INTERNATIONALIZATION OF CLINICAL AND EXPERIMENTAL MEMORY RESEARCH

A problem-oriented retrospective information search in MEDLINE on CD-ROM in 1981-1993 revealed the relevant publications devoted mainly to physiology and pharmacology of human and animal memory. The annual dynamics of a set of bibliometric parameters (number of articles and journals containing these articles; number of countries of authors and journals; number of publications in own and foreign journals; number of interdisciplinary and international journals, language of papers, etc.) was studied to identify some essential patterns of internationalization of the interdisciplinary memory research. There were a total of 5597 papers by authors from 48 countries in 809 journals from 40 countries. In 1988-1993 only, there were 1361 papers (48,47 %) in foreign journals. In 42 international journals from 9 countries a total of 231 papers were published while 50 interdisciplinary journals from 13 countries contained 579 papers. Bulgarian memory research was relatively insufficiently presented in this data-base

Sustained oscillations, irregular firing, and chaotic dynamics in hierarchical modular networks with mixtures of electrophysiological cell types

The cerebral cortex exhibits neural activity even in the absence of externalstimuli. This self-sustained activity is characterized by irregular firing ofindividual neurons and population oscillations with a broad frequency range.Questions that arise in this context, are: What are the mechanismsresponsible for the existence of neuronal spiking activity in the cortexwithout external input? Do these mechanisms depend on the structural organization of the cortical connections? Do they depend onintrinsic characteristics of the cortical neurons? To approach the answers to these questions, we have used computer simulations of cortical network models. Our networks have hierarchical modular architecture and are composedof combinations of neuron models that reproduce the firing behavior of the five main cortical electrophysiological cell classes: regular spiking (RS), chattering (CH), intrinsically bursting (IB), low threshold spiking (LTS) and fast spiking (FS). The population of excitatory neurons is built of RS cells(always present) and either CH or IB cells. Inhibitoryneurons belong to the same class, either LTS or FS. Long-lived self-sustained activity states in our networksimulations display irregular single neuron firing and oscillatoryactivity similar to experimentally measured ones. The duration of self-sustained activity strongly depends on the initial conditions,suggesting a transient chaotic regime. Extensive analysis of the self-sustainedactivity states showed that their lifetime expectancy increases with the numberof network modules and is favored when the network is composed of excitatory neurons of the RS and CH classes combined with inhibitory neurons of the LTS class. These results indicate that the existence and properties of the self-sustained cortical activity states depend on both the topology of the network and the neuronal mixture that comprises the network

Tactics of treatment of acute left colon cancer obstruction

Back ground: Advanced colorectal cancer is commonly associated with colon obstruction/between 15-20% of patients with colonic cancer/ or/and tumor infiltration to adjacent organs. We set out to study in-hospital morbidity and mortality after operations of acute left colon cancer obstruction.Methods: From 2000 to 2010 the medical records of 204 cases /15.1%/ of acute left colon cancer obstruction were reviewed from total of 1351 patients who were operated from colorectal cancer. Results: The types of operations were a Hartmann procedure in 78 patients /38.2%/, colostomy in 58 patients /29.4%%, a type of colectomy with ileo-coloanastomosis in 54 patients /26.5%/ and a standard resection in 14 patients /6.8%/. The following early complications were occurred: anastomotic leakage in 4 patients, wound infections in 5 patients, dehiscence of operative wound in 2 patients. The in-hospital mortality rate was 11.3%.Conclusions: The emergency management of acute left-sided colonic obstruction remains controversial. The one-stage resection anastomosis which could be subtotal colectomy or segmental resection is useful and the preferred choice for low risk patients. Simple colostomy or Hartmann procedure should be re served for high risk patients. Colonic stenting is the best option either for palliation or as a bridge to surgery

Transient jets in V617 Sagittarii

Some of the luminous Compact Binary Supersoft X-Ray sources (CBSS) have shown indications of jets, also called satellites due to their appearance in the spectra. In V Sagittae (V Sge) stars, the galactic counterparts of the CBSS, such features have been reported only for WX Cen. If V Sge stars are indeed the analogs of CBSS, one may expect transient jet emission in other objects of this class. Spectroscopic observations of the V Sge star V617 Sgr have been made, both at high photometric state and at decline. We show that V617 Sgr presents Halpha satellites at high photometric state with velocities of +/-780 km/s. This feature confirms, once more, the CBSS nature of the V Sge stars, however the details of the spectral characteristics also suggest that the two groups of stars display some intrinsic spectroscopic differences, which are likely to be due to a selection effect related to chemical abundance.Comment: Four pages, accepted to be published as a Letter in A&

Orbifold projection in supersymmetric QCD at N_f\leq N_c

Supersymmetric orbifold projection of N=1 SQCD with relatively small number of flavors (not larger than the number of colors) is considered. The purpose is to check whether orbifolding commutes with the infrared limit. On the one hand, one considers the orbifold projection of SQCD and obtains the low-energy description of the resulting theory. On the other hand, one starts with the low-energy effective theory of the original SQCD, and only then perfoms orbifolding. It is shown that at finite N_c the two low-energy theories obtained in these ways are different. However, in the case of stabilized run-away vacuum these two theories are shown to coincide in the large N_c limit. In the case of quantum modified moduli space, topological solitons carrying baryonic charges are present in the orbifolded low-energy theory. These solitons may restore the correspondence between the two theories provided that the soliton mass tends to zero in the large N_c limit.Comment: 10 pages; misprint corrected, reference adde

Nova light curves from the Solar Mass Ejection Imager (SMEI) - II. The extended catalogue

We present the results from observing nine Galactic novae in eruption with the Solar Mass Ejection Imager (SMEI) between 2004 and 2009. While many of these novae reached peak magnitudes that were either at or approaching the detection limits of SMEI, we were still able to produce light curves that in many cases contained more data at and around the initial rise, peak, and decline than those found in other variable star catalogs. For each nova, we obtained a peak time, maximum magnitude, and for several an estimate of the decline time (t2). Interestingly, although of lower quality than those found in Hounsell et al. (2010a), two of the light curves may indicate the presence of a pre-maximum halt. In addition the high cadence of the SMEI instrument has allowed the detection of low amplitude variations in at least one of the nova light curves

Fast Rotation of the N=Z Nucleus 36Ar

A highly-deformed rotational band has been identified in the N=Z nucleus 36Ar. At high spin the band is observed to its presumed termination at I=16+, while at low spin it has been firmly linked to previously known states in 36Ar. Spins, parities, and absolute excitation energies have thus been determined throughout the band. Lifetime measurements establish a large low-spin quadrupole deformation (beta_2=0.46+-0.03) and indicate a decreasing collectivity as the band termination is approached. With effectively complete spectroscopic information and a valence space large enough for significant collectivity to develop, yet small enough to be meaningfully approached from the shell model perspective, this rotational band in 36Ar provides many exciting opportunities to test and compare complementary models of collective motion in nuclei

Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial.

BACKGROUND: The infection of a participant with norovirus during the adaptive study of interleukin-2 dose on regulatory T cells in type 1 diabetes (DILT1D) allowed a detailed insight into the cellular and cytokine immune responses to this prevalent gastrointestinal pathogen. METHODS: Serial blood, serum and peripheral blood mononuclear cell (PBMC) samples were collected pre-, and post-development of the infection. To differentiate between the immune response to norovirus and to control for the administration of a single dose of aldesleukin (recombinant interleukin-2, rIL-2) alone, samples from five non-infected participants administered similar doses were analysed in parallel. RESULTS: Norovirus infection was self-limited and resolved within 24 hours, with the subsequent development of anti-norovirus antibodies. Serum pro- and anti-inflammatory cytokine levels, including IL-10, peaked during the symptomatic period of infection, coincident with increased frequencies of monocytes and neutrophils. At the same time, the frequency of regulatory CD4 + T cell (Treg), effector T cell (Teff) CD4 + and CD8 + subsets were dynamically reduced, rebounding to baseline levels or above at the next sampling point 24 hours later.  NK cells and NKT cells transiently increased CD69 expression and classical monocytes expressed increased levels of CD40, HLA-DR and SIGLEC-1, biomarkers of an interferon response. We also observed activation and mobilisation of Teffs, where increased frequencies of CD69 + and Ki-67 + effector memory Teffs were followed by the emergence of memory CD8 + Teff expressing the mucosal tissue homing markers CD103 and β7 integrin. Treg responses were coincident with the innate cell, Teff and cytokine response. Key Treg molecules FOXP3, CTLA-4, and CD25 were upregulated following infection, alongside an increase in frequency of Tregs with the capacity to home to tissues. CONCLUSIONS: The results illustrate the innate, adaptive and counter-regulatory immune responses to norovirus infection. Low-dose IL-2 administration induces many of the Treg responses observed during infection

Cross-National Analysis of the Associations between Traumatic Events and Suicidal Behavior: Findings from the WHO World Mental Health Surveys

Background Community and clinical data have suggested there is an association between trauma exposure and suicidal behavior (i.e., suicide ideation, plans and attempts). However, few studies have assessed which traumas are uniquely predictive of: the first onset of suicidal behavior, the progression from suicide ideation to plans and attempts, or the persistence of each form of suicidal behavior over time. Moreover, few data are available on such associations in developing countries. The current study addresses each of these issues.Methodology/Principal Findings Data on trauma exposure and subsequent first onset of suicidal behavior were collected via structured interviews conducted in the households of 102,245 (age 18+) respondents from 21 countries participating in the WHO World Mental Health Surveys. Bivariate and multivariate survival models tested the relationship between the type and number of traumatic events and subsequent suicidal behavior. A range of traumatic events are associated with suicidal behavior, with sexual and interpersonal violence consistently showing the strongest effects. There is a dose-response relationship between the number of traumatic events and suicide ideation/attempt; however, there is decay in the strength of the association with more events. Although a range of traumatic events are associated with the onset of suicide ideation, fewer events predict which people with suicide ideation progress to suicide plan and attempt, or the persistence of suicidal behavior over time. Associations generally are consistent across high-, middle-, and low-income countries.Conclusions/Significance This study provides more detailed information than previously available on the relationship between traumatic events and suicidal behavior and indicates that this association is fairly consistent across developed and developing countries. These data reinforce the importance of psychological trauma as a major public health problem, and highlight the significance of screening for the presence and accumulation of traumatic exposures as a risk factor for suicide ideation and attempt.African and African American StudiesPsycholog