Mathematical simulation of infiltrating watersheds

January 1971.Bibliography: pages 40-42

Rainfall modeling for integrating radar information into hydrological model

A spatial rainfall model was applied to radar data of air mass thunderstorms to yield a rainstorm representation as a set of convective rain cells. The modeled rainfall was used as input into hydrological model, instead of the standard radar-grid data. This approach allows a comprehensive linkage between runoff responses and rainfall structures. Copyright © 2005 Royal Meteorological Society

Distributed kinematic model of upland watersheds, A

July 1977.Bibliography: pages 35-36

Kinematic cascade as a hydrologic model, The

Bibliography: page 22

Slavic Dialectology: A Survey of Research since 1989

The last 25 years in Slavic dialectology mark the period not only of JSL’s founding but also of major and multiple political, social, and economic reorganizations in predominantly Slavic-speaking states. During this period research institutions and their priorities and projects have both continued and changed; technological innovation has meant moving towards electronic dissemination, “digital humanities,” and innovative modes of presenting research data and findings. In some cases major works (e.g., dialect atlases) have advanced during this period. Moreover, a new generation of scholars has had greater opportunities for mobility and therefore exposure to a variety of linguistic frameworks and approaches, which has fostered cross-border collaboration in the field. The present essay gives an overview of progress made on dialect projects both created institutionally and individually and including both traditional (book, article) and new digital means of dissemination

Influence of simplifications in watershed geometry in simulation of surface runoff

December 1975.Bibliography: pages 49-50

Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer

BACKGROUND: Compounds that can act as agonists for toll-like receptors (TLRs) may be promising candidates for the development of drugs against infectious diseases and cancer. The present study aimed to characterize the immunomodulatory effects of P-MAPA on TLRs in vitro and in vivo, as well as to investigate its potential as adjuvant therapy in infectious diseases and cancer. METHODS: For these purposes, the activity of P-MAPA on TLRs was assayed in vitro through NF-κB activation in HEK293 cells expressing a given TLR, and using an in vivo animal model for bladder cancer (BC). The antimicrobial activity of P-MAPA was tested against Mycobacterium tuberculosis (TB) in vitro in an MIC assay, and in vivo using an aerosol infection model of murine tuberculosis. Antitumor effects of P-MAPA were tested in an animal model with experimentally induced BC. Moxifloxacin (MXF) and Bacillus Calmette-Guerin (BCG) were used as positive controls in the animal models. RESULTS: The results showed that P-MAPA, administered alone or in combination with MXF, induced significant responses in vivo against TB. In contrast, the compound did not show antimicrobial activity in vitro. P-MAPA showed a significant stimulatory effect on human TLR2 and TLR4 in vitro. In BC, TLR2, TLR4 and p53 protein levels were significantly higher in the P-MAPA group than in the BCG group. The most common histopathological changes in each group were papillary carcinoma in BC group, low-grade intraepithelial neoplasia in BCG group and simple hyperplasia in P-MAPA group. Concerning the toxicological analysis performed during BC treatment, P-MAPA did not show evidence for hepatotoxicity and nephrotoxicity. CONCLUSIONS: In conclusion, P-MAPA acted as TLR ligand in vitro and improved the immunological status in BC, increasing TLR2 and TLR4 protein levels. P-MAPA immunotherapy was more effective in restoring p53 and TLRs reactivities and showed significantly greater antitumor activity than BCG. The activation of TLRs and p53 may provide a hypothetical mechanism for the therapeutic effects in both cancer and infectious diseases. Taken together data obtained will encourage the further investigation of P-MAPA as a potential candidate for the treatment of cancer and infectious diseases

Automatic digitization of pluviograph strip charts

An algorithm for automatic digitization of pluviograph strip charts is presented. The rainfall signal is incrementally extracted from the scanned image of a strip chart by combining the moving average method and the curve edge following method. The mechanical properties of float-based rain gauge were used as constraints in the algorithm design. The algorithm was tested on 58 strip chart images. The comparison between the data derived from the algorithm and the data from the Slovenian Environment Agency shows that the algorithm produces an accurate rainfall time series except for the charts that contain ink smudges. Thus, the algorithm is well suited as a main component of an interactive system that would enable visual inspection of the detected rainfall curve and its possible adjustment