The museum-mediator of Ramiouil from Prehistosite to Prehistomuseum : reforming a musealization project in Flémalle (Liège, Belgium)

Le Préhistosite de Ramioul est situé à Flémalle (Liège, Belgique), au pied de la Grotte Ramioul. Es un projet de tourisme culturel déposé par le Musée de la Préhistoire en Wallonie; il est soutenu par des fonds européens (FEDER) et le Commissariat Général du Tourisme du Service Public de Wallonie. La médiation est pour le Préhistomuseum son principe sa fonctio est de désacraliser le patrimoine et la science aux yeux des publics en rendant compte des processus sociétaux qui soustendent à la muséalisation. Pendant les derniers deux décades le Préhistosite à devenu un centre de formation pour visiteurs, enseignants et pour des étudiants d’écoles ou d’universités. Le futur du musée se raffinerais en 2014-2015, agrandira encore son service éducatif. Le Préhistomuseum se définira vis-à-vis du public comme un musée de 30 hectares situés dans la forêt de la Grotte de Ramioul. Le Préhistomuseum désire sensibiliser les publics à la préservation du patrimoine et à la culture scientifique dans un esprit de tolérance et de neutralité, d’humanité, de citoyenneté et de respect de l’environnement.El Prèhistosite de Ramioul está situado en Flémalle (Lieja, Belgica), al pie de la Grotte Ramioul. Es un proyecto de turismo cultural financiado por el Museo de Prehistoria de Wallonie y financiado por diferentes fondos europeos (FEDER) y el Comisariado General de Turismo del Servicio Público de Wallonie. La mediación es para el Prèhistosite su principio. Su función principal es desacralizar el patrimonio y la ciencia para el público no especializado y rinde cuentas a los proPhilipcesos sociales que sustentan la musealización. A lo largo de las dos últimas décadas, el Prèhistosite se ha convertido en un centro de formación para visitantes, educadores y estudiantes escolares o universitarios. El futuro del museo se redefinirá en 2014-2015, cuando se transformará en Prèhistoseum y aumentará aun más los servicios educativos. El Prèhistoseum se presenta de cara al público como un museo de 30 hectáreas situado en el bosque de la Grotte de Ramiouil. El Prèhistomuseum desea sensibilizar al público en la preservación del patrimonio y en la cultura científica dentro de un espíritu de tolerancia y de neutralidad, de humanidad, ciudadanía y respeto por el entorno natural.Ramiouil Prehistosite is located in Flémalle (Liège, Belgium), by Grotte Ramiouil. This project of cultural tourism is funded by the Prehistory Museum of Wallonie and diverse European funding (FEDER) and the General Tourism Commissioner of Wallonie Public Services. The main principle of Prehistosite is mediation, being its principal function to demystify heritage and science for the general public, reporting the social processes which support musealization. During the last two decades, Prehistosite has become an educational centre for visitors, educators and school or university students. The future of this museum will be redefined on 2014-2015, when it will transform into Prehistomuseum and will increase its educational offer. The Prehistomuseum is presented as a 30 ha. museum located in Grotte Ramiouil forest. The Prehistomuseum seeks to make the public aware about heritage preservation and scientific culture embedded in a tolerance and neutrality, humanity, citizenship and respect for natural environment spirit

Le Musée-Médiateur du Préhistosite de Ramioul au Préhistomuseum reformulation d'un projet muséal à Flémalle (Liège, Belgique)

Le Préhistosite de Ramioul est situé à Flémalle (Liège, Belgique), au pied de la Grotte Ramioul. Es un projet de tourisme culturel déposé par le Musée de la Préhistoire en Wallonie; il est soutenu par des fonds européens (FEDER) et le Commissariat Général du Tourisme du Service Public de Wallonie. La médiation est pour le Préhistomuseum son principe sa fonctio est de désacraliser le patrimoine et la science aux yeux des publics en rendant compte des processus sociétaux qui soustendent à la muséalisation. Pendant les derniers deux décades le Préhistosite à devenu un centre de formation pour visiteurs, enseignants et pour des étudiants d'écoles ou d'universités. Le futur du musée se raffinerais en 2014-2015, agrandira encore son service éducatif. Le Préhistomuseum se définira vis-à-vis du public comme un musée de 30 hectares situés dans la forêt de la Grotte de Ramioul. Le Préhistomuseum désire sensibiliser les publics à la préservation du patrimoine et à la culture scientifique dans un esprit de tolérance et de neutralité, d'humanité, de citoyenneté et de respect de l'environnement.El Prèhistosite de Ramioul está situado en Flémalle (Lieja, Belgica), al pie de la Grotte Ramioul. Es un proyecto de turismo cultural financiado por el Museo de Prehistoria de Wallonie y financiado por diferentes fondos europeos (FEDER) y el Comisariado General de Turismo del Servicio Público de Wallonie. La mediación es para el Prèhistosite su principio. Su función principal es desacralizar el patrimonio y la ciencia para el público no especializado y rinde cuentas a los proPhilipcesos sociales que sustentan la musealización. A lo largo de las dos últimas décadas, el Prèhistosite se ha convertido en un centro de formación para visitantes, educadores y estudiantes escolares o universitarios. El futuro del museo se redefinirá en 2014-2015, cuando se transformará en Prèhistoseum y aumentará aun más los servicios educativos. El Prèhistoseum se presenta de cara al público como un museo de 30 hectáreas situado en el bosque de la Grotte de Ramiouil. El Prèhistomuseum desea sensibilizar al público en la preservación del patrimonio y en la cultura científica dentro de un espíritu de tolerancia y de neutralidad, de humanidad, ciudadanía y respeto por el entorno natural.Ramiouil Prehistosite is located in Flémalle (Liège, Belgium), by Grotte Ramiouil. This project of cultural tourism is funded by the Prehistory Museum of Wallonie and diverse European funding (FEDER) and the General Tourism Commissioner of Wallonie Public Services. The main principle of Prehistosite is mediation, being its principal function to demystify heritage and science for the general public, reporting the social processes which support musealization. During the last two decades, Prehistosite has become an educational centre for visitors, educators and school or university students. The future of this museum will be redefined on 2014-2015, when it will transform into Prehistomuseum and will increase its educational offer. The Prehistomuseum is presented as a 30 ha. museum located in Grotte Ramiouil forest. The Prehistomuseum seeks to make the public aware about heritage preservation and scientific culture embedded in a tolerance and neutrality, humanity, citizenship and respect for natural environment spirit

Oncological patients' reactions to COVID-19 pandemic: A single institution prospective study.

peer reviewedBACKGROUND: The spread of the COVID-19 pandemic has led to a rapid reorganization in all human and hospital activities, with impact on cancer patients. AIM: An analysis of cancer patients fears, and awareness of COVID-19 has been done in this study. METHODS AND RESULTS: We analyzed cancer patients' reactions to the pandemic and their perception of oncological care reorganization, through a 12-item survey, proposed at the peak of pandemic and 3 months later. Overall, 237 patients were included in the study. During the peak of pandemic 34.6% of patients were more worried about COVID-19 than cancer versus 26.4% in the post-acute phase (p = .013). Although 49.8% of patients in the acute phase and 42.3% in the post-acute phase considered their risk of death if infected ≥50%, and more than 70% of patients thought to be at higher risk of complications, the majority of them did not consider the possibility to stop or delay their treatment. Patients were more interested in following news about COVID-19 than cancer and they complied with all preventive measures in more than 90% of the cases. CONCLUSIONS: Although cancer patients worried about COVID-19 and evaluated the risk of complication or death due to COVID-19 as extremely high, they were still asking for the best oncological treatment

Le Musée-Médiateur du Préhistosite de Ramioul au Préhistomuseum reformulation d'un projet muséal à Flémalle (Liège, Belgique)

Le Préhistosite de Ramioul est situé à Flémalle (Liège, Belgique), au pied de la Grotte Ramioul. Es un projet de tourisme culturel déposé par le Musée de la Préhistoire en Wallonie; il est soutenu par des fonds européens (FEDER) et le Commissariat Général du Tourisme du Service Public de Wallonie. La médiation est pour le Préhistomuseum son principe sa fonctio est de désacraliser le patrimoine et la science aux yeux des publics en rendant compte des processus sociétaux qui soustendent à la muséalisation. Pendant les derniers deux décades le Préhistosite à devenu un centre de formation pour visiteurs, enseignants et pour des étudiants d'écoles ou d'universités. Le futur du musée se raffinerais en 2014-2015, agrandira encore son service éducatif. Le Préhistomuseum se définira vis-à-vis du public comme un musée de 30 hectares situés dans la forêt de la Grotte de Ramioul. Le Préhistomuseum désire sensibiliser les publics à la préservation du patrimoine et à la culture scientifique dans un esprit de tolérance et de neutralité, d'humanité, de citoyenneté et de respect de l'environnement.El Prèhistosite de Ramioul está situado en Flémalle (Lieja, Belgica), al pie de la Grotte Ramioul. Es un proyecto de turismo cultural financiado por el Museo de Prehistoria de Wallonie y financiado por diferentes fondos europeos (FEDER) y el Comisariado General de Turismo del Servicio Público de Wallonie. La mediación es para el Prèhistosite su principio. Su función principal es desacralizar el patrimonio y la ciencia para el público no especializado y rinde cuentas a los proPhilipcesos sociales que sustentan la musealización. A lo largo de las dos últimas décadas, el Prèhistosite se ha convertido en un centro de formación para visitantes, educadores y estudiantes escolares o universitarios. El futuro del museo se redefinirá en 2014-2015, cuando se transformará en Prèhistoseum y aumentará aun más los servicios educativos. El Prèhistoseum se presenta de cara al público como un museo de 30 hectáreas situado en el bosque de la Grotte de Ramiouil. El Prèhistomuseum desea sensibilizar al público en la preservación del patrimonio y en la cultura científica dentro de un espíritu de tolerancia y de neutralidad, de humanidad, ciudadanía y respeto por el entorno natural.Ramiouil Prehistosite is located in Flémalle (Liège, Belgium), by Grotte Ramiouil. This project of cultural tourism is funded by the Prehistory Museum of Wallonie and diverse European funding (FEDER) and the General Tourism Commissioner of Wallonie Public Services. The main principle of Prehistosite is mediation, being its principal function to demystify heritage and science for the general public, reporting the social processes which support musealization. During the last two decades, Prehistosite has become an educational centre for visitors, educators and school or university students. The future of this museum will be redefined on 2014-2015, when it will transform into Prehistomuseum and will increase its educational offer. The Prehistomuseum is presented as a 30 ha. museum located in Grotte Ramiouil forest. The Prehistomuseum seeks to make the public aware about heritage preservation and scientific culture embedded in a tolerance and neutrality, humanity, citizenship and respect for natural environment spirit

AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.

AMP-activated protein kinase (AMPK) alpha1 is activated in platelets on thrombin or collagen stimulation, and as a consequence, phosphorylates and inhibits acetyl-CoA carboxylase (ACC). Because ACC is crucial for the synthesis of fatty acids, which are essential for platelet activation, we hypothesized that this enzyme plays a central regulatory role in platelet function. To investigate this, we used a double knock-in (DKI) mouse model in which the AMPK phosphorylation sites Ser79 on ACC1 and Ser212 on ACC2 were mutated to prevent AMPK signaling to ACC. Suppression of ACC phosphorylation promoted injury-induced arterial thrombosis in vivo and enhanced thrombus growth ex vivo on collagen-coated surfaces under flow. After collagen stimulation, loss of AMPK-ACC signaling was associated with amplified thromboxane generation and dense granule secretion. ACC DKI platelets had increased arachidonic acid-containing phosphatidylethanolamine plasmalogen lipids. In conclusion, AMPK-ACC signaling is coupled to the control of thrombosis by specifically modulating thromboxane and granule release in response to collagen. It appears to achieve this by increasing platelet phospholipid content required for the generation of arachidonic acid, a key mediator of platelet activation

Platelet Acetyl-CoA Carboxylase Phosphorylation A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients

Adenosine monophosphate–activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) signaling is activated in platelets by atherogenic lipids, particularly by oxidized low-density lipoproteins, through a CD36-dependent pathway. More interestingly, increased platelet AMPK–induced ACC phosphorylation is associated with the severity of coronary artery calcification as well as acute coronary events in coronary artery disease patients. Therefore, AMPK–induced ACC phosphorylation is a potential marker for risk stratification in suspected coronary artery disease patients. The inhibition of ACC resulting from its phosphorylation impacts platelet lipid content by down-regulating triglycerides, which in turn may affect platelet function

Contrasting evolutionary genome dynamics between domesticated and wild yeasts

International audienceStructural rearrangements have long been recognized as an important source of genetic variation, with implications in phenotypic diversity and disease, yet their detailed evolutionary dynamics remain elusive. Here we use long-read sequencing to generate end-to-end genome assemblies for 12 strains representing major subpopulations of the partially domesticated yeast Saccharomyces cerevisiae and its wild relative Saccharomyces paradoxus. These population-level high-quality genomes with comprehensive annotation enable precise definition of chromosomal boundaries between cores and subtelomeres and a high-resolution view of evolutionary genome dynamics. In chromosomal cores, S. paradoxus shows faster accumulation of balanced rearrangements (inversions, reciprocal translocations and transpositions), whereas S. cerevisiae accumulates unbalanced rearrangements (novel insertions, deletions and duplications) more rapidly. In subtelomeres, both species show extensive interchromosomal reshuffling, with a higher tempo in S. cerevisiae. Such striking contrasts between wild and domesticated yeasts are likely to reflect the influence of human activities on structural genome evolution