44 research outputs found

    Basement and Regional Structure Along Strike of the Queen Charlotte Fault in the Context of Modern and Historical Earthquake Ruptures

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    The Queen Charlotte fault (QCF) is a dextral transform system located offshore of southeastern Alaska and western Canada, accommodating similar to 4.4 cm/yr of relative motion between the Pacific and North American plates. Oblique convergence along the fault increases southward, and how this convergence is accommodated is still debated. Using seismic reflection data, we interpret offshore basement structure, faulting, and stratigraphy to provide a geological context for two recent earthquakes, an M-w 7.5 strike-slip event near Craig, Alaska, and an M-w 7.8 thrust event near Haida Gwaii, Canada. We map downwarped Pacific oceanic crust near 54 degrees N, between the two rupture zones. Observed downwarping decreases north and south of 54 degrees N, parallel to the strike of the QCF. Bending of the Pacific plate here may have initiated with increased convergence rates due to a plate motion change at similar to 6 Ma. Tectonic reconstruction implies convergence-driven Pacific plate flexure, beginning at 6 Ma south of a 10 degrees bend the QCF (which is currently at 53.2 degrees N) and lasting until the plate translated past the bend by similar to 2 Ma. Normal-faulted approximately late Miocene sediment above the deep flexural depression at 54 degrees N, topped by relatively undeformed Pleistocene and younger sediment, supports this model. Aftershocks of the Haida Gwaii event indicate a normal-faulting stress regime, suggesting present-day plate flexure and underthrusting, which is also consistent with reconstruction of past conditions. We thus favor a Pacific plate underthrusting model to initiate flexure and accommodation space for sediment loading. In addition, mapped structures indicate two possible fault segment boundaries along the QCF at 53.2 degrees N and at 56 degrees N.USGS Earthquake Hazards External Grants ProgramNational Earthquake Hazards Reduction ProgramUTIG Ewing/Worzel FellowshipInstitute for Geophysic

    Forming a Mogi Doughnut in the Years Prior to and Immediately Before the 2014 M8.1 Iquique, Northern Chile, Earthquake

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    Asperities are patches where the fault surfaces stick until they break in earthquakes. Locating asperities and understanding their causes in subduction zones is challenging because they are generally located offshore. We use seismicity, interseismic and coseismic slip, and the residual gravity field to map the asperity responsible for the 2014M8.1 Iquique, Chile, earthquake. For several years prior to the mainshock, seismicity occurred exclusively downdip of the asperity. Two weeks before the mainshock, a series of foreshocks first broke the upper plate then the updip rim of the asperity. This seismicity formed a ring around the slip patch (asperity) that later ruptured in the mainshock. The asperity correlated both with high interseismic locking and a circular gravity low, suggesting that it is controlled by geologic structure. Most features of the spatiotemporal seismicity pattern can be explained by a mechanical model in which a single asperity is stressed by relative plate motion

    Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group.

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    Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse events (irAEs). Many of these are driven by the same immunologic mechanisms responsible for the drugs\u27 therapeutic effects, namely blockade of inhibitory mechanisms that suppress the immune system and protect body tissues from an unconstrained acute or chronic immune response. Skin, gut, endocrine, lung and musculoskeletal irAEs are relatively common, whereas cardiovascular, hematologic, renal, neurologic and ophthalmologic irAEs occur much less frequently. The majority of irAEs are mild to moderate in severity; however, serious and occasionally life-threatening irAEs are reported in the literature, and treatment-related deaths occur in up to 2% of patients, varying by ICI. Immunotherapy-related irAEs typically have a delayed onset and prolonged duration compared to adverse events from chemotherapy, and effective management depends on early recognition and prompt intervention with immune suppression and/or immunomodulatory strategies. There is an urgent need for multidisciplinary guidance reflecting broad-based perspectives on how to recognize, report and manage organ-specific toxicities until evidence-based data are available to inform clinical decision-making. The Society for Immunotherapy of Cancer (SITC) established a multidisciplinary Toxicity Management Working Group, which met for a full-day workshop to develop recommendations to standardize management of irAEs. Here we present their consensus recommendations on managing toxicities associated with immune checkpoint inhibitor therapy

    The Cascadia Initiative : a sea change In seismological studies of subduction zones

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    Author Posting. © The Oceanography Society, 2014. This article is posted here by permission of The Oceanography Society for personal use, not for redistribution. The definitive version was published in Oceanography 27, no. 2 (2014): 138-150, doi:10.5670/oceanog.2014.49.Increasing public awareness that the Cascadia subduction zone in the Pacific Northwest is capable of great earthquakes (magnitude 9 and greater) motivates the Cascadia Initiative, an ambitious onshore/offshore seismic and geodetic experiment that takes advantage of an amphibious array to study questions ranging from megathrust earthquakes, to volcanic arc structure, to the formation, deformation and hydration of the Juan De Fuca and Gorda Plates. Here, we provide an overview of the Cascadia Initiative, including its primary science objectives, its experimental design and implementation, and a preview of how the resulting data are being used by a diverse and growing scientific community. The Cascadia Initiative also exemplifies how new technology and community-based experiments are opening up frontiers for marine science. The new technology—shielded ocean bottom seismometers—is allowing more routine investigation of the source zone of megathrust earthquakes, which almost exclusively lies offshore and in shallow water. The Cascadia Initiative offers opportunities and accompanying challenges to a rapidly expanding community of those who use ocean bottom seismic data.The Cascadia Initiative is supported by the National Science Foundation; the CIET is supported under grants OCE- 1139701, OCE-1238023, OCE‐1342503, OCE-1407821, and OCE-1427663 to the University of Oregon

    Correction to “Elastic wave speeds and moduli in polycrystalline ice Ih, sI methane hydrate, and sII methane-ethane hydrate”

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    Author Posting. © American Geophysical Union, 2009. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 114 (2009): B04299, doi:10.1029/2009JB006451

    The continental margin off Oregon from seismic investigations

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    In April and May 1996, a geophysical study of the Cascadia continental margin off Oregon and Washington was carried out aboard the German RV Sonne as a cooperative experiment between GEOMAR, the USGS and COAS. Offshore central Oregon, which is the subject of this study, the experiment involved the collection of wide-angle refraction and reflection data along three profiles across the continental margin using ocean-bottom seismometers (OBS) and hydrophones (OBH) as well as land recorders. Two-dimensional modelling of the travel times provides a detailed velocity structure beneath these profiles. The subducting oceanic crust of the Juan de Fuca plate can be traced from the trench to its position some 10 km landward of the coastline. At the coastline, the Moho has a depth of 30 km. The dip of the plate changes from 1.5° westward of the trench to about 6.5° below the accretionary complex and to about 16° further eastward below the coast. The backstop forming western edge of the Siletz terrane, an oceanic plateau that was accreted to North America about 50 Ma ago, is well defined by the observations. It is located about 60 km to the east of the deformation front and has a seaward dip of 40°. At its seaward edge, the base of the Siletz terrane seems to be in contact with the subducting oceanic crust implying that sediments are unlikely to be subducted to greater depths. The upper oceanic crust is thinner to the east of this contact than to the west. At depths greater than 18 km, the top of the oceanic crust is the origin of pre-critical reflections observable in several land recordings and in the data of one ocean bottom instrument. These reflections are most likely caused by fluids that are released from the oceanic crust by metamorphic facies transition

    Hydrate Ridge—A Gas Hydrate System in a Subduction Zone Setting

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    Hydrate Ridge is a 6–10 km wide, 22 km long N–S striking thrust ridge within the Cascadia accretionary prism offshore of Oregon in the NE Pacific Ocean. Over the past four decades it has been a primary focus site for studies of gas hydrate/free gas systems within a convergent margin setting. A local peak called the North Hydrate Ridge (NHR), located at a depth of 590 m, hosts the first documented cold seep system driven by convergent margin processes and supports chemosynthetic communities sustained by the anaerobic oxidation of methane. A southern peak at 780 m depth, known as the South Hydrate Ridge (SHR), is actively venting gas around an area of seafloor bacterial mats and a 40 m high carbonate chimney within a long-lived vent system separate from NHR. Bottom simulating reflections (BSRs) observed in seismic profiles indicate these vents are part of a broad gas hydrate province that extends across all of Hydrate Ridge. Hydrate Ridge has been the focus of extensive geophysical surveys, water column acoustic and sampling surveys, high-resolution seafloor mapping using remotely operated, autonomous and deep-towed vehicles, seafloor fluid flow monitoring, and a site for the Ocean Observatories Initiative (OOI). All of these are in support or complementing Ocean Drilling Program (ODP) drilling efforts during Legs 146 and 204 to quantify and characterize the gas hydrate/free gas system. Hydrate concentrations are up to 45% of pore space (30% of total volume), but typically 2–20%, and are strongly coupled with the structure and stratigraphy within the thrust ridge
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