Lo funcional y lo estético, un equilibrio para habitar el centro deportivo y cultural ACRO

Los aspectos funcionales y estéticos en la arquitectura han cobrado mayor importancia que algunos aspectos humanos en el desarrollo de la misma, esto conduce a que la idea de habitar un espacio no predomine en la esencia poética de la arquitectura, por lo tanto este proyecto reflexiona sobre la idea de habitar, con el objeto de exaltar los aspectos funcionales y estéticos para así reforzar el concepto de habitar, a partir de esto el desarrollo del proyecto contribuirá a vigorizar la relación del hombre con el espacio a fin de crear ambientes funcionales que aporten al diseño interior y exterior del proyecto, a través de un centro deportivo y cultural ACRO, ubicado en localidad de Puente Aranda.The functional and aesthetic aspects in architecture have become more important than some human aspects in its development, this leads to the idea of inhabiting a space not prevailing in the poetics of architecture, therefore this project reflects on the idea of inhabiting, in order to exalt the functional and aesthetic aspects in order to reinforce the concept of inhabiting, from this the development of the project will contribute to invigorate the relationship between man and space in order to create functional environments that contribute to the design interior and exterior of the project, through an ACRO sports and cultural center, located in the town of Puente Aranda

Antiradical and functional properties of subcritical water extracts from edible mushrooms and from commercial counterparts

This study deals with the antioxidant and functional potential of subcritical water extracts from edible mushrooms, in comparison to commercial products. Pleurotus citrinopileatus extracts showed the highest phenolic content and antioxidant properties. Similar results were determined in commercial extracts of Coriolus versicolor. The highest growth inhibition in selected human carcinogenic cells was identified for the P. citrinopileatus extract obtained during heating up to 160 °C. Rheological studies confirmed that glucan-based hydrogels prepared with mushroom extracts exhibited enhanced viscoelastic properties compared to those formulated with commercial products. The extracts providing the strongest gels were obtained from Pleurotus eryngii, followed by Hericium erinaceus and Pleurotus citrinopileatus. No water syneresis for the proposed hydrogels was observed. The formulated hydrogels could be interesting for their application in the food sector.Ministerio de Ciencia e Innovación | Ref. BES-2016-076840Ministerio de Ciencia, Innovación y Universidades | Ref. RYC2018-024454-

Genomic analysis of Mycobacterium brumae sustains its nonpathogenic and immunogenic phenotype

Mycobacterium brumae is a rapid-growing, non-pathogenic Mycobacterium species, originally isolated from environmental and human samples in Barcelona, Spain. Mycobacterium brumae is not pathogenic and it's in vitro phenotype and immunogenic properties have been well characterized. However, the knowledge of its underlying genetic composition is still incomplete. In this study, we first describe the 4 Mb genome of the M. brumae type strain ATCC 51384T assembling PacBio reads, and second, we assess the low intraspecies variability by comparing the type strain with Illumina reads from three additional strains. Mycobacterium brumae genome is composed of a circular chromosome with a high GC content of 69.2% and containing 3,791 CDSs, 97 pseudogenes, one prophage and no CRISPR loci. Mycobacterium brumae has shown no pathogenic potential in in vivo experiments, and our genomic analysis confirms its phylogenetic position with other non-pathogenic and rapid growing mycobacteria. Accordingly, we determined the absence of virulence-related genes, such as ESX-1 locus and most PE/PPE genes, among others. Although the immunogenic potential of M. brumae was proved to be as high as Mycobacterium bovis BCG, the only mycobacteria licensed to treat cancer, the genomic content of M. tuberculosis T cell and B cell antigens in M. brumae genome is considerably lower than those antigens present in M. bovis BCG genome. Overall, this work provides relevant genomic data on one of the species of the mycobacterial genus with high therapeutic potential

Sustainable Solar Drying of Brewer’s Spent Grains: A Comparison with Conventional Electric Convective Drying

Spent grains from microbreweries are mostly formed by malting barley (or malt) and are suitable for a further valorization process. Transforming spent grains from waste to raw materials, for instance, in the production of nontraditional flour, requires a previous drying process. A natural convection solar dryer (NCSD) was evaluated as an alternative to a conventional electric convec-tive dryer (CECD) for the dehydration process of local microbrewers’ spent grains. Two types of brewer’s spent grains (BSG; Golden ale and Red ale) were dried with both systems, and sustainability indices, specific energy consumption (eC), and CO2 emissions were calculated and used to assess the environmental advantages and disadvantages of the NCSD. Then, suitable models (empirical, neural networks, and computational fluid dynamics) were used to simulate both types of drying processes under different conditions. The drying times were 30–85 min (depending on the drying temperature, 363.15 K and 333.15 K) and 345–430 min (depending on the starting daytime hour at which the drying process began) for the CECD and the NCSD, respectively. However, eC and CO2 emissions for the CECD were 1.68–1.88 · 10−3 (kW h)/kg and 294.80–410.73 kg/(kW h) for the different drying temperatures. Using the NCSD, both indicators were null, considering this aspect as an environmental benefit.Fil: Capossio, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; ArgentinaFil: Fabani, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; ArgentinaFil: Reyes Urrutia, Ramón Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; ArgentinaFil: Torres Sciancalepore, Rodrigo Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; ArgentinaFil: Deng, Yimin. Katholikie Universiteit Leuven; BélgicaFil: Baeyens, Jan. Katholikie Universiteit Leuven; Bélgica. Beijing University Of Chemical Technology; ChinaFil: Rodriguez, Rosa Ana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Patagonia Confluencia. Instituto de Investigacion y Desarrollo En Ingenieria de Procesos, Biotecnologia y Energias Alternativas. Grupo Vinculado Instituto de Ingenieria Quimica | Universidad Nacional del Comahue. Instituto de Investigacion y Desarrollo En Ingenieria de Procesos, Biotecnologia y Energias Alternativas. Grupo Vinculado Instituto de Ingenieria Quimica.; ArgentinaFil: Mazza, German Delfor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; Argentin

Modelo de Negocio Segmentado Guascas Tradición, Nutrición y Sabor

Con el pasar de los años y el desgaste de los mismos, el cuerpo sufre numerosas transformaciones que hacen que nuestro estilo de vida con el pasar de los años cambie. Por ejemplo, la textura de la piel, la descalcificación de los huesos, la pérdida de flexibilidad, movilidad, sueño y apetito, enfermedades cardíacas y digestivas, entre otras, son el diario vivir de un gran porcentaje de los adultos mayores. Pero, pasamos desapercibido el papel fundamental que cumple una buena alimentación para controlar o aliviar las enfermedades y más, cuando nuestro ritmo de vida se ve apaciguado por la vejez

La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia, en los municipios de Fusagasugá, Pasca, San Vicente del Caguán y Santa Marta

El proyecto de análisis de la imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia, tiene como fin demostrar los impactos psicosociales del conflicto armado en el territorio colombiano, siendo que quienes se enfrentan a episodios traumáticos requieren de una especial atención y orientación no solo para el restablecimiento de sus derechos, sino además para forjar su proyecto de vida, el cual se ve interrumpido por situaciones circunstanciales que no le permiten desarrollarse plenamente y vivir en dignidad. A lo anterior, se genera el análisis del caso Modesto Pacaya, desde el cual se plantean una serie de preguntas circulares, reflexivas y estratégicas, con el objetivo de que el sujeto sea capaz desde sus recursos de afrontar y superar el estado de vulneración, para consiguientemente, analizar el caso de Peñas Coloradas, una comunidad campesina que se vio obligada a abandonar su territorio a causa de la mala práctica del estado y las fuerzas militares, dando respuesta a los emergentes psicosociales propios del proceso de la expropiación de tierras, así como estrategias integrales para la mejora de estos escenarios. Para finalmente, encontrar un informe reflexivo acerca del ejercicio foto voz, consolidado en los municipios de Fusagasugá, Pasca, San Vicente del Caguan, y la ciudad de Santa Marta, así como una página Wix, que da cuenta de una exposición de los resultados obtenidos, en miras a identificar tanto aspectos negativos como positivos de las comunidades, para solventar y mitigar desde la praxis psicológica los impactos del conflicto armado.The image and narrative analysis project as tools for psychosocial approach in scenarios of violence, aims to demonstrate the psychosocial impacts of the armed conflict in Colombia, whereas those facing traumatic events require special attention and guidance not only for the restoration of their rights, but also for shaping their life project, which is interrupted by circumstantial situations that do not allow it to develop fully and live in dignity. To the foregoing, the analysis of the Modesto Pacaya case is generated, from which a series of circular, thoughtful and strategic questions are posed, with the aim of making the subject capable from his resources of confronting and overcoming the state of violation, in order to consequently, to analyze the case of Peñas Coloradas, a peasant community that was forced to leave its territory due to the bad practice of the state and the military, responding to the emerging psychosocial processes of land expropriation, as well as comprehensive strategies for improving these scenarios. To finally find a reflective report about the exercise photo voice, consolidated in the municipalities of Fusagasuga, Pasca, San Vicente del Caguan, and the city of Santa Marta, as well as a Wix page, which gives an account of the results obtained, with a view to identifying both negative and positive aspects of the communities, to solve and mitigate the impacts of the armed conflict from the psychological praxis

Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia

Aberrant DNA methylation is one of the most frequent alterations in patients with Acute Lymphoblastic Leukemia (ALL). Using methylation bead arrays we analyzed the methylation status of 807 genes implicated in cancer in a group of ALL samples at diagnosis (n = 48). We found that 154 genes were methylated in more than 10% of ALL samples. Interestingly, the expression of 13 genes implicated in the TP53 pathway was downregulated by hypermethylation. Direct or indirect activation of TP53 pathway with 5-aza-29-deoxycitidine, Curcumin or Nutlin-3 induced an increase in apoptosis of ALL cells. The results obtained with the initial group of 48 patients was validated retrospectively in a second cohort of 200 newly diagnosed ALL patients. Methylation of at least 1 of the 13 genes implicated in the TP53 pathway was observed in 78% of the patients, which significantly correlated with a higher relapse (p = 0.001) and mortality (p,0.001) rate being an independent prognostic factor for disease-free survival (DFS) (p = 0.006) and overall survival (OS) (p = 0.005) in the multivariate analysis. All these findings indicate that TP53 pathway is altered by epigenetic mechanisms in the majority of ALL patients and correlates with prognosis. Treatments with compounds that may reverse the epigenetic abnormalities or activate directly the p53 pathway represent a new therapeutic alternative for patients with ALL

Study of the production of Λb0\Lambda_b^0 and B‾0\overline{B}^0 hadrons in pppp collisions and first measurement of the Λb0→J/ψpK−\Lambda_b^0\rightarrow J/\psi pK^- branching fraction

The product of the $\Lambda_b^0$ ($\overline{B}^0$) differential production cross-section and the branching fraction of the decay $\Lambda_b^0\rightarrow J/\psi pK^-$ ($\overline{B}^0\rightarrow J/\psi\overline{K}^*(892)^0$) is measured as a function of the beauty hadron transverse momentum, $p_{\rm T}$, and rapidity, $y$. The kinematic region of the measurements is $p_{\rm T}<20~{\rm GeV}/c$ and $2.0<y<4.5$. The measurements use a data sample corresponding to an integrated luminosity of $3~{\rm fb}^{-1}$ collected by the LHCb detector in $pp$ collisions at centre-of-mass energies $\sqrt{s}=7~{\rm TeV}$ in 2011 and $\sqrt{s}=8~{\rm TeV}$ in 2012. Based on previous LHCb results of the fragmentation fraction ratio, $f_{\Lambda_B^0}/f_d$, the branching fraction of the decay $\Lambda_b^0\rightarrow J/\psi pK^-$ is measured to be \begin{equation*} \mathcal{B}(\Lambda_b^0\rightarrow J/\psi pK^-)= (3.17\pm0.04\pm0.07\pm0.34^{+0.45}_{-0.28})\times10^{-4}, \end{equation*} where the first uncertainty is statistical, the second is systematic, the third is due to the uncertainty on the branching fraction of the decay $\overline{B}^0\rightarrow J/\psi\overline{K}^*(892)^0$, and the fourth is due to the knowledge of $f_{\Lambda_b^0}/f_d$. The sum of the asymmetries in the production and decay between $\Lambda_b^0$ and $\overline{\Lambda}_b^0$ is also measured as a function of $p_{\rm T}$ and $y$. The previously published branching fraction of $\Lambda_b^0\rightarrow J/\psi p\pi^-$, relative to that of $\Lambda_b^0\rightarrow J/\psi pK^-$, is updated. The branching fractions of $\Lambda_b^0\rightarrow P_c^+(\rightarrow J/\psi p)K^-$ are determined.Comment: 29 pages, 19figures. All figures and tables, along with any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2015-032.htm