Defects in the Tri-critical Ising model

We consider two different conformal field theories with central charge c=7/10. One is the diagonal invariant minimal model in which all fields have integer spins; the other is the local fermionic theory with superconformal symmetry in which fields can have half-integer spin. We construct new conformal (but not topological or factorised) defects in the minimal model. We do this by first constructing defects in the fermionic model as boundary conditions in a fermionic theory of central charge c=7/5, using the folding trick as first proposed by Gang and Yamaguchi. We then acting on these with interface defects to find the new conformal defects. As part of the construction, we find the topological defects in the fermionic theory and the interfaces between the fermionic theory and the minimal model. We also consider the simpler case of defects in the theory of a single free fermion and interface defects between the Ising model and a single fermion as a prelude to calculations in the tri-critical Ising model.Comment: 54 pages, 5 figures, version as accepted for publication with minor change

The reflection coefficient for minimal model conformal defects from perturbation theory

We consider a class of conformal defects in Virasoro minimal models that have been defined as fixed points of the renormalisation group and calculate the leading contribution to the reflection coefficient for these defects. This requires several structure constants of the operator algebra of the defect fields, for which we present a derivation in detail. We compare our results with our recent work on conformal defects in the tricritical Ising model.Comment: 22 pages; v2: minor changes, defect field transformation law clarified, reference adde

Reflection and Transmission for Conformal Defects

We consider conformal defects joining two conformal field theories along a line. We define two new quantities associated to such defects in terms of expectation values of the stress tensors and we propose them as measures of the reflectivity and transmissivity of the defect. Their properties are investigated and they are computed in a number of examples. We obtain a complete answer for all defects in the Ising model and between certain pairs of minimal models. In the case of two conformal field theories with an enhanced symmetry we restrict ourselves to non-trivial defects that can be obtained by a coset construction.Comment: 32 pages + 13 pages appendix, 12 figures; v2: added eqns (2.7), (2.8) and refs [6,7,39,40], version published in JHE

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Tsunami Generation by Submarine Mass Failure

Abstract: Based on numerical simulations presented in Part I, we derive predictive empirical equations describing tsunami generation by submarine mass failure �SMF � that are only valid in the vicinity of the tsunami sources. We give equations for slides and slumps, along with some cautions about their appropriate use. We further discuss results obtained here and in Part I and their practical application to case studies. We show that initial acceleration is the primary parameter describing SMF center of mass motion during tsunami generation. We explain an apparent paradox, raised in Part I, in slump center of mass motion, whereby the distance traveled is proportional to shear strength along the failure plane. We stress that the usefulness of predictive equations depends on the quality of the parameters they rely on. Parameter ranges are discussed in the paper, and we propose a method to estimate slump motion and shear strength and discuss SMF thickness to length values, for case studies. We derive the analytical tools needed to characterize SMF tsunami sources in propagation models. Specifically, we quantify three-dimensional �3D � effects on tsunami characteristic amplitude, and we propose an analytical method to specify initial 3D tsunami elevations, shortly after tsunami generation, in long wave tsunami propagation models. This corresponds to treating SMF tsunami sources like coseismic displacement tsunami sources. We conduct four case studies of SMF tsunamis and show that our predictive equations can provide rapid rough estimates of overall tsunami observations that might be useful in crisis situations, when time is too short to run propagation models. Thus, for each case, we show that the characteristic tsunami amplitude is a reasonable predictor of maximum runup in actual 3D geometry. We refer to the latter observation as the correspondence principle, which we propose to apply for rapid tsunami hazard assessment, in combination with the predictive tsunami amplitude equations

Newton’s Gravitational Law for Link Prediction in Social Networks

Link prediction is an important research area in network science due to a wide range of real-world application. There are a number of link prediction methods. In the area of social networks, these methods are mostly inspired by social theory, such as having more mutual friends between two people in a social network platform entails higher probability of those two people becoming friends in the future. In this paper we take our inspiration from a different area, which is Newton’s law of universal gravitation. Although this law deals with physical bodies, based on our intuition and empirical results we found that this could also work in networks, and especially in social networks. In order to apply this law, we had to endow nodes with the notion of mass and distance. While node importance could be considered as mass, the shortest path, path count, or inverse similarity (AdamicAdar, Katz score etc.) could be considered as distance. In our analysis, we have primarily used degree centrality to denote the mass of the nodes, while the lengths of shortest paths between them have been used as distances. In this study we compare the proposed link prediction approach to 7 other methods on 4 datasets from various domains. To this end, we use the ROC curves and the AUC measure to compare the methods. As the results show that our approach outperforms the other 7 methods on 2 out of the 4 datasets, we also discuss the potential reasons of the observed behaviour