The challenges and opportunities of addressing particle size effects in sediment source fingerprinting: A review

publisher: Elsevier articletitle: The challenges and opportunities of addressing particle size effects in sediment source fingerprinting: A review journaltitle: Earth-Science Reviews articlelink: http://dx.doi.org/10.1016/j.earscirev.2017.04.009 content_type: article copyright: © 2017 Elsevier B.V. All rights reserved

Maladie d'Alzheimer et profil normal des biomarqueurs du liquide céphalo-rachidien

LILLE2-BU Santé-Recherche (593502101) / SudocSudocFranceF

Mycotoxines dans l'alimentation (évaluation et gestion du risque sanitaire pour l'homme et son environnement)

LILLE2-BU Santé-Recherche (593502101) / SudocSudocFranceF

Copper-Catalyzed Silylcupration of Activated Alkynes

A highly efficient catalytic silylcupration of activated alkynes is reported. Upon reaction with silylboronates and methanol in THF at room temperature in the presence of copper(I) fluoride tris(triphenylphosphine), a range of ynamides and propiolates were found to undergo a smooth silylcupration. This reaction, which tolerates various functional groups, affords a straightforward and efficient entry to the corresponding beta-silyl- enamides and acrylates which were formed with high levels of regio- and stereo- selectivities.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Cu-I/Pd-0 cooperative dual catalysis : tunable stereoselective construction of tetra-substituted alkenes

This paper describes a tunable and stereoselective dual catalytic system that uses copper and palladium reagents. This cooperative silylcupration and palladium-catalyzed allylation readily affords trisubstituted alkenylsilanes. Fine-tuning the reaction conditions allows selective access to one stereoisomer over the other. This new methodology tolerates different substituents on both coupling partners with high levels of stereoselectivity. The one-pot reaction involving a Cu-I/Pd-0 cooperative dual catalyst directly addresses the need to develop more time-efficient and less-wasteful synthetic pathways

Collective migration during a gap closure in a two-dimensional haptotactic model

The ability of cells to respond to substrate-bound protein gradients is crucial for many physiological processes, such as immune response, neurogenesis and cancer cell migration. However, the difficulty to produce well-controlled protein gradients has long been a limitation to our understanding of collective cell migration in response to haptotaxis. Here we use a photopatterning technique to create circular, square and linear fibronectin (FN) gradients on two-dimensional (2D) culture substrates. We observed that epithelial cells spread preferentially on zones of higher FN density, creating rounded or elongated gaps within epithelial tissues over circular or linear FN gradients, respectively. Using time-lapse experiments, we demonstrated that the gap closure mechanism in a 2D haptotaxis model requires a significant increase of the leader cell area. In addition, we found that gap closures are slower on decreasing FN densities than on homogenous FN-coated substrate and that fresh closed gaps are characterized by a lower cell density. Interestingly, our results showed that cell proliferation increases in the closed gap region after maturation to restore the cell density, but that cell–cell adhesive junctions remain weaker in scarred epithelial zones. Taken together, our findings provide a better understanding of the wound healing process over protein gradients, which are reminiscent of haptotaxis

Plasma soluble ST2 receptor is increased in human alcoholic liver disease and correlates with the pronostic index in alcoholic hepatitis

info:eu-repo/semantics/publishe