Improved Performance of DNA Microarray Multiplex Hybridization Using Probes Anchored at Several Points by Thiol-Ene or Thiol-Yne Coupling Chemistry

[EN] Nucleic acid microarray-based assay technology has shown lacks in reproducibility, reliability, and analytical sensitivity. Here, a new strategy of probe attachment modes for silicon-based materials is built up. Thus, hybridization ability is enhanced by combining thiol-ene or thiol-yne click chemistry reactions with a multipoint attachment of polythiolated probes. The viability and performance of this approach was demonstrated by specifically determining Salmonella PCR products up to a 20 pM sensitivity level.The authors thank Dr. Elena Pinilla for her helpful discussion about AFM results. This work was funded by EU’s program Horizon 2020 ICT-26-2014-644242, Spanish Ministry MINECO CTQ/2013/45875-R FEDER, and local administration GVA PROMETEO II 2014/40. The authors acknowledge Luis Tortajada-Genaro and Regina Niñoles Rodenes for kindly providing the Salmonella and Campylobacter PCR products. F.M. is member of Inserm.Bañuls Polo, M.; Jimenez-Meneses, P.; Meyer, A.; Vasseur, J.; Morvan, F.; Escorihuela Fuentes, J.; Puchades, R.... (2017). Improved Performance of DNA Microarray Multiplex Hybridization Using Probes Anchored at Several Points by Thiol-Ene or Thiol-Yne Coupling Chemistry. Bioconjugate Chemistry. 28(2):496-506. https://doi.org/10.1021/acs.bioconjchem.6b00624S49650628

Associative algebraic approach to logarithmic CFT in the bulk: the continuum limit of the gl(1|1) periodic spin chain, Howe duality and the interchiral algebra

We develop in this paper the principles of an associative algebraic approach to bulk logarithmic conformal field theories (LCFTs). We concentrate on the closed $gl(1|1)$ spin-chain and its continuum limit - the $c=-2$ symplectic fermions theory - and rely on two technical companion papers, "Continuum limit and symmetries of the periodic gl(1|1) spin chain" [Nucl. Phys. B 871 (2013) 245-288] and "Bimodule structure in the periodic gl(1|1) spin chain" [Nucl. Phys. B 871 (2013) 289-329]. Our main result is that the algebra of local Hamiltonians, the Jones-Temperley-Lieb algebra JTL_N, goes over in the continuum limit to a bigger algebra than the product of the left and right Virasoro algebras. This algebra, S - which we call interchiral, mixes the left and right moving sectors, and is generated, in the symplectic fermions case, by the additional field $S(z,\bar{z})=S_{ab}\psi^a(z)\bar{\psi}^b(\bar{z})$, with a symmetric form $S_{ab}$ and conformal weights (1,1). We discuss in details how the Hilbert space of the LCFT decomposes onto representations of this algebra, and how this decomposition is related with properties of the finite spin-chain. We show that there is a complete correspondence between algebraic properties of finite periodic spin chains and the continuum limit. An important technical aspect of our analysis involves the fundamental new observation that the action of JTL_N in the $gl(1|1)$ spin chain is in fact isomorphic to an enveloping algebra of a certain Lie algebra, itself a non semi-simple version of $sp(N-2)$. The semi-simple part of JTL_N is represented by $Usp(N-2)$, providing a beautiful example of a classical Howe duality, for which we have a non semi-simple version in the full JTL image represented in the spin-chain. On the continuum side, simple modules over the interchiral algebra S are identified with "fundamental" representations of $sp(\infty)$.Comment: 69 pp., 10 figs, v2: the paper has been substantially modified - new proofs, new refs, new App C with inductive limits construction, et

Weak-strong uniqueness of dissipative measure-valued solutions for polyconvex elastodynamics

For the equations of elastodynamics with polyconvex stored energy, and some related simpler systems, we define a notion of dissipative measure-valued solution and show that such a solution agrees with a classical solution with the same initial data when such a classical solution exists. As an application of the method we give a short proof of strong convergence in the continuum limit of a lattice approximation of one dimensional elastodynamics in the presence of a classical solution. Also, for a system of conservation laws endowed with a positive and convex entropy, we show that dissipative measure-valued solutions attain their initial data in a strong sense after time averaging

Production and Decay of D_1(2420)^0 and D_2^*(2460)^0

We have investigated $D^{+}\pi^{-}$ and $D^{*+}\pi^{-}$ final states and observed the two established $L=1$ charmed mesons, the $D_1(2420)^0$ with mass $2421^{+1+2}_{-2-2}$ MeV/c$^{2}$ and width $20^{+6+3}_{-5-3}$ MeV/c$^{2}$ and the $D_2^*(2460)^0$ with mass $2465 \pm 3 \pm 3$ MeV/c$^{2}$ and width $28^{+8+6}_{-7-6}$ MeV/c$^{2}$. Properties of these final states, including their decay angular distributions and spin-parity assignments, have been studied. We identify these two mesons as the $j_{light}=3/2$ doublet predicted by HQET. We also obtain constraints on {\footnotesize $\Gamma_S/(\Gamma_S + \Gamma_D)$} as a function of the cosine of the relative phase of the two amplitudes in the $D_1(2420)^0$ decay.Comment: 15 pages in REVTEX format. hardcopies with figures can be obtained by sending mail to: [email protected]

Time-integrated luminosity recorded by the BABAR detector at the PEP-II e+e- collider

This article is the Preprint version of the final published artcile which can be accessed at the link below.We describe a measurement of the time-integrated luminosity of the data collected by the BABAR experiment at the PEP-II asymmetric-energy e+e- collider at the ϒ(4S), ϒ(3S), and ϒ(2S) resonances and in a continuum region below each resonance. We measure the time-integrated luminosity by counting e+e-→e+e- and (for the ϒ(4S) only) e+e-→μ+μ- candidate events, allowing additional photons in the final state. We use data-corrected simulation to determine the cross-sections and reconstruction efficiencies for these processes, as well as the major backgrounds. Due to the large cross-sections of e+e-→e+e- and e+e-→μ+μ-, the statistical uncertainties of the measurement are substantially smaller than the systematic uncertainties. The dominant systematic uncertainties are due to observed differences between data and simulation, as well as uncertainties on the cross-sections. For data collected on the ϒ(3S) and ϒ(2S) resonances, an additional uncertainty arises due to ϒ→e+e-X background. For data collected off the ϒ resonances, we estimate an additional uncertainty due to time dependent efficiency variations, which can affect the short off-resonance runs. The relative uncertainties on the luminosities of the on-resonance (off-resonance) samples are 0.43% (0.43%) for the ϒ(4S), 0.58% (0.72%) for the ϒ(3S), and 0.68% (0.88%) for the ϒ(2S).This work is supported by the US Department of Energy and National Science Foundation, the Natural Sciences and Engineering Research Council (Canada), the Commissariat à l’Energie Atomique and Institut National de Physique Nucléaire et de Physiquedes Particules (France), the Bundesministerium für Bildung und Forschung and Deutsche Forschungsgemeinschaft (Germany), the Istituto Nazionale di Fisica Nucleare (Italy), the Foundation for Fundamental Research on Matter (The Netherlands), the Research Council of Norway, the Ministry of Education and Science of the Russian Federation, Ministerio de Ciencia e Innovación (Spain), and the Science and Technology Facilities Council (United Kingdom). Individuals have received support from the Marie-Curie IEF program (European Union) and the A.P. Sloan Foundation (USA)

Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events

The $B^0$-$\bar B^0$ oscillation frequency has been measured with a sample of 23 million \B\bar B pairs collected with the BABAR detector at the PEP-II asymmetric B Factory at SLAC. In this sample, we select events in which both B mesons decay semileptonically and use the charge of the leptons to identify the flavor of each B meson. A simultaneous fit to the decay time difference distributions for opposite- and same-sign dilepton events gives $\Delta m_d = 0.493 \pm 0.012{(stat)}\pm 0.009{(syst)}$ ps$^{-1}$.Comment: 7 pages, 1 figure, submitted to Physical Review Letter

Observation of the baryonic decay B \uaf 0 \u2192 \u39bc+ p \uaf K-K+

We report the observation of the baryonic decay B\uaf0\u2192\u39bc+p\uafK-K+ using a data sample of 471 7106 BB\uaf pairs produced in e+e- annihilations at s=10.58GeV. This data sample was recorded with the BABAR detector at the PEP-II storage ring at SLAC. We find B(B\uaf0\u2192\u39bc+p\uafK-K+)=(2.5\ub10.4(stat)\ub10.2(syst)\ub10.6B(\u39bc+)) 710-5, where the uncertainties are statistical, systematic, and due to the uncertainty of the \u39bc+\u2192pK-\u3c0+ branching fraction, respectively. The result has a significance corresponding to 5.0 standard deviations, including all uncertainties. For the resonant decay B\uaf0\u2192\u39bc+p\uaf\u3c6, we determine the upper limit B(B\uaf0\u2192\u39bc+p\uaf\u3c6)<1.2 710-5 at 90% confidence level