FDI存量作为衡量跨国公司海外分支机构活动的指标有失偏颇

人们对FDI一词的使用往往是不严谨的。本文解释了这一不严谨使用的起源以及FDI和MNEs两者之间的关系。FDI存量是考量MNE活动的多种方式的一种，但比其他的考量方式更有优势，因为我们有许多国家的长期（虽然不完美）FDI存量系列数据。如果能过谨慎处理，那么FDI存量仍是衡量MNE活动的良好指标

FDI stocks are a biased measure of MNE affiliate activity: A response

The term FDI is often used loosely. This Perspective explains the historical genesis of that loose use and the relationship between FDI and MNEs. FDI stock is one of many measures of MNE activities, but has advantage over the others, since we have long, albeit imperfect, series on FDI stock. Handled with care, along with a keen recognition of the data limitations, FDI continues to serve as one excellent indicator of MNE activities

The Animalistic Gullet and the Godlike Soul: Reframing Sacrifice in Midrash Leviticus Rabbah

This article proposes an analysis of two homiletic units in the Palestinian Midrash Leviticus Rabbah, which revolve around biblical chapters pertaining to sacrifices. A theme that pervades these units is that of eating as an animalistic activity that often entails moral depravity. In contrast, the act of sacrificing is constructed in these units as one in which one is willing to give up one's own nourishment, and in a sense one's own “soul,” in order to offer it to God. Many of the motifs used to vilify eating in the Midrash can be traced in moralistic Greek, Roman, and early Christian diatribes preaching for moderation in eating or for asceticism; the homilists in Leviticus Rabbah, however, utilize these popular motifs in order to present sacrifice as the spiritual contrary of eating, and thus to give the obsolete practice of sacrifice cultural cachet and compelling meanings

Observing the host galaxies of high-redshift quasars with JWST: predictions from the BLUETIDES simulation

The bright emission from high-redshift quasars completely conceals their host galaxies in the rest-frame ultraviolet/optical, with detection of the hosts in these wavelengths eluding even the Hubble Space Telescope (HST) using detailed point spread function (PSF) modelling techniques. In this study, we produce mock images of a sample of z = 7 quasars extracted from the BLUETIDES simulation, and apply Markov chain Monte Carlo-based PSF modelling to determine the detectability of their host galaxies with the James Webb Space Telescope (JWST). While no statistically significant detections are made with HST, we predict that at the same wavelengths and exposure times JWST NIRCam imaging will detect ∼ 50 per cent of quasar host galaxies. We investigate various observational strategies, and find that NIRCam wide-band imaging in the long-wavelength filters results in the highest fraction of successful quasar host detections, detecting > 80 per cent of the hosts of bright quasars in exposure times of 5 ks. Exposure times of > 5 ks are required to detect the majority of host galaxies in the NIRCam wide-band filters, however, even 10 ks exposures with MIRI result in < 30 per cent successful host detections. We find no significant trends between galaxy properties and their detectability. The PSF modelling can accurately recover the host magnitudes, radii, and spatial distribution of the larger scale emission, when accounting for the central core being contaminated by residual quasar flux. Care should be made when interpreting the host properties measured using PSF modelling

Proteomic profiling of Burkholderia cenocepacia clonal isolates with different virulence potential retrieved from a cystic fibrosis patient during chronic lung infection

Respiratory infections with Burkholderia cepacia complex (Bcc) bacteria in cystic fibrosis (CF) are associated with a worse prognosis and increased risk of death. In this work, we assessed the virulence potential of three B. cenocepacia clonal isolates obtained from a CF patient between the onset of infection (isolate IST439) and before death with cepacia syndrome 3.5 years later (isolate IST4113 followed by IST4134), based on their ability to invade epithelial cells and compromise epithelial monolayer integrity. The two clonal isolates retrieved during late-stage disease were significantly more virulent than IST439. Proteomic profiling by 2-D DIGE of the last isolate recovered before the patient's death, IST4134, and clonal isolate IST439, was performed and compared with a prior analysis of IST4113 vs. IST439. The cytoplasmic and membrane-associated enriched fractions were examined and 52 proteins were found to be similarly altered in the two last isolates compared with IST439. These proteins are involved in metabolic functions, nucleotide synthesis, translation and protein folding, cell envelope biogenesis and iron homeostasis. Results are suggestive of the important role played by metabolic reprogramming in the virulence potential and persistence of B. cenocepacia, in particular regarding bacterial adaptation to microaerophilic conditions. Also, the content of the virulence determinant AidA was higher in the last 2 isolates. Significant levels of siderophores were found to be secreted by the three clonal isolates in an iron-depleted environment, but the two late isolates were more tolerant to low iron concentrations than IST439, consistent with the relative abundance of proteins involved in iron uptake.This work was supported by FEDER and FCT – Fundação para a Ciência e a Tecnologia (contract PEst-OE/EQB/LA0023/2011_ research line: Systems and Synthetic Biology; PhD grant to A.M. – SFRH/BD/37012/2007, and PD grants to S.S. – SFRH/BPD/75483/2010 and C.C. – SFRH/BPD/ 81220/2011. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.info:eu-repo/semantics/publishedVersio

Presbyopia:Effectiveness of correction strategies

Presbyopia is a global problem affecting over a billion people worldwide. The prevalence of unmanaged presbyopia is as high as 50% of those over 50 years of age in developing world populations due to a lack of awareness and accessibility to affordable treatment, and is even as high as 34% in developed countries. Definitions of presbyopia are inconsistent and varied, so we propose a redefinition that states “presbyopia occurs when the physiologically normal age-related reduction in the eye's focusing range reaches a point, when optimally corrected for distance vision, that the clarity of vision at near is insufficient to satisfy an individual's requirements”. Presbyopia is inevitable if one lives long enough, but intrinsic and extrinsic risk factors including cigarette smoking, pregnancy history, hyperopic or astigmatic refractive error, ultraviolet radiation, female sex (although accommodation is similar to males), hotter climates and some medical conditions such as diabetes can accelerate the onset of presbyopic symptoms. Whilst clinicians can ameliorate the symptoms of presbyopia with near vision spectacle correction, bifocal and progressive spectacle lenses, monovision, translating or multifocal contact lenses, monovision, extended depth of focus, multifocal (refractive, diffractive and asymmetric designs) or ‘accommodating’ intraocular lenses, corneal inlays, scleral expansion, laser refractive surgery (corneal monovision, corneal shrinkage, corneal multifocal profiles and lenticular softening), pharmacologic agents, and electro-stimulation of the ciliary muscle, none fully overcome presbyopia in all patients. While the restoration of natural accommodation or an equivalent remains elusive, guidance is gives on presbyopic correction evaluation techniques