Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Factores asociados al fatalismo ante la COVID-19 en 20 ciudades del Perú en marzo 2020

Introduction: The COVID-19 pandemic has generated diverse reactions, but these have not yet been measured in the Latin American population.Objective: To determine the factors associated with the perception of fatalism in the face of COVID-19 infection in inhabitants of 20 cities in Peru.Material and Methods: A cross-sectional, multicenter study with a sample size of 2 466 people from 20 cities of Peru that measured fatalism during the COVID-19 pandemic was conducted through a validated survey (Cronbach´s alpha: 0,78) consisting of 7 items. Statistical analysis was conducted in terms of each city, and p < 0,05 was considered significant.Results: Of the 2 466 respondents, 36 % were depressed, 26 % thought that they might die, 17 % say that this was evidence of the end of the world, and 9 % could make a fatal decision. Women were more likely to engage in three of the fatalistic behaviors (becoming infected, p = 0,020; infecting others, p = 0,004, and becoming depressed, p = 0,020). At an older age there were 5 perceptions (infecting others, p = 0,007; becoming complicated, p < 0,001; becoming depressed, p < 0,001, thinking they would die, p < 0,001; or committing suicide, p = 0,014). Those at risk of complications of COVID-19 had 4 perceptions (infecting others, p = 0,024; becoming complicated, p = 0,002; thinking they would die, p < 0,001; and thinking that this is a sign of the end of the world, p = 0,039). Respondents who were agnostic exhibited a lower frequency in 5 perceptions, while atheist respondents showed a lower frequency in 2 perceptions.Conclusion: Many fatalistic ideas are found among the population in the face of the coronavirus pandemic.Introducción: la pandemia del COVID-19 ha generado reacciones diversas, pero estas aún no han sido medidas en la población latinoamericana.Objetivo: determinar los factores asociados a la percepción de fatalismo ante la infección del COVID-19 en pobladores de 20 departamentos del Perú. Material y Métodos: estudio transversal analítico, de tipo multicéntrico que con una muestra de 2466 personas en 20 departamentos del Perú midió el fatalismo ante la pandemia del COVID – 19 a través de una encuesta validada (Alpha Crombach: 0,78) que consistía en 7 ítems. El análisis estadístico fue realizado en función de cada ciudad y se consideró significativos p < 0,05.Resultados: de los 2466 encuestados, el 36 % se deprimirían, el 26 % piensa que podrían fallecer, el 17 % dice que esto es evidencia del fin del mundo y el 9 % podrían tomar una decisión fatal. Las mujeres tuvieron mayor frecuencia de 3 de las conductas fatalistas (contagiarse p=0,020; contagiar a otros p=0,004 y deprimirse p=0,020). A mayor edad hubo 5 percepciones (contagiar a otros p=0,007; complicarse p<0,001; deprimirse p<0,001, pensar que morirían p<0,001 o suicidarse p=0,014). Los que tenían un riesgo para complicación por COVID-19 tuvieron 4 percepciones (contagiar a otros p=0,024; complicarse p=0,002; pensar que morirían p<0,001 y que esto es señal del fin del mundo p=0,039). El ser agnóstico tuvo menor frecuencia de 5 percepciones, el ser ateo en 2.Conclusión: Se halló muchas ideas fatalistas entre la población ante la pandemia de coronavirus

Factors associated with fatalism in the face of COVID-19 in 20 Peruvian cities in March 2020

Introducción: La pandemia del COVID-19 ha generado reacciones diversas, pero estas aún no han sido medidas en la población latinoamericana. Objetivo: Determinar los factores asociados a la percepción de fatalismo ante la infección del COVID-19 en pobladores de 20 departamentos del Perú. Material y Métodos: Estudio transversal analítico, de tipo multicéntrico que con una muestra de 2466 personas en 20 departamentos del Perú midió el fatalismo ante la pandemia del COVID-19 a través de una encuesta validada (Alpha Crombach: 0,78) que consistía en 7 ítems. El análisis estadístico fue realizado en función de mundo y el 9 % podrían tomar una decisión fatal. Las mujeres tuvieron mayor frecuencia de 3 de las conductas fatalistas (contagiarse p=0,020; contagiar a otros p=0,004 y deprimirse p=0,020). A mayor edad hubo 5 percepciones (contagiar a otros p=0,007; complicarse p<0,001; deprimirse p<0,001, pensar que morirían p<0,001 o suicidarse p=0,014). Los que tenían un riesgo para complicación por COVID-19 tuvieron 4 percepciones (contagiar a otros p=0,024; complicarse p=0,002; pensar que morirían p<0,001 y que esto es señal del fin del mundo p=0,039). El ser agnóstico tuvo menor frecuencia de 5 percepciones, el ser ateo en 2. Conclusión: Se halló muchas ideas fatalistas entre la población ante la pandemia de coronavirus

Fear perception of the covid-19 pandemic in Peru

Introduction: Fear is a natural response to something unknown. In the current scenario, it is important to assess it in relation to the coronavirus disease-19 (COVID-19) pandemic in Latin American countries. Objective: To determine the fear perception according to factors associated with the COVID-19 pandemic in Peru. Methods: An analytical cross-sectional study was conducted based on a virtual questionnaire. The main question was “how much fear people had of COVID-19?”, using a scale from zero (without fear) to 10 (very fear). This scale was divided into tertiles, and the upper tertile was the reference category (compared to the middle and lower tertiles). Statistical significances between fear perception of COVID-19 and sociodemographic data were calculated. Results: A total of 3887 participants responded the questionnaire about fear perception. In the multivariate analysis was found that women (adjusted prevalence ratio (aPR): 1.37; 95% confidence interval (CI) : 1.26-1.48; p<0.001), people aged 20-29 (aPR: 1.84; 95% CI: 1.06-1.50; p=0.005), 30-39 (aPR: 1.53; 95% CI : 1.28-1.82; p<0.001), 50-59 (aPR: 1.43; 95% CI: 1.12-1.84; p=0.005), and with 60 or more years (aPR: 1.46; 95% CI: 1.03-2.07; p=0.032), as well as respondents who had some risk for complications due to COVID-19 (aPR: 1.49; 95% CI: 1.32-1.69; p<0.001) were very afraid of the disease. On the other hand, people affiliated with evangelical religions (aPR: 0.79; 95% CI: 0.65-0.96; p=0.018), agnostics (aPR: 0.80; 95% CI: 0.68-0.94; p=0.008), atheists (aPR: 0.67; 95% CI: 0.48-0.95; p=0.024), and health professionals (aPR: 0.81; 95% CI: 0.70-0.93; p=0.003) were less afraid of COVID-19. Conclusion: There was a notorious fear perception of the COVID-19 pandemic by the Peruvian population. In this context, the fear was associated with important variables. Thus, the provision of further emotional support services for this population should be considered in the face of the current pandemic