LONDRES (Reino Unido). Perspectivas de ciudades. 1737 (1560)

Comprende además la antigua ciudad, hoy barrio de WestminsterRelación de los principales edificios indicados por clave alfabéticaNota explicativa sobre el área representadaNota enmarcada en cartela barroca y título flanqueado por los escudos de la Casa Real y de la ciudadAdornado con la representación de varios barcosForma parte de la Colección Mendoz

LONDRES (Reino Unido). Planos de población. 1723 (1666). 1:1900

Dedicatoria : "Ut memoria saltem pristinae Londinii formae diruno quo subsidit incendium supervivat : Tabulam eiusdem umbratilem Societati Antiquariae Londinensi dedicat Georgius Vertue. MDCCXXIII"Escala gráfica de 300 yardas [= 14,7 cm]. Orientado con lis en rosa de treinta y dos vientosToponimia de las principales calles y plazas de la ciudad, señalándose además sus edificios más relevantesEn servilleta, tabla con las líneas punteadas utilizadas para indicar la extensión del incendio que sufrió la ciudad, las ampliaciones de las calle y las líneas que seguían las mismas antes de aquélDedicatoria enmarcada en un muro de ruinas sobre el cual hay una lámpara encendida y filactería con la leyenda: "Non etinguetur"Forma parte de la Colección MendozaInserta : "A plan of the City of London and Westminster". Relación de los principales edificios y parques, indicados por clave alfabética. Siete vias de los más importantes edificios. tanto civiles como religiosos, de la ciuda

Measurement of atmospheric black carbon in the Vaal Triangle and Highveld Priority Areas

Atmospheric black carbon is an important atmospheric pollutant; it has impacts on human health and a strong climate impact. Black carbon particles are functionally defined by their optical properties (viz. characteristics in light absorption). As a result, black carbon particles are derived from a wide range of sources, but are largely the result of incomplete combustion processes. In order to quantify the atmospheric load of black carbon particles, multi angle absorption photometer (MAAP) instruments have been installed in 8 of the ambient air quality monitoring stations in the Vaal Triangle and Highveld Priority areas. Three of the instruments have been in operation since 2012 and the other 5 were installed in August 2013. This paper presents an analysis of the initial black carbon monitoring data. The impacts of seasonality and meteorological conditions as well as the relationship of the black carbon concentration to PM10and PM2.5 concentrations are discussed

Youth ministry at the margins and/or centre as space of the other: Reflections on the resolutions of the Anglican dioceses in the Western Cape 2017

Youth within the context of faith-based organisations carry with them certain power relations and misconstrued connotations. These power relations and connotations can contribute to alienation and marginalisation. The resolutions taken at the recent synods of the three dioceses within the Western Cape reflect and identify the areas - both liturgical and governance - of marginalisation of youth within the Anglican Church in southern Africa. The resolutions also call on the church governing bodies and the leaders to create safe spaces for the youth to be a central part of the mission of the church. Areas such as liturgy, training and formation, contemporary worship and nurturing relationships are identified within the resolutions. Theological notions of personhood within the Anglican tradition are to be investigated as possible motivations for more acceptable power relations of the youth and leaders and governance structures. What implications do such theological formulations have for the space that the youth occupy within the margins of the church? A critical reflection of the synod resolutions answers such questions and points to some contours for sense making of the youth within the margins of the church from a faith-based organisational perspective

The impact of the Netherlandish landscape tradition on poetry and painting in early modern England

Copyright © 2013 The University of Chicago Press.The relationship between poetry and painting has been one of the most debated issues in the history of criticism. The present article explores this problematic relationship in the context of sixteenth- and seventeenth-century England, taking into account theories of rhetoric, visual perception, and art. It analyzes a rare case in which a specific school of painting directly inspired poetry: in particular, the ways in which the Netherlandish landscape tradition influenced natural descriptions in the poem Poly-Olbion (1612, 1622) by Michael Drayton (1563–1631). Drayton — under the influence of the artistic principles of landscape depiction as explained in Henry Peacham’s art manuals, as well as of direct observation of Dutch and Flemish landscape prints and paintings — successfully managed to render pictorial landscapes into poetry. Through practical examples, this essay will thoroughly demonstrate that rhetoric is capable of emulating pictorial styles in a way that presupposes specialized art-historical knowledge, and that pictorialism can be the complex product as much of poetry and rhetoric as of painting and art-theoretical vocabulary

Social anxiety in first-episode psychosis: the role of childhood trauma and adult attachment

Background: Social anxiety is among the most prevalent affective disturbances among people with psychosis. The developmental pathways associated with its emergence in psychosis, however, remain unclear. The aim of this study is to identify the developmental risk factors associated with social anxiety disorder in first-episode psychosis and to investigate whether social anxiety in psychosis and nonpsychosis is associated with similar or different adult attachment styles. Method: This is a cross-sectional study. A sample of individuals with social anxiety disorder (with or without psychosis) was compared with a sample with psychosis only and healthy controls on childhood trauma, dysfunctional parenting and adult attachment. Results: Childhood trauma and dysfunctional parenting (po0.05) were significantly elevated in people with social anxiety (with or without psychosis) compared to those with psychosis only and healthy controls. There were no differences in childhood trauma and dysfunctional parenting between socially anxious people with and without psychosis. Higher levels of insecure adult attachment (x2₁=38.5, p<0.01) were reported in the social anxiety group (with or without psychosis) compared to the psychosis only and healthy controls. Childhood adversities were not associated with insecure adult attachment in people with social anxiety (with or without psychosis). Limitations: Due to the cross-sectional nature of the study we cannot infer causal relationships between early risk factors, including childhood trauma and dysfunctional parenting, and social anxiety. Also, the use of self-report measures of attachment could be subject to biases. Conclusion: Shared developmental risk factors are implicated in the emergence of affective disorders in psychosis and non-psychosis. Social anxiety in psychosis is associated with insecurity in adult attachments which does not arise a result of adverse developmental pathways. Understanding the bio-psycho-social risk factors for affective dysregulation in psychosis could inform psychological interventions about the role of developmental anomaly and trauma in the emergence of affective dysregulation in psychosis

Using trained dogs and organic semi-conducting sensors to identify asymptomatic and mild SARS-CoV-2 infections: an observational study

BACKGROUND: A rapid, accurate, non-invasive diagnostic screen is needed to identify people with SARS-CoV-2 infection. We investigated whether organic semi-conducting (OSC) sensors and trained dogs could distinguish between people infected with asymptomatic or mild symptoms, and uninfected individuals, and the impact of screening at ports-of-entry. METHODS: Odour samples were collected from adults, and SARS-CoV-2 infection status confirmed using RT-PCR. OSC sensors captured the volatile organic compound (VOC) profile of odour samples. Trained dogs were tested in a double-blind trial to determine their ability to detect differences in VOCs between infected and uninfected individuals, with sensitivity and specificity as the primary outcome. Mathematical modelling was used to investigate the impact of bio-detection dogs for screening. RESULTS: About, 3921 adults were enrolled in the study and odour samples collected from 1097 SARS-CoV-2 infected and 2031 uninfected individuals. OSC sensors were able to distinguish between SARS-CoV-2 infected individuals and uninfected, with sensitivity from 98% (95% CI 95–100) to 100% and specificity from 99% (95% CI 97–100) to 100%. Six dogs were able to distinguish between samples with sensitivity ranging from 82% (95% CI 76–87) to 94% (95% CI 89–98) and specificity ranging from 76% (95% CI 70–82) to 92% (95% CI 88–96). Mathematical modelling suggests that dog screening plus a confirmatory PCR test could detect up to 89% of SARS-CoV-2 infections, averting up to 2.2 times as much transmission compared to isolation of symptomatic individuals only. CONCLUSIONS: People infected with SARS-CoV-2, with asymptomatic or mild symptoms, have a distinct odour that can be identified by sensors and trained dogs with a high degree of accuracy. Odour-based diagnostics using sensors and/or dogs may prove a rapid and effective tool for screening large numbers of people. Trial Registration NCT04509713 (clinicaltrials.gov)

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease