New perspectives for preventing hepatitis C virus liver graft infection

publisher: Elsevier articletitle: New perspectives for preventing hepatitis C virus liver graft infection journaltitle: The Lancet Infectious Diseases articlelink: http://dx.doi.org/10.1016/S1473-3099(16)00120-1 content_type: article copyright: © 2016 Elsevier Ltd. All rights reserved

Being stuck in (live) time : the sticky sociological imagination

Recently, Savage and Burrows (2007) have argued that one way to invigorate sociology's ‘empirical crisis’ is to take advantage of live, web-based digital transactional data. This paper argues that whilst sociologists do indeed need to engage with this growing digital data deluge, there are longer-term risks involved that need to be considered. More precisely, C. Wright Mills' ‘sociological imagination’ is used as the basis for the kind of sociological research that one might aim for, even within the digital era. In so doing, it is suggested that current forms of engaging with transactional social data are problematic to the sociological imagination because they tend to be ahistorical and focus mainly on ‘now casting’. The ahistorical nature of this genre of digital research, it is argued, necessarily restricts the possibility of developing a serious sociological imagination. In turn, it is concluded, there is a need to think beyond the digitized surfaces of the plastic present and to consider the impact that time and temporality, particularly within the digital arena, have on shaping our sociological imagination

Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology

BACKGROUND: Approximately 4-25% of patients with early prostate cancer develop disease recurrence following radical prostatectomy. OBJECTIVE: To identify a molecular subgroup of prostate cancers with metastatic potential at presentation resulting in a high risk of recurrence following radical prostatectomy. DESIGN, SETTING, AND PARTICIPANTS: Unsupervised hierarchical clustering was performed using gene expression data from 70 primary resections, 31 metastatic lymph nodes, and 25 normal prostate samples. Independent assay validation was performed using 322 radical prostatectomy samples from four sites with a mean follow-up of 50.3 months. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Molecular subgroups were identified using unsupervised hierarchical clustering. A partial least squares approach was used to generate a gene expression assay. Relationships with outcome (time to biochemical and metastatic recurrence) were analysed using multivariable Cox regression and log-rank analysis. RESULTS AND LIMITATIONS: A molecular subgroup of primary prostate cancer with biology similar to metastatic disease was identified. A 70-transcript signature (metastatic assay) was developed and independently validated in the radical prostatectomy samples. Metastatic assay positive patients had increased risk of biochemical recurrence (multivariable hazard ratio [HR] 1.62 [1.13-2.33]; p=0.0092) and metastatic recurrence (multivariable HR=3.20 [1.76-5.80]; p=0.0001). A combined model with Cancer of the Prostate Risk Assessment post surgical (CAPRA-S) identified patients at an increased risk of biochemical and metastatic recurrence superior to either model alone (HR=2.67 [1.90-3.75]; p<0.0001 and HR=7.53 [4.13-13.73]; p<0.0001, respectively). The retrospective nature of the study is acknowledged as a potential limitation. CONCLUSIONS: The metastatic assay may identify a molecular subgroup of primary prostate cancers with metastatic potential. PATIENT SUMMARY: The metastatic assay may improve the ability to detect patients at risk of metastatic recurrence following radical prostatectomy. The impact of adjuvant therapies should be assessed in this higher-risk population

Living in the future: environmental concerns, parenting, and low-impact lifestyles

Existing work has demonstrated how the presence of children of different ages in families can impact on people’s ability to make imaginative connections to longer-term socio-environmental futures and maintain these links in the context of everyday pressures. This chapter explores such connections by presenting selected data extracts from residents of a low-impact ecovillage. The ecovillage represents a relatively unusual case site where people showed strong connections to the future, which had an impact on their present lifestyle choices. In particular, the way in which parents spoke about their children as central to their decision to live a low-impact rural lifestyle is highlighted. The ecovillage data is contextualized via an extended literature review covering issues regarding parenting, rural childhoods, low-impact living, and how these areas relate to a connection with the future. Drawing together these insights, the relevance of resilience is discussed as a concept for thinking about how particular visions of the future may create lifestyles that make possible flexibility and adaptability in the face of uncertainty. In summary, this chapter highlights how parents’ views of wider environmental futures can impact on the lifestyles they foster for children in the present