Luminescent calcium carbonate micro ‘bow ties’

Calcium carbonate (CaCO3) is a ubiquitous material which has been studied for centuries due to its integral nature across various fields and its vast range of applications. Here we report, for the first time, a low temperature dry ice carbonation method for the production of unique rare earth-doped calcium carbonate ‘bow ties’. CaCO3 exhibits retrograde solubility, an interesting property in which its solubility increases with decreasing temperature. In this synthesis, dry ice acts not only as a CO2 source, but as a coolant, increasing the solubility of CaCO3 and CO2 and allowing specific growth to occur. The incorporation of trivalent lanthanide ions Eu3+ and Tb3+ into the CaCO3 synthesis results in the formation of these unique luminescent calcite ‘bow tie’ microstructures which cannot be produced using either standard gaseous CO2 carbonation, or chemical precipitation methods. This new method and materials might find potential applications including, but not limited to, radionuclide sequestration, imaging and photonics

Swimmer-tracer scattering at low Reynolds number

Understanding the stochastic dynamics of tracer particles in active fluids is important for identifying the physical properties of flow generating objects such as colloids, bacteria or algae. Here, we study both analytically and numerically the scattering of a tracer particle in different types of time-dependent, hydrodynamic flow fields. Specifically, we compare the tracer motion induced by an externally driven colloid with the one generated by various self-motile, multi-sphere swimmers. Our results suggest that force-free swimmers generically induce loop-shaped tracer trajectories. The specific topological structure of these loops is determined by the hydrodynamic properties of the microswimmer. Quantitative estimates for typical experimental conditions imply that the loops survive on average even if Brownian motion effects are taken into account.Comment: 14 pages, to appear in Soft Matte

Low Reynolds number hydrodynamics of asymmetric, oscillating dumbbell pairs

Active dumbbell suspensions constitute one of the simplest model system for collective swimming at low Reynolds number. Generalizing recent work, we derive and analyze stroke-averaged equations of motion that capture the effective hydrodynamic far-field interaction between two oscillating, asymmetric dumbbells in three space dimensions. Time-averaged equations of motion, as those presented in this paper, not only yield a considerable speed-up in numerical simulations, they may also serve as a starting point when deriving continuum equations for the macroscopic dynamics of multi-swimmer suspensions. The specific model discussed here appears to be particularly useful in this context, since it allows one to investigate how the collective macroscopic behavior is affected by changes in the microscopic symmetry of individual swimmers.Comment: 10 pages, to appear in EPJ Special Topic

Outer-Disk Populations in NGC 7793: Evidence for Stellar Radial Migration

We analyzed the radial surface brightness profile of the spiral galaxy NGC 7793 using HST/ACS images from the GHOSTS survey and a new HST/WFC3 image across the disk break. We used the photometry of resolved stars to select distinct populations covering a wide range of stellar ages. We found breaks in the radial profiles of all stellar populations at 280" (~5.1 kpc). Beyond this disk break, the profiles become steeper for younger populations. This same trend is seen in numerical simulations where the outer disk is formed almost entirely by radial migration. We also found that the older stars of NGC 7793 extend significantly farther than the underlying HI disk. They are thus unlikely to have formed entirely at their current radii, unless the gas disk was substantially larger in the past. These observations thus provide evidence for substantial stellar radial migration in late-type disks.Comment: 8 pages, 6 figure. Accepted for publication in Ap

The role of hepatitis E virus infection in adult Americans with acute liver failure

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135129/1/hep28649-sup-0001-suppinfo.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135129/2/hep28649.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135129/3/hep28649_am.pd

A farewell to brake reaction times? Kinematics-dependent brake response in naturalistic rear-end emergencies

Driver braking behavior was analyzed using time-series recordings from naturalistic rear-end conflicts (116 crashes and 241 near-crashes), including events with and without visual distraction among drivers of cars, heavy trucks, and buses. A simple piecewise linear model could be successfully fitted, per event, to the observed driver decelerations, allowing a detailed elucidation of when drivers initiated braking and how they controlled it. Most notably, it was found that, across vehicle types, driver braking behavior was strongly dependent on the urgency of the given rear-end scenario’s kinematics, quantified in terms of visual looming of the lead vehicle on the driver’s retina. In contrast with previous suggestions of brake reaction times (BRTs) of 1.5 s or more after onset of an unexpected hazard (e.g., brake light onset), it was found here that braking could be described as typically starting less than a second after the kinematic urgency reached certain threshold levels, with even faster reactions at higher urgencies. The rate at which drivers then increased their deceleration (towards a maximum) was also highly dependent on urgency. Probability distributions are provided that quantitatively capture these various patterns of kinematics-dependent behavioral response. Possible underlying mechanisms are suggested, including looming response thresholds and neural evidence accumulation. These accounts argue that a naturalistic braking response should not be thought of as a slow reaction to some single, researcher-defined “hazard onset”, but instead as a relatively fast response to the visual looming cues that build up later on in the evolving traffic scenario

How Do We Study Pedestrian Interaction with Automated Vehicles? Preliminary Findings from the European interACT Project

This paper provides an overview of a set of behavioural studies, conducted as part of the European project interACT, to understand road user behaviour in current urban settings. The paper reports on a number of methodologies used to understand how humans currently interact in urban traffic, in order to establish what information would be useful for the design of future AVs, when interacting with other road users, especially pedestrians. In addition to summarising the results from a number of observation studies, we report on preliminary results from Virtual Reality studies, investigating if, in the absence of a human vehicle controller, externally presented interfaces can be used for communication between AVs and pedestrians. Finally, an overview of the mathematical and computational modelling techniques used to understand how AV and pedestrian behaviour can be both cooperative, and effective is provided. The hope is that future AVs can be designed with an understanding of how humans cooperate and communicate in mixed traffic, promoting good traffic flow, user acceptance and user trust

A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation

Northwestern Europeans are among the tallest of human populations. The increase in body height in these people appears to have reached a plateau, suggesting the ubiquitous presence of an optimal environment in which genetic factors may have exerted a particularly strong influence on human growth. Therefore, we performed a genome-wide association study (GWAS) of body height using 2.2 million markers in 10 074 individuals from three Dutch and one German population-based cohorts. Upon genotyping, the 12 most significantly height-associated single nucleotide polymorphisms (SNPs) from this GWAS in 6912 additional individuals of Dutch and Swedish origin, a genetic variant (rs6717918) on chromosome 2q37.1 was found to be associated with height at a genome-wide significance level (Pcombined= 3.4 × 10-9). Notably, a second SNP (rs6718438) located ∼450 bp away and in strong LD (r2= 0.77) with rs6717918 was previously found to be suggestive of a height association in 29 820 individuals of mainly northwestern European ancestry, and the over-expression of a nearby natriuretic peptide precursor type C (NPPC) gene, has been associated with overgrowth and skeletal anomalies. We also found a SNP (rs10472828) located on 5p14 near the natriuretic peptide receptor 3 (NPR3) gene, encoding a receptor of the NPPC ligand, to be associated with body height (Pcombined= 2.1 × 10-7). Taken together, these results suggest that variation in the C-type natriuretic peptide signaling pathway, involving the NPPC and NPR3 genes, plays an important role in determining human body height

Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations

OBJECTIVE—Using the genome-wide association approach, we recently identified the glucokinase regulatory protein gene (GCKR, rs780094) region as a novel quantitative trait locus for plasma triglyceride concentration in Europeans. Here, we sought to study the association of GCKR variants with metabolic phenotypes, including measures of glucose homeostasis, to evaluate the GCKR locus in samples of non-European ancestry and to fine- map across the associated genomic interval