Pengaruh Cooperative Learning Terhadap Resiliensi Akademik Remaja

Resiliensi akademik merupakan kemampuan yang dimiliki individu untuk mempertahankan diri dalam menghadapi tekanan maupun permasalahan akademik. Remaja yang sedang berada dalam fase storm and stress dapat memunculkan rasa tertekan ketika dihadapkan dengan permasalahan akademik sehingga rentan untuk mengalami stress, depresi, ataupun bunuh diri. Penelitian ini bertujuan untuk mengetahui efektivitas metode cooperative learning pada pembelajaran remaja dalam meningkatkan resiliensi akademik. Metode penelitian yang digunakan dalam penelitian adalah quasi-experiment (one-group pretest-posttest design) dengan purposive sampling dalam pemilihan partisipan. Partisipan yang terlibat dalam penelitian ini berjumlah 14 orang remaja, usia 12-17 tahun yang berada dibawah naungan WVI (Wahana Visi Indonesia). Dalam penelitian ini, pengambilan data dilakukan menggunakan skala resiliensi akademik ARS-30 (Academic Resilience Scale). Hasil dari penelitian ini menunjukkan bahwa metode cooperative learning tidak signifikan dalam meningkatkan resiliensi akademik dengan hasil p=0,475 ( p>0,05)Academic resilience is a person's ability to maintain academic achievements even under the presence of academic pressure. Due to experiencing the storm and stress phase, adolescents may  feel depressed over academic problems and be prone to stress, depression, and even suicide. The aim of this research was to discover the effectiveness of cooperative learning method to increase academic resilience in adolescents' learning process. This research used a quasi-experiment method with one-group pretest- posttest design. Purposive sampling was used as the participant sampling technique. The participants are 14 adolescents at the age of 12 to 17 years old who are under the management of WVI (World Vision Indonesia). ARS-30 scale (Academic Resilience Scale) was used to collect participants’ academic resilience data. The result of this research showed that cooperative learning method is not significant to increase academic resilience with p=0,475 (p>0,05)

PENANAMAN BIBIT POHON DAN BUAH-BUAHAN SEBAGAI AKSI PEDULI LINGKUNGAN DI MASYARAKAT

Kegiatan KKN-T Kelompok 63 Desa Cempaka Mulia Timur bertujuan untuk melatih komunikasi dan kepekaan mahasiswa terhadap masyarakat terlebih di desa Cempaka Mulia Timur. Berdasarkan tujuan tersebut luaran yang dihasilkan akan memberi gambaran umum serta analisis terkait kesenjangan di desa yang ditentukan oleh program dengan tepat dan sesuai. Berdasarkan potensi desa Cempaka Mulia Timur pada bidang ekonomi, yaitu bidang perkebunan, hal tersebut juga mendukung program kerja KKN didesa Cempaka Mulia Timur seperti melakukan penanaman bibit pohon dan buah – buahan sebagai aksi peduli lingkungan serta pemanfaatan lahan perkarangan untuk menanam berbagai sayur mayur guna penambah penghasilan bagi desa tersebut, pengkatan SDGs Desa melalui pendidikan, dan melakukan sosialisasi pencegahan stunting dan gizi buruk serta pemberian makanan tambaha

Laporan Praktik Kerja Lapangan(PKL) di Kelurahan Ujung Kecamatan Semampir Kota Surabaya

Puji syukur kami panjatkan kehadirat Allah SWT karena berkat rahmat dan hidayah-Nya kami dapat menyelesaikan laporan PKL (Praktik Kerja Lapangan) dengan tepat waktu. Adapun maksud dan tujuan kami dalam menyelesaikan laporan PKL ini adalah untuk menambah pengetahuan kami mengenai masalah kesehatan di masyarakat, meningkatkan softskill pemecahan masalah di masyarakat tersebut yang selanjutnya dapat menerapkan ilmu yang kami telah pelajari di lapangan kerja atau tempat kita berorganisasi. Dengan upaya yang kami lakukan, semoga Ibu dosen selalu memberikan bimbingan pada kami. Tentunya ada hal-hal yang ingin kami berikan kepada masyarakat dari hasil laporan PKL ini. Karena itu kami berharap semoga laporan ini dapat menjadi sesuatu yang berguna bagi kita bersama

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

Customer Satisfaction During the Covid-19 Pandemic Period at Private Clinic X Surabaya

In an effort to provide public services, there are still many shortcomings when viewed from a quality perspective. It is still far from what the community expects. If this condition is not responded to, it will cause a bad image. During a pandemic period, the health system maintains a balance between meeting the needs for handling a pandemic and fulfilling essential health services. With a health protocol that must be carried out in order to break the chain of the spread of COVID-19, it is necessary to make technical adjustments to health services carried out by the FKTP. This, of course, can affect the quality of service which can also affect the satisfaction felt by patients. This study is an analytic observational study using non-probability techniques with an accidental sampling method with a sample of 200 people who are patients of clinic X in Surabaya and review patient satisfaction documents in the previous year. The variables studied were reliability, responsiveness, assurance, empathy and tangible aspects. The satisfaction received by clink X patients during the COVID-19 pandemic in 2020 was 3.60. In 2019, Clinic X received 3.85 satisfaction. The decline in the average score of patient satisfaction was at least in the assurance aspect (0.21), while the other four aspects experienced a decrease (0.26). There is a need for improvement efforts according to the current conditions of the COVID-19 pandemic to improve service and customer satisfaction at clinic X in Surabaya

ANALISIS MINAT ANAK Uol SEKOLAH DI PEDESAAN Ur MENUNTASKAN PROGRAM PENDIDIKAN WAJIB BELAJAI SEMBILAN TAHUN ( Studi Kasus : Desa Growong Lor, Kecamatan Juana, Kabnpaten Pati)

ABSTRACT This study aims to descrbe the social economic characteristics of school age children in the rural areas to finish nine year compulsory education programme, also to analyse dependent variable that is interest of school age children in rural areas to finish nine year compulsory education programme which is influenced by independent variable. They are parent's income, the parent's burden, school fee, education offamily head school distance, and parent's marriage status The Analysis model used in this reseacrh is Binary Logistic Regression, because the form of dependent variabll is dummy that consist of 1 and o. Growong Lor Village, Juana district in Pats regency is one of rural areas which describes the unsuccessfulness of nine year compulsory education programme. The traditional characetristic of Growong Lor village becomes environtmental factor whichsupport this village as the object ofthe study. As the result ofthis study, there are two independent variables that have significant influence to the dependent variable. Those variables are parent's income which is significant at a= S% andthe education offamily head which is significant at a= 10'916 . The otherfour variables are not significant at a= S% or a= 10A Key words: Binary Logistic Regression, interest ofschool age children in rural areas to finish nine year compulsory education programme, parent's income, the gent's burden school fee, education offamily head, school distance, parent's marriage statu

Whole-genome sequencing reveals host factors underlying critical COVID-19

Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.11Nsciescopu

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies