Abastecimiento Eficiente: El Efecto Cola en los Hospitales.

15 p.Se diseñó un sistema de verificación experimental sobre la base de un prototipo, destinado a cuantificar el efecto cola de los inventarios. Los resultados obtenidos permiten concluir que un hospital puede reducir su inventario hasta en un 40%, mediante el uso de un sistema centralizado de información

Beneficios de un Centro de Distribución Regional de Medicamentos.

10 p.Las organizaciones de diversas industrias se han visto obligadas a enfrentar demandas inciertas, para esto han aplicado técnicas con “just-in-time” (JIT), han debido implantar programas de respuesta rápida, sin embargo el éxito no ha sido el esperado (Fischer, 1994). Mediante el método de simulación, se modeló la operación de tres hospitales atendiendo infartos cardiacos y suponiendo que la función distribución de probabilidad de llegada de infartados sigue una Poisson de media tres, se concluyó que es más eficiente contar con un centro de distribución que cuente con la información de demanda e inventario de cada hospital, a que cada hospital tenga su propio inventario

On a Liouville-type equation with sign-changing weight

In this paper we study the existence, non-existence and multiplicity of non-negative solutions for a family of elliptic problems with exponential nonlienarity and sign-changing weights. The techniques used in the proofs are a combination of upper and lower solutions, the Trudinger-Moser inequality and variational methods

A priori bounds for superlinear problems involving the N-Laplacian

In this paper we establish a priori bounds for positive solution of the N-Laplace equation in a bounded smooth domain in R^N, and with a nonlinearity having at most exponential growth. The techniques used in the proofs are a generalization of the methods of Brezis-Merle to the N-Laplacian, in combination with the Trudinger-Moser inequality,the Moving Planes method and a Comparison Principle for the N-Laplacian

Palaeoecological analysis of two Late Pleistocene continental mollusc assemblages from Uruguay

Ponencia presentada en World Congress of Malacology, 1-5 Aug. 2022, Münich - Alemania, organizado por UNITAS Malacologica y Ludwig-Maximilians-Universität.Extant continental (freshwater and terrestrial) molluscs are very informative from an environmental point of view. The specific environmental requirements of different taxa can be extrapolated to the fossil assemblages in order to reconstruct past environments. This is especially true for the Quaternary, when fossil assemblages are mostly composed by extant species. We analysed two associations of continental molluscs from the Late Pleistocene of Uruguay, with the goal of reconstruct the depositional environments for each assemblage. For this analysis, 11 localities from the Sopas Formation and 10 from the Dolores Formation were selected. The statistical analyses aimed to understand the diversity of each locality and to make comparisons among them, using traditional diversity indices (Shannon, Simpson, Equitability). To estimate the diversity Rarefaction and Chao1 were applied. Lastly, the species occurrence in all localities were compared, using several multivariate analyses: NMDS with axes rotation by Principal Components Analysis, Correspondence Analysis, and Cluster Analysis. The multivariate analyses show that all local assemblages are distributed in two main associations: one composed mostly by Sopas Formation localities (Sopas Association) and the other composed mostly by Dolores Formation localities (Dolores Association). Only one locality from each Formation was interchanged. The Sopas Association records mostly the families Cyrenidae (36.1 %), Tateidae (32 %), Cochliopidae (26.1 %), and the only record of the family Chilinidae. Also, the large, massive species Diplodon charruanus, D. wymanii and D. peraeformis are present. Meanwhile, the Dolores Association records mostly representatives of Cochliopidae (54.4 %), Planorbinae (20.2 %), Sphaeridae (16 %), and has the only records of Physidae and Succineidae. Cochliopidae (Heleobia) are present in both associations, which is logical since currently they are quite ubiquitous in most lotic and lentic environments. Ampullariidae and the subfamily Ancylinae are also present in both associations, along with the delicate species Diplodon rhuacoicus, which is the only Diplodon from the Dolores Association. Presently, the communities that include Sopas-like assemblages are mostly found in high to moderate current lotic environments, with rocky to coarse bottoms. Meanwhile, the communities that include the taxa typical of the Dolores Association are common in lentic or very calm lotic environments, with fine sediments and abundant aquatic vegetation.ANII: FCE_3_2018_1_148922ANII: POS_NAC_2015_1_10947

Effects of parity order and reproductive management on the efficiency of rabbit productive systems.

The aim of this work was to study the effect of parity order and reproductive management systems on rabbit production performance. A total of 73 rabbit does (I group) were submitted to a 35-day intensive rhythm [artificial insemination (AI) on day 4 post-partum (pp) and weaning at 25 days of lactation], and 108 rabbit does (SI group) were submitted to a 42-day semi-intensive rhythm (AI on day 11 pp and weaning at 35 days of lactation) during 9 months. Primiparous does had the lowest live body weight at parturition (P < 0.0001) and at 21 days of lactation (P < 0.0001). They also had lower milk production (P < 0.0001) than does with later parities. I group animals needed a higher number of AI than SI group to become pregnant (1.70 ± 0.03 vs. 1.39 ± 0.03; P < 0.0001: especially after the third). Prolificacy was not affected by the management system. Parturition interval (PI) was longer than expected in both groups [56.0 ± 1.4 and 50.9 ± 1.38 days in I and SI groups, respectively (P < 0.05)]. Mean productivity, estimated as number of weaned rabbits per female and year, was 12 kits higher in rabbit does of the SI group (P < 0.05). From the third parturition onward, an increase in live body weight of kits at different ages was observed. At 21 (P < 0.05) and 25 days of age (P < 0.01), kits from the I group rabbit does weighed more than those from the SI group; however, the latter showed a higher weight at 35 (P < 0.05) and 60 days of age (P < 0.05). Rabbit does with two or three parturitions had higher litter size at 21 and 25 days of age (P < 0.0001 and P < 0.001, respectively). Kit mortality between 21 and 25 days of age and between 35 and 60 days of age was not affected by treatments but was higher in the I group between 25 and 35 days (18.2 vs. 5.03% in the I and SI groups, respectively; P < 0.0001) and as age of does increased (P < 0.05). In light of these results, we could conclude that long term doe reproductive performance is negatively affected and litter viability decreased when using intensive compared to a semi-intensive reproductive management

Influence of coronary artery disease and subclinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis

A genetic component influences the development of atherosclerosis in the general population and also in rheumatoid arthritis (RA). However, genetic polymorphisms associated with atherosclerosis in the general population are not always involved in the development of cardiovascular disease (CVD) in RA. Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2). In the present study, we assessed the potential association of these polymorphisms with CVD in Southern European RA patients. We also assessed if polymorphisms implicated in the increased risk of subclinical atherosclerosis in non-rheumatic Caucasians (ZHX2, PINX1, SLC17A4, LRIG1 and LDLR) may influence the risk for CVD in RA. 2,609 Spanish patients were genotyped by TaqMan assays. Subclinical atherosclerosis was determined in 1,258 of them by carotid ultrasonography (assessment of carotid intima media thickness and presence/absence of carotid plaques). No statistically significant differences were found when each polymorphism was assessed according to the presence/absence of cardiovascular events and subclinical atherosclerosis, after adjustment for potential confounder factors. Our results do not show an association between these 15 polymorphisms and atherosclerosis in RA

Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis

Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis and cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 exert an influence on elevated CRP serum levels in non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes in the development of CV events and subclinical atherosclerosis in RA patients. Three tag CRP polymorphisms and HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were genotyped in 2,313 Spanish patients by TaqMan. Subclinical atherosclerosis was determined in 1,298 of them by carotid ultrasonography (by assessment of carotid intima-media thickness-cIMT-and presence/absence of carotid plaques). CRP serum levels at diagnosis and at the time of carotid ultrasonography were measured in 1,662 and 1,193 patients, respectively, by immunoturbidimetry. Interestingly, a relationship between CRP and CRP serum levels at diagnosis and at the time of the carotid ultrasonography was disclosed. However, no statistically significant differences were found when CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were evaluated according to the presence/absence of CV events, carotid plaques and cIMT after adjustment. Our results do not confirm an association between these genes and CV disease in RA

The fossil record of South American short-faced bears (Ursidae, Tremarctinae)

The present study includes a review of the geographic and stratigraphic distribution of short-faced bears (Ursidae, Tremarctinae) in South America. In addition, the authors discuss biogeographic hypotheses regarding the origin of South American tremarctines. The Tremarctinae subfamily is distributed exclusively in America, from Alaska to southern Patagonia. Its biochron comprises the temporal lapse between Late Miocene and recent times; the first record of Tremarctinae in North America corresponds to the Hemphillian and the last to the Rancholabrean. In South America, the first record corresponds to the Ensenadan. In the present day, it corresponds to the only living tremarctine, the "Andean Bear," but short-faced bears became extinct during the early Holocene. The extinction of short-faced bears in North and South America appears to have been approximately synchronous. Finally, the fossil record in South America indicates species turnover between the Ensenadan and Bonaerian, during which time the giant species Arctotherium angustidens was replaced by Arctotherium tarijense, Arctotherium bonaeriense, and Arctotherium vetustum (and probably Arctotherium wingei).Museo de La Plat