Resolving the MYSO binaries PDS 27 and PDS 37 with VLTI/PIONIER

Context. Binarity and multiplicity appear to be a common outcome in star formation. In particular, the binary fraction of massive (OB-type) stars can be very high. In many cases, the further stellar evolution of these stars is affected by binary interactions at some stage during their lifetime. The origin of this high binarity and the binary parameters are poorly understood because observational constraints are scarce, which is predominantly due to a dearth of known young massive binary systems. Aims. We aim to identify and describe massive young binary systems in order to fill in the gaps of our knowledge of primordial binarity of massive stars, which is crucial for our understanding of massive star formation. Methods. We observed the two massive young stellar objects (MYSOs) PDS 27 and PDS 37 at the highest spatial resolution provided by VLTI/PIONIER in the H-band (1.3 mas). We applied geometrical models to fit the observed squared visibilities and closure phases. In addition, we performed a radial velocity analysis using published VLT/FORS2 spectropolarimetric and VLT/X-shooter spectroscopic observations. Results. Our findings suggest binary companions for both objects at 12 mas (30 au) for PDS 27 and at 22–28 mas (42–54 au) for PDS 37. This means that they are among the closest MYSO binaries resolved to date. Conclusions. Our data spatially resolve PDS 27 and PDS 37 for the first time, revealing two of the closest and most massive (>8 M⊙) YSO binary candidates to date. PDS 27 and PDS 37 are rare but great laboratories to quantitatively inform and test the theories on formation of such systems

Sexual Priming, Gender Stereotyping, and Likelihood to Sexually Harass: Examining the Cognitive Effects of Playing a Sexually-Explicit Video Game

The present study examines the short-term cognitive effects of playing a sexually explicit video game with female “objectification” content on male players. Seventy-four male students from a university in California, U.S. participated in a laboratory experiment. They were randomly assigned to play either a sexually-explicit game or one of two control games. Participants’ cognitive accessibility to sexual and sexually objectifying thoughts was measured in a lexical decision task. A likelihood-to-sexually-harass scale was also administered. Results show that playing a video game with the theme of female “objectification” may prime thoughts related to sex, encourage men to view women as sex objects, and lead to self-reported tendencies to behave inappropriately towards women in social situations

ATP7A is a novel target of retinoic acid receptor β2 in neuroblastoma cells

Increased retinoic acid receptor β (RARβ2) gene expression is a hallmark of cancer cell responsiveness to retinoid anticancer effects. Moreover, low basal or induced RARβ2 expression is a common feature of many human cancers, suggesting that RARβ2 may act as a tumour suppressor gene in the absence of supplemented retinoid. We have previously shown that low RARβ2 expression is a feature of advanced neuroblastoma. Here, we demonstrate that the ABC domain of the RARβ2 protein alone was sufficient for the growth inhibitory effects of RARβ2 on neuroblastoma cells. ATP7A, the copper efflux pump, is a retinoid-responsive gene, was upregulated by ectopic overexpression of RARβ2. The ectopic overexpression of the RARβ2 ABC domain was sufficient to induce ATP7A expression, whereas, RARβ2 siRNA blocked the induction of ATP7A expression in retinoid-treated neuroblastoma cells. Forced downregulation of ATP7A reduced copper efflux and increased viability of retinoid-treated neuroblastoma cells. Copper supplementation enhanced cell growth and reduced retinoid-responsiveness, whereas copper chelation reduced the viability and proliferative capacity. Taken together, our data demonstrates ATP7A expression is regulated by retinoic acid receptor β and it has effects on intracellular copper levels, revealing a link between the anticancer action of retinoids and copper metabolism

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary.

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Comparative genomic and phylogeographic analysis of Mycobacterium leprae

Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M. leprae strain Br4923 from Brazil was obtained by conventional methods (6 x coverage), and Illumina resequencing technology was used to obtain the sequences of strains Thai53 (38 x coverage) and NHDP63 (46 x coverage) from Thailand and the United States, respectively. Whole-genome comparisons with the previously sequenced TN strain from India revealed that the four strains share 99.995% sequence identity and differ only in 215 polymorphic sites, mainly SNPs, and by 5 pseudogenes. Sixteen interrelated SNP subtypes were defined by genotyping both extant and extinct strains of M. leprae from around the world. The 16 SNP subtypes showed a strong geographical association that reflects the migration patterns of early humans and trade routes, with the Silk Road linking Europe to China having contributed to the spread of leprosy