Manned simulations of the SRMS in SIMFAC

SIMFAC is a general purpose real-time simulation facility currently configured with an Orbiter-like Crew Compartment and a Displays and Controls (D and C) Subsystem to support the engineering developments of the Space Shuttle Remote Manipulator (SRMS). The simulation consists of a software model of the anthropomorphic SRMS manipulator arm including the characteristics of its control system and joint drive modules. The following are discussed: (1) simulation and scene generation subsystems; (2) the SRMS task in SIMFAC; (3) operator tactics and options; (4) workload; (5) operator errors and sources; (6) areas for further work; and (7) general observations

Stress, glucocorticoids and bone: A review from mammals and fish

Glucocorticoids (GCs) are the final effector products of a neuroendocrine HPA/HPI axis governing energy balance and stress response in vertebrates. From a physiological point of view, basal GC levels are essential for intermediary metabolism and participate in the development and homeostasis of a wide range of body tissues, including the skeleton. Numerous mammalian studies have demonstrated that GC hormones exert a positive role during bone modeling and remodeling as they promote osteoblastogenesis to maintain the bone architecture. Although the pharmacological effect of the so-called stress hormones has been widely reported, the role of endogenous GCs on bone mineral metabolism as result of the endocrine stress response has been largely overlooked across vertebrates. In addition, stress responses are variable depending on the stressor (e.g., starvation, predation, and environmental change), life cycle events (e.g., migration and aging), and differ among vertebrate lineages, which react differently according to their biological, social and cognitive complexity (e.g., mineral demands, physical, and psychological stress). This review intends to summarize the endogenous GCs action on bone metabolism of mammals and fish under a variety of challenging circumstances. Particular emphasis will be given to the regulatory loop between GCs and the parathyroid hormone (PTH) family peptides, and other key regulators of mineral homeostasis and bone remodeling in vertebrates.Spanish Economy and Competitiveness Ministry projects [AGL2014-52473R, AGL2017-89648P]; Portuguese Foundation for Science and Technology [PTDC/BIA-ANM/4225/2012]info:eu-repo/semantics/publishedVersio

Robust Multi-Agent Path Finding

In the multi-agent path-finding (MAPF) problem, the task is to find a plan for moving a set of agents from their initial locations to their goals without collisions. Following this plan, however, may not be possible due to unexpected events that delay some of the agents. We explore the notion of k-robust MAPF, where the task is to find a plan that can be followed even if a limited number of such delays occur. k-robust MAPF is especially suitable for agents with a control mechanism that guarantees that each agent is within a limited number of steps away from its pre-defined plan. We propose sufficient and required conditions for finding a k-robust plan, and show how to convert several MAPF solvers to find such plans. Then, we show the benefit of using a k-robust plan during execution, and for finding plans that are likely to succeed