluate the effects of GF therapy on left ventricular ejection fraction (LVEF) and Canadian Cardiovascular Society (CCS) angina class. Relative risk (RR) was used to evaluate the effects of GF therapy on all-cause mortality, major adverse cardiovascular events (MACE) and revascularization. Meta-analysis, meta-regression analysis and publication bias analysis were performed by RevMan 5.3 or Stata 15.1 software. Twenty-nine studies involving 2899 IHD patients (1,577 patients in GF group and 1,322 patients in control group) were included. Compared with the control group, GF therapy did not reduce all-cause mortality (RR: 0.82; 95% CI: 0.54–1.24; p = 0.341), MACE [(RR: 0.83; 95% CI: 0.61–1.12; p = 0.227), revascularization (RR: 1.27, 95% CI: 0.82–1.96, p = 0.290) and CCS angina class (WMD: −0.08, 95% CI: −0.36 to 0.20, p = 0.560). However, GF therapy could increase LVEF during short-term follow-up (<1 year).Conclusion: GF for therapeutic angiogenesis was beneficial for increasing LVEF during short-term follow-up (<1 year), however, the therapy was not efficacious in decreasing all-cause mortality, MACE and revascularization
Atmospheric new particle formation from sulfuric acid and amines in a Chinese megacity
Atmospheric new particle formation (NPF) is an important global phenomenon that is nevertheless sensitive to ambient conditions. According to both observation and theoretical arguments, NPF usually requires a relatively high sulfuric acid (H2SO4) concentration to promote the formation of new particles and a low preexisting aerosol loading to minimize the sink of new particles. We investigated NPF in Shanghai and were able to observe both precursor vapors (H2SO4) and initial clusters at a molecular level in a megacity. High NPF rates were observed to coincide with several familiar markers suggestive of H2SO4-dimethylamine (DMA)water (H2O) nucleation, including sulfuric acid dimers and H2SO4-DMA clusters. In a cluster kinetics simulation, the observed concentration of sulfuric acid was high enough to explain the particle growth to similar to 3 nanometers under the very high condensation sink, whereas the subsequent higher growth rate beyond this size is believed to result fromthe added contribution of condensing organic species. These findings will help in understanding urban NPF and its air quality and climate effects, as well as in formulating policies to mitigate secondary particle formation in China.Peer reviewe
Use of triazole-ring formation to attach a Ru/TsDPEN complex for asymmetric transfer hydrogenation to a soluble polymer
The cycloaddition of a chiral ligand containing a terminal alkyne to a soluble polymer containing an azide provides a convenient means for the attachment of an asymmetric transfer hydrogenation catalyst to a soluble polymer support. Using these ligands in complexes with Ru(II), gave good results in terms of conversion and enantioselectivity (up to 95% ee) in ketone reduction reactions
The gut microbiome in atherosclerotic cardiovascular disease
The gut microbiota may play a role in cardiovascular diseases. Here, the authors perform a metagenome-wide association study on stools from individuals with atherosclerotic cardiovascular disease and healthy controls, identifying microbial strains and functions associated with the disease
Enantiopure distorted ribbon-shaped nanographene combining two-photon absorptionbased upconversion and circularly polarized luminescence
Herein we describe a distorted ribbon-shaped nanographene exhibiting unprecedented combination of
optical properties in graphene-related materials, namely upconversion based on two-photon absorption
(TPA-UC) together with circularly polarized luminescence (CPL). The compound is a graphene molecule
of ca. 2 nm length and 1 nm width with edge defects that promote the distortion of the otherwise planar
lattice. The edge defects are an aromatic saddle-shaped ketone unit and a [5]carbohelicene moiety. This
system is shown to combine two-photon absorption and circularly polarized luminescence and
a remarkably long emission lifetime of 21.5 ns. The [5]helicene is responsible for the chiroptical activity
while the push–pull geometry and the extended network of sp2 carbons are factors favoring the
nonlinear absorption. Electronic structure theoretical calculations support the interpretation of the results.This project has received funding from the European Research
Council (ERC) under the European Union's Horizon 2020
research and innovation program (ERC-2015-STG-677023). We
also thank the Ministerio de Economía y Competitividad
(MINECO, Spain) (CTQ2015-70283-P, CTQ2014-53598-R,
MAT2014-54231-C4-1P, FIS2016-77578-R) and the “Unidad de
Excelencia Química Aplicada a Biomedicina y Medioambiente
(UGR)”. A. G. C., C. S. S. and C. M. C. acknowledge funding from
MINECO (Spain) for RyC-2013-12943, IJCI-2014-19291 and
BES-2016-076371 contracts, respectively. I. R. M. thanks UGR
(Spain) for a postdoctoral scholarship. I. M. and E. M. thank the
Fundação para a Ciência e a Tecnologia for financial support
(IF/00759/2013 and post-doc grant SFRH/BPD/75782/2011). We
thank the CSIRC-Alhambra for supercomputing facilities
Precision Measurement of the Mass of the Lepton
An energy scan near the pair production threshold has been performed
using the BESIII detector. About pb of data, distributed over four
scan points, was collected. This analysis is based on pair decays to
, , , , , , , and
final states, where denotes a charged or . The mass of the
lepton is measured from a maximum likelihood fit to the pair production
cross section data to be )
MeV/, which is currently the most precise value in a single measurement.Comment: 13 pages, 7 figure
Search for the radiative transitions and
By using a 2.92 fb data sample taken at GeV with
the BESIII detector operating at the BEPCII collider, we search for the
radiative transitions and
through the hadronic decays . No
significant excess of signal events above background is observed. We set upper
limits at a 90% confidence level for the product branching fractions to be
and
. Combining our result with world-average
values of , we find the
branching fractions
and at a 90%
confidence level.Comment: 10 pages, 4 figure
Search for C-parity violation in and
Using events recorded in
collisions at 3.686 GeV with the BESIII at the BEPCII collider, we
present searches for C-parity violation in and decays via . No significant
signals are observed in either channel. Upper limits on the branching fractions
are set to be and
at the 90\%
confidence level. The former is one order of magnitude more stringent than the
previous upper limit, and the latter represents the first limit on this decay
channel.Comment: 7 pages, 2 figure
Measurement of the proton form factor by studying
Using data samples collected with the BESIII detector at the BEPCII collider,
we measure the Born cross section of at 12
center-of-mass energies from 2232.4 to 3671.0 MeV. The corresponding effective
electromagnetic form factor of the proton is deduced under the assumption that
the electric and magnetic form factors are equal . In
addition, the ratio of electric to magnetic form factors, , and
are extracted by fitting the polar angle distribution of the proton
for the data samples with larger statistics, namely at 2232.4 and
2400.0 MeV and a combined sample at = 3050.0, 3060.0 and 3080.0 MeV,
respectively. The measured cross sections are in agreement with recent results
from BaBar, improving the overall uncertainty by about 30\%. The
ratios are close to unity and consistent with BaBar results in
the same region, which indicates the data are consistent with the
assumption that within uncertainties.Comment: 13 pages, 24 figure
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