Image Guided Reconstruction of Un-sampled Data: A Filling Technique for Cultural Heritage Models

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On the Complete Non-Malleability of the Fujisaki-Okamoto Transform

The Fujisaki-Okamoto (FO) transform (CRYPTO 1999 and JoC 2013) turns any weakly (i.e., IND-CPA) secure public-key encryption (PKE) scheme into a strongly (i.e., IND-CCA) secure key encapsulation method (KEM) in the random oracle model (ROM). Recently, the FO transform re-gained momentum as part of CRISTAL-Kyber, selected by the NIST as the PKE winner of the post-quantum cryptography standardization project. Following Fischlin (ICALP 2005), we study the complete non-malleability of KEMs obtained via the FO transform. Intuitively, a KEM is completely non-malleable if no adversary can maul a given public key and ciphertext into a new public key and ciphertext encapsulating a related key for the underlying blockcipher. On the negative side, we find that KEMs derived via FO are not completely non-malleable in general. On the positive side, we show that complete non-malleability holds in the ROM by assuming the underlying PKE scheme meets an additional property, or by a slight tweak of the transformation

Bacterial Endophytes Contribute to Rice Seedling Establishment Under Submergence

Flooding events caused by severe rains and poor soil drainage can interfere with plant germination and seedling establishment. Rice is one of the cereal crops that has unique germination strategies under flooding. One of these strategies is based on the fast coleoptile elongation in order to reach the water surface and re-establish the contact with the air. Microorganisms can contribute to plant health via plant growth promoters and provide protection from abiotic stresses. To characterise the community composition of the microbiome in rice germination under submergence, a 16S rRNA gene profiling metagenomic analysis was performed of temperate japonica rice varieties Arborio and Lamone seedlings, which showed contrasting responses in terms of coleoptile length when submerged. This analysis showed a distinct microbiota composition of Arborio seeds under submergence, which are characterised by the development of a long coleoptile. To examine the potential function of microbial communities under submergence, culturable bacteria were isolated, identified and tested for plant growth-promoting activities. A subgroup of isolated bacteria showed the capacity to hydrolyse starch and produce indole-related compounds under hypoxia. Selected bacteria were inoculated in seeds to evaluate their effect on rice under submergence, showing a response that is dependent on the rice genotype. Our findings suggest that endophytic bacteria possess plant growth-promoting activities that can substantially contribute to rice seedling establishment under submergence

Curcumin-Based β-Diketo Ligands for Ga3+: Thermodynamic Investigation of Potential Metal-Based Drugs

Curcumin is known for its therapeutic properties; among these, antioxidant, anti-inflammatory and anti-cancer ones stand out. Besides, curcumin metal complexes have shown widespread application in medicine and can be exploited as lead structures for developing metal-based drugs. Unfortunately, curcumin is poorly bioavailable, mainly due to its instability in physiological conditions; this weakness is tightly connected to the presence of the β-diketo moiety undergoing tautomeric equilibrium. Stability and metal-chelating ability can be tuned by modulating the electronic effects and steric hindrance close to the β-diketo moiety; in addition, formation of a metal complex shifts the tautomeric equilibrium towards the β-keto–enol form and increases stability in biological media. Among the metals used in clinical therapy, gallium nitrate has shown to have significant antitumor activity against non-Hodgkin lymphoma and bladder cancer, thus indicating that gallium-based drugs have potential for further development as antineoplastic agents with improved therapeutic activity. Curcuminoids have demonstrated high affinity for gallium(III), allowing the formation of stable positively charged M:L 1:2 β-diketonate complexes that benefit from the therapeutic activity of both the metal and the ligand. Seven new curcumin derivatives were synthesized and completely characterized. The new derivatives retain the solvent-dependent keto–enol tautomerism, with the prevalence of the diketo form in aqueous solution. Enhanced stability in simulated physiological conditions was observed in comparison to the lead compound curcumin. The presence of Ga3+ anticipates the dissociation of the enolic proton, allowing chelate complex formation, and simultaneously it shifts the tautomeric equilibrium towards the keto–enol form. A complete 1H/13C NMR and UV–Vis study was performed to define the metal-to-ligand stoichiometry ratio and the overall stability constants. In addition, we demonstrated that some of the derivatives have increased antiproliferative activity on colon cancer cells compared to curcumin and antioxidant properties. On the whole, the synthesized curcumin-based molecules may act as new gallium(III) chelators with improved stability with respect to curcumin and could open interesting perspectives for the development of novel therapeutic agents for cancer

Plasmon-enhanced circular dichroism spectroscopy of chiral drug solutions

We investigate the potential of surface plasmon polaritons at noble metal interfaces for surface-enhanced chiroptical sensing of dilute chiral drug solutions with nano-litre volume. The high quality factor of surface plasmon resonances in both Otto and Kretschmann configurations enables the enhancement of circular dichroism thanks to the large near-field intensity of such plasmonic excitations. Furthermore, the subwavelength confinement of surface plasmon polaritons is key to attain chiroptical sensitivity to small amounts of drug volumes placed around $\simeq$ 100 nm by the metal surface. Our calculations focus on reparixin, a pharmaceutical molecule currently used in clinical studies for patients with community-acquired pneumonia, including COVID-19 and acute respiratory distress syndrome. Considering realistic dilute solutions of reparixin dissolved in water with concentration $\leq$ 5 mg/ml and nl volume, we find a circular-dichroism differential absorption enhancement factor of the order $\simeq$ 20 and chirality-induced polarization distortion upon surface plasmon polariton excitation. Our results are relevant for the development of innovative chiroptical sensors capable of measuring the enantiomeric imbalance of chiral drug solutions with nl volume

Anestesia locale computerizzata con il sistema Wand®STA®. Valutazione dell’efficacia nella terapia estrattiva dei terzi molari e della percezione dolorosa evocata in fase iniettiva

Il dolore percepito durante l’iniezione intraorale rappresenta la causa principale di ansia per molti pazienti che devono sottoporsi alle cure odontoiatriche. Lo studio presentato valuta la percezione del dolore e l’efficacia della metodica anestetica a flusso controllato con il dispositivo Wand® STA® in 50 pazienti sottoposti a terapia estrattiva di terzo molare. I pazienti riferiscono, attraverso la compilazione di questionari comprendenti la scala VAS (Scala Visuo-Analogica) e la scala MDAS (Modified Dental Anxiety Scale), una netta riduzione del dolore e dell’ansia in relazione alla metodica di erogazione (computerizzata rispetto a quella tradizionale), evidente soprattutto in soggetti con uno stato d’ansia basale maggiore. Il protocollo ha evidenziato l’efficacia di questa metodica anestetica pari al 90%, in una delle procedure di chirurgia orale più comuni e complesse in odontoiatria, che richiedono un effetto anestetico completo

“Officina degli Errori”: A Tinkering Experience in an Informal Environment

Since 2012 we have been working together with teachers to design, promote and deliver hands-on, self-directed and playful activities to engage children with STEM. The most powerful method we used is tinkering, which is a holistic way to engage people with STEM disciplines mixing them with art and combining hi-tech material with low-tech and recycled material. Knowledge is not simply transmitted from teacher to learner, but actively constructed by the mind (and the hands) of the learner. Constructionism (Papert 1980) suggested that learners are more likely to develop new insights and understandings while actively engaged in making an external artifact. This method supports the construction of knowledge within the context of building personally meaningful artifacts, and the more self-directed the work is the more meaningful the learning becomes. From 2014 we proposed to the pupils of our local community several workshops based on the activities originally developed by the Tinkering Studio. Our labs are now mature and ready to be brought in a larger arena. For this reason, in the past months (Oct-Dec 2017) we brought tinkering into the Museo del Patrimonio Industriale under the name of “Officina degli Errori”, a set of 4 tinkering activities in this informal environment. We engaged a group of 20 kids, from 6 to 12 years old, during 4 workshops held on Saturday afternoon in the conference area of the museum. We expect this successful test will open a new branch of activities in this museum that is already offering lessons and experiences to the pupils in the Bologna area. These experiences are democratically free of charge. Our idea is to offer a tinkering lab and a learning opportunity to the pupils, a fruitful form of training to the teachers and some guidance in the collection of materials

Recurrent radio outbursts at the center of the NGC1407 galaxy group

We present deep Giant Metrewave Radio Telescope (GMRT) radio observations at 240, 330 and 610 MHz of the complex radio source at the center of the NGC1407 galaxy group. Previous GMRT observations at 240 MHz revealed faint, diffuse emission enclosing the central twin-jet radio galaxy. This has been interpreted as an indication of two possible radio outbursts occurring at different times. Both the inner double and diffuse component are detected in the new GMRT images at high levels of significance. Combining the GMRT observations with archival Very Large Array data at 1.4 and 4.9 GHz, we derive the total spectrum of both components. The inner double has a spectral index \alpha=0.7, typical for active, extended radio galaxies, whereas the spectrum of the large-scale emission is very steep, with \alpha=1.8 between 240 MHz and 1.4 GHz. The radiative age of the large-scale component is very long, ~300 Myr, compared to ~30 Myr estimated for the central double, confirming that the diffuse component was generated during a former cycle of activity of the central galaxy. The current activity have so far released an energy which is nearly one order of magnitude lower than that associated with the former outburst. The group X-ray emission in the Chandra and XMM-Newton images and extended radio emission show a similar swept-back morphology. We speculate that the two structures are both affected by the motion of the group core, perhaps due to the core sloshing in response to a recent encounter with the nearby elliptical galaxy NGC1400.Comment: 15 pages, 12 figures and 5 tables. Accepted for publication in Ap

Parsec-scale Properties of Brightest Cluster Galaxies

We present new VLBI observations at 5 GHz of a complete sample of Brightest Cluster Galaxies (BCGs) in nearby Abell Clusters (distance class <3). Combined with data from the literature, this provides parsec-scale information for 34 BCGs. Our analysis of their parsec scale radio emission and cluster X-ray properties shows a possible dichotomy between BCGs in cool core clusters and those in non cool core clusters. Among resolved sources, those in cool core clusters tend to have two-sided parsec-scale jets, while those in less relaxed clusters have predominantly one-sided parsec-scale jets. We suggest that this difference could be the result of interplay between the jets and the surrounding medium. The one-sided structure in non cool core clusters could be due to Doppler boosting effects in relativistic, intrinsically symmetric jets; two-sided morphology in cool core clusters is likely related to the presence of heavy and mildly relativistic jets slowed down on the parsec-scale. Evidence of recurrent activity are also found in BCGs in cool core clusters.Comment: 20 pages, 10 figures, accepted for publication in A&

Radio multifrequency observations of Abell 781 with the WSRT

The Main galaxy cluster in the Abell 781 system is undergoing a significant merger and accretion process with peripheral emission to the north and south-eastern flanks of the merging structure. Here we present a full polarimetric study of this field, using radio interferometric data taken at 21 and 92 cm with the Westerbork Synthesis Radio Telescope (WSRT), to a sensitivity better than any 21 cm (L band) observation to date. We detect evidence of extended low-level emission of 1.9 mJy associated with the Main cluster at 21 cm, although this detection necessitates further follow-up by modern instruments due to the limited resolution of the WSRT. Our polarimetric study indicates that, most likely, the peripheral emission associated with this cluster is not a radio relic