Simple oxidation of pyrimidinylhydrazones to triazolopyrimidines and their inhibition of Shiga toxin trafficking

The oxidative cyclisation of a range of benzothieno[2,3-d]pyrimidine hydrazones (7a–j) to the 1,2,4-triazolo[4,3-c]pyrimidines (8a–j) catalysed by lithium iodide or to the 1,2,4-triazolo[1,5-c]pyrimidines (10a–j) with sodium carbonate is presented. A complementary synthesis of the 1,2,4-triazolo[1,5-c]pyrimidines starting from the amino imine 11 is also reported. The effect of these compounds on Shiga toxin (STx) trafficking in HeLa cells and comparison to the previously reported Exo2 is also detailed

RAFT dispersion polymerization : a method to tune the morphology of thymine-containing self-assemblies

YesThe synthesis and self-assembly of thymine-containing polymers were performed using RAFT dispersion polymerization. A combination of microscopy and scattering techniques was used to analyze the resultant complex morphologies. The primary observation from this study is that the obtained aggregates induced during the polymerization were well-defined despite the constituent copolymers possessing broad dispersities. Moreover, a variety of parameters, including the choice of polymerization solvent, the degree of polymerization of both blocks and the presence of an adenine-containing mediator, were observed to affect the resultant size and shape of the assembly.University of Warwick, National Science Foundation (U.S.) (NSF), Engineering and Physical Sciences Research Council (EPSRC

Controlled radical polymerization of styrene by reverse iodine transfer polymerization (RITP)

International audienc

Use of Sodium Iodide as the Precursor to the Control Agent in ab initio Emulsion Polymerization

International audienc

Polymérisation radicalaire contrôlée par transfert d'iode en mode direct (ITP) et en mode inverse (RITP) en milieux aqueux dispersés

MONTPELLIER-BU Sciences (341722106) / SudocSudocFranceF

One-Pot Surfactant-Free Functional Latexes by Controlled Radical Polymerization in ab initio Emulsion

International audienc

Controlled radical polymerization of styrene by iodine transfer polymerization (ITP) in ab initio emulsion

International audienc