45 research outputs found
The Key Events Dose-Response Framework: Its Potential for Application to Foodborne Pathogenic Microorganisms
The Key Events Dose-Response Framework (KEDRF) is an analytical approach that facilitates the use of currently available data to gain insight regarding dose-response relationships. The use of the KEDRF also helps identify critical knowledge gaps that once filled, will reduce reliance on assumptions. The present study considers how the KEDRF might be applied to pathogenic microorganisms, using fetal listeriosis resulting from maternal ingestion of food contaminated with L. monocytogenes as an initial example. Major biological events along the pathway between food ingestion and the endpoint of concern are systematically considered with regard to dose (i.e., number of organisms), pathogen factors (e.g., virulence), and protective host mechanisms (e.g., immune response or other homeostatic mechanisms). It is concluded that the KEDRF provides a useful structure for systematically evaluating the complex array of host and pathogen factors that influence the dose-response relationship. In particular, the KEDRF supports efforts to specify and quantify the sources of variability, a prerequisite to strengthening the scientific basis for food safety decision making
Measurement of the Depth of Maximum of Extensive Air Showers above 10^18 eV
We describe the measurement of the depth of maximum, Xmax, of the
longitudinal development of air showers induced by cosmic rays. Almost four
thousand events above 10^18 eV observed by the fluorescence detector of the
Pierre Auger Observatory in coincidence with at least one surface detector
station are selected for the analysis. The average shower maximum was found to
evolve with energy at a rate of (106 +35/-21) g/cm^2/decade below 10^(18.24 +/-
0.05) eV and (24 +/- 3) g/cm^2/decade above this energy. The measured
shower-to-shower fluctuations decrease from about 55 to 26 g/cm^2. The
interpretation of these results in terms of the cosmic ray mass composition is
briefly discussed.Comment: Accepted for publication by PR
The exposure of the hybrid detector of the Pierre Auger Observatory
The Pierre Auger Observatory is a detector for ultra-high energy cosmic rays.
It consists of a surface array to measure secondary particles at ground level
and a fluorescence detector to measure the development of air showers in the
atmosphere above the array. The "hybrid" detection mode combines the
information from the two subsystems. We describe the determination of the
hybrid exposure for events observed by the fluorescence telescopes in
coincidence with at least one water-Cherenkov detector of the surface array. A
detailed knowledge of the time dependence of the detection operations is
crucial for an accurate evaluation of the exposure. We discuss the relevance of
monitoring data collected during operations, such as the status of the
fluorescence detector, background light and atmospheric conditions, that are
used in both simulation and reconstruction.Comment: Paper accepted by Astroparticle Physic
Trigger and Aperture of the Surface Detector Array of the Pierre Auger Observatory
The surface detector array of the Pierre Auger Observatory consists of 1600
water-Cherenkov detectors, for the study of extensive air showers (EAS)
generated by ultra-high-energy cosmic rays. We describe the trigger hierarchy,
from the identification of candidate showers at the level of a single detector,
amongst a large background (mainly random single cosmic ray muons), up to the
selection of real events and the rejection of random coincidences. Such trigger
makes the surface detector array fully efficient for the detection of EAS with
energy above eV, for all zenith angles between 0 and
60, independently of the position of the impact point and of the mass
of the primary particle. In these range of energies and angles, the exposure of
the surface array can be determined purely on the basis of the geometrical
acceptance.Comment: 29 pages, 12 figure
Measurement of the Depth of Maximum of Extensive Air Showers above 10^(18) eV
We describe the measurement of the depth of maximum, X_(max), of the longitudinal development of air
showers induced by cosmic rays. Almost 4000 events above 10^(18) eV observed by the fluorescence
detector of the Pierre Auger Observatory in coincidence with at least one surface detector station are selected for the analysis. The average shower maximum was found to evolve with energy at a rate of
(106_(-21)^(+35))
g/cm^2/decade below 10^(18:24±0.05) eV, and (24±3) g/cm^ 2=decade above this energy. The
measured shower-to-shower fluctuations decrease from about 55 to 26 g/cm^2. The interpretation of these
results in terms of the cosmic ray mass composition is briefly discussed