Modified human factor analysis and classification system for passenger vessel accidents (HFACS-PV)

With the increase in the carrying capacity of passenger vessels parallel to technological developments over the last 25 years, accidents resulting in loss of lives have increased. Thus, accidents involving passenger vessels have become a major issue of concern in the maritime industry. In this study, 70 ship collision & contact accidents involving passenger vessels between 1991 and 2015 were examined. Unlike other studies in the literature, this investigation proposes a customized Human Factors Analysis and Classification System for Passenger Vessel Accidents (HFACS-PV) to facilitate analysing the human factor in passenger vessel accidents. In addition to the core HFACS structure, an additional operational condition level has been defined. The violations framework has been divided into the three sub-categories of rule violations, procedure violations, and abuse of authority, instead of the two broad categories of routine and exceptional violations. Abuse of authority is an intentional violation made knowingly and wilfully, therefore, abuse of authority has been considered separately. Furthermore, appropriate modifications have been made to the headings under the second level of HFACS-Preconditions for Unsafe Acts for compliance with the maritime industry. © 2018 Elsevier Lt

Spatial and Statistical Analysis of Operational Conditions Contributing to Marine Accidents in the Singapore Strait

Narrow waterways are important connection hubs, also known as logistics transfer nodes, within maritime transport, where maritime traffic can become very dense and congested. Heavy traffic, unsuitable environmental conditions and human errors make narrow waterways risky areas for marine accident occurrence. Accidents in narrow waterways cause ship damage, loss of cargo, loss of life and environmental disasters, as well as interruption of maritime transport and negative impact on the economy. Thus, the sustainability of navigational safety in narrow waterways has been the focus of attention of all beneficiaries in the maritime industry. The Singapore Strait is one of the busiest narrow waterways in the world in terms of the number of ships transiting. Sustaining and safe maritime transport in the Singapore Strait is significantly important for the sustainability of the global trade. Therefore, it is vitally important to appropriately identify the threats to safety of navigation in the Singapore Strait. In this study, the operational conditions that have played a role in the occurrence of accidents in the Singapore Strait are examined. For this purpose, using the Geographical Information System (GIS), the areas where marine accidents are concentrated were determined by the Kernel Density Analysis method and a “Marine Accidents Density Map” was created for the Singapore Strait. The relationship between the dense areas in the marine accidents density map and the operational conditions that play a role in the accidents in the Singapore Strait were examined using the Chi-Square Test and expert opinions. The results of the study indicate that if there is a condition (e.g., turning, joining to the traffic stream, or failure in propulsion/steering systems) that directly or indirectly disturbs the normal flow of traffic in the Singapore Strait, the risk of having an accident increases. The results of this study can be used to determine the measures to be taken for the prevention of possible accidents, as well as to help manage the risks associated with the ships that pass through the region

Tyrosine phosphorylation directs TACE into extracellular vesicles via unconventional secretion

When studying how HIV-1 Nef can promote packaging of the proinflammatory transmembrane protease TACE (tumor necrosis factor-alpha converting enzyme) into extracellular vesicles (EVs) we have revealed a novel tyrosine kinase-regulated unconventional protein secretion (UPS) pathway for TACE. When TACE was expressed without its trafficking cofactor iRhom allosteric Hck activation by Nef triggered translocation of TACE into EVs. This process was insensitive to blocking of classical secretion by inhibiting endoplasmic reticulum (ER) to Golgi transport, and involved a distinct form of TACE devoid of normal glycosylation and incompletely processed for prodomain removal. Like most other examples of UPS this process was Golgi reassembly stacking protein (GRASP)-dependent but was not associated with ER stress. These data indicate that Hck-activated UPS provides an alternative pathway for TACE secretion that can bypass iRhom-dependent ER to Golgi transfer, and suggest that tyrosine phosphorylation might have a more general role in regulating UPS.Peer reviewe

Investigation of Heschl's gyrus and planum temporale in patients with schizophrenia and bipolar disorder: A proton magnetic resonance spectroscopy study

Background: Superior temporal cortices include brain regions dedicated to auditory processing and several lines of evidence suggest structural and functional abnormalities in both schizophrenia and bipolar disorder within this brain region. However, possible glutamatergic dysfunction within this region has not been investigated in adult patients. Methods: Thirty patients with schizophrenia (38.67 ± 12.46. years of age), 28 euthymic patients with bipolar I disorder (35.32 ± 9.12. years of age), and 30 age-, gender- and education-matched healthy controls were enrolled. Proton magnetic resonance spectroscopy data were acquired using a 3.0. T Siemens MAGNETOM TIM Trio MR system and single voxel Point REsolved Spectroscopy Sequence (PRESS) in order to quantify brain metabolites within the left and right Heschl's gyrus and planum temporale of superior temporal cortices. Results: There were significant abnormalities in glutamate (Glu) (F(2,78) = 8.52, p < 0.0001), N-acetyl aspartate (tNAA) (F(2,81) = 5.73, p = 0.005), creatine (tCr) (F(2,83) = 5.91, p = 0.004) and inositol (Ins) (F(2,82) = 8.49, p < 0.0001) concentrations in the left superior temporal cortex. In general, metabolite levels were lower for bipolar disorder patients when compared to healthy participants. Moreover, patients with bipolar disorder exhibited significantly lower tCr and Ins concentrations when compared to schizophrenia patients. In addition, we have found significant correlations between the superior temporal cortex metabolites and clinical measures. Conclusion: As the left auditory cortices are associated with language and speech, left hemisphere specific abnormalities may have clinical significance. Our findings are suggestive of shared glutamatergic abnormalities in schizophrenia and bipolar disorder. © 2013 Elsevier B.V

Do sexist mothers change more diapers? Ambivalent sexism, maternal gatekeeping and the division of childcare

This study examined the role of ambivalent sexist ideologies in the division of childcare responsibilities. It proposed maternal gatekeeping as a mediator through which hostile sexist attitudes toward men and women facilitate gendered division of childcare. A sample of 207 mothers with at least one child aged 6 years or younger completed extensive questionnaires. As hypothesized, the mother’s hostile sexist attitudes toward men and women were positively related to maternal gatekeeping tendencies. Gatekeeping, in turn, was related to the mother’s greater time investment in childcare and greater share of childcare tasks relative to the father. Finally, hostile sexist attitudes toward men and women had an indirect effect on the mother’s hours of care and relative share of childcare tasks, mediated though maternal gatekeeping. The findings underscore the importance of investigating the mechanisms through which sexist ideologies are translated into daily behaviors that help maintain a gendered social structure. They may be utilized to inform parenting interventions aimed at increasing collaborative family work and fathers’ participation

An analysis and comparison of multinational officers of the watch in the global maritime labor market

Officer of the watch (OOW) is an important part of the maritime labor market. For many years, countries have been improving their development of OOWs for the maritime market, in terms of both quantity and quality. As the supply of qualified OOWs for maritime transportation is such an important issue, shipping companies recruit multinational OOWs for both economic and socio-cultural reasons. This study aims to identify the qualifications of an ideal officer that holds office on commercial ships, and to make a comparison among Filipino, Chinese, Indian, Eastern European and Turkish OOWs. The research takes into account expert opinions of a number of shipping companies that employ multinational seafarers. A Fuzzy Analytic Hierarchy Process (FAHP) technique is applied in this study to assist in the comparison of officers. A number of main and sub-criteria are outlined to determine both positive and negative aspects of OOWs from the selected countries for decision making purposes. This study allows maritime countries to evaluate their maritime education and training policies for selection and assessment of OOWs. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group

Real-world efficacy and safety of Ledipasvir plus Sofosbuvir and Ombitasvir/Paritaprevir/Ritonavir +/- Dasabuvir combination therapies for chronic hepatitis C: A Turkish experience

Background/Aims: This study aimed to evaluate the real-life efficacy and tolerability of direct-acting antiviral treatments for patients with chronic hepatitis C (CHC) with/without cirrhosis in the Turkish population.Material and Methods: A total of 4,352 patients with CHC from 36 different institutions in Turkey were enrolled. They received ledipasvir (LDV) and sofosbuvir (SOF)+/- ribavirin (RBV) ombitasvir/paritaprevir/ritonavir +/- dasabuvir (PrOD)+/- RBV for 12 or 24 weeks. Sustained virologic response (SVR) rates, factors affecting SVR, safety profile, and hepatocellular cancer (HCC) occurrence were analyzed.Results: SVR12 was achieved in 92.8% of the patients (4,040/4,352) according to intention-to-treat and in 98.3% of the patients (4,040/4,108) according to per-protocol analysis. The SVR12 rates were similar between the treatment regimens (97.2%-100%) and genotypes (95.6%-100%). Patients achieving SVR showed a significant decrease in the mean serum alanine transaminase (ALT) levels (50.90 +/- 54.60 U/L to 17.00 +/- 14.50 U/L) and model for end-stage liver disease (MELD) scores (7.51 +/- 4.54 to 7.32 +/- 3.40) (p<0.05). Of the patients, 2 were diagnosed with HCC during the treatment and 14 were diagnosed with HCC 37.0 +/- 16.0 weeks post-treatment. Higher initial MELD score (odds ratio [OR]: 1.92, 95% confidence interval [CI]: 1.22-2.38; p=0.023]), higher hepatitis C virus (HCV) RNA levels (OR: 1.44, 95% CI: 1.31-2.28; p=0.038), and higher serum ALT levels (OR: 1.38, 95% CI: 1.21-1.83; p=0.042) were associated with poor SVR12. The most common adverse events were fatigue (12.6%), pruritis (7.3%), increased serum ALT (4.7%) and bilirubin (3.8%) levels, and anemia (3.1%).Conclusion: LDV/SOF or PrOD +/- RBV were effective and tolerable treatments for patients with CHC and with or without advanced liver disease before and after liver transplantation. Although HCV eradication improves the liver function, there is a risk of developing HCC.Turkish Association for the Study of The Liver (TASL

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems

New information on the lethal and sublethal effects of neonicotinoids and fipronil on organisms is presented in this review, complementing the previous WIA in 2015. The high toxicity of these systemic insecticides to invertebrates has been confirmed and expanded to include more species and compounds. Most of the recent research has focused on bees and the sublethal and ecological impacts these insecticides have on pollinators. Toxic effects on other invertebrate taxa also covered predatory and parasitoid natural enemies and aquatic arthropods. Little, while not much new information has been gathered on soil organisms. The impact on marine coastal ecosystems is still largely uncharted. The chronic lethality of neonicotinoids to insects and crustaceans, and the strengthened evidence that these chemicals also impair the immune system and reproduction, highlights the dangers of this particular insecticidal classneonicotinoids and fipronil. , withContinued large scale – mostly prophylactic – use of these persistent organochlorine pesticides has the potential to greatly decreasecompletely eliminate populations of arthropods in both terrestrial and aquatic environments. Sublethal effects on fish, reptiles, frogs, birds and mammals are also reported, showing a better understanding of the mechanisms of toxicity of these insecticides in vertebrates, and their deleterious impacts on growth, reproduction and neurobehaviour of most of the species tested. This review concludes with a summary of impacts on the ecosystem services and functioning, particularly on pollination, soil biota and aquatic invertebrate communities, thus reinforcing the previous WIA conclusions (van der Sluijs et al. 2015)