Alpha-mangostin inhibits the migration and invasion of A549 lung cancer cells

Several studies have indicated that α-mangostin exerts anti-metastasis and anti-subsistence effects on several types of cancer cells. Especially, the anti-metastatic effect of α-mangostin on cancer cells is a prospective function in cancer treatment. However, the metastasis process is complicated, and includes migration, invasion, intravasation, and extravasation; thus, the main target of anti-metastatic effect of α-mangostin is not known. In this study, we investigated the effects of α-mangostin on the invasion, subsistence, and migration of lung cancer cells under co-culture conditions with normal cells and regular mono-culture conditions. We found that α-mangostin killed the lung cancer and normal cells in a dose-dependent manner. Furthermore, the alteration in the surface mechanical properties of cells was examined by using atomic force microscopy. Although the α-mangostin concentrations of 5 and 10 µM did not affect the short-term cell viability, they considerably decreased the Young’s modulus of lung cancer cells implying a decline in cell surface actin cytoskeletal properties. Additionally, these concentrations of α-mangostin inhibited the migration of lung cancer cells. In co-culture conditions (cancer cells with normal cells), the invasive activities of cancer cells on normal cells were discernibly observed, and was inhibited after treatment with 5 and 10 µM of α-mangostin. Taken together, α-mangostin suppressed the subsistence of lung cancer cells and displayed anti-metastatic activities by inhibiting the migration and invasion, and reducing the actin cytoskeleton of cancer cells. Our findings suggest that α-mangostin could be a potential therapeutic agent for cancer treatment

RMDM: A Multilabel Fakenews Dataset for Vietnamese Evidence Verification

In this study, we present a novel and challenging multilabel Vietnamese dataset (RMDM) designed to assess the performance of large language models (LLMs), in verifying electronic information related to legal contexts, focusing on fake news as potential input for electronic evidence. The RMDM dataset comprises four labels: real, mis, dis, and mal, representing real information, misinformation, disinformation, and mal-information, respectively. By including these diverse labels, RMDM captures the complexities of differing fake news categories and offers insights into the abilities of different language models to handle various types of information that could be part of electronic evidence. The dataset consists of a total of 1,556 samples, with 389 samples for each label. Preliminary tests on the dataset using GPT-based and BERT-based models reveal variations in the models' performance across different labels, indicating that the dataset effectively challenges the ability of various language models to verify the authenticity of such information. Our findings suggest that verifying electronic information related to legal contexts, including fake news, remains a difficult problem for language models, warranting further attention from the research community to advance toward more reliable AI models for potential legal applications.Comment: ISAILD@KSE 202

When Intervention Becomes Imperative: A Case Report of Spontaneous Vulvar Edema During Pregnancy

Spontaneous idiopathic vulvar edema during the second trimester is a rare condition. The approach to managing this condition involves relieving symptoms, identifying underlying causes, and implementing appropriate treatment. Managing such cases during pregnancy is challenging because of concerns for potential adverse fetal outcomes. Conservative management expects the condition to be relieved spontaneously postpartum, whereas invasive treatment offers a more rapid resolution. Treatment choices are controversial because each method has its pros and cons and influences the delivery process to a certain extent. Surgical drainage becomes a viable option when patients are not responsive to medications. We report a case of spontaneous massive vulvar edema in a 22-year-old primigravida in her 23rd week of pregnancy. After ruling out other notable causes of vulvar edema, we decided to intervene using an invasive procedure because she complained of progressive symptoms and discomfort. Subsequently, the edema subsided postprocedure, and the patient experienced successful labor with no complications. This report aims to alert clinicians that drainage attempts should be considered in pregnant patients with worsening symptoms

The impacts of lead recycling activities to human health and environment in Dong Mai craft village, Hung Yen, Vietnam

Lead (Pb) recycling activities in Dong Mai village, Chi Dao commune, Van Lam district, Hung Yen province have been taking place for more than 30 years. The development of recycling activities contributed to the improvement of the local economics. However, along with economic development, Dong Mai craft village is facing to serious pollution. Soil, air and water polluted by lead (Pb) caused food containing Pb at higher levels than allowed limit from 20 to 40 times. The pollution had the bad effect on human health in this village. The investigation results showed that 100 % of employee who participated on melting lead and 63.5 % of local children were poisoned by Pb. Besides, the local people got diseases relating to skin, eyes, etc. This situation requires the provincial authorities to find immediate solutions to reduce the impacts of Pb recycling activities to environment and human.Hoạt động tái chế chì của thôn Đông Mai, xã Chỉ Đạo, huyện Văn Lâm, tỉnh Hưng Yên đã diễn ra hơn 30 năm nay. Sự phát triển của nghề tái chế đã làm góp phần cải thiện kinh tế của địa phương. Tuy nhiên, cùng với sự phát triển kinh tế, làng nghề Đông Mai đã và đang đối mặt với ô nhiễm môi trường nghiêm trọng. Môi trường đất, nước không khí bị ô nhiễm bởi chì (Pb) dẫn đến thực phẩm nhiễm chì ở hàm lượng cao hơn mức cho phép từ 20- 40 lần. Sự ô nhiễm gây ra những ảnh hưởng xấu tới sức khỏe của người dân làng nghề. Kết quả điều tra cho thấy 100% công nhân tham gia nấu chì và 63.5% trẻ em địa phương bị nhiễm độc chì. Bên cạnh đó, người dân địa phương còn bị mắc của các loại bệnh ngoài da, bệnh về mắt, …. Tình trạng này đòi hỏi chính quyền địa phương phải tìm ra giải pháp khẩn cấp để giảm thiểu tác động của những hoạt động tái chế chì tới môi trường và con người

The institutional experience of the implementing 4DCT in NSCLC radiotherapy planning

Background: The study was to evaluate the effectiveness of dose distribution of four-dimensional computed tomography (4DCT) simulation. Materials and methods: The gross tumor volume (GTV) and clinical target volume (CTV) were contoured in all 10 respiratory phases of 4DCT in 30 patients with non-small cell lung cancer (NSCLC). Both 3D and 4D treatment plans were made individually for each patient using the planning volume (PTV). The PTV3D was taken from a single CTV plus the recommended margin, and the PTV4D was taken from the 4D internal target volume, including all 10 CTVs plus the setup margins. Results The mean PTV was 460 ± 179 (69–820) cm3 for 3DCT and 401 ± 167 (127–854) cm3 for 4DCT (p = 0.0018). The dose distribution (DD) of organs at risk, especially the lungs, was lower for the 4DCT simulation. The V5%, V10%, and V20% of the total lung dose for 4DCT were significantly lower for the 3DCT. However, lung V30% the heart, esophagus, and spinal cord were not significantly different. In addition, the conformity index and the dose heterogeneity index of the PTV were not significantly different. The normal tissue complication probability (NTCP) of the lung and heart was significantly lower for 4DCT than for 3DCT. Conclusions: The 4DCT simulation gives better results on the NTCP. The organs at risk, especially the lungs, receive a significantly lower DD compared with the 3DCT. The conformity index (CI), heterogeneity index (HI) and the DD to the heart, spinal cord, and esophagus were not significantly different between the two techniques

Factors affecting consumer’s bargaining behavior: The case of fashionable clothing

Shopping is one of the current trends of the Vietnamese. According to Nielsen’s research results about consumer confidence in the fourth quarter of 2017, more than half of Vietnamese people (51%) use their spare money to buy new clothes at modern business models such as supermarkets, shopping centers, or at very traditional models like street vendors and wet markets where haggling (also known as bargaining) is considered as a common habit for Vietnamese. This is due to business characteristics from a very long time ago in Viet Nam. The bargaining behavior is not so hard to recognize in shopping. Even now, a large part of foreign tourists is familiar with the bargaining culture. This study aimed to discover bargaining behavior, the factors affecting such a behavior in buying fashionable clothing of the consumers in Ho Chi Minh City, and to consider whether the differences in bargaining behavior exist among different groups of gender, age, and income. The research was conducted using mixed methods concluding qualitative research (in-depth interview and focus group) and quantitative one (survey). The results showed that Attitude towards bargaining, Perceived behavioral control, Interest in bargaining affect Consumer’s bargaining behavior when buying fashionable clothes. Results were validated in Ho Chi Minh City context, and some conclusions were also presented

Polyphasic evaluation and cytotoxic investigation of isolated cyanobacteria with an emphasis on potent activities of a Scytonema strain

DATA AVAILABILITY STATEMENT : The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found in the article/supplementary material.Cyanobacteria are phototrophic organisms widely found in most types of natural habitats in the tropical regions of the world. In this study, we isolated and identified cyanobacterial strains from paddy soil in Hanoi (Vietnam) and investigated their cytotoxic activities. Five isolated cyanobacterial strains showed distinctive profiles of gene sequences (rRNA 16S and rbcL), phylogenetic placements, and morphological characteristics. Based on the polyphasic evaluation, they were classified as Scytonema bilaspurense NK13, Hapalosiphon welwitschii MD2411, Aulosira sp. XN1103, Desikacharya sp. NS2000, and Desmonostoc sp. NK1813. The cytotoxic screening revealed that the extract of strain Scytonema bilaspurense NK13 exhibited potent cytotoxic activities against four human cell lines of HeLa cells, OVCAR-8 cells, HaCaT cells, and HEK-293T cells, with IC50 values of 3.8, 34.2, 21.6, and 0.6μg/mL, respectively. This is the first time a well-classified Scytonema strain from tropical habitat in Southeast Asia has been recognized as a potential producer of cytotoxic compounds.The Vietnam National University, Hanoi (VNU).http://www.frontiersin.org/Microbiologyam2023BiochemistryGeneticsMicrobiology and Plant Patholog

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke

Designing a Service Manual for Employees : A Case Study of Huone Events Hotel Helsinki

The constantly growing service sector in Finland, especially in the capital city Helsinki, requires continuous efforts from organisations to not only provide the most excellent services, but also to maintain a consistently high quality standard. One solution for ensuring consistency in the working performance of various employees within an organisation is to utilise a working manual where the most crucial information on how to conduct a desired operation is clearly described. Understanding the tremendous benefits of a working manual, Huone, the first event hotel in Helsinki and which is expanding internationally, decided to adopt a working “service manual” for their service department. This thesis aims at providing information on how to develop the service manual, its contents and benefits in a general context. The outcome of the project is an actual service manual delivered to Huone Helsinki as the end result. The theoretical background supporting the reliability and validity of this thesis is derived from textbooks, digital materials, academic journals and articles, as well as educational webpages. In addition, official handbooks and guidelines providing instructions on creating employee manuals together with insights from hospitality management also form the core knowledge base for this thesis. A qualitative approach was taken to for data collection, utilising such methods as open-ended surveys, observations, interviews, and the construction of a service blueprint based on the analysis of a self-designed customer journey. Analysis of the research results shows that delivering a service manual boosts the standardisation of working processes, which is important to ensure the consistent quality service of one company, especially during an expansion phase, as in the case of Huone Helsinki. A comprehensive understanding of the service manual creation process including its content details is crucial in constructing a successful service manual. The main outcome of the project was an actual service manual distributed to Huone Helsinki staff and based on the assessment of feedback results received, the functionality and use value of the designed service manual is highly appreciated, especially within the service department. In the future, possible updates to the service manual should be conducted periodically, and more manuals for other departments in Huone Helsinki can also be developed

RESEARCH ON FACTORS AFFECTING THE CONVERSION OF CROP COMPOSITION ON RICE-LAND IN HAU GIANG PROVINCE – VIET NAM

Research on factors affecting the conversion of crop composition on rice-land was carried out from April to September 2017 to study the outcomes of the conversion of crop composition on rice-land as well as to identify the reasons why farmers decided to change their crop composition. Data were collected from May 2017 by conducting questionnaire interviews with 180 farming households. Results show that households who grow 2 rice crops and 1 other crop can earn more profits as compared to those who grow 3 rice crops a year. Profit margin (net income/revenue) earned by farming households who grow 2 rice crops and 1 other crop is 0.49 and this is higher than that (0.41) earned by farming households who grow 3 rice crops a year. Households growing leaf vegetable can earn higher profits as compared to that earned by households who grow other crops on rice land. Testing the difference of costs, profits and profit margin between the two compositions show that there\u27s a difference with α=5%. Factors affecting the outcomes of crop composition conversion include: financial resources, effects from FFS training course, support from the Government and Local authorities, irrigation system (canals) and water quality. Among these factors, financial resources variable has the biggest impact on the outcome of crop composition conversion