60 research outputs found
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
- Author
- Aamir A
- Abbas J
- Abbas N
- Abbott TEF
- Abdalla M
- Abdikadir H
- Abuhussein N
- Acquaah F
- Adamson R
- Adeleye O
- Adeogun A
- Adlan A
- Aftab R
- Afzal Z
- Agarwal M
- Aglan H
- Agnew CJF
- Agrawal R
- Ahern D
- Ahluwalia J
- Ahluwalia V
- Ahmad A
- Ahmad K
- Ahmed H
- Ahmed I
- Ahmed L
- Ahmed N
- Ahmed P
- Ainger E
- Ainsworth P
- Aishwarya G
- Ajibola-Taylor O
- Akhbari M
- Akhtar A
- Akhtar R
- Akpenyi O
- Al-Ausi M
- Al-Huneidi R
- Al-Khudairi R
- Al-Masri S
- Al-Mousawi A
- Al-Saadi N
- Alagappan A
- Alberts J
- Alfa-Wali M
- Ali A
- Ali B
- Ali I
- Ali M
- Ali Q
- Ali S
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- Alwandi A
- Amani L
- Amarnath T
- Amer M
- Amin H
- Amin MN
- Amoah R
- Amoah-Arko A
- Anandarajah C
- Ananthavarathan P
- Andah EJE
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- Appleton S
- Aquilina T
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- Auluck I
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- Renukanthan A
- Renwick P
- Reynolds J
- Reza N
- Richards C
- Richards T
- Richardson E
- Rickard L
- Rickards C
- Ridgway P
- Riley BJ
- Rimmer L
- Rinkoff S
- Riyat H
- Roberts B
- Roberts G
- Roberts J
- Robertson D
- Robinson A
- Robinson H
- Robinson K
- Robinson SD
- Rockall T
- Rodman L
- Roe T
- Rogers A
- Rogers D
- Roper L
- Roscoe HW
- Ross F
- Rothnie K
- Rothwell L
- Rotundo A
- Roy C
- Runkel M
- Rushd A
- Russell J
- Rutherford A
- Rutherford D
- Rutler L
- Ryan G
- Saad M
- Saat MI
- Sadanand KS
- Sadhra SS
- Sadiq S
- Saeed F
- Saggar S
- Sagoo H
- Saha A
- Sait MS
- Sait S
- Saito R
- Sajid M
- Salciccioli J
- Saleem H
- Salekin D
- Sales A
- Salman M
- Samaraweera S
- Sammut T
- Samuel R
- Sanders E
- Sandhu A
- Sandhu J
- Sandhu N
- Sandland-Taylor L
- Sangal P
- Sansome S
- Sarathy PP
- Saravanabavan S
- Sardar M
- Sarens N
- Sasapu K
- Sathiyakeerthy A
- Sattar M
- Sattar Z
- Saunders I
- Saunders M
- Sawers N
- Sawkins H
- Schade A
- Schinle P
- Schramm M
- Scotcher S
- Scott K
- Scott M
- Searle C
- Seehra H
- Seehra J
- Seelarbokus A
- Seetharam P
- Sellahewa C
- Selvadurai S
- Sen P
- Seraj SS
- Serry M
- Seth I
- Sethi R
- Shafi A
- Shafiq N
- Shaid M
- Shaman S
- Shang E
- Sharif I
- Sharkey E
- Sharma A
- Sharma E
- Sharma S
- Shaw A
- Shaw C
- Sheik-Ali S
- Sheikh A
- Sheikh S
- Sheikh Z
- Shergill M
- Shergill S
- Sherlock J
- Shields P
- Shingles C
- Shirazi S
- Shurovi BN
- Siddiqui A
- Siddiqui I
- Silke E
- Sim DPY
- Sim R
- Simmonds L
- Simon A
- Simpson L
- Simpson R
- Sinclair E
- Singagireson S
- Singh K
- Singh KKR
- Sinha C
- Sivagnanasithiyar T
- Sivakumar C
- Sivakumar R
- Skulsky S
- Slade G
- Slade RD
- Sleight S
- Small S
- Smallwood J
- Smart B
- Smart G
- Smart YW
- Smith ACD
- Smith C
- Smith F
- Smith H
- Smith J
- Smith M
- Smith R
- Sonagara V
- Song A
- Soonawalla Z
- Soor P
- Spencer R
- Spiers H
- Spoor H
- Springford LR
- Srikanthan M
- Sriram A
- Stageman N
- Standfield N
- Stanger S
- Stanier P
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators, Nepogodiev, D
- Stechman M
- Stewart D
- Stewart E
- Stewart H
- Stewart R
- Stickler E
- Stoddart MT
- Stokes E
- Stott G
- Strang S
- Stringer H
- Stringfellow TD
- Stubbing-Moore A
- Sturrock S
- Subar D
- Subratty SM
- Sukirthan N
- Sukumar S
- Sulaiman SK
- Sultan S
- Sun L
- Sundaram K
- Suresh R
- Suresh S
- Sureshkumar A
- Suri A
- Svolkinas D
- Swan A
- Swan I
- Swaray A
- Swartbol T
- Symons L
- Szczap A
- Szuman A
- Tailor S
- Tam J
- Tam JP
- Tan CY
- Tan KL
- Tan L
- Tan LC
- Tan S
- Tan TSE
- Tang A
- Tang M
- Tanna A
- Taribagil P
- Tariq A
- Tate S
- Tayeh S
- Taylor K
- Taylor O
- Taylor R
- Taylor Z
- Telfer R
- Teng T
- Tenters F
- Teo R
- Thachettu A
- Thakrar D
- Thatcher A
- Theodoropoulou K
- Thomas A
- Thomas D
- Thomas M
- Thomas O
- Thomas S
- Thompson G
- Thompson J
- Thoms BL
- Thomson F
- Thorley N
- Thorn C
- Thornton T
- Thorpe O
- Tilliridou V
- Titu L
- Tod N
- Toellner H
- Toh C
- Toma T
- Tonks A
- Torrance HD
- Townsend D
- Traish M
- Trenear R
- Tresidder S
- Trevett J
- Triniman MC
- Trotter M
- Tsang JCH
- Tsang K
- Tseu B
- Tsui A
- Tullett A
- Tummon R
- Turlejski T
- Turner J
- Turner S
- Tyson N
- Ubhi HK
- Ujjal S
- Underhill R
- Vadgama N
- Vaidya A
- Vakharia A
- Van Den Berg N
- Van der Laan S
- Van Winsen K
- Vara S
- Varathan Y
- Varatharasasingam K
- Varcada M
- Vaughan R
- Vella-Baldacchino M
- Ventre C
- Venturini S
- Verma N
- Vernet G
- Victor L
- Vig S
- Vine M
- Vipond M
- Virani N
- Vizor R
- Vyas M
- Wadood Q
- Waite K
- Wakeford W
- Walford B
- Walker EY
- Walker G
- Walker K
- Walker L
- Walker NR
- Walls L
- Walsh T
- Wang H
- Wang L
- Wang X
- Ward AE
- Ward J
- Ward N
- Ward T
- Warren L
- Warren O
- Warusavitarne J
- Waterman A
- Waters S
- Watkinson G
- Watson L
- Watson N
- Waugh D
- Wayman J
- Webb E
- Webb R
- Weegenaar C
- Wei R
- Welsh K
- Whewell H
- Whitcroft I
- White C
- White F
- White P
- Whitham R
- Whyte M
- Widdison A
- Wiffen L
- Wigley C
- Wijeyaratne M
- Williams C
- Williams G
- Williams H
- Williams I
- Williams LM
- Williams P
- Williams S
- Wilson H
- Wilson J
- Wilson R
- Wilson V
- Wimalathasan A
- Woin E
- Wong C
- Wong E
- Wong J
- Wong MHY
- Wood CM
- Woodhams K
- Woolley A
- Wootton E
- Worley E
- Worsfold M
- Wright OW
- Wright R
- Wright S
- Wroe N
- Wynell-Mayow W
- Xu Y
- Yahaya AA
- Yalamarthi S
- Yang DD
- Yang N
- Yap J
- Yardimci E
- Yarham E
- Yasin IH
- Yasin T
- Yates J
- Ye W
- Yeo A
- Yeoh T
- Yeung J
- Yin ZD
- Yip J
- Yoganayagam N
- Yogeswara T
- York J
- Yousaf A
- Youssef H
- Yu T
- Yule A
- Zaat S
- Zanichelli D
- Zaver V
- Zeng R
- Zhang Y
- Zheleniakova T
- Zhu Y
- Zornoza A
- Zubikarai G
- Zulkifli A
- Zuzarte L
- Publication venue
- 'Wiley'
- Publication date
- 18/05/2018
- Field of study
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
Near-Infrared Variability in the Orion Nebula Cluster
- Author
- Ambartsumian V. A.
- Billot N.
- Bo Reipurth
- Brun A.
- Cargile P. A.
- Carpenter J. M.
- Cody A. M.
- Da Rio N.
- Da Rio N.
- Da Rio N.
- Eisner J. A.
- Findeisen K.
- Fischer W. J.
- Flaherty K. M.
- Getman K. V.
- Glasby J. S.
- Haro G.
- Herbig G. H.
- Herbst W.
- Hillenbrand L. A.
- Hoffmeister C.
- Hoffmeister C.
- Kearns K. E.
- Koenig X. P.
- Koornneef J.
- Lada C. J.
- Ludendorff H.
- Luiz Paulo Vaz
- Megeath S. T.
- Morales-Calderón M.
- Morales-Calderón M.
- Muench A.
- Muench A. A.
- N. J. G. Cross
- O’Dell C. R.
- Palmer D. M.
- Parenago P. P.
- Parks J. R.
- Parsamian E. S.
- Pillitteri I.
- Plavchan P.
- Prisinzano L.
- Rebull L. M.
- Rice T. S.
- Robberto M.
- Robberto M.
- Robitaille T. P.
- Rosino L.
- Samus N. N.
- Scott J. Wolk
- Stassun K. G.
- Stassun K. G.
- Stassun K. G.
- Stauffer J.
- Szegedi-Elek E.
- Thomas S. Rice
- Vaz L. P. R.
- Wilson R. E. ed Leung K.-C.
- Windemuth D.
- Wiramihardja S. D.
- Wolk S. J.
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2015
- Field of study
Using the United Kingdom Infrared Telescope on Mauna Kea, we have carried out
a new near-infrared J, H, K monitoring survey of almost a square degree of the
star-forming Orion Nebula Cluster with observations on 120 nights over three
observing seasons, spanning a total of 894 days. We monitored ~15,000 stars
down to J=20 using the WFCAM instrument, and have extracted 1203 significantly
variable stars from our data. By studying variability in young stellar objects
(YSOs) in the H-K, K color-magnitude diagram, we are able to distinguish
between physical mechanisms of variability. Many variables show color behavior
indicating either dust-extinction or disk/accretion activity, but we find that
when monitored for longer periods of time, a number of stars shift between
these two variability mechanisms. Further, we show that the intrinsic timescale
of disk/accretion variability in young stars is longer than that of
dust-extinction variability. We confirm that variability amplitude is
statistically correlated with evolutionary class in all bands and colors. Our
investigations of these 1203 variables have revealed 73 periodic AA Tau type
variables, many large-amplitude and long-period (P > 15 day) YSOs, including
three stars showing widely-spaced periodic brightening events consistent with
circumbinary disk activity, and four new eclipsing binaries. These phenomena
and others indicate the activity of long-term disk/accretion variability
processes taking place in young stars. We have made the light curves and
associated data for these 1203 variables available online.Comment: Corrected typo in author nam
Pre-operative pulmonary assessment for patients with hip fracture
- Author
- A Bottle
- A Qaseem
- A Rodgers
- AM Arozullah
- AM Arozullah
- AM Møller
- American College of Physicians
- American Society of Anesthesiologists Task Force on Perioperative Management of Patients with Obstructive Sleep Apnea
- BI Eriksson
- BI Eriksson
- BW Fisher
- C Archer
- C Cooper
- C.-W. Siu
- CA Polanczyk
- Clinical Practice Guideline Treating Tobacco Use and Dependence 2008 Update Panel Liaisons, and Staff
- CS Kabalin
- D Wong
- DC McCrory
- DD French
- DJ Kearney
- DO Warner
- DO Warner
- DO Warner
- E Martinod
- ED Bateman
- EL Raaymakers
- ER Swenson
- F Buhling
- F Chung
- F. Leung
- FA McAlister
- G Ramakrishna
- GD Gass
- GF Marx
- GL Lu-Yao
- GM Orosz
- GW Smetana
- GW Smetana
- GW Smetana
- H.-F. Tse
- HH Handoll
- HS Joo
- I.-L. Lo
- J Magaziner
- JA Brooks-Brunn
- JA Thomas
- JN Awad
- JS Milledge
- JT Hays
- K Kroenke
- K Manku
- K Ulnick
- KF Rabe
- L Davies
- LC Pien
- LF Stead
- LG Bluman
- LL Liu
- M Alifano
- M Johnson
- M Stein
- M. Wong
- MA Warner
- MA Warner
- MC Stock
- MJ Goldacre
- MT Silvanus
- P Rock
- P Williams-Russo
- R Barrera
- R Castillo
- R Grupta
- R Niaura
- R Pellegrino
- R Wilson
- RD Hull
- RG Johnson
- RL Schiff
- RS Morrison
- SC Urwin
- SF Khuri
- SK Epstein
- T Shiga
- T Yonezawa
- T.-W. Lau
- TS Dharmarajan
- V Squadrone
- VA Lawrence
- VA Lawrence
- VA Lawrence
- VA Lawrence
- WD Owens
- WH Geerts
- WJ Gillespie
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2010
- Field of study
Hip fracture is a common injury among the elderly. Although patients who receive hip fracture surgery carry the best functional recovery compared to other treatment modalities, the presence of postoperative pulmonary complications, such as atelectasis, pneumonia, and pulmonary thromboembolism, may contribute to increased length of hospital stay, perioperative morbidity, and mortality. This review aims to provide evidence-based recommendations for preoperative assessment and perioperative strategies to reduce the risk of pulmonary complications after hip fracture surgery. Clinical assessment and basic laboratory results are sufficient to stratify the risk of postoperative pulmonary complications. Well-documented risk factors for pulmonary complications include advanced age, poor general health status, current infections, pre-existing cardiopulmonary diseases, hypoalbuminemia, and impaired renal function. Apart from optimizing the patient's medical conditions, interventions such as lung expansion maneuvers and thromboprophylaxis have been proven to be effective in reducing the risk of pulmonary complications after hip fracture surgery
Team Learning: the Missing Construct from a Cross-Cultural Examination of Higher Education?
- Author
- A Bandura
- A Bandura
- A Jassawalla
- A Srivastava
- A Tashchian
- AC Edmondson
- AC Edmondson
- AC Edmondson
- AC Edmondson
- AD Sperber
- AE Akgun
- AM Raes
- AP Geus De
- BG Tabachnick
- BM Byrne
- C Gibson
- C Quian
- D Ahlstrom
- D Tjosvold
- DD Bowen
- DG Collings
- DH Schunk
- E Molnar
- ED Smith
- F Pichault
- FS Tsai
- G Chen
- G Hirst
- G Hofstede
- G Hofstede
- G-W Bock
- GB Graen
- GL Siebold
- H Akbar
- H Bresman
- H He
- H Yang
- HA Reed
- HTM Bui
- I Nonaka
- IM Kinchin
- J Bell
- J Bishop
- J Prichard
- J Wilson
- JP Meyer
- JS Prichard
- K Leung
- K Strauss
- K-B Ooi
- KC Kostopoulos
- KC Kostopoulos
- KE Baron
- KJ Klein
- KM Bartol
- L Sackney
- LD Milia
- LW Porter
- M Alvesson
- M Gagne
- M Ipe
- M Seo
- MA West
- N Bacon
- N Hakima
- P Dalin
- P Hendriks
- P Lee
- P Senge
- P Tierney
- PM Podsakoff
- PM Podsakoff
- PM Senge
- PR Pintrich
- R Bennett
- R Hogan
- RB Kline
- RG Malgady
- RJ Boland
- RJ Ely
- S Faraj
- S Park
- S Woodfield
- S Xu
- S-P Nissala
- TN Nguyen
- TN Thêm
- TQ Vuong
- TQ Vượng
- TW Han
- UR Hülsheger
- VJ Marsick
- Y Baruch
- Y Baruch
- Y Li
- Y Li
- Z Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 27/08/2015
- Field of study
Team learning should be an important construct in organizational management research because team learning can enhance organizational learning and overall performance. However, there is limited understanding of how team learning works in different cultural contexts. Using an international comparative research approach, we developed a framework of antecedents and outcomes in the higher education context and tested it with samples from the UK and Vietnam. The results show that a common framework is applicable in the two different contexts, subject to slight modifications. However, this study does not find that team learning (measured via the proxy of “attitude towards team learning”) exhibits any statistically significant relationship as a predictor of the proposed outcomes. Other findings from this study on educational contexts are important not only to scholars in this field, but also for practicing managers, particularly those who study and operate in the extensive global market
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
- Author
- Abantanga F
- Abbas M
- Abbo O
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elrasoul Y
- Abdallah E
- Abdel-Wahab NYE
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelkader M
- Abdelkareem A
- Abdelraheim M
- Abdelshafy M
- Abdulgawad M
- Abdullah AAN
- Abdullah NAN
- Abebe NS
- Abebe NS
- Aber A
- Abington E
- Aboarab A
- Aboraya M
- Aboraya M
- Abouelnasr A
- Abouzahra A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abudeeb H
- Abuseif M
- Acharya P
- Adams R
- Adebanjo A
- Adekoya A
- Adel A
- Adel A
- Ademuyiwa A
- Ademuyiwa AO
- Adeniran J
- Adeniyi A
- Adesanya O
- Adesina A
- Adesuyi A
- Adeyeye A
- Adham W
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agarwal A
- Agius M
- Aguilar-Jimenez J
- Aguilera M
- Aguilera O
- Ahlqvist S
- Ahmed A
- Ahmed EA
- Ahmed H
- Ahmed SM
- Aigrain Y
- Ajao AE
- Akeel N
- Akhtar M
- Al Awwad S
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Faifi JJ
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-Mallah A
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-shammari A
- Alahmady O
- Alakaloko F
- Alamoudi U
- Albeladi B
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alfarsi MA
- Alghamdi B
- Alghamdi M
- Algohary O
- Alhabli I
- Alhendy M
- Ali A
- Ali A
- Ali H
- Ali SS
- Alimi Q
- Aljiffry M
- Aljohani E
- Aljohani S
- Alkammash A
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnawam E
- Alnuqaydan SA
- Alomar IN
- Alqahtani E
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Altaf A
- Altamimi A
- Althwainy A
- Altoe F
- Altwigry AM
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alwafai MG
- Aly AK
- Alyami R
- AlYoussef I
- Alzahrani M
- Alzayat T
- Amandito R
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin J
- Ammar M
- Ammar MS
- Amreia M
- Anandkumar D
- Anderson D
- Anderson R
- Anderson-Knight H
- Andersson L
- Andres Garcia-Marin J
- Ansaloni L
- Antar S
- Anthoulakis C
- Anwar AW
- Anwer W
- Anyanwu L-J
- Aql S
- Arachchi PP
- Arachchige LAJJ
- Aranzabal Durand SY
- Araujo R
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arulampalam T
- Asal M
- Asele FA
- Ashraf SF
- Ashton A
- Assouto PA
- Ata AAA
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia AM
- Aung KP
- Austraite A
- Awuku-Asabre J
- Ayad S
- Ayandipo OO
- Ayyar S
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Badr A
- Badwi NM
- Badwy A
- Baheeg M
- Bailey K
- Baillie K
- Baird A
- Bakhaidar M
- Baldacchino M
- Balila RMH
- Balkan AZA
- Balmaceda R
- Bamicha A
- Barakat SAE
- Barker T
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basson S
- Batista Lemaire S
- Batt J
- Beasley W
- Beaton C
- Behar N
- Beisa V
- Benevento A
- Benger M
- Benons N
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhattacharya S
- Bhopal KF
- Bin Mahamood A
- Birring A
- Bjorklund I
- Blencowe N
- Blower E
- Blundell R
- Boakye-Yiadom K
- Boal M
- Boddy A
- Bode C
- Boereboom C
- Boijsen M
- Bokhari S
- Bonavina L
- Bondurri A
- Bonnard A
- Borda Luque G
- Borg E
- Borin E
- Bortolasi L
- Boshnaq M
- Botes S
- Botto N
- Bouali O
- Bowe R
- Bowley D
- Bowman C
- Boyce T
- Bradulskis S
- Bratu R-M
- Braungart S
- Bray LD
- Breitenstein S
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
- Browning DRL
- Bugaev N
- Bugeja R
- Bukari M
- Burns H
- Cabala Chiong JA
- Cacurri A
- Cadogan DD
- Cahill R
- Camacho R
- Cameron B
- Camilleri-Brennan J
- Camilleri-Brennan JF
- Capleton P
- Careta MC
- Carlucci M
- Carreira J-A
- Carreiro De Freitas AV
- Castro Mollo M
- Cengiz Y
- Cengiz Y
- Ceriani C
- Chachulski W
- Chambers A
- Chan E
- Chan Z
- Chandrakumar C
- Chang K
- Chang KY-C
- Chapman A
- Chapman SJ
- Chen CY
- Chen JHC
- Chenn R
- Chew LS
- Chhabra S
- Chidambaram S
- Chiu S
- Chiu SMY
- Choi J
- Chong BFHK
- Chong CL
- Chong HY
- Chowdhury A
- Chun A
- Chun T
- Chung S
- Cirocchi R
- Clark DJ
- Clark T
- Clement KD
- Clements JM
- Clifford C
- Cloro LM
- Coasaca Huaraya R
- Coccolini F
- Cocker DM
- Collaborative G
- Colombani J-F
- Connor K
- Contreras Merida SM
- Contreras Urquizu M
- Contreras Vergara AL
- Coomber R
- Corro-Diaz Gonzalez S
- Costa-Maia J
- Court E
- Cragg J
- Cross K
- Cruz H
- Cucumazzo S
- Currow C
- D'aguzan N
- D'amours SK
- D'cruz R
- D'Souza R
- Da Silva LA
- Dabessa D
- Dablouk M
- Dablouk MO
- Dal Canto M
- Dambrauskas Z
- Dan I
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf AM
- Abdelrouf DM
- Abdelshafy M
- Abdelshakour M
- Abdrabou AK
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem EM
- Abdullah AAN
- Abdullah MA
- Abdullah N
- Abdullah NAN
- Abdullah NAN
- Abdullahi L
- Abdurrazzaaq A
- Abebe NS
- Abebe NS
- Abem OE
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud MR
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga MS
- Abouzahra A
- Abouzaid A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abu Qumbos A
- Abu-toyour M
- Abubakr M
- Abudeeb H
- Abuowda Y
- Abuqwaider E
- Abusalem L
- Abuseif M
- Abushamleh S
- Acharya P
- Ackom E
- Acquah E
- Adam A
- Adam N
- Adams R
- Adamu A
- Adawi I
- Adawi M
- Adebanjo A
- Adebanjo A
- Adebola O
- Adedeji A
- Adekoya A
- Adel A
- Adel A
- Adel BE
- Adel I
- Adella FJ
- Adelshone A
- Ademuyiwa A
- Ademuyiwa A
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Adenekan B
- Adeniran J
- Adeniran J
- Adeniyi A
- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
- Adeyeye A
- Adeyeye A
- Adham W
- Adhitama N
- Adil M
- Adisa AO
- Adisa AO
- Adu-Aryee N
- Afana S
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agalianos C
- Agarwal A
- Agarwal A
- Agarwal A
- Agbedinu K
- Agius M
- Aglan A
- Aguado Suarez N
- Aguilar-Jimenez J
- Aguilera M
- Aguilera ML
- Aguilera ML
- Aguilera ML
- Aguilera O
- Aguilera-Arevalo M-L
- Ahlonsou G
- Ahlqvist S
- Ahlqvist S
- Ahlqvist S
- Ahmed A
- Ahmed A
- Ahmed A
- Ahmed EA
- Ahmed H
- Ahmed H
- Ahmed H
- Ahmed LAM
- Ahmed S
- Ahmed S
- Ahmed SM
- Ahounou EYS
- Aigrain Y
- Aiyaman C
- Ajah J
- Ajai O
- Ajao A
- Ajao AE
- Ajiboye A
- Akatibo E
- Akeel N
- Akhtar M
- Akoto E
- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi JJ
- Al-faqawi M
- Al-farram H
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-saqqa S
- Al-Saqqa SW
- Al-Saqqa SW
- Al-shammari A
- Al-Slaibi I
- Al-taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Alcca Ticona W
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alejos Bermudez YE
- Alexander P
- Alexander P
- Alexander P
- Alexandre C
- Alfarsi MA
- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi MSA
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali CDM
- Ali E
- Ali FM
- Ali H
- Ali S
- Ali SAWEW
- Ali SS
- Ali THA
- Ali W
- Alihonou T
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allam M
- Allam Y
- Allegri A
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby MH
- Alnawam E
- Alnuqaydan SA
- Alnusairat A
- Alomar IN
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Alsaggaf MU
- Alser OH
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry AM
- Altwijri A
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alvi AR
- Alwafai MG
- Aly AK
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani A
- Alzahrani M
- Alzahrani M
- Alzayat T
- Aman NF
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin HAA
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar MS
- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika FFA
- Andreotti D
- Andres Garcia-Marin J
- Andress C
- Andriola V
- Ang YL
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar AW
- Anwar N
- Anwer W
- Anyanwu L-J
- Anyanwu L-J
- Aonzo P
- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
- Arachchige LAJJ
- Arafa O
- Arafa S
- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arman S
- Armando ChunguiBravo J
- Armellini A
- Arnaud A
- Arnaud AP
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arshad MM
- Arslan E
- Arsyad HM
- Arthur T
- Arulampalam T
- Aruldas N
- Asal M
- Asar YH
- Asare-Bediako K
- Asele FA
- Ashour A
- Ashour A
- Ashour K
- Ashraf SF
- Ashtari M
- Ashton A
- Asi F
- Asilah SMD
- Assal A
- Assouto PA
- Asturia S
- Asumah H
- Ata A
- Ata AAA
- Ata AY
- Atiyeh A
- Atkins ET
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia A
- Attia AM
- Augestad KM
- Aung KP
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad SA
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
- Aziz NA
- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Azzie G
- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki MA
- Badicel M
- Badr A
- Badr MFM
- Badwi NM
- Badwi NM
- Badwy A
- Bahar S
- Baheeg M
- Bailey K
- Baillie K
- Baillie K
- Baird A
- Bakhaidar M
- Baki BE
- Bakr A
- Bakry HM
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila RMH
- Balkan AZA
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baraka H
- Barakat SAE
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas GN
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basilico S
- Basir ERM
- Bassem M
- Bassit KA
- Basso SMM
- Basson S
- Batt J
- Bayram S
- Beamon M
- Beasley W
- Beaton C
- Bedada AG
- Bediako-Bowan A
- Behar N
- Beisa V
- Beisa V
- Bekhet AH
- Bekhet NM
- Beleno AEM
- Belkouchi A
- Belli A
- Bello B
- Benammi S
- Benevento A
- Benevento A
- Benger M
- Bennai RM
- Benons N
- Bentounsi Z
- Benyaiche C
- Berti S
- Bertuello I
- Beuran M
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhang A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal KF
- Bhopal KF
- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Bin Ismail MJ
- Bin Mahamood A
- Birindelli A
- Birring A
- Bisset C
- Bjorklund I
- Bjorklund I
- Blacker S
- Blackwell J
- Blanco R
- Blanco-Colino R
- Blencowe N
- Blencowe N
- Bliksoen M
- Blower E
- Bluelle R
- Blundell R
- Boakye-Yiadom K
- Boal M
- Bocchetti T
- Boddy A
- Bode C
- Bode C
- Bodur S
- Boereboom C
- Boggon A
- Boijsen M
- Bokhari S
- Bonavia K
- Bonavina L
- Bonavina L
- Bond-Smith G
- Bondin J
- Bondurri A
- Bondurri A
- Boni S
- Bonnard A
- Bonney W
- Borda Luque G
- Borda-Luque G
- Borda-Luque G
- Borg E
- Borg E
- Borg E
- Borin E
- Bortolasi L
- Bortolasi L
- Boshnaq M
- Botes S
- Bottini C
- Botto N
- Bouali O
- Bougard H
- Boukhal K
- Bowabsak A
- Bowe R
- Bowley D
- Bowling K
- Bowman C
- Boyce T
- Bradulskis S
- Bradulskis S
- Bratu M
- Bratu MR
- Bratu R-M
- Braungart S
- Bray LD
- Breaud J
- Breistrand M
- Breitenstein S
- Breslin R
- Brincat SD
- Broch A
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
- Browning DRL
- Brunoni B
- Bsisu I
- Bucci L
- Bugaev N
- Bugeja R
- Buisson P
- Bukari M
- Bunting D
- Burger S
- Burmistrovas A
- Burns H
- Bustangi N
- Butt MT
- Cabala Chiong JA
- Cabala Chiong JA
- Cacurri A
- Cadogan DD
- Cahill R
- Cakaloglu HC
- Caliman C
- Callan R
- Camacho R
- Cameron B
- Camilleri GM
- Camilleri-Brennan J
- Camilleri-Brennan J
- Camilleri-Brennan JF
- Camilo Correa J
- Campagnaro T
- Canta Calua A
- Capito C
- Capleton P
- Carabott K
- Careta MC
- Carlucci M
- Carmela Lapitan M
- Carmona JM
- Carpio J
- Carrasco N
- Carreira J-A
- Carreiro De Freitas AV
- Cassar K
- Castro Mollo M
- Catani M
- Cautiero R
- Caydiid H
- Cecilia T
- Celik S
- Cengiz TB
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Ceriani C
- Cevik M
- Chabok A
- Chachulski W
- Chai C-A
- Chai FY
- Chambers A
- Chambers A
- Chan E
- Chan L
- Chan T-YK
- Chan XW
- Chan Z
- Chandrakumar C
- Chang K
- Chang KY-C
- Chapman A
- Chapman SJ
- Charles A
- Cheah AEZ
- Chen CY
- Chen KY
- Chen T-L
- Chenn R
- Cheong YJ
- Chetta N
- Cheung YHE
- Chew LS
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
- Chilton G
- Chin PX
- Chin YR
- Chiu S
- Chiu S
- Chiu SMY
- Choi J
- Choi P
- Chong BFHK
- Chong CL
- Chong CL
- Chong CL
- Chong CS
- Chong H-Y
- Chong HY
- Choudhry A
- Chow CYN
- Chowdhury A
- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung KJ
- Chung S
- Ciccioli E
- Cirocchi R
- Ciubotaru C
- Claire R
- Clarissa A
- Clark DJ
- Clark T
- Clegg-Lampety J-N
- Clegg-Lamptey J-N
- Clement KD
- Clements JM
- Clerico G
- Clifford C
- Cloro LM
- Coasaca Huaraya R
- Coccolini F
- Coccolini F
- Coccolini F
- Coccolini F
- Cocker DM
- Cocorullo G
- Cohen DM
- Cohen F
- Cole S
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- Coletti M
- Colombani J-F
- Cona C
- Conci S
- Confalonieri G
- Conlon KC
- Connor K
- Connor K
- Contreras Merida SM
- Contreras Urquizu M
- Contreras Vergara AL
- Contreras E
- Coomber R
- Coompson CL
- Corbellini C
- Corbellino M
- Cornick J
- Coronel J
- Corro-Diaz Gonzalez S
- Corro-Diaz S
- Costa C
- Costa-Maia J
- Costa-Maia J
- Costas-Chavarri A
- Costas-Chavarri A
- Courboin E
- Court E
- Cox D
- Cox M
- Coyoy-Gaitan O
- Cragg J
- Craus-Miguel A
- Cross K
- Cruz DH
- Cruz H
- Cucumazzo S
- Cullen F
- Curletti G
- Currow C
- Currow C
- D'aguzan N
- D'Amours S
- D'amours SK
- D'cruz R
- D'Souza MS
- D'Souza R
- Da Silva LA
- Dabboor M
- Dabbour K
- Dabessa D
- Dablouk M
- Dablouk MO
- Dagoe E
- Dahy A
- Dainius E
- Dakubo J
- Dal Canto M
- Dalli J
- Dally C
- Dambrauskas Z
- Dambrauskas Z
- Dan I
- Danelli P
- Daniels I
- Daniyan M
- Danys D
- Dao W
- Daqeeq A
- Dar M
- Dar W
- Dardenne S
- Darweesh M
- Darwish AKZ
- Das A
- Das K
- Das S
- Dasari M
- Dashnyam E
- Dassah V
- Datta U
- Davenport R
- Davies J
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- Dawoud H
- Dayie M
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- De Bono P
- De Bono P
- De Franciscis S
- De Luca E
- De Marco P
- De Sousa AV
- Deal R
- Dean R
- Deane C
- Debrah S
- Deckelbaum DL
- Decker E
- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- del Pilar Paucar A
- Delforge X
- Dell A
- Dempster E
- Denakpo M
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar GH
- Dharamshi HA
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu I-B
- Dias S
- Diaz Vico T
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
- Dindyal S
- Dione Parreno-Sacdalan M
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani RMNR
- Dorisme A
- dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake TM
- Drake TM
- Drake TM
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy MM
- Ebrahim OS
- Eduard P
- Edwards J
- Edye M
- Eid MM
- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahmy MAB
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat MM
- Faraz A
- Fares M
- Farhad M
- Farhan-Alanie MMH
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fermani C
- Fermani CG
- Fernandes C
- Fernandez C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferrero E
- Fievet L
- Filatau A
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- Wold TB
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- Yifieyeh A
- Yildirim R
- Yip C
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- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
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- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
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- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
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- Zilinskas J
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- Zilinskiene R
- Zilinskiene R
- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Dominância fiscal : uma investigação empírica sobre o caso brasileiro no período de 2003 a 2014
- Author
- A Youn
- AB Olshen
- AM Dulak
- Annie S Y Chan
- Anthony K W Chan
- April S Chan
- AS Wilson
- B Guan
- BK Koo
- BK Koo
- C Greenman
- C Kandoth
- C Yau
- CD Bae
- CH Mermel
- CT Saunders
- DN Church
- E Garcia
- E Hodis
- E Sahai
- E Sahai
- E Sahai
- E Sahai
- EA Cox
- ED Pleasance
- GH Kang
- GR van den Brink
- Grace H W Cheng
- H Mutoh
- H Tuncel
- H Zheng
- H Zouridis
- Hans Clevers
- Helen H N Yan
- Hoi Cheong Siu
- HY Yoo
- IJ Majewski
- J Hu
- J Staaf
- J Wang
- J Wang
- JA Kwon
- JC Pang
- JD Storey
- Jiangchun Xu
- Jonathan L K Man
- Julio Fernandez
- K Matsusaka
- K Matsuzaki
- K Wang
- K Wang
- K Wang
- K Watanabe
- K Yoshioka
- Kai Wang
- Kent Man Chu
- Kok Hoe Chan
- LG van der Flier
- M Kanehisa
- M Ramalho-Santos
- M Sakata-Yanagimoto
- Man Kin Ng
- Mao Mao
- MC Blank
- ML Coleman
- ML Coleman
- MS Lawrence
- N Ahuja
- N Barker
- N Deng
- N Nagarajan
- N Oue
- NG Nagl Jr.
- OH Kwon
- Paul A Rejto
- R Dvorsky
- R Govindan
- R Maesaki
- RN Sehgal
- S Bogaerts
- SH Park
- Shibing Deng
- Simon Law
- Siu Lun Ho
- Siu Po Lee
- Siu Tsan Yuen
- Stephanie T Shi
- Suet Yi Leung
- T Matsuoka
- T Palomero
- T Sato
- Tao Xie
- TT Rau
- Valentina Foglizzo
- Vivian S W Li
- VM Braga
- Wai Yin Tsui
- X Chen
- Y Fujii
- Y Kimura
- Y Nakanishi
- Yick Pang Ching
- ZJ Zang
- Publication venue
- 'Revista de Contabilidade do Mestrado em Ciencias Contabeis da UERJ'
- Publication date
- 01/01/2014
- Field of study
A estabilização econômica dos anos de 1990 e a adoção do tripé econômico, a partir de
1999, marcam o fim de um capítulo delicado da história brasileira; a partir de então, era
necessária a existência de certa sintonia de políticas monetária e fiscal para a
manutenção do controle dos diversos indicadores econômicos. Contudo, com essa
reciprocidade na política econômica, são incitadas discussões sobre a orientação do
governo na hora de definir suas prioridades nesse campo: as variáveis fiscais são
priorizadas e, por conseguinte, determinadas, forçando as monetárias a se ajustarem –
ou o contrário? A resposta para esse questionamento leva à discussão sobre a
dominância fiscal. Assim, esse trabalho visa verificar empiricamente, usando das
modelagens econométricas VAR e estudo de eventos, se há dominância fiscal ou
monetária na economia brasileira e se a eficácia da política monetária mudou na
transição do governo Lula para o governo Dilma. O resultado foi inconclusivo para o
governo Lula e indicou dominância fiscal no governo Dilma. Ainda verificou-se não
haver modificação na eficácia da política monetária.Economic stabilization, in the 1990s, and utilization of an economic tripod, after 1999,
represents the end of a delicate chapter in Brazilian history. Ever since, it was necessary
the existence of a certain agreement between monetary and fiscal politic, in order to
maintain under control a variety of economic indicators. However, this reciprocity (in
economic politic) starts discussions about the real government orientations when it
comes to define its priority on this subject: are the fiscal variables priorized, and then,
determined, forcing monetary variables to adjust themselves, or the opposite? The
answer to these questions emerge from the fiscal dominance discussion. This paper
intends to empiric verify, using econometric modeling VAR and event study, if there is
fiscal dominance or monetary in Brazilian economy and whether the effectiveness of
monetary politic has changed in the transition from Lula's government to the Dilma
government. The result was inconclusive for the Lula government and indicated fiscal
dominance in the Dilma government. There was still no change in the efficiency of the
monetary politic.CAPE
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
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- Ziviani E
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- Zorzano A
- Zou W
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- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
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- The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
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- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
- Abate Kalkidan Hassen
- Abate Yohannes Habtegiorgis
- Abbafati Cristiana
- Abbasgholizadeh Rouzbeh
- Abbasi Madineh Akram
- Abbasi-Kangevari Mohsen
- Abbasian Mohammadreza
- Abbasifard Mitra
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdi Parsa
- Abdollahi Mohammad
- Abdoun Meriem
- Abdulah Deldar Morad
- Abdullahi Auwal
- Abebe Mesfin
- Abedi Aidin
- Abedi Armita
- Abegaz Tadesse M
- Abeldaño Zuñiga Roberto Ariel
- Abiodun Olumide
- Abiso Temesgen Lera
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abouzid Mohamed
- Aboye Girma Beressa
- Abreu Lucas Guimarães
- Abu-Gharbieh Eman
- Abu-Zaid Ahmed
- Abualruz Hasan
- Abubakar Bilyaminu
- Abukhadijah Hana Jihad Jihad
- Aburuz Salahdein
- Adane Mesafint Molla
- Addo Isaac Yeboah
- Addolorato Giovanni
- Adedoyin Rufus Adesoji
- Adekanmbi Victor
- Aden Bashir
- Adetunji Juliana Bunmi
- Adeyeoluwa Temitayo Esther
- Adha Rishan
- Adibi Amin
- Adnani Qorinah Estiningtyas Sakilah
- Adzigbli Leticia Akua
- Afolabi Aanuoluwapo Adeyimika
- Afolabi Rotimi Felix
- Afshin Ashkan
- Afyouni Shadi
- Afzal Muhammad Sohail
- Afzal Saira
- Agampodi Suneth Buddhika
- Agbozo Faith
- Aghamiri Shahin
- Agodi Antonella
- Agrawal Anurag
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Noah
- Ahmad Shahzaib
- Ahmad Tauseef
- Ahmed Ali
- Ahmed Anisuddin
- Ahmed Ayman
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ahmed Safoora
- Ahmed Syed Anees
- Ajami Marjan
- Akalu Gizachew Taddesse
- Akara Essona Matatom
- Akbarialiabad Hossein
- Akhlaghi Shiva
- Akinosoglou Karolina
- Akinyemiju Tomi
- Akkaif Mohammed Ahmed
- Akkala Sreelatha
- Akombi-Inyang Blessing
- Al Awaidy Salah
- Al Hasan Syed Mahfuz
- AL-Ahdal Tareq Mohammed Ali
- Al-Aly Ziyad
- Al-Fatly Bassam
- Al-Gheethi Adel Ali Saeed
- Al-Habbal Khairat
- Al-Marwani Sabah
- Al-Mekhlafi Hesham M
- Al-Raddadi Rajaa M
- Al-Rifai Rami Hani
- Al-Sabah Salman Khalifah
- Al-Tawfiq Jaffar A
- Al-Wardat Mohammad Sami
- Al-Worafi Yaser Mohammed
- Al-Zyoud Walid
- Alahdab Fares
- Alalalmeh Samer O
- Alalwan Tariq A
- Alam Khurshid
- Alam Nazmul
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Albakri Almaza
- AlBataineh Mohammad T
- Aldhaleei Wafa A
- Aldridge Robert W
- Alemayohu Mulubirhan Assefa
- Alemu Yihun Mulugeta
- Alhabib Khalid F
- Alhassan Robert Kaba
- Ali Abid
- Ali Amjad
- Ali Beriwan Abdulqadir
- Ali Iman
- Ali Liaqat
- Ali Mohammed Usman
- Ali Rafat
- Ali Syed Shujait Shujait
- Ali Waad
- Alicandro Gianfranco
- Alif Sheikh Mohammad
- Aljunid Syed Mohamed
- Alla François
- Almustanyir Sami
- Alomari Mahmoud A
- Alonso Jordi
- Alqahtani Jaber S
- Alqutaibi Ahmed Yaseen
- Alrawashdeh Ahmad
- Alrousan Sahel Majed
- Alshahrani Najim Z
- Altaany Zaid
- Altaf Awais
- Altirkawi Khalid A
- Aluh Deborah Oyine
- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J
- Alwafi Hassan
- Aly Hany
- Aly Safwat
- Alzoubi Karem H
- Amaechi Uchenna Anderson
- Aman Mohammadi Masous
- Amani Reza
- Amiri Sohrab
- Amirzade-Iranaq Mohammad Hosein
- Ammirati Enrico
- Amu Hubert
- Amugsi Dickson A
- Amusa Ganiyu Adeniyi
- Ancuceanu Robert
- Anderlini Deanna
- Anderson Jason A
- Andrade Pedro Prata
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- Andrei Tudorel
- Anenberg Susan C
- Angappan Dhanalakshmi
- Angus Colin
- Anil Abhishek
- Anil Sneha
- Anjum Afifa
- Anoushiravani Amir
- Antonazzo Ippazio Cosimo
- Antony Catherine M
- Antriyandarti Ernoiz
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- Anvari Davood
- Anvari Saeid
- Anwar Saleha
- Anwar Sumadi Lukman
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- Anyasodor Anayochukwu Edward
- Apostol Geminn Louis Carace
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- Arafat Mosab
- Aravkin Aleksandr Y
- Areda Demelash
- Aregawi Brhane Berhe
- Aremu Abdulfatai
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- Arndt Michael Benjamin
- Arooj Mahwish
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- Arumugam Ashokan
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- Asgary Saeed
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- Ayala Quintanilla Beatriz Paulina
- Ayatollahi Haleh
- Ayestas Portugal Carlos
- Ayuso-Mateos Jose L
- Azadnajafabad Sina
- Azevedo Rui M S
- Azhar Gulrez Shah
- Azizi Hosein
- Azzam Ahmed Y
- Ärnlöv Johan
- Backhaus Insa Linnea
- Badar Muhammad
- Badiye Ashish D
- Bagga Arvind
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- Bagheri Nasser
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- Baker Jennifer L
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- Bensenor Isabela M
- Benzian Habib
- Beran Azizullah
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- Bernstein Robert S
- Bettencourt Paulo J G
- Béjot Yannick
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- Bhatti Jasvinder Singh
- Bhatti Manpreet S
- Bhatti Rajbir
- Bhuiyan Mohiuddin Ahmed
- Bhutta Zulfiqar A
- Bikbov Boris
- Bishai Jessica Devin
- Bisignano Catherine
- Biswas Atanu
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- Bjørge Tone
- Boachie Micheal Kofi
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- Bodolica Virginia
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- Botero Carvajal Alejandro
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- Boxe Christopher
- Braithwaite Dejana
- Brant Luisa C
- Brar Amanpreet
- Brauer Michael
- Breitborde Nicholas J K
- Breitner Susanne
- Brenner Hermann
- Briko Andrey Nikolaevich
- Britton Gabrielle
- Brown Colin Stewart
- Browne Annie J
- Brunoni Andre R
- Bryazka Dana
- Bulamu Norma B
- Bulto Lemma N
- Buonsenso Danilo
- Burkart Katrin
- Burns Richard A
- Busse Reinhard
- Bustanji Yasser
- Butt Nadeem Shafique
- Butt Zahid A
- Caetano dos Santos Florentino Luciano
- Cagney Jack
- Cahuana-Hurtado Lucero
- Calina Daniela
- Campos Luciana Aparecida
- Campos-Nonato Ismael R
- Cao Chao
- Cao Fan
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- Capodici Angelo
- Carr Sinclair
- Carreras Giulia
- Carrero Juan J
- Carugno Andrea
- Carvalho Felix
- Carvalho Márcia
- Castaldelli-Maia Joao Mauricio
- Castañeda-Orjuela Carlos A
- Castelpietra Giulio
- Catalá-López Ferrán
- Catapano Alberico L
- Cattaruzza Maria Sofia
- Caye Arthur
- Cámera Luis Alberto
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- Cegolon Luca
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- Chen Haowei
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- Cheng Esther T W
- Cherbuin Nicolas
- Chi Gerald
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- Chimed-Ochir Odgerel
- Chimoriya Ritesh
- Ching Patrick R
- Chirinos-Caceres Jesus Lorenzo
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- Cho William C S
- Chong Bryan
- Chopra Hitesh
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- Chu Dinh-Toi
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- Chung Eric
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- Cioffi Iolanda
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- Costanzo Simona
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- Cruz Jessica A
- Cruz-Martins Natália
- Culbreth Garland T
- D'Amico Emanuele
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- Zhai Chunxia
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- Zhang Meixin
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- Zhang Zhenyu
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- Zhao Hanqing
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- Zhao Yang
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- Zheng Peng
- Zhong Chenwen
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- Zhu Bin
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- Zhu Zhaohua
- Ziaeian Boback
- Ziafati Makan
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- Zyoud Sa'ed H
- Zyoud Samer H
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensive estimates of exposure levels, relative health risks, and attributable burden of disease for 88 risk factors in 204 countries and territories and 811 subnational locations, from 1990 to 2021. Methods: The GBD 2021 risk factor analysis used data from 54 561 total distinct sources to produce epidemiological estimates for 88 risk factors and their associated health outcomes for a total of 631 risk–outcome pairs. Pairs were included on the basis of data-driven determination of a risk–outcome association. Age-sex-location-year-specific estimates were generated at global, regional, and national levels. Our approach followed the comparative risk assessment framework predicated on a causal web of hierarchically organised, potentially combinative, modifiable risks. Relative risks (RRs) of a given outcome occurring as a function of risk factor exposure were estimated separately for each risk–outcome pair, and summary exposure values (SEVs), representing risk-weighted exposure prevalence, and theoretical minimum risk exposure levels (TMRELs) were estimated for each risk factor. These estimates were used to calculate the population attributable fraction (PAF; ie, the proportional change in health risk that would occur if exposure to a risk factor were reduced to the TMREL). The product of PAFs and disease burden associated with a given outcome, measured in disability-adjusted life-years (DALYs), yielded measures of attributable burden (ie, the proportion of total disease burden attributable to a particular risk factor or combination of risk factors). Adjustments for mediation were applied to account for relationships involving risk factors that act indirectly on outcomes via intermediate risks. Attributable burden estimates were stratified by Socio-demographic Index (SDI) quintile and presented as counts, age-standardised rates, and rankings. To complement estimates of RR and attributable burden, newly developed burden of proof risk function (BPRF) methods were applied to yield supplementary, conservative interpretations of risk–outcome associations based on the consistency of underlying evidence, accounting for unexplained heterogeneity between input data from different studies. Estimates reported represent the mean value across 500 draws from the estimate's distribution, with 95% uncertainty intervals (UIs) calculated as the 2·5th and 97·5th percentile values across the draws. Findings: Among the specific risk factors analysed for this study, particulate matter air pollution was the leading contributor to the global disease burden in 2021, contributing 8·0% (95% UI 6·7–9·4) of total DALYs, followed by high systolic blood pressure (SBP; 7·8% [6·4–9·2]), smoking (5·7% [4·7–6·8]), low birthweight and short gestation (5·6% [4·8–6·3]), and high fasting plasma glucose (FPG; 5·4% [4·8–6·0]). For younger demographics (ie, those aged 0–4 years and 5–14 years), risks such as low birthweight and short gestation and unsafe water, sanitation, and handwashing (WaSH) were among the leading risk factors, while for older age groups, metabolic risks such as high SBP, high body-mass index (BMI), high FPG, and high LDL cholesterol had a greater impact. From 2000 to 2021, there was an observable shift in global health challenges, marked by a decline in the number of all-age DALYs broadly attributable to behavioural risks (decrease of 20·7% [13·9–27·7]) and environmental and occupational risks (decrease of 22·0% [15·5–28·8]), coupled with a 49·4% (42·3–56·9) increase in DALYs attributable to metabolic risks, all reflecting ageing populations and changing lifestyles on a global scale. Age-standardised global DALY rates attributable to high BMI and high FPG rose considerably (15·7% [9·9–21·7] for high BMI and 7·9% [3·3–12·9] for high FPG) over this period, with exposure to these risks increasing annually at rates of 1·8% (1·6–1·9) for high BMI and 1·3% (1·1–1·5) for high FPG. By contrast, the global risk-attributable burden and exposure to many other risk factors declined, notably for risks such as child growth failure and unsafe water source, with age-standardised attributable DALYs decreasing by 71·5% (64·4–78·8) for child growth failure and 66·3% (60·2–72·0) for unsafe water source. We separated risk factors into three groups according to trajectory over time: those with a decreasing attributable burden, due largely to declining risk exposure (eg, diet high in trans-fat and household air pollution) but also to proportionally smaller child and youth populations (eg, child and maternal malnutrition); those for which the burden increased moderately in spite of declining risk exposure, due largely to population ageing (eg, smoking); and those for which the burden increased considerably due to both increasing risk exposure and population ageing (eg, ambient particulate matter air pollution, high BMI, high FPG, and high SBP). Interpretation: Substantial progress has been made in reducing the global disease burden attributable to a range of risk factors, particularly those related to maternal and child health, WaSH, and household air pollution. Maintaining efforts to minimise the impact of these risk factors, especially in low SDI locations, is necessary to sustain progress. Successes in moderating the smoking-related burden by reducing risk exposure highlight the need to advance policies that reduce exposure to other leading risk factors such as ambient particulate matter air pollution and high SBP. Troubling increases in high FPG, high BMI, and other risk factors related to obesity and metabolic syndrome indicate an urgent need to identify and implement interventions
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