Cannibalism of Juveniles by Adult Common Snook (Centropomus undecimalis)

Cannibalism is probably common to many fish species, but has been documented for relatively few. This study provides the first documentation of intercohort cannibalism (juveniles cannibalized by adults) for common snook, Centropomus undecimalis, all instances of which occurred in putative nursery habitats

Helical distribution of the bacterial chemoreceptor via colocalization with the Sec protein translocation machinery

In Escherichia coli, chemoreceptor clustering at a cell pole seems critical for signal amplification and adaptation. However, little is known about the mechanism of localization itself. Here we examined whether the aspartate chemoreceptor (Tar) is inserted directly into the polar membrane by using its fusion to green fluorescent protein (GFP). After induction of Tar–GFP, fluorescent spots first appeared in lateral membrane regions, and later cell poles became predominantly fluorescent. Unexpectedly, Tar–GFP showed a helical arrangement in lateral regions, which was more apparent when a Tar–GFP derivative with two cysteine residues in the periplasmic domain was cross-linked to form higher oligomers. Moreover, similar distribution was observed even when the cytoplasmic domain of the double cysteine Tar–GFP mutant was replaced by that of the kinase EnvZ, which does not localize to a pole. Observation of GFP–SecE and a translocation-defective MalE–GFP mutant, as well as indirect immunofluorescence microscopy on SecG, suggested that the general protein translocation machinery (Sec) itself is arranged into a helical array, with which Tar is transiently associated. The Sec coil appeared distinct from the MreB coil, an actin-like cytoskeleton. These findings will shed new light on the mechanisms underlying spatial organization of membrane proteins in E. coli

epsilon'/epsilon at the NLO: 10 Years Later

During the last four years several parameters relevant for the analysis of the CP-violating ratio epsilon'/epsilon improved and/or changed significantly. In particular, the experimental value of epsilon'/epsilon and the strange quark mass decreased, the uncertainty in the CKM factor has been reduced, and for a value of the hadronic matrix element of the dominant electroweak penguin operator Q_8, some consensus has been reached among several theory groups. In view of this situation, ten years after the first analyses of epsilon'/epsilon at the next-to-leading order, we reconsider the analysis of epsilon'/epsilon within the SM and investigate what can be said about the hadronic Q_6 matrix element of the dominant QCD penguin operator on the basis of the present experimental value of epsilon'/epsilon and todays values of all other parameters. Employing a conservative range for the reduced electroweak penguin matrix element R_8=1.0+-0.2 from lattice QCD, and present values for all other input parameters, on the basis of the current world average for epsilon'/epsilon, we obtain the reduced hadronic matrix element of the dominant QCD penguin operator R_6=1.23+-0.16 implying _0^NDR(m_c) ~ -0.8 _2^NDR(m_c). We compare these results with those obtained in large-N_c approaches in which generally R_6 ~ R_8 and _0^NDR(m_c) is chirally suppressed relatively to _2^NDR(m_c). We present the correlation between R_6 and R_8 that is implied by the data on epsilon'/epsilon provided new physics contributions to epsilon'/epsilon can be neglected.Comment: 18 pages, 1 eps figure, version to appear in JHE

Time evolution of condensed state of interacting bosons with reduced number fluctuation in a leaky box

We study the time evolution of the Bose-Einstein condensate of interacting bosons confined in a leaky box, when its number fluctuation is initially (t=0) suppressed. We take account of quantum fluctuations of all modes, including k = 0. We identify a ``natural coordinate'' b_0 of the interacting bosons, by which many physical properties can be simply described. Using b_0, we successfully define the cosine and sine operators for interacting many bosons. The wavefunction, which we call the ``number state of interacting bosons'' (NSIB), of the ground state that has a definite number N of interacting bosons can be represented simply as a number state of b_0. We evaluate the time evolution of the reduced density operator \rho(t) of the bosons in the box with a finite leakage flux J, in the early time stage for which Jt << N. It is shown that \rho(t) evolves from a single NSIB at t = 0, into a classical mixture of NSIBs of various values of N at t > 0. We define a new state called the ``number-phase squeezed state of interacting bosons'' (NPIB). It is shown that \rho(t) for t>0 can be rewritten as the phase-randomized mixture (PRM) of NPIBs. It is also shown that the off-diagonal long-range order (ODLRO) and the order parameter defined by it do not distinguish the NSIB and NPIB. On the other hand, the other order parameter \Psi, defined as the expectation value of the boson operator, has different values among these states. For each element of the PRM of NPIBs, we show that \Psi evolves from zero to a finite value very quickly. Namely, after the leakage of only two or three bosons, each element acquires a full, stable and definite (non-fluctuating) value of \Psi.Comment: 25 pages including 3 figures. To appear in Phys. Rev. A (1999). The title is changed to stress the time evolution. Sections II, III and IV of the previous manuscript have been combined into one section. The introduction and summary of the previous manuscript have been combined into the Introduction and Summary. The names and abbreviations of quantum states are changed to stress that they are for interacting many bosons. More references are cite

Potential role of the posterior cruciate ligament synovio-entheseal complex in joint effusion in early osteoarthritis: a magnetic resonance imaging and histological evaluation of cadaveric tissue and data from the Osteoarthritis Initiative

Objective: This study explored posterior cruciate ligament (PCL) synovio-entheseal complex (SEC) microanatomy to determine whether it may participate in the early osteoarthritis (OA) disease process. Methods: SEC microanatomy and OA features were evaluated in 14 non-arthritic cadaveric knees (mean age = 69.9) using magnetic resonance imaging (MRI) and histology. MRI images of 49 subjects selected from the progression cohort of the Osteoarthritis Initiative (OAI) were evaluated by a musculoskeletal radiologist using an original semi-quantitative method for features associated with OA at the PCL tibial enthesis. Statistical analysis was performed using chi-square and Wilcoxon signed-rank tests to evaluate associations between SEC configuration and OA features. Results: The PCL formed a SEC-like structure encompassing bone- and ligament-lining intra-articular cartilages to which the posterior root of the medial meniscus contributed. Degenerative features at the PCL-SEC included: neovascularisation (44%), enthesis chondrocyte clustering (44%), collagen matrix fissuring at the enthesis (56%) and in the PCL itself (67%), tidemark duplication (44%), bone remodelling (44%) and microscopic inflammatory changes (33%). In the OAI cohort, SEC-related pathology included bone marrow lesions (BMLs) (69%) and osteophytosis (94%) at locations that corresponded to SEC-related cartilages. Posterior joint recess effusion (49%) was linked to MRI abnormalities at PCL-SEC cartilages (χ2 = 7.27, P = 0.007). Conclusions: The PCL has a prominent SEC configuration that is associated with microscopic OA changes in aged clinically non-diseased joints. MRI determined knee OA commonly exhibited pathological features at this site which was associated with adjacent joint effusion. Thus, the PCL-SEC could play a hitherto unappreciated role in the early OA disease process

Acute cocoa flavanol supplementation improves muscle macro- and microvascular but not anabolic responses to amino acids in older men

The anabolic effects of nutrition on skeletal muscle may depend on adequate skeletal muscle perfusion, which is impaired in older people. Cocoa flavanols have been shown to improve flow-mediated dilation, an established measure of endothelial function. However, their effect on muscle microvascular blood flow is currently unknown. Therefore, the objective of this study was to explore links between the consumption of cocoa flavanols, muscle microvascular blood flow and muscle protein synthesis (MPS) in response to nutrition in older men. To achieve this objective leg blood flow (LBF), muscle microvascular blood volume (MBV) and MPS were measured under postabsorptive and postprandial (I.V glamin, dextrose to sustain glucose ~7.5 mmol·l-1) conditions in 20 older men. Ten of these men were studied with no cocoa flavanol intervention and a further 10 were studied with the addition of 350 mg of cocoa flavanols at the same time as nutrition began. Leg [femoral artery] blood flow was measured by Doppler ultrasound, muscle MBV by contrast-enhanced ultrasound (CEUS) using DefinityTM perflutren contrast agent and MPS using [1, 2-13C2] leucine tracer techniques. Our results show that although older individuals do not show an increase in LBF or MBV in response to feeding, these absent responses are apparent when cocoa flavanols are given acutely with nutrition. However this restoration in vascular responsiveness is not associated with improved MPS responses to nutrition. We conclude that acute cocoa flavanol supplementation improves muscle macro- and microvascular responses to nutrition, independently of modifying muscle protein anabolism

The Impact of |Delta I|=5/2 Transitions in K-> pi pi Decays

We consider the impact of isospin violation on the analysis of K-> pi pi decays. We scrutinize, in particular, the phenomenological role played by the additional weak amplitude, of |Delta I|=5/2 in character, incurred by the presence of isospin violation. We show that Watson's theorem is appropriate in O(m_d-m_u), so that the inferred pi-pi phase shift at sqrt{s}=m_K determines the strong phase difference between the I=0 and I=2 amplitudes in K-> pi pi decay. We find the magnitude of the |Delta I|=5/2 amplitude thus implied by the empirical branching ratios to be larger than expected from estimates of isospin-violating strong and electromagnetic effects. We effect a new determination of the octet and 27-plet coupling constants with strong-interaction isospin violation and with electromagnetic effects, as computed by Cirigliano, Donoghue, and Golowich, and find that we are unable to resolve the difficulty. Exploring the role of |Delta I|=5/2 transitions in the CP-violating observable epsilon'/epsilon, we determine that the presence of a |Delta I|=5/2 amplitude impacts the empirical determination of omega, the ratio of the real parts of the |Delta I|=3/2 to |Delta I|=1/2 amplitudes, and that it generates a decrease in the estimation of epsilon'/epsilon.Comment: 29 pages, 1 ps fig, refs. added, to appear in Phys. Rev.

Global Search for New Physics with 2.0/fb at CDF

Data collected in Run II of the Fermilab Tevatron are searched for indications of new electroweak-scale physics. Rather than focusing on particular new physics scenarios, CDF data are analyzed for discrepancies with the standard model prediction. A model-independent approach (Vista) considers gross features of the data, and is sensitive to new large cross-section physics. Further sensitivity to new physics is provided by two additional algorithms: a Bump Hunter searches invariant mass distributions for "bumps" that could indicate resonant production of new particles; and the Sleuth procedure scans for data excesses at large summed transverse momentum. This combined global search for new physics in 2.0/fb of ppbar collisions at sqrt(s)=1.96 TeV reveals no indication of physics beyond the standard model.Comment: 8 pages, 7 figures. Final version which appeared in Physical Review D Rapid Communication