Novel Small-molecule Antibacterials against Gram-positive Pathogens of Staphylococcus and Enterococcus Species

Defeat of the antibiotic resistance of pathogenic bacteria is one great challenge today and for the future. In the last century many classes of effective antibacterials have been developed, so that upcoming resistances could be met with novel drugs of various compound classes. Meanwhile, there is a certain lack of research of the pharmaceutical companies, and thus there are missing developments of novel antibiotics. Gram-positive bacteria are the most important cause of clinical infections. The number of novel antibacterials in clinical trials is strongly restricted. There is an urgent need to find novel antibacterials. We used synthetic chemistry to build completely novel hybrid molecules of substituted indoles and benzothiophene. In a simple one-pot reaction, two novel types of thienocarbazoles were yielded. Both indole substituted compound classes have been evaluated as completely novel antibacterials against the Staphylococcus and Enterococcus species. The evaluated partly promising activities depend on the indole substituent type. First lead compounds have been evaluated within in vivo studies. They confirmed the in vitro results for the new classes of small-molecule antibacterials

Momenta praecipua ad liberaliorem Veteris testamenti interpretationem, quae nostris temporibus est introducta : e collatione Scriptorum veterum Graecorum et Romanorum cum scriptoribus sacris

Programma, quod pro aditu Magisterii theologici ... scripsit Michael WeckleinMünster, Univ., Magisterarbei

Ueber die Textüberlieferung des Aeschylos und anderer griechischer Tragiker/

Extracted from: Munich. Akademie der Wissenschaften. Philosophisch-philologische Classe. Sitzungsberichte. Dezember 1888. p. 327-374Mode of access: Internet