Improved Nutation Damper for a Spin-Stabilized Spacecraft

A document proposes an improved liquid- ring nutation damper for a spin-stabilized spacecraft. The improvement addresses the problem of accommodating thermal expansion of the damping liquid. Heretofore, the problem has been solved by either (1) filling the ring completely with liquid and accommodating expansion by attaching a bellows or (2) partially filling the ring and accepting the formation of bubbles. The disadvantage of (1) is that a bellows is expensive and may not be reliable; the disadvantage of (2) is that bubbles can cause fluid lockup and consequent loss of damping. In the improved damper, the ring would be nearly completely filled with liquid, and expansion would be accommodated, but not by a bellows. Instead, an escape tube would be attached to the ring. The escape tube would be positioned and oriented so that the artificial gravitation and the associated buoyant force generated by the spin of the spacecraft would cause the bubbles to migrate toward the tip of the tube. In addition, when the spacecraft was on the launch pad, the escape tube would be at the top of the ring, so that bubbles would rise into the tube

Optimal attitude maneuver execution for the Advanced Composition Explorer (ACE) mission

The Advanced Composition Explorer (ACE) spacecraft will require frequent attitude reorientations in order to maintain the spacecraft high gain antenna (HGA) within 3 deg of earth-pointing. These attitude maneuvers will be accomplished by employing a series of ground-commanded thruster pulses, computed by ground operations personnel, to achieve the desired change in the spacecraft angular momentum vector. With each maneuver, attitude nutation will be excited. Large nutation angles are undesirable from a science standpoint. It is important that the thruster firings be phased properly in order to minimize the nutation angle at the end of the maneuver so that science collection time is maximized. The analysis presented derives a simple approximation for the nutation contribution resulting from a series of short thruster burns. Analytic equations are derived which give the induced nutation angle as a function of the number of small thruster burns used to execute the attitude maneuver and the phasing of the burns. The results show that by properly subdividing the attitude burns, the induced nutation can be kept low. The analytic equations are also verified through attitude dynamics simulation and simulation results are presented. Finally, techniques for quantifying the post-maneuver nutation are discussed

Processing GPS Receiver Data for Improved Fermi GLAST Navigation

Fermi GLAST s 5-year mission objectives: a) Explore the most extreme environments in the Universe. b) Search for signs of new laws of physics and what composes the mysterious Dark Matter. c) Explain how black holes accelerate immense jets of material to nearly light speed. d) Help crack the mysteries of gamma-ray bursts. e) Answer long-standing questions across a broad range of topics, including solar flares, pulsars and the origin of cosmic rays

Landsat Data Continuity Mission (LDCM) Ascent and Operational Orbit Design

For the past 40-years, Landsat Satellites have collected Earth's continental data and enabled scientists to assess change in the Earth's landscape. The Landsat Data Continuity Mission (LDCM) is the next generation satellite supporting the Landsat science program. LDCM will fly a 16-day ground repeat cycle, Sun-synchronous, frozen orbit with a mean local time of the descending node ranging between 10:10 am and 10:15 am. This paper presents the preliminary ascent trajectory design from the injection orbit to its final operational orbit. The initial four burn ascent design is shown to satisfy all the LDCM mission goals and requirement and to allow for adequate flexibility in re-planning the ascent

Survey of variation in human transcription factors reveals prevalent DNA binding changes

Published in final edited form as: Science. 2016 Mar 25; 351(6280): 1450–1454. Published online 2016 Mar 24. doi: 10.1126/science.aad2257Sequencing of exomes and genomes has revealed abundant genetic variation affecting the coding sequences of human transcription factors (TFs), but the consequences of such variation remain largely unexplored. We developed a computational, structure-based approach to evaluate TF variants for their impact on DNA binding activity and used universal protein-binding microarrays to assay sequence-specific DNA binding activity across 41 reference and 117 variant alleles found in individuals of diverse ancestries and families with Mendelian diseases. We found 77 variants in 28 genes that affect DNA binding affinity or specificity and identified thousands of rare alleles likely to alter the DNA binding activity of human sequence-specific TFs. Our results suggest that most individuals have unique repertoires of TF DNA binding activities, which may contribute to phenotypic variation.National Institutes of Health; NHGRI R01 HG003985; P50 HG004233; A*STAR National Science Scholarship; National Science Foundatio

Stochastic Inflation Revisited: Non-Slow Roll Statistics and DBI Inflation

Stochastic inflation describes the global structure of the inflationary universe by modeling the super-Hubble dynamics as a system of matter fields coupled to gravity where the sub-Hubble field fluctuations induce a stochastic force into the equations of motion. The super-Hubble dynamics are ultralocal, allowing us to neglect spatial derivatives and treat each Hubble patch as a separate universe. This provides a natural framework in which to discuss probabilities on the space of solutions and initial conditions. In this article we derive an evolution equation for this probability for an arbitrary class of matter systems, including DBI and k-inflationary models, and discover equilibrium solutions that satisfy detailed balance. Our results are more general than those derived assuming slow roll or a quasi-de Sitter geometry, and so are directly applicable to models that do not satisfy the usual slow roll conditions. We discuss in general terms the conditions for eternal inflation to set in, and we give explicit numerical solutions of highly stochastic, quasi-stationary trajectories in the relativistic DBI regime. Finally, we show that the probability for stochastic/thermal tunneling can be significantly enhanced relative to the Hawking-Moss instanton result due to relativistic DBI effects.Comment: 38 pages, 2 figures. v3: minor revisions; version accepted into JCA

The genomes of two key bumblebee species with primitive eusocial organization

Background: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats. Results: We report the high quality draft genome sequences of Bombus terrestris and Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly eusocial honeybee Apis mellifera and other Hymenoptera, we identify deeply conserved similarities, as well as novelties key to the biology of these organisms. Some honeybee genome features thought to underpin advanced eusociality are also present in bumblebees, indicating an earlier evolution in the bee lineage. Xenobiotic detoxification and immune genes are similarly depauperate in bumblebees and honeybees, and multiple categories of genes linked to social organization, including development and behavior, show high conservation. Key differences identified include a bias in bumblebee chemoreception towards gustation from olfaction, and striking differences in microRNAs, potentially responsible for gene regulation underlying social and other traits. Conclusions: These two bumblebee genomes provide a foundation for post-genomic research on these key pollinators and insect societies. Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation

Jugoslavija u međunarodnoj trgovini ribom, ribljim proizvodima i prerađevinama

Sulfonamides are profoundly important in pharmaceutical design. C–N cross-coupling of sulfonamides is an effective method for fragment coupling and structure–activity relationship (SAR) mining. However, cross-coupling of the important <i>N</i>-arylsulfonamide pharmacophore has been notably unsuccessful. Here, we present a solution to this problem via oxidative Cu-catalysis (Chan–Lam cross-coupling). Mechanistic insight has allowed the discovery and refinement of an effective cationic Cu catalyst to facilitate the practical and scalable Chan–Lam <i>N</i>-arylation of primary and secondary <i>N</i>-arylsulfonamides at room temperature. We also demonstrate utility in the large scale synthesis of a key intermediate to a clinical hepatitis C virus treatment