Impact of Aisami Solid Waste dumping site, Kano Metropolis, Nigeria on the quality of ground water of the neighbouring environment

Open dumping and uncontrolled landfilling of solid wastes are the most widely practiced waste disposal methods in many cities of the less-developed regions, especially those in sub Saharan Africa. These practices are unsustainable and pose a major threat to the environment and public health. Of particular concern is the leachate produced at the disposal sites, which is concentrated with biological and chemical substances that could contaminate the soil, surface and groundwater sources in the environment. The effects of leachate percolation on the quality of groundwater sources is of great concern especially in sub Saharan Africa, where untreated self-supply groundwater options represent a major source of water supply for many inhabitants. Given this perspective, the physicochemical characteristics of some groundwater samples from wells around a major waste disposal site; Aisami in Kano metropolis, Nigeria, were examined. The samples were collected from the north, east, south and west directions around the disposal site and analysed for parameters that include: pH, turbidity, total dissolved solids, electrical conductivity, total alkalinity, total hardness, Ca+2, Mg+2, Na+, K+, NO3-, SO4(2-), Cl-, Cu+2, Fe+2 ,Mn+2, Pb, Zn, and Cr. Significant concentrations of most parameters were revealed, often above the WHO recommended thresholds. Accordingly, some measures were highlighted towards protecting, preserving and sustaining groundwater quality as a strategic source of water supply in the area and beyond

Assessment of phytoremediation potential of Telfaira occidentalis in the removal of Cu, Cd, and Pb in contaminated soil along River Salanta

A Field study was carried out to examine the phytoremediation potential of some plants metals (Cd, Cu and Pb) in contaminated soils along Sallanta river, Kano. A total of one hundred and eighty (100) samples comprising of 40 (soils), 20 (effluents), and 40 (plant parts) of T. 0ccidentalis were analyzed. 0.50g of the plant tissue and 1.0g of soil sample and 50mL of the effluent sample were digested using triacid digestion method and the levels of the metals were determined by the use of atomic absorption spectrophotometry. The mean levels of the metals in plants and soils from contaminated and control sites were found to be in the sequence of Cu (27.08±3.15)> Cd (24.57±8.25)>Pb (3.00±0.52) and Cu (10.10±2.50)> Cd (2.80±0.05)>Pb (2.00±0.63) respectively. The contamination factor (CF) of all the metals in the plants were found to be in the sequence of Cd (8.35±1.53)> Cu (2.52±1.20)>Pb (1.50±0.21). The results showed that these plants can be used for the phytoextraction of the metals from contaminated soils. The values of bioaccumulation and translocation factors were also found to be more than one in almost all cases. From these results it could be recommended that the three plants investigated would be ideal for phytoremediation in multi-metal contaminated soils

Studies on mosquito density in urban Kano: a study to calculate larval indices in municipal area of Gwale, Kano, Nigeria

The study is carried out to standardize larval indices namely House Index, Container Index and Breteau Index and also to identify the major breeding sources of mosquitoes in the residential environment in and around the Gwale Local government area of  Kano, Nigeria. A cross-sectional study by selecting 50 houses randomly from the 6 wards of Municipality was employed. Every water holding container indoors and outdoors were counted and searched for larval presence and noted on a pretested format. In this study, 300 houses were surveyed in 21 days out of which 94.33% (283 houses) were found to have potential sources for mosquito breeding. All the entomological indices were found to be above the critical level. House Index = 28.67%; Container Index = 12.14%; Breteau Index = 64.00% showing high chances for outbreaks of mosquito borne diseases. The area is prone to mosquito borne disease like malaria and therefore warrants interventions from the competent

Status of occupational safety and health in GCC construction

The construction projects in Gulf Cooperation Council (GCC)-member countries are peaking as the region is in the stage of improving its infrastructures. This briefing presents the current status of occupational safety and health in the region by providing a brief comparison with some of the advanced countries where improved safety performance is guaranteed and maintained. The comparison of the available data shows that, in general, GCC countries display a poor occupational safety and health performance. The briefing suggests the key areas for research which could help the GCC construction industry to improve its performance. These areas include the awareness and importance of safety, cost of accidents, environmental and climatic factors which affect the workers, occupational safety and health regulations and their implementation, workers’ well-being, safety culture and safety climate

Individual differences in perception and response to experimental pain in a young Nigerian population

Background: Pain is a protective sensation that alerts an individual to injury from the environment. Experience of pain is characterised by robust individual differences and complex environmental and genetic factors lead to individual variations in pain. Studies of experimental pain are free from the confound of disease progression, but can be highly relevant to clinical pain states. The aim of this study is to evaluate individual differences in perception and response to experimental pain among young Nigerian population. Methods: One hundred and thirty apparently healthy subjects (age 12 to 20 years) were used. Pain was accessed using cold pressor test and ischemic pain models. VAS and VRS were used to access pain catastrophizing. Data were presented as mean ± SD. Differences and statistical significance between the means were determined using t test. Values of P < 0.05 were considered significant. Results: The results showed significant differences among the study population in experimental pain threshold and tolerance. Conclusion: The study proved that there is variation in perception and response to experimental pain among secondary school students in Zaria, Northern Nigeri

Modulatory role of vitamins A and E on memory and motor functions of cyanide induced neurotoxicity in adult swiss mice

Summary: Cyanide is a potent neurotoxic substance that can initiate series of intracellular reactions leading to oxidative stress. To evaluate effect of sublethal administration of potassium cyanide (KCN) on sensorimotor functions and long term visuo-spatial learning and memory in adult Swiss mice and possible ameliorative role of vitamins A and E. These vitamins A and E (dietary) are antioxidants that have scavenging properties against free radicals and reactive oxygen species as a result of oxidative stress induced by cyanide. Thirty-five mice weighing between 18-22 g were used for the study. The animals were randomly divided into five groups (n = 7) and exposed to sublethal concentration of potassium cyanide (10% LD50; 1.5 mg/kg). KCN was administered orally while vitamin A (25 mg/kg) and vitamin E (50 mg/kg) were administered intra-peritoneal (IP) once daily for 28 days. Potassium cyanide (KCN) was first administered and after 10 minutes intervals, followed by vitamin A and then E after 5 minutes, vitamin E were administered across the different treatment groups. Mice were examined for signs of toxicity. Vitamins pre-treatment ameliorated toxic signs. In the dynamics of wire grid, coat hanger and stationary beam test, the latency to fall in weeks 2 and 4 were statistically significant. In acquisition and retention, using elevated plus maze (EPM), KCN treated group recorded high transfer latencies in seconds (50.40±1.72 secs) and (57.60±0.93 secs) as compared to group IV (29.40±0.68 secs; 5.60±0.60 secs). Cyanide is a neurotoxin that affects motor functions with progressive decline in motor strength and coordination. KCN affects acquisition and retention memory while pre-treatment with antioxidant vitamins A and E ameliorated these deficits.Keywords: Cyanide; Neurotoxicity; Memory; Motor functionNiger. J. Physiol. Sci. 33(December 2018) 183-18

Assessment of growth variables and regression models for the tree volume prediction of Azardirachta indica (a. Juss) at Warwade plantation, Dutse, Jigawa state, Nigeria

Savannah is well known with less diverse ecosystem. Tree growth dynamics is a major technique in quantifying the forest composition. However, there is need to determine community structure and model which is suitable for Azadiractha indica in arid land.Therefore, the experiment was carried out to assess the tree growth variables and regression models for tree volume prediction of Azadiractha indica in Warwade plantation. Four (4) plots of 25m x 25m were using random sampling technique at interval of 100m from each other. Tree growth variables such as: diameter at breast height (DBH), diameter at the base (Db) middle (Dm), top (Dt) and height were taken with aid of Spiegel relascope. Frequency of occurrence of all tree with diameter at breast height (DBH) ≥10cm were measured. Three regression models were developed which are exponential, Quadratic and Vapour pressure. A total of eighty-one (81) stems ha-1 of the species were identified and counted. The tree growth variables measure showed that Azadiractha indica plantation had total volume of 14126.59m3 per ha-1 and basal area was 339998.19m2. The range of 61-70cm of diameter class had the highest number of terms per hectare (33.33%). The models developed showed that exponential model volume was found to be more suitable and good fit for tree volume prediction in the context of the data used. Therefore, exponential model generated in this study is recommended for volume prediction at Warwade Forest Reserve, Dutse, and Jigawa State. Keywords: Growth Assessment, Regression Models, Tree Volume Prediction, Azardirachta indica and Warwade

Electrolyte and oxidative stress profile of healthy adult population in Zaria, Nigeria, and their relationship with experimental pain response

Background: Electrolyte imbalance and oxidative stress (OS) are known to impair physiological functions, which can alter health and wellbeing. The reactive species produced due to OS are detoxified by endogenous antioxidants to maintain homeostasis. This study investigated the electrolyte and oxidative stress profile of a healthy adult population in Zaria, Nigeria and their relationship with experimental pain outcome. Method: Participants were apparently healthy adult volunteers between the ages of 20 to 65 years and drawn from the city of Zaria and its environs. Experimental pain was induced using pressure algometry. About 5 ml of blood was collected for determination of serum electrolytes, malondialdehyde (MDA), reduced glutathione (GSH) and superoxide dismutase (SOD). Result: The results showed that serum concentrations of sodium, potassium and chloride as well as oxidative stress profile did not vary with sex, age and ethnicity among the studied population. There was a significant negative correlation between pressure pain threshold and serum concentration of potassium (r = 0.2330, p = 0.003) and chloride (r = 0.2126, p = 0.007), while serum sodium correlated positively (r = 0.3439, p = 0.000). Serum MDA, SOD and GSH did not show statistically significant correlation with pressure pain threshold (p > 0.05). Conclusion: Serum electrolytes, but not oxidative stress markers, correlate significantly with experimental pressure pain threshold among healthy adult population in Zaria, Nigeria Keywords: Electrolytes, oxidative stress, pressure pain, sex, age, ethnicit

Tracking development assistance for health and for COVID-19 : a review of development assistance, government, out-of-pocket, and other private spending on health for 204 countries and territories, 1990-2050

Background The rapid spread of COVID-19 renewed the focus on how health systems across the globe are financed, especially during public health emergencies. Development assistance is an important source of health financing in many low-income countries, yet little is known about how much of this funding was disbursed for COVID-19. We aimed to put development assistance for health for COVID-19 in the context of broader trends in global health financing, and to estimate total health spending from 1995 to 2050 and development assistance for COVID-19 in 2020. Methods We estimated domestic health spending and development assistance for health to generate total health-sector spending estimates for 204 countries and territories. We leveraged data from the WHO Global Health Expenditure Database to produce estimates of domestic health spending. To generate estimates for development assistance for health, we relied on project-level disbursement data from the major international development agencies' online databases and annual financial statements and reports for information on income sources. To adjust our estimates for 2020 to include disbursements related to COVID-19, we extracted project data on commitments and disbursements from a broader set of databases (because not all of the data sources used to estimate the historical series extend to 2020), including the UN Office of Humanitarian Assistance Financial Tracking Service and the International Aid Transparency Initiative. We reported all the historic and future spending estimates in inflation-adjusted 2020 US$, 2020 US$ per capita, purchasing-power parity-adjusted US$per capita, and as a proportion of gross domestic product. We used various models to generate future health spending to 2050. Findings In 2019, health spending globally reached$8. 8 trillion (95% uncertainty interval [UI] 8.7-8.8) or $1132 (1119-1143) per person. Spending on health varied within and across income groups and geographical regions. Of this total,$40.4 billion (0.5%, 95% UI 0.5-0.5) was development assistance for health provided to low-income and middle-income countries, which made up 24.6% (UI 24.0-25.1) of total spending in low-income countries. We estimate that $54.8 billion in development assistance for health was disbursed in 2020. Of this,$13.7 billion was targeted toward the COVID-19 health response. $12.3 billion was newly committed and$1.4 billion was repurposed from existing health projects. $3.1 billion (22.4$2.4 billion (17.9%) was for supply chain and logistics. Only $714.4 million (7.7$1519 (1448-1591) per person in 2050, although spending across countries is expected to remain varied. Interpretation Global health spending is expected to continue to grow, but remain unequally distributed between countries. We estimate that development organisations substantially increased the amount of development assistance for health provided in 2020. Continued efforts are needed to raise sufficient resources to mitigate the pandemic for the most vulnerable, and to help curtail the pandemic for all. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

Global Retinoblastoma Presentation and Analysis by National Income Level

Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4) were female. Most patients (n = 3685 84.7%) were from low-and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 62.8%), followed by strabismus (n = 429 10.2%) and proptosis (n = 309 7.4%). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 95% CI, 12.94-24.80, and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 95% CI, 4.30-7.68). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs. © 2020 American Medical Association. All rights reserved