Natural refuges associated with the Qhapaq Ñan in the southern extreme of Tawantinsuyu

Se presentan resultados de los análisis crono-estratigráficos y del material cerámico, lítico, arqueobotánico y zooarqueológico recuperado de un alero ubicado en la Cordillera Principal, sobre la traza del ramal transversal más meridional del Qhapaq Ñan. Este alero se emplaza en un área con características ambientales particulares que la hicieron una posta obligada para ascender hacia el paso Cristo Redentor o descender desde este. Al articular la información procedente de los análisis del registro arqueológico con información contextual, se ha logrado inferir las actividades que allí se desarrollaron, la procedencia de sus ocupantes y algunas de las funciones que cumplieron los refugios naturales en este sector del Qhapaq Ñan.We present the results of chronostratigraphic analysis and the analysis of ceramic, lithic, archaeobotanical and zooarchaeological material, recovered from a rocky eaves located in the Cordillera Principal, on the trace of the southernmost transversal branch of the Qhapaq Ñan. This eave is located in an area with particular environmental characteristics that made it an obligatory post to ascend to or descend from the Cristo Redentor pass. By articulating the information from the analysis of the archaeological record with contextual information, we have been able to infer the activities that took place in the site, the origin of its occupants and some of the functions that the natural shelters fulfilled in this sector of the Qhapaq Ñan.Sociedad Argentina de Antropologí

Initiation of lightning flashes simultaneously observed from space and the ground: Narrow bipolar events

We investigate the initiation of four lightning flashes detected from ground by means of the Colombia Lightning Mapping Array (Colombia-LMA) and simultaneously observed from space by the optical sensors of the Atmosphere-Space Interactions Monitor (ASIM) on board the International Space Station (ISS), the Geostationary Lightning Mapper (GLM), and the Lightning Imaging Sensor on the ISS. The initiations of the flashes are characterized by isolated and predominant optical blue pulses (337.0 nm). In three of the flashes, red emissions (777.4 nm), a dominant line of hot lightning, were not detected during their initiation. In these cases, the initiations were also accompanied by bipolar VLF/LF waveform with a narrow short duration (<40 μs) and VHF emissions with high radio frequency power (<269 kW). The detection of the blue emissions without any red luminosity supports that the fast breakdown processes at the flash initiation can be exclusively of streamer nature. The onset of the fourth flash was associated with both blue and red radiation, and with weak narrow bipolar waveform in VLF/LF and low VHF power. The flashes initiated between the midlevel negative and upper positive charge regions. This paper presents and discusses the first fast breakdown processes observed simultaneously from ground by means a Lightning Mapping Array (LMA) and from space during the onset of lightning flashes.publishedVersio

Initiation of lightning flashes simultaneously observed from space and the ground: Narrow bipolar events

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).We investigate the initiation of four lightning flashes detected from ground by means of the Colombia Lightning Mapping Array (Colombia-LMA) and simultaneously observed from space by the optical sensors of the Atmosphere-Space Interactions Monitor (ASIM) on board the International Space Station (ISS), the Geostationary Lightning Mapper (GLM), and the Lightning Imaging Sensor on the ISS. The initiations of the flashes are characterized by isolated and predominant optical blue pulses (337.0 nm). In three of the flashes, red emissions (777.4 nm), a dominant line of hot lightning, were not detected during their initiation. In these cases, the initiations were also accompanied by bipolar VLF/LF waveform with a narrow short duration (<40 μs) and VHF emissions with high radio frequency power (<269 kW). The detection of the blue emissions without any red luminosity supports that the fast breakdown processes at the flash initiation can be exclusively of streamer nature. The onset of the fourth flash was associated with both blue and red radiation, and with weak narrow bipolar waveform in VLF/LF and low VHF power. The flashes initiated between the midlevel negative and upper positive charge regions. This paper presents and discusses the first fast breakdown processes observed simultaneously from ground by means a Lightning Mapping Array (LMA) and from space during the onset of lightning flashes. © 2021 The Authors.The UPC contribution: This work was supported by research Grants ESP2013-48032-C5-3-R, ESP2015-69909-C5-5-R and ESP2017-86263-C4-2-R funded by MCIN/AEI/ 10.13039/501100011033 and by “ERDF A way of making Europe”, by the “European Union”; and Grant PID2019-109269RB-C42 funded by MCIN/AEI/ 10.13039/501100011033. The IAA contribution: This work was supported by the Spanish Ministry of Science and Innovation, Ministerio de Ciencia e Innovación (AEI) under project PID2019-109269RB-C43 and the FEDER program. FJPI acknowledges the sponsorship provided by the Federal Ministry for Education and Research of Germany through the Alexander von Humboldt Foundation. AL was supported by the European Research Council (ERC) under European Union Horizon 2020 Framework Programme/ERC Grant Agreement 681257. Authors FJGV, FJPI, and AL acknowledge financial support from the State Agency for Research of the Spanish MCIU through the “Center of Excellence Severo Ochoa” award for the Instituto de Astrofísica de Andalucía (SEV- 2017-0709). The UV contribution: This work was supported by research grants from the Spanish Ministry of Economy and the European Regional Development Fund (FEDER): ESP2013-48032-C5-1-R, ESP2015-69909-C5-1-R and ESP2017-86263-C4-1-R. The UB (University of Bergen) would like to thank the Research Council of Norway under contracts 223252/F50 (CoE). The USP (University of Sao Paulo) contribution: This work was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)— Print Project (grant number: 88887.370081/2019-00). ASIM is a mission of The European Space Agency (ESA). The project is funded by ESA and by national grants of Denmark, Norway, and Spain. We thank Keraunos(Colombia) for the LINET data.Peer reviewe

Long-Term Real-World Effectiveness and Safety of Ustekinumab in Crohn’s Disease Patients: The SUSTAIN Study

Background Large real-world-evidence studies are required to confirm the durability of response, effectiveness, and safety of ustekinumab in Crohn’s disease (CD) patients in real-world clinical practice. Methods A retrospective, multicentre study was conducted in Spain in patients with active CD who had received ≥1 intravenous dose of ustekinumab for ≥6 months. Primary outcome was ustekinumab retention rate; secondary outcomes were to identify predictive factors for drug retention, short-term remission (week 16), loss of response and predictive factors for short-term efficacy and loss of response, and ustekinumab safety. Results A total of 463 patients were included. Mean baseline Harvey-Bradshaw Index was 8.4. A total of 447 (96.5%) patients had received prior biologic therapy, 141 (30.5%) of whom had received ≥3 agents. In addition, 35.2% received concomitant immunosuppressants, and 47.1% had ≥1 abdominal surgery. At week 16, 56% had remission, 70% had response, and 26.1% required dose escalation or intensification; of these, 24.8% did not subsequently reduce dose. After a median follow-up of 15 months, 356 (77%) patients continued treatment. The incidence rate of ustekinumab discontinuation was 18% per patient-year of follow-up. Previous intestinal surgery and concomitant steroid treatment were associated with higher risk of ustekinumab discontinuation, while a maintenance schedule every 12 weeks had a lower risk; neither concomitant immunosuppressants nor the number of previous biologics were associated with ustekinumab discontinuation risk. Fifty adverse events were reported in 39 (8.4%) patients; 4 of them were severe (2 infections, 1 malignancy, and 1 fever). Conclusions Ustekinumab is effective and safe as short- and long-term treatment in a refractory cohort of CD patients in real-world clinical practice

Using Interpretable Machine Learning to Identify Baseline Predictive Factors of Remission and Drug Durability in Crohn’s Disease Patients on Ustekinumab

Ustekinumab has shown efficacy in Crohn's Disease (CD) patients. To identify patient profiles of those who benefit the most from this treatment would help to position this drug in the therapeutic paradigm of CD and generate hypotheses for future trials. The objective of this analysis was to determine whether baseline patient characteristics are predictive of remission and the drug durability of ustekinumab, and whether its positioning with respect to prior use of biologics has a significant effect after correcting for disease severity and phenotype at baseline using interpretable machine learning. Patients' data from SUSTAIN, a retrospective multicenter single-arm cohort study, were used. Disease phenotype, baseline laboratory data, and prior treatment characteristics were documented. Clinical remission was defined as the Harvey Bradshaw Index <= 4 and was tracked longitudinally. Drug durability was defined as the time until a patient discontinued treatment. A total of 439 participants from 60 centers were included and a total of 20 baseline covariates considered. Less exposure to previous biologics had a positive effect on remission, even after controlling for baseline disease severity using a non-linear, additive, multivariable model. Additionally, age, body mass index, and fecal calprotectin at baseline were found to be statistically significant as independent negative risk factors for both remission and drug survival, with further risk factors identified for remission

A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility

We conducted a large-scale genetic analysis on giant cell arteritis (GCA), a polygenic immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with GCA and 15,306 unrelated control subjects from six different countries of European ancestry, was genotyped by the Immunochip array. We also imputed HLA data with a previously validated imputation method to perform a more comprehensive analysis of this genomic region. The strongest association signals were observed in the HLA region, with rs477515 representing the highest peak (p = 4.05 × 10−40, OR = 1.73). A multivariate model including class II amino acids of HLA-DRβ1 and HLA-DQα1 and one class I amino acid of HLA-B explained most of the HLA association with GCA, consistent with previously reported associations of classical HLA alleles like HLA-DRB1∗04. An omnibus test on polymorphic amino acid positions highlighted DRβ1 13 (p = 4.08 × 10−43) and HLA-DQα1 47 (p = 4.02 × 10−46), 56, and 76 (both p = 1.84 × 10−45) as relevant positions for disease susceptibility. Outside the HLA region, the most significant loci included PTPN22 (rs2476601, p = 1.73 × 10−6, OR = 1.38), LRRC32 (rs10160518, p = 4.39 × 10−6, OR = 1.20), and REL (rs115674477, p = 1.10 × 10−5, OR = 1.63). Our study provides evidence of a strong contribution of HLA class I and II molecules to susceptibility to GCA. In the non-HLA region, we confirmed a key role for the functional PTPN22 rs2476601 variant and proposed other putative risk loci for GCA involved in Th1, Th17, and Treg cell function

Proyecto, investigación e innovación en urbanismo, arquitectura y diseño industrial

Actas de congresoLas VII Jornadas de Investigación “Encuentro y Reflexión” y I Jornadas de Investigación de becarios y doctorandos. Proyecto, investigación e innovación en Urbanismo, Arquitectura y Diseño Industrial se centraron en cuatro ejes: el proyecto; la dimensión tecnológica y la gestión; la dimensión social y cultural y la enseñanza en Arquitectura, Urbanismo y Diseño Industrial, sustentados en las líneas prioritarias de investigación definidas epistemológicamente en el Consejo Asesor de Ciencia y Tecnología de esta Universidad Nacional de Córdoba. Con el objetivo de afianzar continuidad, formación y transferencia de métodos, metodología y recursos se incorporó becarios y doctorandos de los Institutos de investigación. La Comisión Honoraria la integraron las tres Secretarias de Investigación de la Facultad, arquitectas Marta Polo, quien fundó y María del Carmen Franchello y Nora Gutiérrez Crespo quienes continuaron la tradición de la buena práctica del debate en la cotidianeidad de la propia Facultad. Los textos que conforman las VII Jornadas son los avances y resultados de las investigaciones realizadas en el bienio 2016-2018.Fil: Novello, María Alejandra. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Repiso, Luciana. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Mir, Guillermo. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Brizuela, Natalia. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Herrera, Fernanda. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Períes, Lucas. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Romo, Claudia. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Gordillo, Natalia. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; ArgentinaFil: Andrade, Elena Beatriz. Universidad Nacional de Córdoba. Facultad de Arquitectura, Urbanismo y Diseño; Argentin

4to. Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad. Memoria académica

Este volumen acoge la memoria académica de la Cuarta edición del Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad, CITIS 2017, desarrollado entre el 29 de noviembre y el 1 de diciembre de 2017 y organizado por la Universidad Politécnica Salesiana (UPS) en su sede de Guayaquil. El Congreso ofreció un espacio para la presentación, difusión e intercambio de importantes investigaciones nacionales e internacionales ante la comunidad universitaria que se dio cita en el encuentro. El uso de herramientas tecnológicas para la gestión de los trabajos de investigación como la plataforma Open Conference Systems y la web de presentación del Congreso http://citis.blog.ups.edu.ec/, hicieron de CITIS 2017 un verdadero referente entre los congresos que se desarrollaron en el país. La preocupación de nuestra Universidad, de presentar espacios que ayuden a generar nuevos y mejores cambios en la dimensión humana y social de nuestro entorno, hace que se persiga en cada edición del evento la presentación de trabajos con calidad creciente en cuanto a su producción científica. Quienes estuvimos al frente de la organización, dejamos plasmado en estas memorias académicas el intenso y prolífico trabajo de los días de realización del Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad al alcance de todos y todas

Congreso Internacional de Responsabilidad Social Apuestas para el desarrollo regional.

Congreso Internacional de Responsabilidad Social: apuestas para el desarrollo regional [Edición 1 / Nov. 6 - 7: 2019 Bogotá D.C.]El Congreso Internacional de Responsabilidad Social “Apuestas para el Desarrollo Regional”, se llevó a cabo los días 6 y 7 de noviembre de 2019 en la ciudad de Bogotá D.C. como un evento académico e investigativo liderado por la Corporación Universitaria Minuto de Dios -UNIMINUTO – Rectoría Cundinamarca cuya pretensión fue el fomento de nuevos paradigmas, la divulgación de conocimiento renovado en torno a la Responsabilidad Social; finalidad adoptada institucionalmente como postura ética y política que impacta la docencia, la investigación y la proyección social, y cuyo propósito central es la promoción de una “sensibilización consciente y crítica ante las situaciones problemáticas, tanto de las comunidades como del país, al igual que la adquisición de unas competencias orientadas a la promoción y al compromiso con el desarrollo humano y social integral”. (UNIMINUTO, 2014). Dicha postura, de conciencia crítica y sensibilización social, sumada a la experiencia adquirida mediante el trabajo articulado con otras instituciones de índole académico y de forma directa con las comunidades, permitió establecer como objetivo central del evento la reflexión de los diferentes grupos de interés, la gestión de sus impactos como elementos puntuales que contribuyeron en la audiencia a la toma de conciencia frente al papel que se debe asumir a favor de la responsabilidad social como aporte seguro al desarrollo regional y a su vez al fortalecimiento de los Objetivos de Desarrollo Sostenible

Congreso Internacional de Responsabilidad Social Apuestas para el desarrollo regional.

Congreso Internacional de Responsabilidad Social: apuestas para el desarrollo regional [Edición 1 / Nov. 6 - 7: 2019 Bogotá D.C.]El Congreso Internacional de Responsabilidad Social “Apuestas para el Desarrollo Regional”, se llevó a cabo los días 6 y 7 de noviembre de 2019 en la ciudad de Bogotá D.C. como un evento académico e investigativo liderado por la Corporación Universitaria Minuto de Dios -UNIMINUTO – Rectoría Cundinamarca cuya pretensión fue el fomento de nuevos paradigmas, la divulgación de conocimiento renovado en torno a la Responsabilidad Social; finalidad adoptada institucionalmente como postura ética y política que impacta la docencia, la investigación y la proyección social, y cuyo propósito central es la promoción de una “sensibilización consciente y crítica ante las situaciones problemáticas, tanto de las comunidades como del país, al igual que la adquisición de unas competencias orientadas a la promoción y al compromiso con el desarrollo humano y social integral”. (UNIMINUTO, 2014). Dicha postura, de conciencia crítica y sensibilización social, sumada a la experiencia adquirida mediante el trabajo articulado con otras instituciones de índole académico y de forma directa con las comunidades, permitió establecer como objetivo central del evento la reflexión de los diferentes grupos de interés, la gestión de sus impactos como elementos puntuales que contribuyeron en la audiencia a la toma de conciencia frente al papel que se debe asumir a favor de la responsabilidad social como aporte seguro al desarrollo regional y a su vez al fortalecimiento de los Objetivos de Desarrollo Sostenible