DATA AVAILABILITY STATEMENT : The datasets presented in this study can be found in
online repositories. The names of the repository/repositories
and accession number(s) can be found in the
article/supplementary material.Cyanobacteria are phototrophic organisms widely found in most types of
natural habitats in the tropical regions of the world. In this study, we isolated
and identified cyanobacterial strains from paddy soil in Hanoi (Vietnam)
and investigated their cytotoxic activities. Five isolated cyanobacterial strains
showed distinctive profiles of gene sequences (rRNA 16S and rbcL),
phylogenetic placements, and morphological characteristics. Based on the
polyphasic evaluation, they were classified as Scytonema bilaspurense NK13,
Hapalosiphon welwitschii MD2411, Aulosira sp. XN1103, Desikacharya sp.
NS2000, and Desmonostoc sp. NK1813. The cytotoxic screening revealed that
the extract of strain Scytonema bilaspurense NK13 exhibited potent cytotoxic
activities against four human cell lines of HeLa cells, OVCAR-8 cells, HaCaT
cells, and HEK-293T cells, with IC50 values of 3.8, 34.2, 21.6, and 0.6μg/mL,
respectively. This is the first time a well-classified Scytonema strain from
tropical habitat in Southeast Asia has been recognized as a potential producer
of cytotoxic compounds.The Vietnam National University, Hanoi (VNU).http://www.frontiersin.org/Microbiologyam2023BiochemistryGeneticsMicrobiology and Plant Patholog
