1,663 research outputs found
The Extrasolar Planet epsilon Eridani b - Orbit and Mass
Hubble Space Telescope observations of the nearby (3.22 pc), K2 V star
epsilon Eridani have been combined with ground-based astrometric and radial
velocity data to determine the mass of its known companion. We model the
astrometric and radial velocity measurements simultaneously to obtain the
parallax, proper motion, perturbation period, perturbation inclination, and
perturbation size. Because of the long period of the companion, \eps b, we
extend our astrometric coverage to a total of 14.94 years (including the three
year span of the \HST data) by including lower-precision ground-based
astrometry from the Allegheny Multichannel Astrometric Photometer. Radial
velocities now span 1980.8 -- 2006.3. We obtain a perturbation period, P = 6.85
+/- 0.03 yr, semi-major axis, alpha =1.88 +/- 0.20 mas, and inclination i =
30.1 +/- 3.8 degrees. This inclination is consistent with a previously measured
dust disk inclination, suggesting coplanarity. Assuming a primary mass M_* =
0.83 M_{\sun}, we obtain a companion mass M = 1.55 +/- 0.24 M_{Jup}. Given the
relatively young age of epsilon Eri (~800 Myr), this accurate exoplanet mass
and orbit can usefully inform future direct imaging attempts. We predict the
next periastron at 2007.3 with a total separation, rho = 0.3 arcsec at position
angle, p.a. = -27 degrees. Orbit orientation and geometry dictate that epsilon
Eri b will appear brightest in reflected light very nearly at periastron.
Radial velocities spanning over 25 years indicate an acceleration consistent
with a Jupiter-mass object with a period in excess of 50 years, possibly
responsible for one feature of the dust morphology, the inner cavity
Boolean delay equations on networks: An application to economic damage propagation
We introduce economic models based on Boolean Delay Equations: this formalism
makes easier to take into account the complexity of the interactions between
firms and is particularly appropriate for studying the propagation of an
initial damage due to a catastrophe. Here we concentrate on simple cases, which
allow to understand the effects of multiple concurrent production paths as well
as the presence of stochasticity in the path time lengths or in the network
structure.
In absence of flexibility, the shortening of production of a single firm in
an isolated network with multiple connections usually ends up by attaining a
finite fraction of the firms or the whole economy, whereas the interactions
with the outside allow a partial recovering of the activity, giving rise to
periodic solutions with waves of damage which propagate across the structure.
The damage propagation speed is strongly dependent upon the topology. The
existence of multiple concurrent production paths does not necessarily imply a
slowing down of the propagation, which can be as fast as the shortest path.Comment: Latex, 52 pages with 22 eps figure
Cost effectiveness analysis of clinically driven versus routine laboratory monitoring of antiretroviral therapy in Uganda and Zimbabwe.
BACKGROUND: Despite funding constraints for treatment programmes in Africa, the costs and economic consequences of routine laboratory monitoring for efficacy and toxicity of antiretroviral therapy (ART) have rarely been evaluated. METHODS: Cost-effectiveness analysis was conducted in the DART trial (ISRCTN13968779). Adults in Uganda/Zimbabwe starting ART were randomised to clinically-driven monitoring (CDM) or laboratory and clinical monitoring (LCM); individual patient data on healthcare resource utilisation and outcomes were valued with primary economic costs and utilities. Total costs of first/second-line ART, routine 12-weekly CD4 and biochemistry/haematology tests, additional diagnostic investigations, clinic visits, concomitant medications and hospitalisations were considered from the public healthcare sector perspective. A Markov model was used to extrapolate costs and benefits 20 years beyond the trial. RESULTS: 3316 (1660LCM;1656CDM) symptomatic, immunosuppressed ART-naive adults (median (IQR) age 37 (32,42); CD4 86 (31,139) cells/mm(3)) were followed for median 4.9 years. LCM had a mean 0.112 year (41 days) survival benefit at an additional mean cost of 7386 [3277,dominated] per life-year gained and 3.78 to become cost-effective (<3xper-capita GDP, following WHO benchmarks). CD4 monitoring at current costs as undertaken in DART was not cost-effective in the long-term. CONCLUSIONS: There is no rationale for routine toxicity monitoring, which did not affect outcomes and was costly. Even though beneficial, there is little justification for routine 12-weekly CD4 monitoring of ART at current test costs in low-income African countries. CD4 monitoring, restricted to the second year on ART onwards, could be cost-effective with lower cost second-line therapy and development of a cheaper, ideally point-of-care, CD4 test
Massive star formation and feedback in W49A: The source of our Galaxy's most luminous water maser outflow
We present high spatial resolution mid-IR images of the ring of UCHII regions
in W49A obtained at Gemini North, allowing us to identify the driving source of
its powerful H2O maser outflow. These data also confirm our previous report
that several radio sources in the ring are undetected in the mid-IR because
they are embedded deep inside the cloud core. We locate the source of the water
maser outflow at the position of the compact mid-IR peak of source G (source
G:IRS1). This IR source is not coincident with any identified compact radio
continuum source, but is coincident with a hot molecular core, so we propose
that G:IRS1 is a hot core driving an outflow analogous to the wide-angle
bipolar outflow in OMC-1. G:IRS1 is at the origin of a larger bipolar cavity
and CO outflow. The water maser outflow is orthogonal to the bipolar CO cavity,
so the masers probably reside near its waist in the cavity walls. Models of the
IR emission require a massive protostar of 45Msun, 3e5Lsun, and an effective
envelope accretion rate of 1e-3Msun/yr. Feedback from the central star could
potentially drive the H2O maser outflow, but it has insufficient radiative
momentum to have driven the large-scale CO outflow, requiring that this massive
star had an active accretion disk over the past 10^4 yr. Combined with the
spatialy resolved morphology in IR images, G:IRS1 in W49 provides compelling
evidence for a massive protostar that formed by accreting from a disk,
accompanied by a bipolar outflow.Comment: 14 pages, MNRAS accepte
Quantum computing with antiferromagnetic spin clusters
We show that a wide range of spin clusters with antiferromagnetic
intracluster exchange interaction allows one to define a qubit. For these spin
cluster qubits, initialization, quantum gate operation, and readout are
possible using the same techniques as for single spins. Quantum gate operation
for the spin cluster qubit does not require control over the intracluster
exchange interaction. Electric and magnetic fields necessary to effect quantum
gates need only be controlled on the length scale of the spin cluster rather
than the scale for a single spin. Here, we calculate the energy gap separating
the logical qubit states from the next excited state and the matrix elements
which determine quantum gate operation times. We discuss spin cluster qubits
formed by one- and two-dimensional arrays of s=1/2 spins as well as clusters
formed by spins s>1/2. We illustrate the advantages of spin cluster qubits for
various suggested implementations of spin qubits and analyze the scaling of
decoherence time with spin cluster size.Comment: 15 pages, 7 figures; minor change
The epidemiology and outcomes of invasive \u3ci\u3eCandida\u3c/i\u3e infections among organ transplant recipients in the United States: results of the Transplant-Associated Infection Surveillance Network (TRANSNET)
Background: Invasive candidiasis (IC) is a common cause of mortality in solid organ transplant recipients (OTRs), but knowledge of epidemiology in this population is limited.
Method: The present analysis describes data from 15 US centers that prospectively identified IC from nearly 17 000 OTRs. Analyses were undertaken to determine predictors of infection and mortality.
Results: A total of 639 cases of IC were identified. The most common species was Candida albicans (46.3%), followed by Candida glabrata (24.4%) and Candida parapsilosis (8.1%). In 68 cases \u3e1 species was identified. The most common infection site was bloodstream (44%), followed by intra-abdominal (14%). The most frequently affected allograft groups were liver (41.1%) and kidney (35.3%). All-cause mortality at 90 days was 26.5% for all species and was highest for Candida tropicalis (44%) and C. parapsilosis (35.2%). Non-white race and female gender were more commonly associated with non-albicans species. A high rate of breakthrough IC was seen in patients receiving antifungal prophylaxis (39%). Factors associated with mortality include organ dysfunction, lung transplant, and treatment with a polyene antifungal. The only modifiable factor identified was choice of antifungal drug class based upon infecting Candida species.
Conclusion: These data highlight the common and distinct features of IC in OTRs
"It doesn't do any harm, but patients feel better": a qualitative exploratory study on gastroenterologists' perspectives on the role of antidepressants in inflammatory bowel disease
Background: Interest in psychological factors in patients with inflammatory bowel disease (IBD) has increased in recent years. It has even been proposed that treating psychological co-morbidities with antidepressants may control disease activity and improve quality of life. Despite this, there is no data on gastroenterologists' attitudes to, and experiences with, antidepressant therapy in patients with IBD. Methods: We conducted semi-structured interviews with 18 gastroenterologists associated with metropolitan teaching hospitals. Qualitative content analysis was used to examine their responses. Results: Seventy-eight percent of gastroenterologists had treated IBD patients with antidepressants for pain, depression and/or anxiety, and insomnia. Antidepressants were reported to be useful in improving psychosocial well-being, quality of life, and self-management of the disease by patients. However, in this group of gastroenterologists, there appears to be skepticism towards psychological disorders themselves or antidepressant therapy having a central role in either the causation of IBD or its clinical course. Nevertheless, these gastroenterologists were receptive to the idea of conducting a trial of the role of antidepressants in IBD. Conclusion: While the majority of specialists have treated IBD patients with antidepressants, there is considerable skepticism with regard to efficacy of antidepressive therapy or the role of psychological factors in the outcome of IBD patients.Antonina A Mikocka-Walus, Deborah A Turnbull, Nicole T Moulding, Ian G Wilson, Jane M Andrews and Gerald J Holtman
Anaesthesia and airway management in mucopolysaccharidosis
Abstract This paper provides a detailed overview and dis-cussion of anaesthesia in patients with mucopolysacchari-dosis (MPS), the evaluation of risk factors in these patients and their anaesthetic management, including emergency airway issues. MPS represents a group of rare lysosomal storage disorders associated with an array of clinical mani-festations. The high prevalence of airway obstruction and restrictive pulmonary disease in combination with cardio-vascular manifestations poses a high anaesthetic risk to these patients. Typical anaesthetic problems include airway obstruction after induction or extubation, intubation diffi-culties or failure [can’t intubate, can’t ventilate (CICV)], possible emergency tracheostomy and cardiovascular and cervical spine issues. Because of the high anaesthetic risk, the benefits of a procedure in patients with MPS shoul
Acupuncture, chiropractic and osteopathy use in Australia: a national population survey
Background There have been no published national studies on the use in Australia of the manipulative therapies, acupuncture, chiropractic or osteopathy, or on matters including the purposes for which these therapies are used, treatment outcomes and the socio-demographic characteristics of users. Methods This study on the three manipulative therapies was a component of a broader investigation on the use of complementary and alternative therapies. For this we conducted a cross-sectional, population survey on a representative sample of 1,067 adults from the six states and two territories of Australia in 2005 by computer-assisted telephone interviews. The sample was recruited by random digit dialling. Results Over a 12-month period, approximately one in four adult Australians used either acupuncture (9.2%), chiropractic (16.1%) or osteopathy (4.6%) at least once. It is estimated that, adult Australians made 32.3 million visits to acupuncturists, chiropractors and osteopaths, incurring personal expenditure estimated to be A$1.58 billion in total. The most common conditions treated were back pain and related problems and over 90% of the users of each therapy considered their treatment to be very or somewhat helpful. Adverse events are reported. Nearly one fifth of users were referred to manipulative therapy practitioners by medical practitioners. Conclusion There is substantial use of manipulative therapies by adult Australians, especially for back-related problems. Treatments incur considerable personal expenditure. In general, patient experience is positive. Referral by medical practitioners is a major determinant of use of these manipulative therapies
Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer
Introduction: Tamoxifen is the most widely prescribed anti-estrogen treatment for patients with estrogen receptor (ER)-positive breast cancer. However, there is still a need for biomarkers that reliably predict endocrine sensitivity in breast cancers and these may well be expressed in a dynamic manner. Methods: In this study we assessed gene expression changes at multiple time points (days 1, 2, 4, 7, 14) after tamoxifen treatment in the ER-positive ZR-75-1 xenograft model that displays significant changes in apoptosis, proliferation and angiogenesis within 2 days of therapy. Results: Hierarchical clustering identified six time-related gene expression patterns, which separated into three groups: two with early/transient responses, two with continuous/late responses and two with variable response patterns. The early/transient response represented reductions in many genes that are involved in cell cycle and proliferation (e.g. BUB1B, CCNA2, CDKN3, MKI67, UBE2C), whereas the continuous/late changed genes represented the more classical estrogen response genes (e.g. TFF1, TFF3, IGFBP5). Genes and the proteins they encode were confirmed to have similar temporal patterns of expression in vitro and in vivo and correlated with reduction in tumour volume in primary breast cancer. The profiles of genes that were most differentially expressed on days 2, 4 and 7 following treatment were able to predict prognosis, whereas those most changed on days 1 and 14 were not, in four tamoxifen treated datasets representing a total of 404 patients. Conclusions: Both early/transient/proliferation response genes and continuous/late/estrogen-response genes are able to predict prognosis of primary breast tumours in a dynamic manner. Temporal expression of therapy-response genes is clearly an important factor in characterising the response to endocrine therapy in breast tumours which has significant implications for the timing of biopsies in neoadjuvant biomarker studies.Publisher PDFPeer reviewe
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