Informational content vs. discourse orientation: experimental and computational perspectives

The aim of this study is to investigate how human speakers and computational language models process (i) the informational content and (ii) the discourse orientation of natural language sentences. These two dimensions of meaning have received little attention outside theoretical literature, especially in the computational linguistics domain. To help fill this void, we present the results of four experiments that exploit the specific semantics of two French adverbs, namely presque (≃ ’almost’) and à peine (≃ ’barely’), which put these two dimensions of meaning at odds. Each experiment focuses on one kind of population (humans or language models), and one kind of meaning (informational content or discourse orientation). Our results show that humans are indeed sensitive to informational content and discourse direction, as assumed in the theoretical literature. Language models exhibit a less transparent behavior. Their performances in dealing with the semantics of presque appear in line with predictions based on the way these models are trained, but this does not extend to à peine

Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium.

This corrects the article DOI: 10.1038/bjc.2017.231

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men