Differential Protein Expression in Small Intestinal Neuroendocrine Tumors and Liver Metastases

OBJECTIVE: Small intestinal neuroendocrine tumors (SI-NETs) are often detected after they have become metastatic. Using a novel protein array, we identified pathways important in SI-NET metastasis development in surgically resected patients. METHODS: Paired primary tumors and liver metastases from 25 patients undergoing surgical resection for metastatic SI-NETs were harvested. Extracted proteins were separated by sodium dodecyl sulfate gel and multiplex immunoblots were performed with 136 antibodies. Significant Analysis of Microarray was used to select for differentially expressed proteins. A tissue microarray was constructed from 27 archived specimens and stained by immunohistochemistry. RESULTS: Comparing primary SI-NETs with matched normal small-bowel mucosa, 9 proteins were upregulated and cyclin E was downregulated. The SI-NET liver metastases demonstrated upregulation of P-ERK and p27 but downregulation of CDK2 and CDC25B. When comparing primary SI-NET with their paired liver metastases, cyclin E demonstrated a significant upregulation in the liver metastasis. Tissue microarray demonstrated higher p38 expression and lower Cdc 25b expression in SI-NETs versus liver metastases and confirmed higher expression of p27 in liver metastases versus normal liver. CONCLUSIONS: Few studies have compared protein expression in paired primary and metastatic SI-NETs. Our findings reveal changes in a limited number of proteins, suggesting that these may be targets for therapy

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Benchmarking Gate Fidelities in a Si/SiGe Two-Qubit Device

We report the first complete characterization of single-qubit and two-qubit gate fidelities in silicon-based spin qubits, including cross talk and error correlations between the two qubits. To do so, we use a combination of standard randomized benchmarking and a recently introduced method called character randomized benchmarking, which allows for more reliable estimates of the two-qubit fidelity in this system, here giving a 92% fidelity estimate for the controlled-Z gate. Interestingly, with character randomized benchmarking, the two-qubit gate fidelity can be obtained by studying the additional decay induced by interleaving the two-qubit gate in a reference sequence of single-qubit gates only. This work sets the stage for further improvements in all the relevant gate fidelities in silicon spin qubits beyond the error threshold for fault-tolerant quantum computation.QCD/Vandersypen LabQuTechQuantum Information and SoftwareQuantum Internet DivisionQN/Vandersypen La

A programmable two-qubit quantum processor in silicon

Now that it is possible to achieve measurement and control fidelities for individual quantum bits (qubits) above the threshold for fault tolerance, attention is moving towards the difficult task of scaling up the number of physical qubits to the large numbers that are needed for fault-tolerant quantum computing. In this context, quantum-dot-based spin qubits could have substantial advantages over other types of qubit owing to their potential for all-electrical operation and ability to be integrated at high density onto an industrial platform. Initialization, readout and single- and two-qubit gates have been demonstrated in various quantum-dot-based qubit representations. However, as seen with small-scale demonstrations of quantum computers using other types of qubit, combining these elements leads to challenges related to qubit crosstalk, state leakage, calibration and control hardware. Here we overcome these challenges by using carefully designed control techniques to demonstrate a programmable two-qubit quantum processor in a silicon device that can perform the Deutsch-Josza algorithm and the Grover search algorithm - canonical examples of quantum algorithms that outperform their classical analogues. We characterize the entanglement in our processor by using quantum-state tomography of Bell states, measuring state fidelities of 85-89 per cent and concurrences of 73-82 per cent. These results pave the way for larger-scale quantum computers that use spins confined to quantum dots.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.QCD/Vandersypen LabQuTechQN/Quantum TransportQCD/Veldhorst LabQN/Vandersypen La

Flight test results of an adaptive guidance system for reusable launch vehicles /

To enable autonomous operations in future Reusable Launch Vehicles (RLVs), reconfigurable control and adaptive guidance will often be required to facilitate recovery of the mission following a major anomalous event such as an effector failure. An adaptive guidance system that works in conjunction with a reconfigurable controller and an autonomous trajectory command reshaping algorithm is presented. The guidance law utilizes a backstepping architecture to generate pitch rate commands that drive the inner-loop control system. Under extreme failure conditions the control surfaces can saturate in an attempt to meet commanded moments. In these cases, the guidance feedback gains are reduced to preserve stability margins in the guidance loops. A case study is presented that shows the benefits of the guidance gain adaptation. Without adjusting the gains, the guidance loops go unstable, whereas stability is maintained with gain reduction.Photocopy."Conference Paper Preprint.""February 2004."Includes bibliographic refereces (page 16).To enable autonomous operations in future Reusable Launch Vehicles (RLVs), reconfigurable control and adaptive guidance will often be required to facilitate recovery of the mission following a major anomalous event such as an effector failure. An adaptive guidance system that works in conjunction with a reconfigurable controller and an autonomous trajectory command reshaping algorithm is presented. The guidance law utilizes a backstepping architecture to generate pitch rate commands that drive the inner-loop control system. Under extreme failure conditions the control surfaces can saturate in an attempt to meet commanded moments. In these cases, the guidance feedback gains are reduced to preserve stability margins in the guidance loops. A case study is presented that shows the benefits of the guidance gain adaptation. Without adjusting the gains, the guidance loops go unstable, whereas stability is maintained with gain reduction.Report prepared by Barron Associates, Inc., Charlottesville, Virginia, under contract numberMode of access: Internet

Uranium raw materials process cost estimates one through ten, November 15, 1955 /

"Date issued: Jun. 15, 1956."At head of title: Materials Chemistry Division, Engineering Section.Bibliography: p. 95.Operated by Union Carbide Nuclear CompanyMode of access: Internet

Scope of the raw materials cost evaluation studies /

"Date issued: Sep. 8, 1955.""Pilot Plant Section.""Materials Chemistry Division."Includes bibliographical references.Operated by Union Carbide Nuclear CompanyMode of access: Internet

Measurement of charged particle multiplicities and densities in pp collisions at s√=7 TeV in the forward region

Charged particle multiplicities are studied in proton–proton collisions in the forward region at a centre-ofmass energy of √ s = 7 TeV with data collected by the LHCb detector. The forward spectrometer allows access to a kinematic range of 2.0 < η < 4.8 in pseudorapidity, momenta greater than 2 GeV/c and transverse momenta greater than 0.2 GeV/c. The measurements are performed using events with at least one charged particle in the kinematic acceptance. The results are presented as functions of pseudorapidity and transverse momentum and are compared to predictions from several Monte Carlo event generators