Vi och Dem : en studie av Sydsvenskans etniska framställning

I det mångkulturella samhälle Sverige idag är, har dagstidningar en viktig roll i att spegla detta samhälle på ett korrekt sätt. Vi har intresserat oss för hur personer med annan etnicitet presenteras och hur ämnen som immigration och integration framställs i Sydsvenskan. Vi vill undersöka hur representationen ser ut och om den kan tänkas vara en bidragande orsak till vardagens problem, såsom diskriminering och rasism. Vi valde en kvalitativ metod, nämligen text- och diskursanalys på ett 20-tal upplagor från april 2013. Dessutom analyserade vi samma period 1979 för att få ett tidsperspektiv till den moderna upplagan. Vi studerade inrikesnyheter och koncentrerade oss särskilt på de artiklar som innehöll personer med utländsk bakgrund, samt rapporter och diskussioner om invandring och integration. Vi använde oss av ett flertal teorier som forskats fram om medias rapportering kring etnicitet. Det var övervägande en representativ behandling i de texter vi analyserade, men vi kunde urskilja en del problematiska framställningar av framförallt flyktingar och asylpolitik. Något som stämde väl överens med vårt teoretiska material. Vi fastslog även att tidningen genom åren har utvecklats, främst i sina rapporter om invandrare där de 2013 deltar på ett mer representativt sätt än 1979. Medie- och kommunikationsvetenskap, vid instutionen för kommunikation och medier, Lunds universitet

Automated Tumour Recognition and Digital Pathology Scoring Unravels New Role for PD-L1 in Predicting Good Outcome in ER-/HER2+ Breast Cancer

The role of PD-L1 as a prognostic and predictive biomarker is an area of great interest. However, there is a lack of consensus on how to deliver PD-L1 as a clinical biomarker. At the heart of this conundrum is the subjective scoring of PD-L1 IHC in most studies to date. Current standard scoring systems involve separation of epithelial and inflammatory cells and find clinical significance in different percentages of expression, e.g., above or below 1%. Clearly, an objective, reproducible and accurate approach to PD-L1 scoring would bring a degree of necessary consistency to this landscape. Using a systematic comparison of technologies and the application of QuPath, a digital pathology platform, we show that high PD-L1 expression is associated with improved clinical outcome in Triple Negative breast cancer in the context of standard of care (SoC) chemotherapy, consistent with previous findings. In addition, we demonstrate for the first time that high PD-L1 expression is also associated with better outcome in ER- disease as a whole including HER2+ breast cancer. We demonstrate the influence of antibody choice on quantification and clinical impact with the Ventana antibody (SP142) providing the most robust assay in our hands. Through sampling different regions of the tumour, we show that tumour rich regions display the greatest range of PD-L1 expression and this has the most clinical significance compared to stroma and lymphoid rich areas. Furthermore, we observe that both inflammatory and epithelial PD-L1 expression are associated with improved survival in the context of chemotherapy. Moreover, as seen with PD-L1 inhibitor studies, a low threshold of PD-L1 expression stratifies patient outcome. This emphasises the importance of using digital pathology and precise biomarker quantitation to achieve accurate and reproducible scores that can discriminate low PD-L1 expression

Fish consumption in mid-childhood and its relationship to neuropsychological outcomes measured in 7–9 year old children using a NUTRIMENTHE neuropsychological battery

Background Long-chain polyunsaturated fatty acids (LCPUFA), particularly n-3 LCPUFA, play a central role in neuronal growth and the development of the human brain. Fish is the main dietary source of n-3 LCPUFA. To assess the relation between fish consumption, estimated dietary n-3 LCPUFA intake and cognition and behaviour in childhood in a multi-centre European sample. Methods Children from 2 European studies, CHOP and NUHEAL, were assessed at 8 and 7.5 years of age, respectively. Different outcomes of neuropsychological development (assessed with the standardized NUTRIMENTHE Neuropsychological Battery (NNB) consisting of 15 subtests) were related with outcomes from a food-frequency questionnaire (FFQ) focussing on the consumption of fish. Results A total of 584 children completed the FFQ and the neuropsychological tests. We found no associations with calculated DHA or EPA intakes for any of the neuropsychological domains. Children who consumed 2 fish meals per week including one of fatty fish, showed no substantive differences in the cognitive domains from the children who did not. However negative associations with fatty fish consumption were found for social problems (p\ua0=\ua00.019), attention problems (p\ua0=\ua00.012), rule-breaking problems (p\ua0=\ua00.019) and aggressive behaviour problems (p\ua0=\ua00.032). No association was observed with internalizing problems. Higher levels of externalizing problems (p\ua0=\ua00.018) and total problems (p\ua0=\ua00.018) were associated with eating less fatty fish. Conclusions Children who consumed 2 fish meals per week including one of fatty fish were less likely to show emotional and behavioural problems than those who did not

Metal homeostasis in plant mitochondria

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