Thermal magnetic resonance: physics considerations and electromagnetic field simulations up to 23.5 Tesla (1GHz)

Background: Glioblastoma multiforme is the most common and most aggressive malign brain tumor. The 5-year survival rate after tumor resection and adjuvant chemoradiation is only 10 %, with almost all recurrences occurring in the initially treated site. Attempts to improve local control using a higher radiation dose were not successful so that alternative additive treatments are urgently needed. Given the strong rationale for hyperthermia as part of a multimodal treatment for patients with glioblastoma, non-invasive radio frequency (RF) hyperthermia might significantly improve treatment results. Methods: A non-invasive applicator was constructed utilizing the magnetic resonance (MR) spin excitation frequency for controlled RF hyperthermia and MR imaging in an integrated system, which we refer to as thermal MR. Applicator designs at RF frequencies 300 MHz, 500 MHz and 1GHz were investigated and examined for absolute applicable thermal dose and temperature hotspot size. Electromagnetic field (EMF) and temperature simulations were performed in human voxel models. RF heating experiments were conducted at 300 MHz and 500 MHz to characterize the applicator performance and validate the simulations. Results: The feasibility of thermal MR was demonstrated at 7.0 T. The temperature could be increased by ~11 °C in 3 min in the center of a head sized phantom. Modification of the RF phases allowed steering of a temperature hotspot to a deliberately selected location. RF heating was monitored using the integrated system for MR thermometry and high spatial resolution MRI. EMF and thermal simulations demonstrated that local RF hyperthermia using the integrated system is feasible to reach a maximum temperature in the center of the human brain of 46.8 °C after 3 min of RF heating while surface temperatures stayed below 41 °C. Using higher RF frequencies reduces the size of the temperature hotspot significantly. Conclusion: The opportunities and capabilities of thermal magnetic resonance for RF hyperthermia interventions of intracranial lesions are intriguing. Employing such systems as an alternative additive treatment for glioblastoma multiforme might be able to improve local control by "fighting fire with fire". Interventions are not limited to the human brain and might include temperature driven targeted drug and MR contrast agent delivery and help to understand temperature dependent bio- and physiological processes in-vivo

Molecular Gas in NUclei of GAlaxies (NUGA) XIV. The barred LINER/Seyfert 2 galaxy NGC 3627

We present CO(1-0) and CO(2-1) maps of the interacting barred LINER/Seyfert 2 galaxy NGC 3627 obtained with the IRAM interferometer at resolutions of 2.1" x 1.3" and 0.9" x 0.6", respectively. The molecular gas emission shows a nuclear peak, an elongated bar-like structure of ~18" (~900 pc) diameter in both CO maps and, in CO(1-0), a two-arm spiral feature from r~9" (~450 pc) to r~16" (~800 pc). The inner ~18" bar-like structure, with a north/south orientation (PA = 14{\deg}), forms two peaks at the extremes of this elongated emission region. The kinematics of the inner molecular gas shows signatures of non-circular motions associated both with the 18" bar-like structure and the spiral feature detected beyond it. The 1.6 micron H-band 2MASS image of NGC 3627 shows a stellar bar with a PA = -21{\deg}, different from the PA (= 14{\deg}) of the CO bar-like structure, indicating that the gas is leading the stellar bar. The torques computed with the HST-NICMOS F160W image and our PdBI maps are negative down to the resolution limit of our images, ~60 pc in CO(2-1). If the bar ends at ~3 kpc, coincident with corotation (CR), the torques are negative between the CR of the bar and the nucleus, down to the resolution limit of our observations. This scenario is compatible with a recently-formed rapidly rotating bar which has had insufficient time to slow down because of secular evolution, and thus has not yet formed an inner Lindblad resonance (ILR). The presence of molecular gas inside the CR of the primary bar, where we expect that the ILR will form, makes NGC 3627 a potential smoking gun of inner gas inflow. The gas is fueling the central region, and in a second step could fuel directly the active nucleus.Comment: 24 pages, 28 figures, 2 tables. Accepted for publication in Astronomy and Astrophysic

Cinema-going trajectories in the digital age

The activity of cinema-going constantly evolves and gradually integrates the use of digital data and platforms to become more engaging for the audiences. Combining methods from the fields of Human Computer Interaction and Film Studies, we conducted two workshops seeking to understand cinema audiences’ digital practices and explore how the contemporary cinema-going experience is shaped in the digital age. Our findings suggest that going to the movies constitutes a trajectory during which cinemagoers interact with multiple digital platforms. At the same time, depending on their choices, they construct unique digital identities that represent a set of online behaviours and rituals that cinemagoers adopt before, while and after cinema-going. To inform the design of new, engaging cinemagoing experiences, this research establishes a preliminary map of contemporary cinema-going including digital data and platforms. We then discuss how audiences perceive the potential improvement of the experience and how that would lead to the construction of digital identities

Improving communication in urban planning using TOPIC-COHESIE

Decision making in spatial planning often takes place in a complex and illdefined context. It includes a large number of actors, factors and -often uncertain- relations. Each of the actors or stakeholders has his or her individual perceptions, values and priorities. This paper presents the TOPIC system, which aims to support this process by interactively collecting and managing the information in a participatory stakeholder process. We focus on a specific version of TOPIC - named COHESIE - which includes functionality for qualitative, participatory modelling. By representing actor perspectives in an explicit and transparent way, the modelling process facilitates the discussion and improves the communication between the different parties. This paper will illustrate the use of TOPIC-COHESIE with a practical example related to urban planning in the Netherlands. The participants of the case study have evaluated TOPIC-COHESIE a useful tool for early stakeholder involvement, and obtaining a more integrated plan

Schaeden an Hochbauten durch Luftverschmutzung Querschnittsbericht zum Stand der Erkenntnisse. Abschlussbericht

TIB: RN 5973 (2010) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Gebaeudeschaeden durch Luftverschmutzung Querschnittsbericht zum Stand der Erkenntnisse

Copy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman