Frances Madigan, \u2744, Traveling Journalist

An address book in which names are listed according to cities instead of in alphabetical order is one of the most indispensable companions of Frances Madigan, \u2744

Rising temperature reduces divergence in resource use strategies in coexisting parasitoid species.

International audienceCoexistence of species sharing the same resources is often possible if species are phylogenetically divergent in resource acquisition and allocation traits, decreasing competition between them. Developmental and life-history traits related to resource use are influenced by environmental conditions such as temperature, but thermal trait responses may differ among species. An increase in ambient temperature may, therefore, affect trait divergence within a community, and potentially species coexistence. Parasitoids are interesting models to test this hypothesis, because multiple species commonly attack the same host, and employ divergent larval and adult host use strategies. In particular, development mode (arrested or continued host growth following parasitism) has been recognized as a major organiser of parasitoid life histories. Here, we used a comparative trait-based approach to determine thermal responses of development time, body mass, egg load, metabolic rate and energy use of the coexisting Drosophila parasitoids Asobara tabida, Leptopilina heterotoma, Trichopria drosophilae and Spalangia erythromera. We compared trait values between species and development modes, and calculated trait divergence in response to temperature, using functional diversity indices. Parasitoids differed in their thermal response for dry mass, metabolic rate and lipid use throughout adult life, but only teneral lipid reserves and egg load were affected by developmental mode. Species-specific trait responses to temperature were probably determined by their adaptations in resource use (e.g. lipogenesis or ectoparasitism). Overall, trait values of parasitoid species converged at the higher temperature. Our results suggest that local effects of warming could affect host resource partitioning by reducing trait diversity in communities

Killing spectroscopy of closed timelike curves

We analyse the existence of closed timelike curves in spacetimes which possess an isometry. In particular we check which discrete quotients of such spaces lead to closed timelike curves. As a by-product of our analysis, we prove that the notion of existence or non-existence of closed timelike curves is a T-duality invariant notion, whenever the direction along which we apply such transformations is everywhere spacelike. Our formalism is straightforwardly applied to supersymmetric theories. We provide some new examples in the context of D-branes and generalized pp-waves.Comment: 1+35 pages, no figures; v2, new references added. Final version to appear in JHE

The common good balance sheet, an adequate tool to capture non-financials?

In relation to organizational performance measurement, there is a growing concern about the creation of value for people, society and the environment. The traditional corporate reporting does not adequately satisfy the information needs of stakeholders for assessing an organization's past and future potential performance. Practitioners and scholars have developed new non-financial reporting frameworks from a social and environmental perspective, giving birth to the field of Integrated Reporting (IR). The Economy for the Common Good (ECG) model and its tools to facilitate sustainability management and reporting can provide a framework to do it. The present study depicts the theoretical foundations from the business administration field research on which the ECG model relies. Moreover, this paper is the first one that empirically validates such measurement scales by applying of Exploratory Factor Analysis on a sample of 206 European firms. Results show that two out of five dimensions are appropriately defined, along with some guidelines to refine the model. Consequently, it allows knowledge to advance as it assesses the measurement scales' statistical validity and reliability. However, as this is the first quantitative-driven research on the ECG model, the authors' future research will confirm the present results by means of Confirmatory Factor Analysis (CFA)

The Iowa Homemaker vol.25, no.2

Keeping Up With Today, Jeanne O’Connor, page 2 Veishea Blueprints the Future, Charla Muschott, page 3 This is Merrill Palmer, Marjorie Osenbrug, page 4 Home Economists on the Air, Charlene Stettler, page 5 Vicky Faces a Busy Summer, Josephine Ahern, page 6 Alum Directs Army Kitchen in Wales, Lt. Mary E. Scoltock, page 8 Women Devise Costume Jewelry, Madeline Morrison, page 9 Chile Outgrows Food Traditions, Ruth Gaessler, Carlos Krassa, page 10 Summer School or Summer Positions, Victoria McKibben, page 11 What’s New in Home Economics, Doris Adams, page 12 Restaurants Introduce Apprentice Course, Betsy Nichols, page 14 Teach Toymaking, Marjorie Moodie, page 17 Booklet Discusses Teaching Career, Marian Hoppe, page 19 Frances Madigan, ’44, Traveling Journalist, Joan Visser, page 21 Ever Eaten Eggshells?, Lois Gramlich, page 23 Faculty and Students Revise Curriculum, Jeanne O’Connor, page 2

Tissue-specific suppression of thyroid hormone signaling in various mouse models of aging

DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive. Since thyroid hormone (TH) is a key regulator of metabolism, changes in TH signaling have widespread effects. Here, we reveal a significant common transcriptomic signature in livers from hypothyroid mice, DNA repair-deficient mice with severe (Csbm/m/Xpa-/-) or intermediate (Ercc1-/Δ-7) progeria and naturally aged mice. A strong induction of TH-inactivating deiodinase D3 and decrease of TH-activating D1 activities are observed in Csbm/m/Xpa-/- livers. Similar findings are noticed in Ercc1-/Δ-7, in naturally aged animals and in wild-type mice exposed to a chronic subtoxic dose of DNAdamaging agents. In contrast, TH signaling in muscle, heart and brain appears unaltered. These data show a strong suppression of TH signaling in specific peripheral organs in premature and normal aging, probably lowering metabolism, while other tissues appear to preserve metabolism. D3-mediated TH inactivation is unexpected, given its expression mainly in fetal tissues. Our studies highlight the importance of DNA damage as the underlying mechanism of changes in thyroid state. Tissue-specific regulation of deiodinase activities, ensuring diminished TH signaling, may contribute importantly to the protective metabolic response in aging

Baseline Predictors of Sputum Culture Conversion in Pulmonary Tuberculosis: Importance of Cavities, Smoking, Time to Detection and W-Beijing Genotype

Background: Time to detection (TTD) on automated liquid mycobacterial cultures is an emerging biomarker of tuberculosis outcomes. The M. tuberculosis W-Beijing genotype is spreading globally, indicating a selective advantage. There is a paucity of data on the association between baseline TTD and W-Beijing genotype and tuberculosis outcomes. Aim: To assess baseline predictors of failure of sputum culture conversion, within the first 2 months of antitubercular therapy, in participants with pulmonary tuberculosis. Design: Between May 2005 and August 2008 we conducted a prospective cohort study of time to sputum culture conversion in ambulatory participants with first episodes of smear and culture positive pulmonary tuberculosis attending two primary care clinics in Cape Town, South Africa. Rifampicin resistance (diagnosed on phenotypic susceptibility testing) was an exclusion criterion. Sputum was collected weekly for 8 weeks for mycobacterial culture on liquid media (BACTEC MGIT 960). Due to missing data, multiple imputation was performed. Time to sputum culture conversion was analysed using a Cox-proportional hazards model. Bayesian model averaging determined the posterior effect probability for each variable. Results: 113 participants were enrolled (30.1% female, 10.5% HIV-infected, 44.2% W-Beijing genotype, and 89% cavities). On Kaplan Meier analysis 50.4% of participants underwent sputum culture conversion by 8 weeks. The following baseline factors were associated with slower sputum culture conversion: TTD (adjusted hazard ratio (aHR) = 1.11, 95% CI 1.02; 1.2), lung cavities (aHR = 0.13, 95% CI 0.02; 0.95), ever smoking (aHR = 0.32, 95% CI 0.1; 1.02) and the W-Beijing genotype (aHR = 0.51, 95% CI 0.25; 1.07). On Bayesian model averaging, posterior probability effects were strong for TTD, lung cavitation and smoking and moderate for W-Beijing genotype. Conclusion: We found that baseline TTD, smoking, cavities and W-Beijing genotype were associated with delayed 2 month sputum culture. Larger studies are needed to confirm the relationship between the W-Beijing genotype and sputum culture conversion.Publisher's versio

Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial

Item does not contain fulltextBACKGROUND: Platelet transfusion after acute spontaneous primary intracerebral haemorrhage in people taking antiplatelet therapy might reduce death or dependence by reducing the extent of the haemorrhage. We aimed to investigate whether platelet transfusion with standard care, compared with standard care alone, reduced death or dependence after intracerebral haemorrhage associated with antiplatelet therapy use. METHODS: We did this multicentre, open-label, masked-endpoint, randomised trial at 60 hospitals in the Netherlands, UK, and France. We enrolled adults within 6 h of supratentorial intracerebral haemorrhage symptom onset if they had used antiplatelet therapy for at least 7 days beforehand and had a Glasgow Coma Scale score of at least 8. With use of a secure web-based system that concealed allocation and used biased coin randomisation, study collaborators randomly assigned participants (1:1; stratified by hospital and type of antiplatelet therapy) to receive either standard care or standard care with platelet transfusion within 90 min of diagnostic brain imaging. Participants and local investigators giving interventions were not masked to treatment allocation, but allocation was concealed from outcome assessors and investigators analysing data. The primary outcome was shift towards death or dependence rated on the modified Rankin Scale (mRS) at 3 months, and analysed by ordinal logistic regression, adjusted for stratification variables and the Intracerebral Haemorrhage Score. The primary analysis was done in the intention-to-treat population and safety analyses were done in the intention-to-treat and as-treated populations. This trial is registered with the Netherlands Trial Register, number NTR1303, and is now closed. FINDINGS: Between Feb 4, 2009, and Oct 8, 2015, 41 sites enrolled 190 participants. 97 participants were randomly assigned to platelet transfusion and 93 to standard care. The odds of death or dependence at 3 months were higher in the platelet transfusion group than in the standard care group (adjusted common odds ratio 2.05, 95% CI 1.18-3.56; p=0.0114). 40 (42%) participants who received platelet transfusion had a serious adverse event during their hospital stay, as did 28 (29%) who received standard care. 23 (24%) participants assigned to platelet transfusion and 16 (17%) assigned to standard care died during hospital stay. INTERPRETATION: Platelet transfusion seems inferior to standard care for people taking antiplatelet therapy before intracerebral haemorrhage. Platelet transfusion cannot be recommended for this indication in clinical practice. FUNDING: The Netherlands Organisation for Health Research and Development, Sanquin Blood Supply, Chest Heart and Stroke Scotland, French Ministry of Health

La lección del Nunca Más. Una aproximación interdisciplinar al contenido y alcance jurídico internacional de la obligación estatal de garantizar la no repetición a través de la educación en memoria. Informe Final

Conceptualmente, el proyecto giró en torno a las garantías de no repetición, es decir: medidas orientadas a evitar futuros incumplimientos del Derecho internacional, de muy diversa naturaleza, pues virtualmente pueden consistir en cualquier cosa (siempre que no resulte abusiva), aunque las más habituales en la práctica internacional son la adopción/derogación/reforma de legislación o de medidas administrativas y las medidas de carácter institucional (relativas a la existencia, organización o funcionamiento de órganos del Estado). Cuando un Estado incumple una obligación internacional –y, por tanto, comete un hecho internacionalmente ilícito–, la principal consecuencia que surge para él es la obligación de reparar, en cualquier de sus tres formas –restitución (o, en su caso, compensación por equivalencia), indemnización o satisfacción (reparación moral)–. Además, en circunstancias excepcionales, tendría también la obligación de ofrecer garantías de no repetición1. Esas “circunstancias excepcionales” vienen en esencia delimitadas por la existencia de violaciones graves de normas imperativas de Derecho internacional, como ocurre cuando se lesionan de manera flagrante o sistemática derechos humanos fundamentales, prácticas que a su vez están tipificadas como crímenes internacionales (genocidio o crímenes contra la humanidad). Por tanto, cuando en el interior de un Estado se cometen atrocidades de esa naturaleza, bien por parte de las propias autoridades estatales, bien por parte de actores no estatales cuyo comportamiento no ha sido prevenido o reprimido por el Estado, surgiría para este la obligación de ofrecer garantías de no repetición