76 research outputs found
Variant of TYR and Autoimmunity Susceptibility Loci in Generalized Vitiligo.
- Author
- Alain Taïeb
- Alexandra J.D. Sufit
- Andreas Overbeck
- Anita Amadi-Myers
- Anthony P. Weetman
- Brand OJ
- Christina M. Mailloux
- David J. Gawkrodger
- Dorothy C. Bennett
- E. Helen Kemp
- Giovanni Leone
- Honda Y
- Jo Lambert
- Katherine Gowan
- Khaled Ezzedine
- Margaret R. Wallace
- Mauro Picardo
- Nanny van Geel
- Pamela R. Fain
- Paulene J. Holland
- Richard A. Spritz
- Saunie M. Hutton
- Sheri L. Riccardi
- Stanca A. Birlea
- Thomas Jouary
- Tripathi RK
- Waerner T
- Wang L
- Wayne T. McCormack
- Ying Jin
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2010
- Field of study
BACKGROUND
Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other autoimmune diseases.
METHODS
To identify generalized vitiligo susceptibility loci, we conducted a genomewide association study. We genotyped 579,146 single-nucleotide polymorphisms (SNPs) in 1514 patients with generalized vitiligo who were of European-derived white (CEU) ancestry and compared the genotypes with publicly available control genotypes from 2813 CEU persons. We then tested 50 SNPs in two replication sets, one comprising 677 independent CEU patients and 1106 CEU controls and the other comprising 183 CEU simplex trios with generalized vitiligo and 332 CEU multiplex families.
RESULTS
We detected significant associations between generalized vitiligo and SNPs at several loci previously associated with other autoimmune diseases. These included genes encoding major-histocompatibility-complex class I molecules (P=9.05×10−23) and class II molecules (P=4.50×10−34), PTPN22 (P=1.31×10−7), LPP (P=1.01×10−11), IL2RA (P=2.78×10−9), UBASH3A (P=1.26×10−9), and C1QTNF6 (P=2.21×10−16). We also detected associations between generalized vitiligo and SNPs in two additional immune-related loci, RERE (P=7.07×10−15) and GZMB (P=3.44×10−8), and in a locus containing TYR (P=1.60×10−18), encoding tyrosinase.
CONCLUSIONS
We observed associations between generalized vitiligo and markers implicating multiple genes, some associated with other autoimmune diseases and one (TYR) that may mediate target-cell specificity and indicate a mutually exclusive relationship between susceptibility to vitiligo and susceptibility to melanoma
Common variants in FOXP1 are associated with generalized vitiligo
- Author
- A Alkhateeb
- Alain Taïeb
- Andreas Overbeck
- Anthony P Weetman
- C Shi
- Christina M Mailloux
- David J Gawkrodger
- DF Luo
- Dorothy C Bennett
- E Helen Kemp
- Giovanni Leone
- H Hu
- HD Ochs
- JC Barrett
- Jo Lambert
- Katherine Gowan
- Khaled Ezzedine
- Margaret R Wallace
- Mauro Picardo
- Nanny van Geel
- Pamela R Fain
- Paulene J Holland
- RA Spritz
- Richard A Spritz
- RM Salazar-Gonzalez
- S Horvath
- S Purcell
- SA Birlea
- Sheri L Riccardi
- Stanca A Birlea
- Thomas Jouary
- Wayne T McCormack
- X Feng
- Y Jin
- Ying Jin
- Publication venue
- NATURE PUBLISHING GROUP
- Publication date
- 01/01/2010
- Field of study
In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 × 10−8) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 × 10−7)
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
- Author
- Abano Nenette
- Abbdul-saheb Mudhar
- Adedoyin Temi
- Adell Victoria
- Adesina Tolu
- Adie Katja
- Adil-Smith Jennifer
- Ahmad Nasar
- Ahmed Ashraf
- Ahmed Iman
- Al-Mayhani Talal
- Al-Shahi Salman Rustam
- Al-Shahi Salman Rustam
- Alam Mohammad Irfan
- Albazzaz Mo
- Ali Ali
- Alipio Francis
- Allen Christopher
- Allison Joanna
- Amey Isobel
- Amis Elaine
- Amlani Sageet
- Amoils Shannon
- Amor Kelly
- Anderson Rosemary
- Andole Sreeman
- Anjum Talat
- Ankolekar Sandeep
- Annamalai Arunkumar
- Anthony Alpha
- Anversha Ajmal
- Anwar Ijaz
- Anwar Sajjad
- Appleton Jason
- Argandona Lucia
- Armitage Jane
- Ashton Amy
- Atkinson Natalie
- Auld Grace
- Avis Joanne
- Aweid Basaam
- Ayres Georgina
- Azhar Khalid
- Bagnall Caroline
- Baig Farrukh
- Baigent Colin
- Bailey Duncan
- Baird Yolanda
- Bakawala Rehana
- Baker John
- Baker Pauline
- Balazikova Olga
- Balian Linda
- Baliga Vidya
- Balitska Olesia
- Ball Julie
- Ball Margaret
- Ballantine Robert
- Bamford John
- Banaras Azra
- Barber Mark
- Barbon Emma
- Barker James
- Barr Charlotte
- Barrie Elizabeth
- Barron Luke
- Barry Adrian
- Bateman Gavin
- Bates Michelle
- Bathula Rajaram
- Battersby-Wood Emma
- Bayliss Pauline
- Beadle Hannah
- Bearne Helen
- Beaty Teresa
- Beaves Emily
- Bell Angela
- Bell Jo
- Bell Murdina
- Bellfield Ruth
- Beranova Eva
- Bergin Adrian
- Bhakri Harbens
- Bhalla Ajay
- Bharaj Kiranjit
- Bhargava Maneesh
- Bhaskaran Biju
- Bhatnagar Priya
- Bhatnagar Priya
- Birchall Kathryn
- Birns Jonathan
- Black Toby
- Blades Alex
- Blair Caroline
- Blair Caroline
- Blair Gordon
- Blane Sujata
- Blank Catrin
- Blight Adrian
- Board Joanne
- Board Sarah
- Bokhari Maria
- Bond Kirsty
- Bowring Angela
- Boxall Cherish
- Breeds Joanna
- Brew Helen
- Brezitski Maria
- Bridger Hayley
- Brodie Fiona
- Brotherton Lucy
- Broughton David
- Brown Claire
- Brown Ellen
- Brown Pauline
- Brown Sarah
- Bruce David
- Buchanan David
- Buck Amanda
- Buckle Steve
- Buckle Steve
- Buckley Clare
- Bunea George
- Burger Ilse
- Burgess Laura
- Burgess Seona
- Burssens Evelyne
- Butler Adrian
- Butler Donna
- Butler Rebecca
- Butterworth-Cowin Nicola
- Button Denise
- Buxton Jean
- Byrne Anthony
- Cageao Julie
- Caine Sarah
- Campbell Robert
- Carpenter Michael
- Carpio Racquel
- Carrie Johanna
- Cassidy Tim
- Causley Chelsea
- Chadbourn Indra
- Chadha Dinesh
- Chamberlain Angela
- Chan kelly
- Chandrakumar Aberami
- Chapman Kath
- Chapman Nicola
- Charles Bethan
- Chatterjee Kausic
- Chaudhry Afnan
- Chauhan Meena
- Chenna Srikanth
- Cherian Suja
- Cheripelli Bharath Kumar
- Chopra Neha
- Choulerton James
- Choy Lillian
- Clarke Brian
- Clarke Caroline
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- Crawford Susan
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- Crowther Hannah
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- Cunningham Mishell
- Cvoro Vera
- Dacey Lynne
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- Dallol Bander
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- Datta Prabal
- Davey Richard
- David Anette
- David Owen
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- Davies Ruth
- Davies Silvie
- Davis Fiona
- Davis Michelle
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- Dayal Nilofer
- De Berker Henry
- Deary Ann
- Denic Hayley
- Dennis Martin
- Dennis Martin S
- Denniss Carol
- Devine Joseph
- Devitt Nicola
- Dewar Richard
- Dhakal Mahesh
- Dhar Saikat
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- Dickson Christine
- Dima Sofia
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- Dixon Lynn
- Dobson Tracey
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- Dodd Emily
- Doherty Mandy
- Doherty Mandy
- Donaldson Denise
- Donnelly Richard
- Doubal Fergus
- Dow Lindsey
- Downham Susan
- Doyle Clare
- Doyle Donna
- Drever Jonathan
- du Plessis Johann C
- du Plessis Johannes
- Dube Judith
- Duberley Stephen
- Dunn Linda
- Dunne Karen
- Durairaj Ramesh
- Durman Helen
- Dutta Dipankar
- Dynan Kevin
- Edwards Mandy
- Egerton Shuna
- Eglinton Charlotte
- Eglinton Charlotte
- El Tawil Salwa
- Elfandi Khaled
- Elliot Jennifer
- Elliott Emma
- Ellis Sam
- Emberson Jonathan
- Emsley Hedley
- England Timothy
- Epstein Daniel
- Erande Renuka
- Erumere Esther
- Esisi Bernard
- Esisi Bernard
- Esson Derek
- Esson Derek
- Evans Rachel
- Evans Sue
- Eveson David
- Ewing Jordan
- Fathima Razik
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- Fennelly Ruth
- Ferdinand Phillip
- Findlay Paul
- Finlay Sarah
- Finney Kay
- Fitzell Pauline
- Fitzsimmons Paul
- Fletcher Glyn
- Fletcher Jo
- Fong Rosanna
- Foot Jayne
- Foote Leanne
- Ford Gary
- Foster Eliza
- Fotherby Ken
- Fox Charlotte
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- Francis Jobbin
- Fraser Ruth
- Fraser Ruth
- Fuller Tracy
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- Furnace Jacqueline
- Gadapa Naveen
- Gainard Glyn
- Gainsborough Nicola
- Gallagher Jill
- Gallagher Louise
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- Gamble Ed
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- Garside Mark
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- Gbadamoshi Lukuman
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- Godfrey Margi
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- Grimwood Gemma
- Grocott Jeanette
- Grue Rebecca
- Gulliver Diane
- Guo Fenglin
- Gupwell Karin
- Guthrie Lucy Belle
- Guy Helen
- Guyler Paul
- Hague Adam
- Haider Syed
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- Hakim Eluzai
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- Halse Omid
- Handley Dominic
- Hann Gail
- Hannon Niamh
- Hansen Christian
- Haque Mohammad
- Hardwick Anne
- Harkness Kirsty
- Harrington Frances
- Harrington-Davies Yasmin
- Harrison Louise
- Harrison Melanie
- Harrison Thomas
- Harston George
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- Hayhoe Helen
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- Hedstrom Amanda
- Hedstrom Amanda
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- Howcroft Deborah
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- Hurley Jennifer
- Hussain Malik
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- Hyatt Lisa
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- Iqbal Arshi
- Iqbal Mohammad Shazad
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- Jagpal Baljit
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- Jeyaraj Naomi
- Jha Ratneshwari
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- Jose Josin
- Joshi Yogish
- Joshi Yogish
- Joyson Anu
- Jupp Becky
- Justin Frances
- Kakar Puneet
- Kalathil Latheef
- Kalladka Dheeraj
- Kamara Christine
- Kambafwile Mary
- Kane Ingrid
- Kar Arindam
- Keegan Breffni
- Keeling Elizabeth
- Keenan Samantha
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- Kelly Christine
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- Kennedy Kate
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- Lerpiniere Christine
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- Longland Barbara
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- Lovelock Caroline
- Lowe Gordon
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- Lucas Suzanne
- Luder Robert
- Lyjko Sue
- Maanoosi Mehran
- Maatouk Ahmad
- Macaden Ashish
- MacInnes Brian
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- MacLeod Mary
- MacLiver Linda
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- Minks David P.
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- Murray Gordon D
- Musarrat Kashif
- Myint Min
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- Newby David E
- Newton Sophie
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- Nozedar Tarn
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- O'Brien Richard
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- Redjep Ozlem
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- Rodrigues Mark A
- Rodriguez Aryelly
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- Salek-Haddadi Afraim
- Salih Isam
- Sally Moore
- Sandercock Peter A G
- Sangombe Mirriam
- Sangster Graeme
- Sanyal Ranjan
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- Sarah Procter
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- Sattar Saira
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- Sprigg Nikola
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- Subramonian Santhosh
- Sudlow Cathie
- Sudlow Cathie L M
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- Vickers Carinna
- Walford Jamie
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- Walker Marion
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- Walker Susannah
- Wallace Aine
- Wallace Rebecca
- Wallace Rebecca
- Walstow Deborah
- Walter Deborah
- Walters Ashleigh
- Wani Mushtaq
- Ward Deborah
- Wardlaw Joanna M
- Watchurst Caroline
- Waterfield Kelly
- Waterfield Kelly
- Watson Fran
- Waugh Dean
- Webb Tom
- Webber Adam
- Webster Timothy
- Weinling Marie
- Weir Nic
- Weir Pauline
- Welch Angela
- Werring David
- Werring David J
- Whitcher Alison
- White James
- White Julie
- White Philip M
- White Susan
- Whiteley William
- Whiteley William N
- Whiteman Jessica
- Whiteman Jessica
- Whiting Robert
- Whittamore Katherine
- Wiggam Ivan
- Wilding Peter
- Wilkes Gwendoline
- Wilkinson Mark
- Willberry Angela
- Williams Carol
- Williams Rebecca
- Williams-Yesson Barbara
- Willmot Mark
- Wilson David
- Wilson Duncan
- Wilson Jenny
- Wilson Lisa
- Wilson Sarah
- Wiltshire Alison
- Wood Diane
- Wood Edith
- Wood Lisa
- Woodward Stephen
- Wright Fiona
- Wroath Belinda
- Wynter Inez
- Yadava Rajendra
- Yip Brigitte
- Young Andrew
- Zachariah George
- Zahoor Tajammal
- Zoe Mellor
- Publication venue
- 'Elsevier BV'
- Publication date
- 22/05/2019
- Field of study
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder
- Author
- A Feher
- A Philippe
- AE Vine
- Agatino Battaglia
- AL Price
- Alexander Kolevzon
- Alison Merikangas
- Alistair T. Pagnamenta
- AM Persico
- Ana F. Sequeira
- Andrew Green
- Andrew Pickles
- Ann Le Couteur
- Ann P. Thompson
- Annemarie Poustka
- Annette Estes
- Anthony J. Bailey
- Anthony P. Monaco
- Astrid Vicente
- Barbara Parrini
- Bennett L. Leventhal
- Bernadette Roge
- Brett S. Abrahams
- Brian L. Yaspan
- Bridget A. Fernandez
- C Betancur
- Carine Mantoulan
- Catalina Betancur
- Catarina Correia
- Catherine Lord
- Cecilia Kim
- Christian R. Marshall
- Christina Corsello
- Christine M. Freitag
- Christopher Gillberg
- Christopher J. McDougle
- CM Durand
- CM Durand
- D Castermans
- D Pinto
- DA Kleinjan
- Dalila Pinto
- Daniel H. Geschwind
- David J. Posey
- DE Arking
- Denis C. Shields
- DV Zaykin
- Edwin H. Cook
- Eftichia Duketis
- Elena Bacchelli
- Elena Maestrini
- Ellen M. Wijsman
- Eric Fombonne
- F Dutheil
- F Hildebrandt
- FF Hamdan
- Fiorella Minopoli
- Fred Volkmar
- Frederico Duque
- Fritz Poustka
- Geraldine Dawson
- Gerard D. Schellenberg
- Ghazala K. Mirza
- Gillian Baird
- Gillian Hughes
- Gudrun Nygren
- Guiomar Oliveira
- GW Tam
- Hakon Hakonarson
- Helen McConachie
- Herman Van Engeland
- HG Kim
- Hilary Coon
- HY Zoghbi
- International Molecular Genetic Study of Autism Consortium (IMGSAC)
- Inês Sousa
- J Goudet
- J Hoshino
- JA Lamb
- Jacob A. S. Vorstman
- James S. Sutcliffe
- Jane McGrath
- Janine A. Lamb
- JC Barrett
- Jeff Munson
- Jeremy R. Parr
- Jiannis Ragoussis
- Jillian P. Casey
- Joachim Hallmayer
- Joana Almeida
- John B. Vincent
- John Gilbert
- John I. Nurnberger
- John Tsiantis
- Jonathan Green
- Jonathan L. Haines
- Joseph D. Buxbaum
- Joseph Piven
- Joseph T. Glessner
- Judith M. Conroy
- Judith Miller
- Kai Wang
- Katerina Papanikolaou
- Kathy White
- Kerstin Wittemeyer
- Kirsty Wing
- KP Lesch
- LA Thomas
- Latha Soorya
- LF Martin
- Lonnie Zwaigenbaum
- Louise Gallagher
- LR Cardon
- M Bahlo
- M Manchia
- M Nothnagel
- Marc Coutanche
- Maretha de Jonge
- Margaret A. Pericak-Vance
- Marion Leboyer
- Maïté Tauber
- MB Lauritsen
- MD Rubio
- MF Egan
- Michael Gill
- Michael L. Cuccaro
- Michael L. Rutter
- MJ Laan van der
- ML Sinkus
- MM Motazacker
- MS Yang
- Nadia Bolshakova
- Naisha Shah
- NP Shugalev
- Nuala Sykes
- Patrick F. Bolton
- Penny Farrar
- Peter Szatmari
- Phil Cali
- Raffaella Tancredi
- Regina Regan
- RH Flomen
- Richard Anney
- Richard Delorme
- Richard Holt
- Rita M. Cantor
- Roberta Igliozzi
- S Benko
- S Jamain
- S Purcell
- S Sahara
- SA Currenti
- Sabata C. Lund
- Sabine M. Klauck
- SB Gabriel
- Sean Brennan
- Sean Ennis
- Simon Wallace
- Stanley F. Nelson
- Stephen J. Guter
- Stephen W. Scherer
- Susan E. Folstein
- Susanne Thomson
- Suzanne Foley
- T Lencz
- TC Sudhof
- The International HapMap Consortium
- Thomas Bourgeron
- Thomas H. Wassink
- Tiago Magalhaes
- TL Yang
- Tom Berney
- Vanessa Hus
- Vera Stoppioni
- Veronica J. Vieland
- W Wong
- William M. McMahon
- XQ Liu
- Y Chen
- Y Jia
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2011
- Field of study
Autism spectrum disorder (ASD) is a highly heritable disorder of complex and heterogeneous aetiology. It is primarily characterized by altered cognitive ability including impaired language and communication skills and fundamental deficits in social reciprocity. Despite some notable successes in neuropsychiatric genetics, overall, the high heritability of ASD (~90%) remains poorly explained by common genetic risk variants. However, recent studies suggest that rare genomic variation, in particular copy number variation, may account for a significant proportion of the genetic basis of ASD. We present a large scale analysis to identify candidate genes which may contain low-frequency recessive variation contributing to ASD while taking into account the potential contribution of population differences to the genetic heterogeneity of ASD. Our strategy, homozygous haplotype (HH) mapping, aims to detect homozygous segments of identical haplotype structure that are shared at a higher frequency amongst ASD patients compared to parental controls. The analysis was performed on 1,402 Autism Genome Project trios genotyped for 1 million single nucleotide polymorphisms (SNPs). We identified 25 known and 1,218 novel ASD candidate genes in the discovery analysis including CADM2, ABHD14A, CHRFAM7A, GRIK2, GRM3, EPHA3, FGF10, KCND2, PDZK1, IMMP2L and FOXP2. Furthermore, 10 of the previously reported ASD genes and 300 of the novel candidates identified in the discovery analysis were replicated in an independent sample of 1,182 trios. Our results demonstrate that regions of HH are significantly enriched for previously reported ASD candidate genes and the observed association is independent of gene size (odds ratio 2.10). Our findings highlight the applicability of HH mapping in complex disorders such as ASD and offer an alternative approach to the analysis of genome-wide association data
The Science Performance of JWST as Characterized in Commissioning
- Author
- Abell Jim
- Abney Faith
- Abul-Huda Yasin
- Acton D. Scott
- Adams Evan
- Adler David
- Aguilar Jonathan
- Ahmed Nasif
- Alarcon Rafael Ramos
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Marsha
- Altenburg Martin
- Alvarez Jose Lorenzo
- Andersen Greg
- Anderson Harry
- Anderson Sara
- Argyriou Ioannis
- Armstrong Amber
- Arribas Santiago
- Artigau Etienne
- Arvai Amanda
- Atkinson Charles
- Bacon Gregory
- Bair Thomas
- Banks Kimberly
- Barrientes Jaclyn
- Barringer Bruce
- Bartosik Peter
- Bast William
- Baudoz Pierre
- Beatty Thomas
- Bechtold Katie
- Beck Tracy
- Bergeron Eddie
- Bergkoetter Matthew
- Bhatawdekar Rachana
- Birkmann Stephan
- Blazek Ronald
- Blome Claire
- Boccaletti Anthony
- Boeker Torsten
- Boia John
- Bonaventura Nina
- Bond Nicholas
- Bosley Kari
- Boucarut Ray
- Bourque Matthew
- Bouwman Jeroen
- Bower Gary
- Bowers Charles
- Boyer Martha
- Bradley Larry
- Brady Greg
- Braun Hannah
- Breda David
- Bresnahan Pamela
- Bright Stacey
- Britt Christopher
- Bromenschenkel Asa
- Brooks Brian
- Brooks Keira
- Brown Bob
- Brown Matthew
- Brown Patricia
- Bunker Andy
- Burger Matthew
- Bushouse Howard
- Cale Steven
- Cameron Alex
- Cameron Peter
- Canipe Alicia
- Caplinger James
- Caputo Francis
- Cara Mihai
- Carey Larkin
- Carniani Stefano
- Carrasquilla Maria
- Carruthers Margaret
- Case Michael
- Catherine Riggs
- Chance Don
- Chapman George
- Charlot Stéphane
- Charlow Brian
- Chayer Pierre
- Chen Bin
- Cherinka Brian
- Chichester Sarah
- Chilton Zack
- Chonis Taylor
- Clampin Mark
- Clark Charles
- Clark Kerry
- Coe Dan
- Coleman Benee
- Colon Knicole
- Comber Brian
- Comeau Tom
- Connolly Dennis
- Cooper James
- Cooper Rachel
- Coppock Eric
- Correnti Matteo
- Cossou Christophe
- Coulais Alain
- Coyle Laura
- Cracraft Misty
- Curti Mirko
- Cuturic Steven
- Davis Katherine
- Davis Michael
- de Oliveira Catarina Alves
- Dean Bruce
- Del Pino Bruno Rodriguez
- DeLisa Amy
- deMeester Wim
- Dencheva Nadezhda
- Dencheva Nadia
- DePasquale Joseph
- Deschenes Jeremy
- Detre Örs Hunor
- Diaz Rosa
- Dicken Dan
- DiFelice Audrey
- Dillman Matthew
- Dixon William
- Doggett Jesse
- Donaldson Tom
- Douglas Rob
- Doyon René
- DuPrie Kimberly
- Dupuis Jean
- Durning John
- Easmin Nilufar
- Eck Weston
- Edeani Chinwe
- Egami Eiichi
- Ehrenwinkler Ralf
- Eisenhamer Jonathan
- Eisenhower Michael
- Elie Michelle
- Elliott James
- Elliott Kyle
- Ellis Tracy
- Engesser Michael
- Espinoza Nestor
- Etienne Odessa
- Etxaluze Mireya
- Falini Patrick
- Feeney Matthew
- Feinberg Lee
- Ferruit Pierre
- Ferry Malcolm
- Filippazzo Joseph
- Fincham Brian
- Fix Mees
- Flagey Nicolas
- Florian Michael
- Flynn Jim
- Fontanella Erin
- Ford Terrance
- Forshay Peter
- Fox Ori
- Franz David
- Friedman Scott
- Fu Henry
- Fullerton Alexander
- Galkin Sergey
- Galyer Anthony
- Gardner Jonathan
- Gardner Lisa
- Garland Dennis
- Garrett Bruce
- Gasman Danny
- Gaspar Andras
- Gaudreau Daniel
- Gauthier Peter
- Geers Vincent
- Geithner Paul
- Gennaro Mario
- Giardino Giovanna
- Girard Julien
- Giuliano Mark
- Glasse Alistair
- Glassmire Kirk
- Glauser Adrian
- Glazer Stuart
- Godfrey John
- Golimowski David
- Gollnitz David
- Gong Fan
- Gonzaga Shireen
- Gordon Karl
- Gordon Michael
- Goudfrooij Paul
- Greene Thomas
- Greenhouse Matthew
- Grimaldi Stefano
- Groebner Andrew
- Grundy Timothy
- Guillard Pierre
- Gutman Irvin
- Ha Kong Q.
- Haderlein Peter
- Hagedorn Andria
- Hainline Kevin
- Haley Craig
- Hami Maryam
- Hamilton Forrest
- Hammel Heidi
- Hansen Carl
- Harkins Tom
- Harr Michael
- Hart Jessica
- Hart Quyen
- Hartig George
- Hashimoto Ryan
- Haskins Sujee
- Hathaway William
- Havey Keith
- Hayden Brian
- Hecht Karen
- Heller-Boyer Chris
- Henriques Caroline
- Henry Alaina
- Hermann Karl
- Hernandez Scarlin
- Hesman Brigette
- Hicks Brian
- Hilbert Bryan
- Hines Dean
- Hoffman Melissa
- Holfeltz Sherie
- Holler Bryan J.
- Hoppa Jennifer
- Hott Kyle
- Howard Joseph
- Howard Rick
- Hunter Alexander
- Hunter David
- Hurst Brendan
- Husemann Bernd
- Hustak Leah
- Ignat Luminita Ilinca
- Illingworth Garth
- Irish Sandra
- Jackson Wallace
- Jahromi Amir
- Jakobsen Peter
- James Bryan
- James LeAndrea
- Januszewski William
- Jenkins Ann
- Jirdeh Hussein
- Johnson Phillip
- Johnson Timothy
- Jones Danny
- Jones Olivia
- Jones Ron
- Jones Vicki
- Jordan Ian
- Jordan Margaret
- Jurczyk Sarah
- Jurling Alden
- Kaleida Catherine
- Kalmanson Phillip
- Kammerer Jens
- Kang Huijo
- Kao Shaw-Hong
- Karakla Diane
- Kavanagh Patrick
- Kelly Doug
- Kendrew Sarah
- Kennedy Herbert
- Kenny Deborah
- Keski-kuha Ritva
- Keyes Charles
- Kidwell Richard
- Kimble Randy
- Kinzel Wayne
- Kirk Jeff
- Kirkpatrick Mark
- Kirshenblat Danielle
- Klaassen Pamela
- Knapp Bryan
- Knight J. Scott
- Knollenberg Perry
- Koehler Robert
- Koekemoer Anton
- Kovacs Aiden
- Kulp Trey
- Kumari Nimisha
- Kyprianou Mark
- La Massa Stephanie
- Labador Aurora
- Lagage Pierre-Olivier
- Lajoie Charles-Phillipe
- Lallo Matt
- Lallo Matthew
- Lam May
- Lamb Tracy
- Lambros Scott
- Lampenfield Richard
- Langston James
- Larson Kirsten
- Law David
- Lawrence Jon
- Lee David
- Leisenring Jarron
- Lepo Kelly
- Leveille Michael
- Levenson Nancy
- Levine Marie
- Levy Zena
- Lewis Dan
- Lewis Hannah
- Libralato Mattia
- Lightsey Paul
- Link Miranda
- Liu Lily
- Lo Amy
- Lockwood Alexandra
- Logue Ryan
- Long Chris
- Long Douglas
- Loomis Charles
- Lopez-Caniego Marcos
- Love-Pruitt Jennifer
- Lucy Adrian
- Luetzgendorf Nora
- Maghami Peiman
- Maiolino Roberto
- Major Melissa
- Malla Sunita
- Malumuth Eliot
- Manjavacas Elena
- Mannfolk Crystal
- Marin Macarena Garcia
- Marquez Javier Alvarez
- Marrione Amanda
- Marston Anthony
- Martel André
- Maschmann Marc
- Masci Gregory
- Masciarelli Michaela
- Maszkiewicz Michael
- Mather John
- McElwain Michael
- McKenzie Kenny
- McLean Brian
- McMaster Matthew
- Melbourne Katie
- Meléndez Marcio
- Menzel Michael
- Merz Kaiya
- Meyett Michele
- Meza Luis
- Milam Stefanie
- Miskey Cherie
- Misselt Karl
- Moller Christopher
- Morrison Jane
- Morse Ernie
- Moseley Harvey
- Mosier Gary
- Mountain Matt
- Mueckay Julio
- Mueller Michael
- Mullally Susan
- Murphy Jess
- Murray Claire
- Murray Katherine
- Mustelier David
- Muzerolle James
- Mycroft Matthew
- Myers Richard
- Myrick Kaila
- Nanavati Shashvat
- Nance Elizabeth
- Nayak Omnarayani
- Naylor Bret
- Neff Susan
- Neira Irma Quispe
- Nelan Edmund
- Nickson Bryony
- Nielson Alethea
- Nieto-Santisteban Maria
- Nikolov Nikolay
- Noriega-Crespo Alberto
- O'Shaughnessy Brian
- O'Sullivan Brian
- Ochs William
- Ogle Patrick
- Oleszczuk Brenda
- Olmsted Joseph
- Ortega Alvaro Labiano
- Osborne Shannon
- Ottens Richard
- Owens Beverly
- Pacifici Camilla
- Pagan Alyssa
- Page James
- Park Sang
- Parrish Keith
- Patapis Polychronis
- Paul Lee
- Pauly Tyler
- Pavlovsky Cheryl
- Pedder Andrew
- Peek Matthew
- Pena-Guerrero Maria
- Pennanen Konstantin
- Perez Yesenia
- Perna Michele
- Perriello Beth
- Perrin Marshall
- Phillips Kevin
- Pietraszkiewicz Martin
- Pinaud Jean-Paul
- Pirzkal Norbert
- Pitman Joseph
- Piwowar Aidan
- Platais Vera
- Plate Maurice Te
- Player Danielle
- Plesha Rachel
- Pollizi Joe
- Polster Ethan
- Pontoppidan Klaus
- Porterfield Blair
- Proffitt Charles
- Pueyo Laurent
- Pulliam Christine
- Quirt Brian
- Ramsay Leah
- Rapp Greg
- Rapp Robert
- Rauscher Bernard
- Ravindranath Swara
- Rawle Timothy
- Regan Michael
- Reichard Timothy A.
- Reis Carl
- Ressler Michael E.
- Rest Armin
- Reynolds Paul
- Rhue Timothy
- Richon Karen
- Rickman Emily
- Ridgaway Michael
- Rieke George
- Rieke Marcia
- Rigby Jane
- Ritchie Christine
- Rix Hans-Walter
- Robberto Massimo
- Robinson Gregory
- Robinson Michael
- Robinson Orion
- Rock Frank
- Rodriguez David
- Roellig Thomas
- Rohrbach Scott
- Roman Anthony
- Romelfanger Fred
- Rose Perry
- Roteliuk Anthony
- Roth Marc
- Rothwell Braden
- Rowlands Neil
- Roy Arpita
- Royer Pierre
- Royle Patricia
- Rui Chunlei
- Rumler Peter
- Runnels Joel
- Russ Melissa
- Rustamkulov Zafar
- Ryden Grant
- Ryer Holly
- Sabata Modhumita
- Sabatke Derek
- Sabbi Elena
- Samuelson Bridget
- Sapp Benjamin
- Sappington Bradley
- Sargent B.
- Sauer Arne
- Scheithauer Silvia
- Schlawin Everett
- Schlitz Joseph
- Schmitz Tyler
- Schneider Analyn
- Schreiber Jürgen
- Schulze Vonessa
- Schwab Ryan
- Scott John
- Sembach Kenneth
- Shanahan Clare
- Shaughnessy Bryan
- Shaw Richard
- Shawger Nanci
- Shay Christopher
- Sheehan Evan
- Shen Sharon
- Sherman Allan
- Shiao Bernard
- Shih Hsin-Yi
- Shivaei Irene
- Sienkiewicz Matthew
- Sing David
- Sirianni Marco
- Sivaramakrishnan Anand
- Skipper Joy
- Sloan Gregory
- Slocum Christine
- Slowinski Steven
- Smith Corbett
- Smith Denise
- Smith Eric
- Smith Erin
- Snyder Gregory
- Soh Warren
- Sohn Tony
- Soto Christian
- Spencer Richard
- Stallcup Scott
- Stansberry John
- Stark Christopher
- Starr Carl
- Starr Elysia
- Stewart Alphonso
- Stiavelli Massimo
- Straughn Amber
- Strickland David
- Stys Jeff
- Summers Francis
- Sun Fengwu
- Sunnquist Ben
- Swade Daryl
- Swam Michael
- Swaters Robert
- Swoish Robby
- Taylor Joanna M.
- Taylor Rolanda
- Tea Mason
- Teague Kelly
- Telfer Randal
- Temim Tea
- Thatte Deepashri
- Thompson Christopher
- Thompson Linda
- Thomson Shaun
- Tikkanen Tuomo
- Tippet William
- Todd Connor
- Toolan Sharon
- Tran Hien
- Trejo Edwin
- Truong Justin
- Tsukamoto Chris
- Tustain Samuel
- Tyra Harrison
- Ubeda Leonardo
- Underwood Kelli
- Uzzo Michael
- Valenti Jeff
- Van Campen Julie
- Vandal Thomas
- Vandenbussche Bart
- Vila Begoña
- Volk Kevin
- Wahlgren Glenn
- Waldman Mark
- Walker Chanda
- Wander Michel
- Warfield Christine
- Warner Gerald
- Wasiak Matthew
- Watkins Mitchell
- Weaver Andrew
- Weilert Mark
- Weiser Nick
- Weiss Ben
- Weissman Sarah
- Welty Alan
- West Garrett
- Wheate Lauren
- Wheatley Elizabeth
- Wheeler Thomas
- White Rick
- Whiteaker Kevin
- Whitehouse Paul
- Whiteleather Jennifer
- Whitman William
- Williams Christina
- Willmer Christopher
- Willott Chris
- Willoughby Scott
- Wilson Andrew
- Wirth Gregory
- Wislowski Emily
- Wolf Erin
- Wolfe David
- Wolff Schuyler
- Workman Bill
- Wright Gillian
- Wright Ray
- Wu Carl
- Wu Rai
- Wymer Kristen
- Yates Kayla
- Yeager Christopher
- Yeates Jared
- Yerger Ethan
- Yoon Jinmi
- Young Alice
- Yu Susan
- Zak Dean
- Zeidler Peter
- Zhou Julia
- Zielinski Thomas
- Zincke Cristian
- Zonak Stephanie
- Publication venue
- 'IOP Publishing'
- Publication date
- 10/04/2023
- Field of study
This paper characterizes the actual science performance of the James Webb
Space Telescope (JWST), as determined from the six month commissioning period.
We summarize the performance of the spacecraft, telescope, science instruments,
and ground system, with an emphasis on differences from pre-launch
expectations. Commissioning has made clear that JWST is fully capable of
achieving the discoveries for which it was built. Moreover, almost across the
board, the science performance of JWST is better than expected; in most cases,
JWST will go deeper faster than expected. The telescope and instrument suite
have demonstrated the sensitivity, stability, image quality, and spectral range
that are necessary to transform our understanding of the cosmos through
observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures;
https://iopscience.iop.org/article/10.1088/1538-3873/acb29
Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial
- Author
- Abano Nenette
- Abbdul-saheb Mudhar
- Adedoyin Temi
- Adell Victoria
- Adesina Tolu
- Adie Katja
- Adil-Smith Jennifer
- Ahmad Nasar
- Ahmed Ashraf
- Ahmed Iman
- Al-Mayhani Talal
- Al-Shahi Salman Rustam
- Alam Mohammad Irfan
- Albazzaz Mo
- Ali Ali
- Alipio Francis
- Allen Christopher
- Allison Joanna
- Amey Isobel
- Amis Elaine
- Amlani Sageet
- Amoils Shannon
- Amor Kelly
- Anderson Rosemary
- Andole Sreeman
- Anjum Talat
- Ankolekar Sandeep
- Annamalai Arunkumar
- Anthony Alpha
- Anversha Ajmal
- Anwar Ijaz
- Anwar Sajjad
- Appleton Jason
- Argandona Lucia
- Armitage Jane
- Ashton Amy
- Atkinson Natalie
- Auld Grace
- Avis Joanne
- Aweid Basaam
- Ayres Georgina
- Azhar Khalid
- Bagnall Caroline
- Baig Farrukh
- Baigent Colin
- Bailey Duncan
- Baird Yolanda
- Bakawala Rehana
- Baker John
- Baker Pauline
- Balazikova Olga
- Balian Linda
- Baliga Vidya
- Balitska Olesia
- Ball Julie
- Ball Margaret
- Ballantine Robert
- Bamford John
- Banaras Azra
- Barber Mark
- Barbon Emma
- Barker James
- Barr Charlotte
- Barrie Elizabeth
- Barron Luke
- Barry Adrian
- Bateman Gavin
- Bates Michelle
- Bathula Rajaram
- Battersby-Wood Emma
- Bayliss Pauline
- Beadle Hannah
- Bearne Helen
- Beaty Teresa
- Beaves Emily
- Bell Angela
- Bell Jo
- Bell Murdina
- Bellfield Ruth
- Beranova Eva
- Bergin Adrian
- Bhakri Harbens
- Bhalla Ajay
- Bharaj Kiranjit
- Bhargava Maneesh
- Bhaskaran Biju
- Bhatnagar Priya
- Birchall Kathryn
- Birns Jonathan
- Black Toby
- Blades Alex
- Blair Caroline
- Blair Caroline
- Blair Gordon
- Blane Sujata
- Blank Catrin
- Blight Adrian
- Board Joanne
- Board Sarah
- Bokhari Maria
- Bond Kirsty
- Bowring Angela
- Boxall Cherish
- Breeds Joanna
- Brew Helen
- Brezitski Maria
- Bridger Hayley
- Brodie Fiona
- Brotherton Lucy
- Broughton David
- Brown Claire
- Brown Ellen
- Brown Pauline
- Brown Sarah
- Bruce David
- Buchanan David
- Buck Amanda
- Buckle Steve
- Buckle Steve
- Buckley Clare
- Bunea George
- Burger Ilse
- Burgess Laura
- Burgess Seona
- Burssens Evelyne
- Butler Adrian
- Butler Donna
- Butler Rebecca
- Butterworth-Cowin Nicola
- Button Denise
- Buxton Jean
- Byrne Anthony
- Cageao Julie
- Caine Sarah
- Campbell Robert
- Carpenter Michael
- Carpio Racquel
- Carrie Johanna
- Cassidy Tim
- Causley Chelsea
- Chadbourn Indra
- Chadha Dinesh
- Chamberlain Angela
- Chan Kelly
- Chandrakumar Aberami
- Chapman Kath
- Chapman Nicola
- Charles Bethan
- Chatterjee Kausic
- Chaudhry Afnan
- Chauhan Meena
- Chenna Srikanth
- Cherian Suja
- Cheripelli Bharath Kumar
- Chopra Neha
- Choulerton James
- Choy Lillian
- Clarke Brian
- Clarke Caroline
- Clarke Judith
- Clarke Natasha
- Clarke Rebecca
- Clarke Samantha
- Clarkson Emma
- Clay Caroline
- Clayton Susan
- Clayton-Evans Lisa
- Cluckie Gillian
- Cochrane Helen
- Codd Laura
- Cohen David
- Collins Kayleigh
- Connor Lynda
- Constantin Carmen
- Cook Angela
- Cooper Martin
- Copeland Claire
- Cosier Tracey
- Courtauld Gillian
- Couser Mandy
- Coward Lucy
- Cowie Linda
- Cox Chantel
- Cox Chloe
- Cox Penelope
- Crabtree Karen
- Crawford Pam
- Crawford Susan
- Creeden Robyn
- Crisp Sarah
- Cronin Julie
- Crook Luci
- Crosbie Caroline
- Crouch Nichola
- Crown Rachel
- Crowther Hannah
- Cuddy Sarah
- Cuenoud Larissa
- Cullen Claire
- Culmsee Charlotte
- Cunningham James
- Cunningham Mishell
- Cvoro Vera
- Dacey Lynne
- Dakin Katy
- Dallol Bander
- Dangri Puneet
- Datta Prabal
- Davey Richard
- David Anette
- David Owen
- Davies Caroline
- Davies Ruth
- Davies Silvie
- Davis Fiona
- Davis Michelle
- Day Nicola
- Dayal Nilofer
- De Berker Henry
- Deary Ann
- Denic Hayley
- Dennis MS
- Denniss Carol
- Devine Joseph
- Devitt Nicola
- Dewar Richard
- Dhakal Mahesh
- Dhar Saikat
- Dickinson Christina
- Dickson Christine
- Dima Sofia
- Dinsmore Lynn
- Dixon Lynn
- Dobson Tracey
- Dodd Angela
- Dodd Emily
- Doherty Mandy
- Doherty Mandy
- Donaldson Denise
- Donnelly Richard
- Doubal Fergus
- Dow Lindsey
- Downham Susan
- Doyle Clare
- Doyle Donna
- Drever Jonathan
- du Plessis Johannes
- Dube Judith
- Duberley Stephen
- Dunn Linda
- Dunne Karen
- Durairaj Ramesh
- Durman Helen
- Dutta Dipankar
- Dynan Kevin
- Edwards Mandy
- Egerton Shuna
- Eglinton Charlotte
- Eglinton Charlotte
- El Tawil Salwa
- Elfandi Khaled
- Elliot Jennifer
- Elliott Emma
- Ellis Sam
- Emberson Jonathan
- Emsley Hedley
- England Timothy
- Epstein Daniel
- Erande Renuka
- Erumere Esther
- Esisi Bernard
- Esisi Bernard
- Esson Derek
- Esson Derek
- Evans Rachel
- Evans Sue
- Eveson David
- Ewing Jordan
- Fathima Razik
- Fawcett Michelle
- Feerick Shez
- Fennelly Ruth
- Ferdinand Phillip
- Findlay Paul
- Finlay Sarah
- Finney Kay
- Fitzell Pauline
- Fitzsimmons Paul
- Fletcher Glyn
- Fletcher Jo
- Fong Rosanna
- Foot Jayne
- Foote Leanne
- Ford Gary
- Foster Eliza
- Fotherby Ken
- Fox Charlotte
- Francia Nina
- Francis Jobbin
- Fraser Ruth
- Fraser Ruth
- Fuller Tracy
- Fulton Ailsa
- Furnace Jacqueline
- Gadapa Naveen
- Gainard Glyn
- Gainsborough Nicola
- Gallagher Jill
- Gallagher Louise
- Gallifent Rachel
- Gamble Ed
- Garcia Tatiana
- Gardener Léjeune
- Garfield-Smith Joanne
- Garside Mark
- Gartrell Imogen
- Gascoyne Rachel
- Gattringer Thomas
- Gautam Nikki
- Gaylard Jane
- Gbadamoshi Lukuman
- Geraghty Olivia
- Ghaly George
- Ghatala Rita
- Ghosh Sandip
- Giallombardo Elio
- Gilham Ellie
- Gilmour Danielle
- Gilzeane Nicola
- Glass Jon
- Gleave Laura
- Glover Rachel
- Godfrey Margi
- Goff Anita
- Goorah Neetish
- Gott Valerie
- Gow Heather
- Graham Carol
- Graham Ruth
- Gray Jane
- Green Carole
- Greenwood Richard
- Gregory Bindu
- Greig Jill
- Grimwood Gemma
- Grocott Jeanette
- Grue Rebecca
- Gulliver Diane
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- Patterson Chris
- Paulton Ruth
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- Peixoto Cassilda
- Penge Justin
- Perez Jane
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- Stafford Samantha
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- Taylor Pat
- Taylor Vicky
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- Thant Hlaing
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- Triscott Claire
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- van Someren Chloe
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- Vickers Carinna
- Walford Jamie
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- Walker Marion
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- Wallace Rebecca
- Walstow Deborah
- Walter Deborah
- Walters Ashleigh
- Wani Mushtaq
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- Wardlaw JM
- Watchurst Caroline
- Waterfield Kelly
- Waterfield Kelly
- Watson Fran
- Waugh Dean
- Webb Tom
- Webber Adam
- Webster Timothy
- Weinling Marie
- Weir Nic
- Weir Pauline
- Welch Angela
- Werring DJ
- Whitcher Alison
- White James
- White Julie
- White PM
- White Susan
- Whiteley WN
- Whiteman Jessica
- Whiteman Jessica
- Whiting Robert
- Whittamore Katherine
- Wiggam Ivan
- Wilding Peter
- Wilkes Gwendoline
- Wilkinson Mark
- Willberry Angela
- Williams Carol
- Williams Rebecca
- Williams-Yesson Barbara
- Willmot Mark
- Wilson David
- Wilson Duncan
- Wilson Jenny
- Wilson Lisa
- Wilson Sarah
- Wiltshire Alison
- Wood Diane
- Wood Edith
- Wood Lisa
- Woodward Stephen
- Wright Fiona
- Wroath Belinda
- Wynter Inez
- Yadava Rajendra
- Yip Brigitte
- Young Andrew
- Zachariah George
- Zahoor Tajammal
- Zoe Mellor
- Publication venue
- 'Elsevier BV'
- Publication date
- 29/06/2019
- Field of study
Background:
Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used safely is unclear. We aimed to estimate the relative and absolute effects of antiplatelet therapy on recurrent intracerebral haemorrhage and whether this risk might exceed any reduction of occlusive vascular events.
Methods:
The REstart or STop Antithrombotics Randomised Trial (RESTART) was a prospective, randomised, open-label, blinded endpoint, parallel-group trial at 122 hospitals in the UK. We recruited adults (≥18 years) who were taking antithrombotic (antiplatelet or anticoagulant) therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage, discontinued antithrombotic therapy, and survived for 24 h. Computerised randomisation incorporating minimisation allocated participants (1:1) to start or avoid antiplatelet therapy. We followed participants for the primary outcome (recurrent symptomatic intracerebral haemorrhage) for up to 5 years. We analysed data from all randomised participants using Cox proportional hazards regression, adjusted for minimisation covariates. This trial is registered with ISRCTN (number ISRCTN71907627).
Findings:
Between May 22, 2013, and May 31, 2018, 537 participants were recruited a median of 76 days (IQR 29–146) after intracerebral haemorrhage onset: 268 were assigned to start and 269 (one withdrew) to avoid antiplatelet therapy. Participants were followed for a median of 2·0 years (IQR [1·0– 3·0]; completeness 99·3%). 12 (4%) of 268 participants allocated to antiplatelet therapy had recurrence of intracerebral haemorrhage compared with 23 (9%) of 268 participants allocated to avoid antiplatelet therapy (adjusted hazard ratio 0·51 [95% CI 0·25–1·03]; p=0·060). 18 (7%) participants allocated to antiplatelet therapy experienced major haemorrhagic events compared with 25 (9%) participants allocated to avoid antiplatelet therapy (0·71 [0·39–1·30]; p=0·27), and 39 [15%] participants allocated to antiplatelet therapy had major occlusive vascular events compared with 38 [14%] allocated to avoid antiplatelet therapy (1·02 [0·65–1·60]; p=0·92).
Interpretation:
These results exclude all but a very modest increase in the risk of recurrent intracerebral haemorrhage with antiplatelet therapy for patients on antithrombotic therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage. The risk of recurrent intracerebral haemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention
Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial
- Author
- Abano Nenette
- Abbdul-saheb Mudhar
- Adedoyin Temi
- Adell Victoria
- Adesina Tolu
- Adie Katja
- Adil-Smith Jennifer
- Ahmad Nasar
- Ahmed Ashraf
- Ahmed Iman
- Al-Mayhani Talal
- Al-Shahi Salman Rustam
- Alam Mohammad Irfan
- Albazzaz Mo
- Ali Ali
- Alipio Francis
- Allen Christopher
- Allison Joanna
- Amey Isobel
- Amis Elaine
- Amlani Sageet
- Amoils Shannon
- Amor Kelly
- Anderson Rosemary
- Andole Sreeman
- Anjum Talat
- Ankolekar Sandeep
- Annamalai Arunkumar
- Anthony Alpha
- Anversha Ajmal
- Anwar Ijaz
- Anwar Sajjad
- Appleton Jason
- Argandona Lucia
- Armitage Jane
- Ashton Amy
- Atkinson Natalie
- Auld Grace
- Avis Joanne
- Aweid Basaam
- Ayres Georgina
- Azhar Khalid
- Bagnall Caroline
- Baig Farrukh
- Baigent Colin
- Bailey Duncan
- Baird Yolanda
- Bakawala Rehana
- Baker John
- Baker Pauline
- Balazikova Olga
- Balian Linda
- Baliga Vidya
- Balitska Olesia
- Ball Julie
- Ball Margaret
- Ballantine Robert
- Bamford John
- Banaras Azra
- Barber Mark
- Barbon Emma
- Barker James
- Barr Charlotte
- Barrie Elizabeth
- Barron Luke
- Barry Adrian
- Bateman Gavin
- Bates Michelle
- Bathula Rajaram
- Battersby-Wood Emma
- Bayliss Pauline
- Beadle Hannah
- Bearne Helen
- Beaty Teresa
- Beaves Emily
- Bell Angela
- Bell Jo
- Bell Murdina
- Bellfield Ruth
- Beranova Eva
- Bergin Adrian
- Bhakri Harbens
- Bhalla Ajay
- Bharaj Kiranjit
- Bhargava Maneesh
- Bhaskaran Biju
- Bhatnagar Priya
- Birchall Kathryn
- Birns Jonathan
- Black Toby
- Blades Alex
- Blair Caroline
- Blair Caroline
- Blair Gordon
- Blane Sujata
- Blank Catrin
- Blight Adrian
- Board Joanne
- Board Sarah
- Bokhari Maria
- Bond Kirsty
- Bowring Angela
- Boxall Cherish
- Breeds Joanna
- Brew Helen
- Brezitski Maria
- Bridger Hayley
- Brodie Fiona
- Brotherton Lucy
- Broughton David
- Brown Claire
- Brown Ellen
- Brown Pauline
- Brown Sarah
- Bruce David
- Buchanan David
- Buck Amanda
- Buckle Steve
- Buckle Steve
- Buckley Clare
- Bunea George
- Burger Ilse
- Burgess Laura
- Burgess Seona
- Burssens Evelyne
- Butler Adrian
- Butler Donna
- Butler Rebecca
- Butterworth-Cowin Nicola
- Button Denise
- Buxton Jean
- Byrne Anthony
- Cageao Julie
- Caine Sarah
- Campbell Robert
- Carpenter Michael
- Carpio Racquel
- Carrie Johanna
- Cassidy Tim
- Causley Chelsea
- Chadbourn Indra
- Chadha Dinesh
- Chamberlain Angela
- Chan Kelly
- Chandrakumar Aberami
- Chapman Kath
- Chapman Nicola
- Charles Bethan
- Chatterjee Kausic
- Chaudhry Afnan
- Chauhan Meena
- Chenna Srikanth
- Cherian Suja
- Cheripelli Bharath Kumar
- Chopra Neha
- Choulerton James
- Choy Lillian
- Clarke Brian
- Clarke Caroline
- Clarke Judith
- Clarke Natasha
- Clarke Rebecca
- Clarke Samantha
- Clarkson Emma
- Clay Caroline
- Clayton Susan
- Clayton-Evans Lisa
- Cluckie Gillian
- Cochrane Helen
- Codd Laura
- Cohen David
- Collins Kayleigh
- Connor Lynda
- Constantin Carmen
- Cook Angela
- Cooper Martin
- Copeland Claire
- Cosier Tracey
- Courtauld Gillian
- Couser Mandy
- Coward Lucy
- Cowie Linda
- Cox Chantel
- Cox Chloe
- Cox Penelope
- Crabtree Karen
- Crawford Pam
- Crawford Susan
- Creeden Robyn
- Crisp Sarah
- Cronin Julie
- Crook Luci
- Crosbie Caroline
- Crouch Nichola
- Crown Rachel
- Crowther Hannah
- Cuddy Sarah
- Cuenoud Larissa
- Cullen Claire
- Culmsee Charlotte
- Cunningham James
- Cunningham Mishell
- Cvoro Vera
- Dacey Lynne
- Dakin Katy
- Dallol Bander
- Dangri Puneet
- Datta Prabal
- Davey Richard
- David Anette
- David Owen
- Davies Caroline
- Davies Ruth
- Davies Silvie
- Davis Fiona
- Davis Michelle
- Day Nicola
- Dayal Nilofer
- De Berker Henry
- Deary Ann
- Denic Hayley
- Dennis MS
- Denniss Carol
- Devine Joseph
- Devitt Nicola
- Dewar Richard
- Dhakal Mahesh
- Dhar Saikat
- Dickinson Christina
- Dickson Christine
- Dima Sofia
- Dinsmore Lynn
- Dixon Lynn
- Dobson Tracey
- Dodd Angela
- Dodd Emily
- Doherty Mandy
- Doherty Mandy
- Donaldson Denise
- Donnelly Richard
- Doubal Fergus
- Dow Lindsey
- Downham Susan
- Doyle Clare
- Doyle Donna
- Drever Jonathan
- du Plessis Johannes
- Dube Judith
- Duberley Stephen
- Dunn Linda
- Dunne Karen
- Durairaj Ramesh
- Durman Helen
- Dutta Dipankar
- Dynan Kevin
- Edwards Mandy
- Egerton Shuna
- Eglinton Charlotte
- Eglinton Charlotte
- El Tawil Salwa
- Elfandi Khaled
- Elliot Jennifer
- Elliott Emma
- Ellis Sam
- Emberson Jonathan
- Emsley Hedley
- England Timothy
- Epstein Daniel
- Erande Renuka
- Erumere Esther
- Esisi Bernard
- Esisi Bernard
- Esson Derek
- Esson Derek
- Evans Rachel
- Evans Sue
- Eveson David
- Ewing Jordan
- Fathima Razik
- Fawcett Michelle
- Feerick Shez
- Fennelly Ruth
- Ferdinand Phillip
- Findlay Paul
- Finlay Sarah
- Finney Kay
- Fitzell Pauline
- Fitzsimmons Paul
- Fletcher Glyn
- Fletcher Jo
- Fong Rosanna
- Foot Jayne
- Foote Leanne
- Ford Gary
- Foster Eliza
- Fotherby Ken
- Fox Charlotte
- Francia Nina
- Francis Jobbin
- Fraser Ruth
- Fraser Ruth
- Fuller Tracy
- Fulton Ailsa
- Furnace Jacqueline
- Gadapa Naveen
- Gainard Glyn
- Gainsborough Nicola
- Gallagher Jill
- Gallagher Louise
- Gallifent Rachel
- Gamble Ed
- Garcia Tatiana
- Gardener Léjeune
- Garfield-Smith Joanne
- Garside Mark
- Gartrell Imogen
- Gascoyne Rachel
- Gattringer Thomas
- Gautam Nikki
- Gaylard Jane
- Gbadamoshi Lukuman
- Geraghty Olivia
- Ghaly George
- Ghatala Rita
- Ghosh Sandip
- Giallombardo Elio
- Gilham Ellie
- Gilmour Danielle
- Gilzeane Nicola
- Glass Jon
- Gleave Laura
- Glover Rachel
- Godfrey Margi
- Goff Anita
- Goorah Neetish
- Gott Valerie
- Gow Heather
- Graham Carol
- Graham Ruth
- Gray Jane
- Green Carole
- Greenwood Richard
- Gregory Bindu
- Greig Jill
- Grimwood Gemma
- Grocott Jeanette
- Grue Rebecca
- Gulliver Diane
- Guo Fenglin
- Gupwell Karin
- Guthrie Lucy Belle
- Guy Helen
- Guyler Paul
- Hague Adam
- Haider Syed
- Hairsine Brigid
- Hakim Eluzai
- Hall Andrea
- Halse Omid
- Handley Dominic
- Hann Gail
- Hannon Niamh
- Hansen Christian
- Haque Mohammad
- Hardwick Anne
- Harkness Kirsty
- Harrington Frances
- Harrington-Davies Yasmin
- Harrison Louise
- Harrison Melanie
- Harrison Thomas
- Harston George
- Harvey Kirsten
- Harvey Miriam
- Hassan Ahamad
- Hassan Hardi
- Havard Diane
- Hayes Anne
- Hayhoe Helen
- Hayman Rachel
- Hays Carole
- Hazel Beth
- Hedstrom Amanda
- Hedstrom Amanda
- Hemsley Anthony
- Henry Margo
- Herman Jane
- Hervey Simon
- Hewitt Jonathan
- Hiden Joanne
- Hogan Caroline
- Hogg Valerie
- Holden Melinda
- Holmes Clare
- Homan Jane
- Hooley Michaela
- Horan Kathleen
- Horton Sarah
- Hostettler Isabel
- Hove Dionne
- Howaniec Laura
- Howard Gabriella
- Howard Joanne
- Howard Peter
- Howcroft Deborah
- Howe Jo
- Huang Xuya
- Huggett Isabel
- Hughes Chloe
- Hughes Claire
- Hughes Tom
- Humphreys Louise
- Humphries Fiona
- Hunt Benjamin
- Hunt Nicholas
- Hunter Annemarie
- Hunter Neil
- Hurford Frances
- Hurley Jennifer
- Hussain Malik
- Hutchison Aidan
- Hyams Benjamin
- Hyatt Lisa
- Imam Javed
- Ingham Andrea
- Ingram Tanya
- Innes Karen
- Iqbal Arshi
- Iqbal Mohammad Shahzad
- Irvine Janice
- Ispoglou Sissy
- Ivatts Simone
- Jackson Benjamin
- Jackson Linda
- Jagger Jenny
- Jagpal Baljit
- James Ali
- James Claire
- James Martin
- Jarapa Rowilson
- Jarrett David
- Jeffs Carol
- Jelley Benjamin
- Jenkins Colin
- Jennings-Preece Karla
- Jeyaraj Naomi
- Jha Ratneshwari
- Jinks Emma
- Johnes Mary
- Johnson Sharon
- Jones Ifan
- Jones Ifan
- Jones Kirsty
- Jones Rachael
- Jones Stephanie
- Jones Terry
- Jones Val
- Jordan Carla
- Jose Deepa
- Jose Josin
- Joshi Yogish
- Joyson Anu
- Jupp Becky
- Justin Frances
- Kakar Puneet
- Kalathil Latheef
- Kalladka Dheeraj
- Kamara Christine
- Kambafwile Mary
- Kane Ingrid
- Kar Arindam
- Keegan Breffni
- Keeling Elizabeth
- Keenan Samantha
- Kelavkar Shyam
- Kelly Christine
- Kelly Debs
- Kelly Jim
- Kelly Siobhan
- Keltos Marketa
- Kennedy James
- Kennedy Kate
- Kenton Antony
- Kerin Lourda
- Kerr Enda
- Kerr Gillian
- Keshvara Rekha
- Khan Mohammad
- Khan Shagufta
- Khan Usman
- Khan Uzma
- Kibutu Faith
- King Sam
- Kingwell Hayley
- Kini Manohar
- Klaasen Katrina
- Knops Kerstin
- Krishnamoorthy Shrivakumar
- Krishnamurthy Ramesh
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- Wardlaw JM
- Watchurst Caroline
- Waterfield Kelly
- Waterfield Kelly
- Watson Fran
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- Webb Tom
- Webber Adam
- Webster Timothy
- Weinling Marie
- Weir Nic
- Weir Pauline
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- White Susan
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- Whiteman Jessica
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- Wiggam Ivan
- Wilding Peter
- Wilkes Gwendoline
- Wilkinson Mark
- Willberry Angela
- Williams Carol
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- Willmot Mark
- Wilson David
- Wilson Duncan
- Wilson Jenny
- Wilson Lisa
- Wilson Sarah
- Wiltshire Alison
- Wood Diane
- Wood Edith
- Wood Lisa
- Woodward Stephen
- Wright Fiona
- Wroath Belinda
- Wynter Inez
- Yadava Rajendra
- Yip Brigitte
- Young Andrew
- Zachariah George
- Zahoor Tajammal
- Zoe Mellor
- Publication venue
- 'Elsevier BV'
- Publication date
- 29/06/2019
- Field of study
Background:
Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used safely is unclear. We aimed to estimate the relative and absolute effects of antiplatelet therapy on recurrent intracerebral haemorrhage and whether this risk might exceed any reduction of occlusive vascular events.
Methods:
The REstart or STop Antithrombotics Randomised Trial (RESTART) was a prospective, randomised, open-label, blinded endpoint, parallel-group trial at 122 hospitals in the UK. We recruited adults (≥18 years) who were taking antithrombotic (antiplatelet or anticoagulant) therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage, discontinued antithrombotic therapy, and survived for 24 h. Computerised randomisation incorporating minimisation allocated participants (1:1) to start or avoid antiplatelet therapy. We followed participants for the primary outcome (recurrent symptomatic intracerebral haemorrhage) for up to 5 years. We analysed data from all randomised participants using Cox proportional hazards regression, adjusted for minimisation covariates. This trial is registered with ISRCTN (number ISRCTN71907627).
Findings:
Between May 22, 2013, and May 31, 2018, 537 participants were recruited a median of 76 days (IQR 29–146) after intracerebral haemorrhage onset: 268 were assigned to start and 269 (one withdrew) to avoid antiplatelet therapy. Participants were followed for a median of 2·0 years (IQR [1·0– 3·0]; completeness 99·3%). 12 (4%) of 268 participants allocated to antiplatelet therapy had recurrence of intracerebral haemorrhage compared with 23 (9%) of 268 participants allocated to avoid antiplatelet therapy (adjusted hazard ratio 0·51 [95% CI 0·25–1·03]; p=0·060). 18 (7%) participants allocated to antiplatelet therapy experienced major haemorrhagic events compared with 25 (9%) participants allocated to avoid antiplatelet therapy (0·71 [0·39–1·30]; p=0·27), and 39 [15%] participants allocated to antiplatelet therapy had major occlusive vascular events compared with 38 [14%] allocated to avoid antiplatelet therapy (1·02 [0·65–1·60]; p=0·92).
Interpretation:
These results exclude all but a very modest increase in the risk of recurrent intracerebral haemorrhage with antiplatelet therapy for patients on antithrombotic therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage. The risk of recurrent intracerebral haemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat Rüdeger
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Étienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
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- Walker Jr. Frederick E.
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- Whitehouse Paul
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- Windhorst Rogier
- Wislowski Emily Christine
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- Wondel Amancio
- Woo Cindy
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- Wu Carl
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- Zonak Stephanie
- Zondag Elisabeth
- Álvarez-Márquez Javier
- Östlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
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- Barbaria Joseph A.
- Barbe Valérie
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- Becker Michael
- Bell Emma
- Bell George I.
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- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
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- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
- Boguslavskiy Leonid
- Bolton Christel
- Bolund Lars
- Bondoc Marnel
- Bonfield James
- Bonnett Ralph
- Bonnin David
- Border Richard
- Borowsky Mark
- Borzym Katja
- Boukhgalter Boris
- Bowen Eric
- Bradley Amanda
- Bradshaw-Cordum Holly
- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
- Branscomb Elbert
- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
- Brook Jonathan
- Brooking Shane
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- Buatsi Delali
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- Buckle Veronica
- Buczek Donald
- Budd Claire
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- Bulbul Kerem
- Buller Sarah
- Bunker Nathan
- Burberry Jill
- Burch Paula Ellen
- Burford Deborah
- Burgess Joanne
- Burgin Matt
- Burkett Carrie E.
- Burkhart-Schultz Karolyn
- Burrell Kevin L.
- Burrill Wayne
- Burrows Christine
- Burton Christine
- Burton John
- Butcher Phil
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- Butler Jon
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- Caenepeel Sean
- Cahill Patrick
- Cai Tianjing
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- Cairns Murray
- Calderon Eliana
- Callen David F.
- Camarata Jody
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- Campbell Connie S.
- Campbell Evelyn W.
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- Campo Kevin
- Canning Bruno
- Cao Ting
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- Caoile Chenier
- Cardenas Faviola
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- Carder Carol
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- Carpenter Kelly
- Carrano Anthony V.
- Carriere Jason
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- Caruso Lauren
- Casias Kristal
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- Chapman Jarrod
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- Charles Rachel
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- Chen Baoxian
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- Chen Jianlong
- Chen Jie
- Chen Jin
- Chen Junbao
- Chen Lihong
- Chen Lixia
- Chen Ray
- Chen Shu
- Chen Tong
- Chen Xiaoyun
- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
- Chen Zhu
- Chen Zhu
- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
- Chinwalla Asif
- Chissoe Stephanie
- Chiu Sally
- Chothia Tom
- Christensen Mari
- Christopoulos Constantine
- Chu Joseph
- Chui Connie
- Chung A
- Cinkowsky Michael J.
- Citroen Mieke
- Clack Rob
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- Clark Anthea
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- Clark Lynn
- Clark Lynn M.
- Clark Richard
- Clark Sarah
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- Clarke Adrian
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- Clarke Eddie
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- Clee Chris
- Clegg Shelia
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- Cleveland David
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- Clifton Sandra W.
- Coates Julia
- Cobley Victoria
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- Coffey Alison
- Cofield Jackie
- Coggill Penelope
- Cohn Judith D.
- Colayco Rick
- Cole Lotte
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- Collings Simon
- Collins Francis S.
- Collins John
- Collins Philip
- Collymore Al
- Colman Louise
- Combs Jessie
- Comstock Robin
- Cong Bin
- Conner Richard
- Connolly Anthony
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- Cook April
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- Cox Tony
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- Cummings Kirsti
- Cummings Paul
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- Curwen Valery
- Cutts Jeffrey
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- Da Silva Corinne
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- Dang Michelle
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- Daum Christopher
- David Robert
- Davidson Lucy
- Davidson Stuart
- Davies Jonathon
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- Davila Mary Louise
- Davis Candi Mon\u27et
- Davis Cheryl
- Davis Clay
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- Dawoe Tenzin
- Dawson Elisabeth
- De Anda Claudia
- De Latorre Andrea
- Deadman Rebecca
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- Dear Simon
- Dearden Frances
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- Deaven Larry I.
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- Deere Kerry
- DeGray Stewart
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- Deguzman Maria
- Dehal Paramvir
- Delgado Marcos
- Delgado Oliver
- Delhaunty Kimberley
- Deloukas Panos
- Deng Yajun
- Dennis Janet
- Denson Shawn
- Denys Mirian
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- Desai Anu
- Detter John C.
- Devlin Laurie
- Dewar Ken
- Dhami Pawandeep
- Dhongsar Chemey
- Dias Jennifer
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- Dibartolo Genevieve
- Dibling Catherine
- Dickson Mark
- Diekhans Mark
- Dietz-Band Jeanne
- Digennaro Richard
- Dilts Karen
- Dimitrijevic-Bussod Mira
- Ding Hao
- Ding Keyue
- Ding Li
- Ding Yan
- Dinh Huyen H.
- Dixon Kami
- Do Long
- Dobbs Ruth
- Dobson Richard
- Dockree Catherine
- Doddington Daniel
- Dodsworth Steven
- Doggett Norman
- Doggett Norman A.
- Dong Hui
- Dong Kimberly
- Dong Wei
- Dong Wei
- Dong Xiaojia
- Donlin Jeremy E.
- Dooley Kathy
- Dooling David
- Dorje Passang
- Dorjee Kunsang
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- Doucette-Stamm Lynn
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- Du Feiyu
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- Dubchak Inna
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- Eckenberg Ralph
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- Edionwe Susan Omwanghe Osayanro
- Edwards Carol
- Edwards Jennifer
- Edwards Karen
- Egan Amy
- Eichler Evan
- Eichler Evan
- Ejima Fumio
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- Eveleth Gerald
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- Fan Hongyuan
- Fan Keke
- Fang Jianqiu
- Farina Abderrahim
- Faro Susan
- Faulkner Louisa
- Fawcett Joseph J.
- Fechtel Kim
- Fellingham Charlotte
- Felming Claire
- Felsenfeld Adam
- Feltwell Theresa
- Feng Guodong
- Feng Haiyan
- Feng Jie
- Feng Xiaoli
- Fennell Stephen
- Ferguson Alicia
- Fernandez Sonia
- Fernandez-Suarez Xose
- Fernando Pushpa Ranjani
- Ferriera Pat
- Fertitta Anne
- Fey Jim
- Fidel Patrick
- Fields Elizabeth
- Fink Marie
- Finley Maria C.
- Finn Robert
- Fischer Heather
- Fischer Laurice
- Fisher Shelia
- Fitch Pat
- Fitzgerald Mike
- Flack Tina
- Flagg Nicole
- Flanagan J.
- Fleming Kerry
- Flint Jonathan
- Flint Mark
- Flowers Dave
- Floyd Yvonne
- Foley Karen
- Folta Peg
- Fong Jonathan
- Fonknechten Núrua
- Footman Simon
- Forbes Lisa D.
- Ford Amanda F.
- Foster Myre J.
- Fotopulos Dea
- Fourcade Matthew
- Fowler John
- Fox Jessica
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- Francis Stephen
- Frankel Ken
- Frankish Adam
- Frankland John
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- Fraser David
- Frazier Marvin
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- Frost Daniel
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- Frost Lorna
- Fu Gang
- Fu Gang
- Fu Gang
- Fu Qiushi
- Fujioka Michiru
- Fujiyama Asao
- Fukawa Rintaro
- Fuller Liam
- Fuller Sharin
- Fullerton Kathryn
- Fulton Lucinda A.
- Fulton Robert S.
- Furey Terrence S.
- Furuhashi Mie
- Förste Silke
- Gabisi Abdul M.
- Gage Diane
- Gaige Tony
- Galgoczy Petra
- Gallegos Celsa
- Galvez Michael
- Gammon Stuart
- Gao Anwu
- Gao Jimei
- Gao Quan
- Gao Yang
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- Garcia Carmen
- Garcia Emilio
- Garcia Marvin
- Garcia Ricardo M, III
- Garcia-Martinez Antonio
- Gardner Alison
- Gardner Alison
- Garduno Consuelo
- Gardyna Steph
- Garner Patrick
- Garner Toni T.
- Garnes Jeffrey A.
- Garnett Jane
- Garza Melissa
- Gatewood Joseph M.
- Gatland Leigh
- Gatland Lindsay
- Gattung Stacie
- Gay Laura
- Gearin Gary
- Gebreyesus Binyam
- Gelein Cynthia
- Gelpke Maartin
- Gench Stephanie L.
- Geng Jianing
- Georgescu Anca
- Geotina Amy
- Ghori Jilur
- Ghose Sayantan
- Gibbs Ben
- Gibbs Richard A.
- Gibson Diane
- Gibson Elizabeth
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- Gil Isaias
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- Glithero Rebecca
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- Gold Darren
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- Gomez Maria
- Gong Guanghui
- Gong Jinying
- Gonzales Eidelyn
- Gonzalez Guillermo B.
- Gooderham April
- Goodstadt Leo
- Goodstein David
- Goodwin Lynne A.
- Gordon Catherine
- Gordon Laurie A.
- Gordon Seth
- Gorton Matthew
- Gorvad Ann
- Gould Christine
- Goyea Ernest
- Goyette Audra
- Grady Deborah I.
- Grady Michelle L.
- Grafham Darren
- Graham Joe
- Grandbois Edward
- Grant Jennifer
- Grant Michael
- Grant Susan
- Graves Tina A.
- Gray Bruce
- Gray Emma
- Gray Lain
- Green Lisa
- Greenhalgh James
- Greenhill Joe
- Gregg Philippa
- Gregory Simon
- Grewal Nennu
- Gribble Susan
- Griffith Jeffrey K.
- Griffiths Coline
- Griffiths Ed
- Griffiths Mark
- Griffiths-Jones Sam
- Grigoriev Igor
- Grimwood Jane
- Grocock Russell
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- Gu Jingli
- Gu Jun
- Gu Jun
- Gu Wenyi
- Gu Wenyi
- Gu Xiaochang
- Guan Qiaoning
- Guarin Hannibal
- Guel Metzalli
- Guerra William
- Guevara Whitney V.
- Gui Qi
- Gunaratne Preethi
- Gunning Kate
- Guo Daorong
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- Guo Lili
- Gustafson Erik
- Guthrie Ian
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- Ha Chi
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- Hajek Patrick
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- Hall Brittany
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- Hamada Junko
- Hamilton Cerissa
- Hamilton Keelan A.
- Hamilton Matt
- Hamlett John
- Hamlett John
- Hammon Nancy
- Hammond Martin
- Hammond Sha
- Hammond Sian
- Hamza Khalid
- Han Guiqing
- Han Shunsheng
- Han Xurong
- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
- Harley Joanne
- Harper David
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- Harper Patrik
- Harradence Grant
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- Harrison Charlene-Lou
- Harrison Elliot
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- Hart Elizabeth
- Hasegawa Tomoko
- Hashimoto Etsuko
- Hashimoto Wakako
- Hassan Daniel
- Hatcher Beath
- Hattori Masahira
- Haugen Eric
- Haussler David
- Havlak Paul
- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
- Hawkins Trevor
- Hawley Kellie
- Haydu Lauren
- Hayes Kerry
- He Fengying
- He Jiaying
- He Lin
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- Heath Paul
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- Heilig Roland
- Heiner Cheryl
- Heinze Ivonne
- Heitmann Katja
- Helfenbein Keven
- Heller Andrew
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- Henderson Carl
- Henderson Nicholas
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- Hendrix David
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- Hepa Victor
- Herd Tim
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- Hernandez Judith
- Hernandez Omar
- Herseim Allyson
- Hewitt Stephen
- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
- Hillier LaDeana
- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
- Holden Jane
- Holdgate Janet
- Hollaway Mara
- Hollins Barbara
- Holloway Ele
- Holmes Andrea
- Holmes Ian
- Holmes Sarah
- Holroyd Simon
- Holtz Ann
- Holtzer Caleb
- Homsi Deana K.
- Homsi Farah J.
- Honan Tracy
- Hood Leroy
- Hooper Alison
- Hopewell Lucy
- Hopkins Ben
- Horne Jennifer
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- Hornischer Klaus
- Hornsby Amber
- Hornsby Geoff
- Hornsby Tony
- Horsley Sharon
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- Hosoda Kei
- Hosono Katsuhiro
- Hosseini Roya
- Hou Shunfang
- Hou Xiaodi
- Houde Nathan
- Howard Philip
- Howard Stephanie R.
- Howden Philip
- Howe Kevin
- Howell Gareth
- Howell Latoya Lynette
- Howells Sally Lucinda
- Hsu Fan
- Hu George
- Hu Jie
- Hu Songnian
- Huang Fang
- Huang Guyang
- Huang Katherine
- Huang Mei
- Huang Wayne
- Huang Wei
- Huang Wei
- Huang Wei
- Huang Zhengping
- Hubbard Timothy
- Huber James W.
- Huckle Elizabeth
- Hue Heather
- Hughes Jaime
- Hughes Jennifer
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- Hull Louisa
- Hulme Bill
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- Hume Jennifer
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- Hunt Michael
- Hunt Paul
- Hunt Sarah
- Hunter Giselle
- Hunter Rov, II
- Hupman Matt
- Huynh Sandy
- Hyde David
- Hynds Christopher
- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
- Inagaki Naomi
- Ince Michael
- Ingram Drew
- Inoue Shuuji
- Isak Amber
- Isherwood Judith
- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
- Isozaki Emi
- Israni Sanjay
- Ito Fumiaki
- Ito Noriko
- Itoh Takehiko
- Iwakawa Shinobu
- Iwatate Mariko
- Iwatsu Mikiko
- Iyer Vivek
- Izatt Janet
- Izmajlowicz Monica
- Izumiyama Tomohiro
- Jacintho Mark
- Jackson Laronda R.
- Jackson Terri
- Jacob Leni Susan
- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
- James Kent W.
- Jareborg Niclas
- Jarek Michael
- Jassal Bijay
- Jeffery Grant
- Jeffery Kim
- Jeffrey Colin
- Jekosch Kerstin
- Jenkins Lee
- Jett Jamie
- Jewett Phillip E.
- Jia Jia
- Jia Jia
- Jia Nan
- Jia Xingchang
- Jiang Lu
- Jiang Yanrui
- Jiang Ziyou
- Jimenez Alberto
- Jin Jian
- Jin Yetao
- Jin Yongsan
- Johansen Tina
- Johnson Bennie
- Johnson Cheryl
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- Johnson David
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- Jolley Keith
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- Jones Charlien
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- Jones Matthew
- Jones Michael
- Jones Micheil
- Jones Myrna D.
- Jones Steven
- Jong Pieter De
- Jordan Yun
- Joseph Shirin
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- Jubb Mark
- Jung Eugine
- Järke Doris
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- Kamat Asha
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- Kang Hui
- Kang Kelie
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- Kapur Hitesh
- Karolchik Donna
- Karunaratne Kanchi
- Kasprzyk Arek
- Katayama Takujiro
- Kato Takako
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- Kawagoe Chiharu
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- Kay Michael
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- Keefe Damian
- Keen Gifford
- Keenan Stephen
- Kegelmeyer Laura
- Kegg Lisa
- Kelley Simon
- Kells Cristyn
- Kelly Shayna P.
- Kelly Susan H.
- Kershaw Joanna
- Kettleborough Ross
- Keys David
- Khan Arsi
- Khan Umer F.
- Khan Ziad Mohid
- Khine Susu
- Khurama Divya
- Kidd Cathy
- Kierstan Peter
- Kieu Alix
- Kim Jennifer
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- Kisamo Haika
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- Klages Sven
- Klingle Gillian
- Knights Andrew
- Kobayashi Mai
- Kodira Chinnappa
- Kohlberg Sara
- Kojima Kazuyasu
- Kolbe William
- Kong Yi
- Korf Ian
- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
- Kremitzki Colin
- Kremmidiotis Gabriel
- Krogh Anders
- Kronmiller Brent
- Kruchowski Scott S.
- Kube Michael
- Kubischta Duane
- Kudoh Jun
- Kuehl Jennifer
- Kuharic Patrick
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- Kulish Larissa
- Kuroki Yoko
- Kwan Chinnie
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- LaButti Kurt
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- Lad Heena
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- Lagemann Dorothee
- Lai Jianghua
- Lai Teresa
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- Laing Michael
- Laird Gavin
- Lam Edward
- Lam Marissa
- Lama Dawa
- Lamar Betty
- Lambart Christine
- Lamble Ralph
- Lamerdin Jane E.
- Lander Eric S.
- Landers Tom
- Langford Cordelia
- Lansang Christine
- Lao Victoria
- Lapidus Alla
- Larke Ben
- Lato Bernadette
- Latreille Phil
- Lau Timun
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- Leal Belita
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- Legall Fitzherbert Henderson, III
- Leger Jean Pierre
- Lehman Karl
- Lehmann Rüdiger
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- Lehrach Hans
- Lehvaslaiho Minna
- Lei Meng
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- Leonard Shawn
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- Leongamornlert Daniel
- Lesar Kendra
- Levan Jaclyn M.
- Leversha Margaret
- Levine Rosie
- Levy Andrew
- Levy Michaël
- Lewis Doreen
- Lewis Ernest K.
- Lewis Keith
- Lewis Lakeshia C.
- Lewis Lora R.
- Lewis Tammy
- Leyba Tina
- Li Changfeng
- Li Chenji
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- Li Gang
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- Li Zhangwan
- Lieuallen Kim
- Lightning Julia
- Lim Meng K.
- Lindblad-Toh Kerstin
- Lindo Ken
- Lindquist K.
- Lindsay Sarah
- Lindstrom Kirsten
- LIne Matthew
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- Liu Boyong
- Liu Boyong
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- Liu Ying
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- Liu Yu
- Liu Zhanwei
- Liyanage Dhammika
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- Lock Victoria
- Lock William
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- Longmire Johnathan L.
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- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
- Loveland Jane
- Lovell Jamie
- Lovett Demetria A.
- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
- Lu Tao
- Lu Xiuhua
- Lu Yongxiang
- Lu Yontao T.
- Lu Yue
- Lucas Robert
- Lucas Susan
- Lucier Alice
- Lucier Raymond L.
- Ludeman Thom
- Lui Annie
- Lundgren Lyndsey
- Luo Chunqing
- Luo Chunqing
- Lv Gang
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- Lynch Daniel
- Löhnert Tschong-Hun
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- Machrus Migdad
- Macht Madison
- Macken Catherine A.
- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
- Maeda Hideto
- Maglott Donna
- Maheshwari Manjula
- Mahindartne Mathew
- Mahmoodi Venus
- Mahnke Ryan
- Mailey Brian
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- Malfatti Stephanie
- Malloy Kevin
- Maltbie Mary I.
- Mangum Brian
- Manning Jonathan
- Manohar Chitra
- Mapua Patricia
- Marabella Dick
- Mardis Elaine R.
- Mareth David
- Mariano Marisa
- Marinelli Lisa
- Mark Graham A.
- Marquis-Homeyer Catherine
- Marr Thomas G.
- Marra Marco
- Marriott Neil
- Marrone Anne
- Marroquin Christian
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- Martin Joel
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- Martinez Diego
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- Maslen Gareth
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- Masood Hadi
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- Matsuda Fumihiko
- Matsumoto Shuko
- Matsushita Yoshitaka
- Matthews Charles D.
- Matthews Lucy
- Matthews Nick
- Matthews Paul
- Matthews Sterling D.
- Mauceli Evan
- Maunes Cynthia
- Maupin Rachel
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- McClay Joseph
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- McGurn Phil
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- McLay Kirsten
- McLean James
- McLellan Michael D.
- McLeod Michael P.
- McMurdo John
- McMurray Amanda
- McMurray Des
- McMurray Kimberly
- McMurray Kimberly L.
- McNinch Jenny
- McPherson John
- McPherson John D.
- McVicker Graham
- McWilliams Natalie
- Mead Kelly
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- Medina Catherine
- Mehta Nalini
- Meidi Patrick
- Meier Elke
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- Mejima Mio
- Meldrim James
- Melsopp Craig
- Mendez Sylvia
- Meneus Louis
- Meng Shanshan
- Menuge Noel
- Mercado Christian
- Mercado George
- Mercado Iracema C.
- Mercer Simon
- Merritt Christina E.
- Mesirov Jill P.
- Metzker Michael Lee
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- Meyer Rick
- Miah Asab
- Michaelis Evelyn
- Micklem Gos
- Mieczkowski Carl
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- Mihalkanin Danielle
- Mihova Tanya
- Miles Simon
- Mileur Mason W.
- Miller Christie
- Miller Donald
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- Miner George R.
- Miner Sheri
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- Minja Emmanuel
- Minoshima Shinsei
- Minx Patrick J.
- Misra Monica
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- Morgan Margaret B.
- Morita Hiroko
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- Morton Jerry
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- Mott Richard
- Moyzis Robert K.
- Mu Feng
- Mukherjee Shibani
- Mullenger Ian
- Mullikin Jim
- Mulrain Leon
- Munday Brian
- Munday Elaine
- Mundt Mark O.
- Mungall Andy
- Munidasa Mala
- Munk A. Christine
- Munk Christie A.
- Munson Glen
- Murakami Katsuhiko
- Murayama Yuji
- Murnane Clare
- Murphy Matthew B.
- Murphy Michael
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- Murray Debra Dianne
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- Muzny Donna Marie
- Myers Alison
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- Nagamine Kentaro
- Nagao Syunsuke
- Nagaraja R.
- Nair Latha
- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
- Nakagawa Saori
- Nakamura Etsuko
- Nakato Eriko
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- Nazareth Lynne V.
- Neal Dearl D.
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- Nelson Deborah A.
- Nelson Joanne
- Nelson Kathryn
- Nelson Ward
- Nesbitt Ryan
- Neunkirch Jennifer
- Newes Christian
- Newman April
- Ng Bee
- Ng Terrance
- Ngo Robin Ngoc
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- Nguyen Minh
- Nguyen Na
- Nguyen Natalie M.
- Nguyen Ngoc Bich
- Nguyen Thu
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- Ni Lin
- Niblett David
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- Nickerson Tim
- Nicol Robert
- Nijjar Sukhjit
- Ning Zemin
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- Niu Yuxin
- Nivens Amber
- Noguchi Hideki
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- Norbu Chou Dolma
- Norbu Nyima
- Nordsiek Gabriele
- Norris Sarah Louise
- Novik Karen
- Nowlin Larry
- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
- O\u27Leary Sinead
- O\u27Loughlin Jennifer
- O\u27Neill Keith
- Obayashi Izumi
- Obregon Melissa
- Oddone Paola
- Oddone Pierre
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- Oguh Maryann
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- Ohno Saho
- Ohta Nao
- Ohtsubo Masafumi
- Oinn Tom
- Okoawo Ose
- Okui Michiyo
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- Okwuonu Geoffrey O.
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- Oliver Hayley
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- Olson Maynard V.
- Omotosho Bamidele
- Onoda Junko
- Oomori Nobuhiro
- Ooshima Kenshiro
- Oragunye Njideka
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- Osada Misuzu
- Osborn Anthony
- Osborne Joan
- Osman Sahal
- Ovcharenko Ivan
- Overton-Larty Emma
- Oviedo Rodolfo J.
- Ow David
- Ozawa Ritsuko
- Ozersky Philip
- Pace Araceli C.
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- Padki Anuradha
- Pahlavan Shane
- Palaniappan Krishnaveni
- Palazzolo Michael
- Palmeiri Anthony
- Palmer Sophie
- Pan Jiaofeng
- Pan Sisu
- Panasenko Vladimir
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- Parker Adrian
- Parker David Neil
- Parker Stephen
- Parkin Christopher
- Parkin Kim
- Parks Kenya L.
- Parry-Brown Ginny
- Parson-Quintana Beverly
- Pasternak Shiran
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- Patel Dina
- Patel Jalpa N.
- Patel Ritesh
- Patel Shripa
- Patel Vishal V.
- Patrick James
- Paul Heidie A.
- Paul Shelia
- Paulson Edward
- Payton Brett A.
- Pearce Alexandra
- Pearman Charlene
- Pearson Danita
- Pecherer Robert M.
- Peck Anna
- Peck Richard
- Pedan John
- Pelan Sarah
- Pelletier Eric
- Peng Vivian
- Peng Vivian
- Peng Yi
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- Pennacchio Len A.
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- Percy Chantel
- Perez Agapito
- Perez Lesette M.
- Perito Andrew
- Perrault Isabelle
- Perrier Rene
- Perrier Rene
- Perrin William
- Pesavento Brad
- Peters Anna
- Peters Leonard G.
- Peterson Jane
- Peterson Karl
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- Pettett Roger
- Petz Uta
- Pfeiffer Joyce
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- Piqani Bruno
- Piscia C.
- Pitesky Maurice
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- Playford Emma
- Plopper Farah Jo Homsi
- Plumb Bob
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- Poindexter Alan
- Poliakov Alex
- Pollard Martin
- Polman Jos
- Ponting Chris P.
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- Zhang Guohua
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- Zhang Haiqing
- Zhang Haiqing
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- Zhang Hongbo
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- Zhang Jingjing
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- Zhang Jiuchun
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- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
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- Zhang Ruhua
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- Zhang Wei
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- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial
- Author
- Aberami Chandrakumar
- Abhijit Mate
- Adam Hague
- Adam Webber
- Adrian Barry
- Adrian Bergin
- Adrian Blight
- Adrian Butler
- Adrian Parry-Jones
- Afaq Saulat
- Afaq Saulat
- Afnan Chaudhry
- Afraim Salek-Haddadi
- Aguilar
- Ahamad Hassan
- Ahmad Maatouk
- Ahmed Osman
- Aidan Hutchison
- Aileen McGrath
- Ailsa Fulton
- Aine Wallace
- Ajay Bhalla
- Ajmal Anversha
- Al-Shahi Salman
- Al-Shahi Salman
- Al-Shahi Salman
- Alda Remegoso
- Alex Blades
- Alex Ramshaw
- Alex Shah
- Alexandra Pitt-Ford
- Alfonso Tanate
- Ali Ali
- Ali James
- Alicia Rodgers
- Alison McLoughlin
- Alison Whitcher
- Alison Wiltshire
- Allan MacRaild
- Allan Walker
- Alpha Anthony
- Amanda Buck
- Amanda Hedstrom
- Amanda Hedstrom
- Amanda Smart
- Amber Siddiqui
- Amit Mistri
- Amy Ashton
- Amy Steele
- Anand Nair
- Andrea Hall
- Andrea Ingham
- Andrew Moores
- Andrew Sigsworth
- Andrew Smith
- Andrew Stanners
- Andrew Stone
- Andrew Young
- Anette David
- Angela Bell
- Angela Bowring
- Angela Chamberlain
- Angela Cook
- Angela Dodd
- Angela Stevens
- Angela Welch
- Angela Willberry
- Anita Goff
- Anja Ljubez
- Ann Deary
- Ann Needle
- Anna Verrion
- Anne Hardwick
- Anne Hayes
- Anne Nicolson
- Anne Oshodi
- Anne Suttling
- Annemarie Hunter
- Anoja Rajapakse
- Anthea Parry
- Anthony Byrne
- Anthony Hemsley
- Antony Kenton
- Anu Joyson
- Anwer Siddiqui
- Aparna Pusalkar
- Aravind Manoj
- Arindam Kar
- Arshad Majis
- Arshi Iqbal
- Arumugam Nallasivan
- Arun Singh
- Arunkumar Annamalai
- Aryelly Rodriguez
- Ashish Macaden
- Ashleigh Walters
- Ashraf Ahmed
- Ashraf Nasim
- Audrey Thomson
- Avani Shukla
- Azlisham Mohd Nor
- Azra Banaras
- Baigent
- Balakrishna Kumar
- Baljinder Rai
- Baljit Jagpal
- Bander Dallol
- Barbara Longland
- Barbara Madigan
- Barbara Williams-Yesson
- Barry Moynihan
- Basaam Aweid
- Becky Jupp
- Bejot
- Belinda Wroath
- Bella Richard
- Benjamin Hunt
- Benjamin Hyams
- Benjamin Jackson
- Benjamin Jelley
- Benjamin Tomlinson
- Bernard Esisi
- Bernard Esisi
- Beth Hazel
- Bethan Charles
- Bethan Morse
- Betty Mokoena
- Bev Maund
- Beverley McClelland
- Beverly MacLennan
- Bharath Kumar Cheripelli
- Bhavini Patel
- Biffi
- Biju Bhaskaran
- Bindu Gregory
- Bithi Rahman
- Breffni Keegan
- Brian Clarke
- Brian MacInnes
- Brigid Hairsine
- Brigitte Yip
- Bruno
- Carinna Vickers
- Carla Jordan
- Carmen Constantin
- Carol Denniss
- Carol Graham
- Carol Jeffs
- Carol Williams
- Carole Green
- Carole Hays
- Caroline Bagnall
- Caroline Blair
- Caroline Blair
- Caroline Clarke
- Caroline Clay
- Caroline Crosbie
- Caroline Davies
- Caroline Hogan
- Caroline Lambert
- Caroline Lovelock
- Caroline McGhee
- Caroline Roughan
- Caroline Watchurst
- Cassilda Peixoto
- Catherine Ovington
- Catherine Plewa
- Cathy Mason
- Catrin Blank
- Chakravarthi Rajkumar
- Champa Patel
- Chantel Cox
- Charde Naylor
- Charlotte Barr
- Charlotte Culmsee
- Charlotte Eglinton
- Charlotte Eglinton
- Charlotte Fox
- Charlotte Perkins
- Chelsea Causley
- Cherish Boxall
- Chloe Cox
- Chloe Hughes
- Chloe van Someren
- Chong
- Chris Patterson
- Christian Hansen
- Christina Dickinson
- Christine Dickson
- Christine Kamara
- Christine Kelly
- Christine Lerpiniere
- Christine Lerpiniere
- Christine McAlpine
- Christine Roffe
- Christine Schofield
- Christopher Allen
- Christopher Matthews
- Chukwuka Orefo
- Claire Brown
- Claire Copeland
- Claire Cullen
- Claire Hughes
- Claire James
- Claire Nott
- Claire Nott
- Claire Stephens
- Claire Sutton
- Claire Triscott
- Claire Triscott
- Clare Buckley
- Clare Doyle
- Clare Holmes
- Clark
- CLM Sudlow
- Colin Baigent
- Colin Jenkins
- Connor McGill
- Corinne Pawley
- Counsell
- Damian McArdle
- Daniel Epstein
- Daniel Lasserson
- Daniela Shackcloth
- Danielle Gilmour
- David Broughton
- David Bruce
- David Buchanan
- David Cohen
- David Eveson
- David Jarrett
- David Mangion
- David Minks
- David Ngo
- David Perry
- David Strain
- David Wilson
- Dawn Tomlin
- DE Newby
- Dean Waugh
- Debbie Morgan
- Deborah Howcroft
- Deborah Walstow
- Deborah Walter
- Deborah Ward
- Debs Kelly
- Deepa Jose
- Denise Button
- Denise Donaldson
- Denise Mead
- Dennis
- Derek Esson
- Derek Esson
- Devesh Sinha
- Dheeraj Kalladka
- Diane Gulliver
- Diane Havard
- Diane Wood
- Dinesh Chadha
- Dinesh Tryambake
- Ding
- Dionne Hove
- Dipankar Dutta
- Dipayan Mitra
- Divya Tiwari
- DJ Werring
- Dominic Handley
- Don Sims
- Donna Butler
- Donna Doyle
- Duke Phiri
- Duncan Bailey
- Duncan Wilson
- Ed Gamble
- Edith Wood
- Edward Littleton
- Elaine Amis
- Eleni Sakka
- Elio Giallombardo
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- Srikanth Chenna
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- Stefan Schwarz
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- Steve Buckle
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- Sue Evans
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- Suheil Ponnambath
- Suja Cherian
- Sujata Blane
- Sulaiman Sultan
- Susan Clayton
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- Susan Pound
- Susan Szabo
- Susan Thompson
- Susan Tucker
- Susan White
- Susannah Walker
- Suzanne Lucas
- Suzanne Ragab
- Suzanne Tauro
- Swapna Kunhunny
- Sweni Shah
- Syed Haider
- Tajammal Zahoor
- Talal Al-Mayhani
- Talat Anjum
- Tanya Ingram
- Tara Lawrence
- Tarn Nozedar
- Tatiana Garcia
- Tatjana Roganova
- Temi Adedoyin
- Teo
- Teresa Beaty
- Teresa Thompson
- Terry Jones
- Thayalini Loganathan
- Thomas Gattringer
- Thomas Harrison
- Tim Cassidy
- Timothy England
- Timothy Webster
- Toby Black
- Tolu Adesina
- Tom Hughes
- Tom Webb
- Tony Rudd
- Tracey Cosier
- Tracey Dobson
- Tracy Fuller
- Tracy Marsden
- Tressy Pitt-Kerby
- Una Poultney
- Ursula Schulz
- Usman Khan
- Uzma Khan
- Val Jones
- Valerie Gott
- Valerie Hogg
- van Asch
- Vanessa Pressly
- Varthi Sukdeo
- Vasileios Papavasileiou
- Venetia Vettimootal Johnson
- Vera Cvoro
- Vicky Taylor
- Victoria Adell
- Victoria Little
- Victoria O'Loughlin
- Victoria Sutton
- Victoria Tilley
- Vidya Baliga
- Vinh Nguyen
- Vinodh Krishnamurthy
- Wilma Smith
- WN Whiteley
- Wong
- Wood
- Xuya Huang
- Yasmin Harrington-Davies
- Yogish Joshi
- Yogish Pai
- Yolanda Baird
- Zhe Law
- Zin Naing
- Publication venue
- 'Elsevier BV'
- Publication date
- 21/05/2019
- Field of study
BACKGROUND: Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used safely is unclear. We aimed to estimate the relative and absolute effects of antiplatelet therapy on recurrent intracerebral haemorrhage and whether this risk might exceed any reduction of occlusive vascular events. METHODS: The REstart or STop Antithrombotics Randomised Trial (RESTART) was a prospective, randomised, open-label, blinded endpoint, parallel-group trial at 122 hospitals in the UK. We recruited adults (≥18 years) who were taking antithrombotic (antiplatelet or anticoagulant) therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage, discontinued antithrombotic therapy, and survived for 24 h. Computerised randomisation incorporating minimisation allocated participants (1:1) to start or avoid antiplatelet therapy. We followed participants for the primary outcome (recurrent symptomatic intracerebral haemorrhage) for up to 5 years. We analysed data from all randomised participants using Cox proportional hazards regression, adjusted for minimisation covariates. This trial is registered with ISRCTN (number ISRCTN71907627). FINDINGS: Between May 22, 2013, and May 31, 2018, 537 participants were recruited a median of 76 days (IQR 29-146) after intracerebral haemorrhage onset: 268 were assigned to start and 269 (one withdrew) to avoid antiplatelet therapy. Participants were followed for a median of 2·0 years (IQR [1·0- 3·0]; completeness 99·3%). 12 (4%) of 268 participants allocated to antiplatelet therapy had recurrence of intracerebral haemorrhage compared with 23 (9%) of 268 participants allocated to avoid antiplatelet therapy (adjusted hazard ratio 0·51 [95% CI 0·25-1·03]; p=0·060). 18 (7%) participants allocated to antiplatelet therapy experienced major haemorrhagic events compared with 25 (9%) participants allocated to avoid antiplatelet therapy (0·71 [0·39-1·30]; p=0·27), and 39 [15%] participants allocated to antiplatelet therapy had major occlusive vascular events compared with 38 [14%] allocated to avoid antiplatelet therapy (1·02 [0·65-1·60]; p=0·92). INTERPRETATION: These results exclude all but a very modest increase in the risk of recurrent intracerebral haemorrhage with antiplatelet therapy for patients on antithrombotic therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage. The risk of recurrent intracerebral haemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention. FUNDING: British Heart Foundation
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