Sub-arcsec imaging of the AB Aur molecular disk and envelope at millimeter wavelengths: a non Keplerian disk

We present sub-arcsecond images of AB Auriga obtained with the IRAM Plateau de Bure interferometer in the isotopologues of CO, and in continuum at 3 and 1.3 mm. Instead of being centrally peaked, the continuum emission is dominated by a bright, asymmetric (spiral-like) feature at about 140 AU from the central star. The large scale molecular structure suggests the AB Aur disk is inclined between 23 and 43 degrees, but the strong asymmetry of the continuum and molecular emission prevents an accurate determination of the inclination of the inner parts. We find significant non-Keplerian motion, with a best fit exponent for the rotation velocity law of 0.41 +/- 0.01, but no evidence for radial motions. The disk has an inner hole about 70 AU in radius. The disk is warm and shows no evidence of depletion of CO. The dust properties suggest the dust is less evolved than in typical T Tauri disks. Both the spiral-like feature and the departure from purely Keplerian motions indicates the AB Aur disk is not in quasi-equilibrium. Disk self-gravity is insufficient to create the perturbation. This behavior may be related either to an early phase of star formation in which the Keplerian regime is not yet fully established and/or to a disturbance of yet unknown origin. An alternate, but unproven, possibility is that of a low mass companion located about 40 AU from AB Aur.Comment: 10 pages, 5 figures, accepted for publication in Astronomy & Astrophysic

Astrochemical models of interstellar ices: History matters

Ice is ubiquitous in the interstellar medium. We model the formation of the main constituents of interstellar ices, including H2O, CO2 , CO, and CH3 OH. We strive to understand what physical or chemical parameters influence the final composition of the ice and how they benchmark to what has already been observed, with the aim of applying these models to the preparation and analysis of JWST observations. We used the Nautilus gas-grain model, which computes the gas and ice composition as a function of time for a set of physical conditions, starting from an initial gas phase composition. All important processes (gas-phase reactions, gas-grain interactions, and grain surface processes) are included and solved with the rate equation approximation. We first ran an astrochemical code for fixed conditions of temperature and density mapped in the cold core L429-C to benchmark the chemistry. One key parameter was revealed to be the dust temperature. When the dust temperature is higher than 12 K, CO2 will form efficiently at the expense of H2O, while at temperatures below 12 K, it will not form. Whatever hypothesis we assumed for the chemistry (within realistic conditions), the static simulations failed to reproduce the observed trends of interstellar ices in our target core. In a second step, we simulated the chemical evolution of parcels of gas undergoing different physical and chemical situations throughout the molecular cloud evolution and starting a few 1e7 yr prior to the core formation (dynamical simulations). Our dynamical simulations satisfactorily reproduce the main trends already observed for interstellar ices. Moreover, we predict that the apparent constant ratio of CO2/H2O observed to date is probably not true for regions of low AV , and that the history of the evolution of clouds plays an essential role, even prior to their formation.Comment: Accepted for publication in A&

NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans

10.1038/s41598-017-09177-2Scientific Reports71885

Random volumes from matrices

We propose a class of models which generate three-dimensional random volumes, where each configuration consists of triangles glued together along multiple hinges. The models have matrices as the dynamical variables and are characterized by semisimple associative algebras A. Although most of the diagrams represent configurations which are not manifolds, we show that the set of possible diagrams can be drastically reduced such that only (and all of the) three-dimensional manifolds with tetrahedral decompositions appear, by introducing a color structure and taking an appropriate large N limit. We examine the analytic properties when A is a matrix ring or a group ring, and show that the models with matrix ring have a novel strong-weak duality which interchanges the roles of triangles and hinges. We also give a brief comment on the relationship of our models with the colored tensor models.Comment: 33 pages, 31 figures. Typos correcte

Transient heterogeneity in extracellular protease production by Bacillus subtilis

The most sophisticated survival strategy Bacillus subtilis employs is the differentiation of a subpopulation of cells into highly resistant endospores. To examine the expression patterns of non-sporulating cells within heterogeneous populations, we used buoyant density centrifugation to separate vegetative cells from endospore-containing cells and compared the transcriptome profiles of both subpopulations. This demonstrated the differential expression of various regulons. Subsequent single-cell analyses using promoter-gfp fusions confirmed our microarray results. Surprisingly, only part of the vegetative subpopulation highly and transiently expresses genes encoding the extracellular proteases Bpr (bacillopeptidase) and AprE (subtilisin), both of which are under the control of the DegU transcriptional regulator. As these proteases and their degradation products freely diffuse within the liquid growth medium, all cells within the clonal population are expected to benefit from their activities, suggesting that B. subtilis employs cooperative or even altruistic behavior. To unravel the mechanisms by which protease production heterogeneity within the non-sporulating subpopulation is established, we performed a series of genetic experiments combined with mathematical modeling. Simulations with our model yield valuable insights into how population heterogeneity may arise by the relatively long and variable response times within the DegU autoactivating pathway

Chemistry in Disks. II. -- Poor molecular content of the AB Aur disk

We study the molecular content and chemistry of a circumstellar disk surrounding the Herbig Ae star AB Aur at (sub-)millimeter wavelengths. Our aim is to reconstruct the chemical history and composition of the AB Aur disk and to compare it with disks around low-mass, cooler T Tauri stars. We observe the AB Aur disk with the IRAM Plateau de Bure Interferometer in the C- and D- configurations in rotational lines of CS, HCN, C2H, CH3OH, HCO+, and CO isotopes. Using an iterative minimization technique, observed columns densities and abundances are derived. These values are further compared with results of an advanced chemical model that is based on a steady-state flared disk structure with a vertical temperature gradient, and gas-grain chemical network with surface reactions. We firmly detect HCO+ in the 1--0 transition, tentatively detect HCN, and do not detect CS, C2H, and CH3OH. The observed HCO+ and 13CO column densities as well as the upper limits to the column densities of HCN, CS, C2H, and CH3OH are in good agreement with modeling results and those from previous studies. The AB Aur disk possesses more CO, but is less abundant in other molecular species compared to the DM Tau disk. This is primarily caused by intense UV irradiation from the central Herbig A0 star, which results in a hotter disk where CO freeze out does not occur and thus surface formation of complex CO-bearing molecules might be inhibited.Comment: Accepted by A&

The cometary composition of a protoplanetary disk as revealed by complex cyanides

Observations of comets and asteroids show that the Solar Nebula that spawned our planetary system was rich in water and organic molecules. Bombardment brought these organics to the young Earth's surface, seeding its early chemistry. Unlike asteroids, comets preserve a nearly pristine record of the Solar Nebula composition. The presence of cyanides in comets, including 0.01% of methyl cyanide (CH3CN) with respect to water, is of special interest because of the importance of C-N bonds for abiotic amino acid synthesis. Comet-like compositions of simple and complex volatiles are found in protostars, and can be readily explained by a combination of gas-phase chemistry to form e.g. HCN and an active ice-phase chemistry on grain surfaces that advances complexity[3]. Simple volatiles, including water and HCN, have been detected previously in Solar Nebula analogues - protoplanetary disks around young stars - indicating that they survive disk formation or are reformed in situ. It has been hitherto unclear whether the same holds for more complex organic molecules outside of the Solar Nebula, since recent observations show a dramatic change in the chemistry at the boundary between nascent envelopes and young disks due to accretion shocks[8]. Here we report the detection of CH3CN (and HCN and HC3N) in the protoplanetary disk around the young star MWC 480. We find abundance ratios of these N-bearing organics in the gas-phase similar to comets, which suggests an even higher relative abundance of complex cyanides in the disk ice. This implies that complex organics accompany simpler volatiles in protoplanetary disks, and that the rich organic chemistry of the Solar Nebula was not unique.Comment: Definitive version of the manuscript is published in Nature, 520, 7546, 198, 2015. This is the author's versio

Multilayer modeling of porous grain surface chemistry I. The GRAINOBLE model

Mantles of iced water, mixed with CO, H2CO, and CH3OH are formed during the so called prestellar core phase. In addition, radicals are also thought to be formed on the grain surfaces, and to react to form complex organic molecules later on, during the warm-up phase of the protostellar evolution. We aim to study the formation of the grain mantles during the prestellar core phase and the abundance of H2CO, CH3OH, and radicals trapped in them. We have developed a macrosopic statistic multilayer model that follows the formation of grain mantles with time and that includes two effects that may increase the number of radicals trapped in the mantles: i) at each time of the mantle formation, only the surface layer is chemically active rather than the entire bulk, and ii) the porous structure of grains allows to trap reactive particles. The model considers a network of H, O and CO forming neutral species such as water, CO, formaldehyde, and methanol, plus several radicals. We run a large grid of models to study the impact of the mantle multilayer nature and grain porous structure. In addition, we explored the influence of the uncertainty of other key parameters on the mantle composition. Our model predicts relatively large abundances of radicals. In addition, the multilayer approach makes it possible to follow the chemical differentiation within the grain mantle, showing that the mantles are far from being uniform. For example, methanol is mostly present in the outer layers of the mantles whereas CO and other reactive species are trapped in the inner layers. The overall mantle composition depends on the density and age of the prestellar core, and on some microscopic parameters. Comparison with observations allows us to constrain the value of few parameters and provide some indications on the physical conditions during the formation of the ices.Comment: 20 pages and 19 figures. Accepted in Astronomy & Astrophysic