Unifying W-Algebras

We show that quantum Casimir W-algebras truncate at degenerate values of the central charge c to a smaller algebra if the rank is high enough: Choosing a suitable parametrization of the central charge in terms of the rank of the underlying simple Lie algebra, the field content does not change with the rank of the Casimir algebra any more. This leads to identifications between the Casimir algebras themselves but also gives rise to new, `unifying' W-algebras. For example, the kth unitary minimal model of WA_n has a unifying W-algebra of type W(2,3,...,k^2 + 3 k + 1). These unifying W-algebras are non-freely generated on the quantum level and belong to a recently discovered class of W-algebras with infinitely, non-freely generated classical counterparts. Some of the identifications are indicated by level-rank-duality leading to a coset realization of these unifying W-algebras. Other unifying W-algebras are new, including e.g. algebras of type WD_{-n}. We point out that all unifying quantum W-algebras are finitely, but non-freely generated.Comment: 13 pages (plain TeX); BONN-TH-94-01, DFTT-15/9

Hyperdeformation in the cranked relativistic mean field theory: the Z=40-58 part of nuclear chart

The systematic investigation of hyperdeformation (HD) at high spin in the $Z=40-58$ part of the nuclear chart has been performed in the framework of the cranked relativistic mean field theory. The properties of the moments of inertia of the HD bands, the role of the single-particle and necking degrees of freedom at HD, the spins at which the HD bands become yrast, the possibility to observe discrete HD bands etc. are discussed in detail.Comment: 22 pages, 25 figure

Crossing of shears bands in196Pb

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A one-dimensional lattice model for a quantum mechanical free particle

Two types of particles, A and B with their corresponding antiparticles, are defined in a one dimensional cyclic lattice with an odd number of sites. In each step of time evolution, each particle acts as a source for the polarization field of the other type of particle with nonlocal action but with an effect decreasing with the distance: A -->...\bar{B} B \bar{B} B \bar{B} ... ; B --> A \bar{A} A \bar{A} A ... . It is shown that the combined distribution of these particles obeys the time evolution of a free particle as given by quantum mechanics.Comment: 8 pages. Revte

High-fidelity transmission of entanglement over a high-loss freespace channel

Quantum entanglement enables tasks not possible in classical physics. Many quantum communication protocols require the distribution of entangled states between distant parties. Here we experimentally demonstrate the successful transmission of an entangled photon pair over a 144 km free-space link. The received entangled states have excellent, noise-limited fidelity, even though they are exposed to extreme attenuation dominated by turbulent atmospheric effects. The total channel loss of 64 dB corresponds to the estimated attenuation regime for a two-photon satellite quantum communication scenario. We confirm that the received two-photon states are still highly entangled by violating the CHSH inequality by more than 5 standard deviations. From a fundamental point of view, our results show that the photons are virtually not subject to decoherence during their 0.5 ms long flight through air, which is encouraging for future world-wide quantum communication scenarios.Comment: 5 pages, 3 figures, replaced paper with published version, added journal referenc

Plerixafor for autologous peripheral blood stem cell mobilization in patients previously treated with fludarabine or lenalidomide.

Fludarabine and lenalidomide are essential drugs in the front-line treatment of non-Hodgkin lymphoma (NHL) and multiple myeloma (MM), respectively. Data suggests that fludarabine and lenalidomide therapy may have a deleterious effect on stem cell mobilization. In the European compassionate use program, 48 patients (median age 57 years) previously treated with fludarabine (median 5 cycles; range: 1-7 cycles) were given plerixafor plus granulocyte colony-stimulating factor (G-CSF) for remobilization following a primary mobilization attempt. The overall median number of CD34+ cells collected was 2.3 × 10(6)/kg (range: 0.3-13.4). The minimum required number of CD34+ cells (≥2.0 × 10(6)/kg) was collected from 58% of patients in a median of 2 days. Thirty-five patients (median age = 57 years) previously treated with lenalidomide (median 5 cycles; range: 1-10 cycles) were given plerixafor plus G-CSF for remobilization. The overall median number of CD34+ cells collected was 3.4 × 10(6)/kg (range: 1.1-14.8). The minimum required number of CD34+ cells (≥2.0 × 10(6) per kg) was collected from 69% of patients in a median of 2 days. In conclusion, salvage mobilization with plerixafor plus G-CSF is successful in the majority of patients with MM previously treated with lenalidomide. In fludarabine-exposed patients, only 58% of patients will achieve successful salvage mobilization with plerixafor plus G-CSF, suggesting the need for novel mobilization regimens algorithms in this subgroup of patients

Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking

The Rab family of small GTPases regulate various aspects of cellular dynamics in eukaryotic cells. Membrane trafficking has emerged as central to the functions of leucine-rich repeat kinase 2 (LRRK2), which is associated with inherited and sporadic forms of Parkinson’s disease (PD). Rabs act as both regulators of the catalytic activity and targets for serine/threonine phosphorylation by LRRK2. Rab32, Rab38 and Rab29 have been shown to regulate LRRK2 sub-cellular localization through direct interactions. Recently, Rab29 was shown to escort LRRK2 to the Golgi apparatus and activate the phosphorylation of Rab8 and Rab10. Rab32 is linked to multiple cellular functions including endosomal trafficking, mitochondrial dynamics, and melanosome biogenesis. A missense mutation in Rab32 has also recently been linked to PD. Here, we demonstrate that Rab32 directly interacts with sorting nexin 6 (SNX6). SNX6 is a transient subunit of the retromer, an endosome-Golgi retrieval complex whose Vps35 subunit is strongly associated with PD. We could further show that localization of cation-independent mannose-6-phosphate receptors, which are recycled to the trans-Golgi network (TGN) by the retromer, was affected by both Rab32 and SNX6. These data imply that Rab32 is linked to SNX6/retromer trafficking at the Golgi, and also suggests a possible connection between the retromer and Rab32 in the trafficking and biological functions of LRRK2

Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding

The current obesity epidemic is a major worldwide health concern. Despite the consensus that the brain regulates energy homeostasis, the neural adaptations governing obesity are unknown. Using a combination of high-throughput single-cell RNA sequencing and longitudinal in vivo two-photon calcium imaging, we surveyed functional alterations of the lateral hypothalamic area (LHA) - a highly conserved brain region that orchestrates feeding - in a mouse model of obesity. The transcriptional profile of LHA glutamatergic neurons was affected by obesity, exhibiting changes indicative of altered neuronal activity. Encoding properties of individual LHA glutamatergic neurons were then tracked throughout obesity, revealing greatly attenuated reward responses.These data demonstrate how diet disrupts the function of an endogenous feeding suppression system to promote overeating and obesity

Triaxial Superdeformation in 163 Lu

Abstract High-spin states in 163 Lu have been investigated using the Euroball spectrometer array. The previously known superdeformed band has been extended at low and high energies, and its connection to the normal-deformed states has been established. From its decay the mixing amplitude and interaction strength between superdeformed and normal states are derived. In addition, a new band with a similar dynamic moment of inertia has been found. The experimental results are compared to cranking calculations which suggest that the superdeformed bands in this mass region correspond to shapes with a pronounced triaxiality ( γ ≈±20°)

Spectroscopy around 36^{36}Ca

Expérience GANILInternational audienceAn experiment was performed to study excited states in neutron-deficient nuclei around Ca. A one-neutron knockout reaction was used to produce $^{36}$Ca ions from a $^{37}$Ca secondary beam, and in-beam $\gamma$-rays were measured. The $2^+$ energy in $^{36}$Ca is compared to the mirror nucleus $^{36}$S to deduce information on the isospin dependence of the nuclear force near the proton drip line. The energy of the first excited $2^+$ state in $^{36}$Ca and the cross section for the 1-neutron knock-out reaction from $^{37}$Ca at $\sim$ 45 · AMeV were obtained. Furthermore, for two other $T_z$ = −2 nuclei, $^{28}$S and $^{32}$Ar, the de-excitation of the first $2^+$ state has been observed